71
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

ALTERED DE NOVO SPHINGOLIPID BIOSYNTHESIS IS INVOLVED IN THE SERUM DEPRIVATION-INDUCED CELL DEATH IN LLC-PK1 CELLS

, , , , , , , , & show all
Pages 2085-2094 | Published online: 12 Aug 2010

REFERENCES

  • Bondy , G. S. , Suzuki , C. A. , Mueller , R. W. , Fernie , S. M. , Armstrong  , C. L. , Hierlihy , S. L. , Savard , M. E. and Barker , M. G. 1998 . Gavage administration of the fungal toxin fumonisin B1 to female Sprague-Dawley rats . J. Toxicol. Environ. Health A , 53 : 135 – 151 .
  • Bornfeldt , K. E. , Graves , L. M. , Raines , E. W. , Igarashi , Y. , Wayman , G. , Yamamura , S. , Yatomi , Y. , Sidhu , J. S. , Krebs , E. G. , Hakomori , S. and Ross , R. 1995 . Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: Spatial and temporal modulation of PDGF chemotactic signal transduction . J. Cell Biol. , 130 : 193 – 206 .
  • Cifone , M. G. , Maria , R. , Roncaioli , P. , Rippo , M. R. , Azuma , M. , Lanier , L. L. , Santoni , A. and Testi , R. 1994 . Apoptotic signaling through CD95(Fas/Apo-1) activates an acidic sphingomyelinase . J. Exp. Med. , 180 : 1547 – 1552 .
  • Dobrowsky , R. T. , Kamibayashi , C. , Mumby , M. C. and Hannun , Y. A. 1993 . Ceramide activates heterotrimeric protein phoshatase 2A . J. Biol. Chem. , 268 : 15523 – 15530 .
  • Ferrari , G. , Batistatou , A. and Greene , L. A. 1993 . Gangliosides rescue neuronal cells from death after trophic factor deprivaton . J. Neurosci. , 13 : 1879 – 1887 .
  • Haimovitz-Friedman , A. , Kan , C. C. , Ehleiter , D. , Persaud , R. S. , McLoughlin , M. , Fuks , Z. and Kolesnick , R. N. 1994 . Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis . J. Exp. Med. , 180 : 525 – 535 .
  • Hannun , Y. A. 1996 . Functions of ceramide in coordinating cellular responses to stress . Science , 274 : 1855 – 1859 .
  • Hannun , Y. A. and Bell , R. M. 1989 . Functions of sphingolipids and sphingolipid breakdown products in cellular regulation . Science , 243 : 500 – 507 .
  • Heinrich , M. , Wickel , M. , Winoto-Morbach , S. , Schneider-Brachert , W. , Weber , T. , Brunner , J. , Saftig , P. , Peters , C. , Kronke , M. and Schutze , S. 2000 . Ceramide as an activator lipid of cathepsin D . Adv. Exp. Biol. , 477 : 305 – 315 .
  • Jacobs , L. S. and Kester , M. 1993 . Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells . Am J. Physiol. , 265 : C740 – C747 .
  • Kolesnick , R. and Golde , D. W. 1994 . The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling . Cell , 77 : 325 – 328 .
  • Kwon , Y. G. , Min , J. K. , Kim , K. M. , Lee , D. J. , Billiar , T. R. and Kim , Y. M. 2001 . Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production . J. Biol. Chem. , 276 : 10627 – 10633 .
  • Li , W. , Riley , R. T. , Voss , K. A. and Norred , W. R. 2000 . Role of proliferation in the toxicity of fumonisin B1: Enhanced hepatotoxic response in the partially hepatectomized rat . J. Toxicol. Environ. Health. A , 60 : 441 – 457 .
  • Lozano , J. , Berra , E. , Municio , M. M. , Diaz-Meco , M. T. , Dominguez , I. , Sanz , L. and Moscat , J. 1994 . Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase . J. Biol. Chem. , 269 : 19200 – 19202 .
  • Merrill , A. H. Jr. , Wang , E. , Vales , T. R. , Smith , E. R. , Schroeder , J. J. , Menaldino , D. S. , Alexander , C. , Crane , H. M. , Xia , J. , Liotta , D. C. , Meredith , F. I. and Riley , R. T. 1996 . Fumonisin toxicity and sphingolipid biosynthesis . Adv. Exp. Med. Biol. , 392 : 297 – 306 .
  • Miyake , Y. , Kozutsumi , Y. , Nakamura , S. , Fujita , T. and Kawasaki , T. 1995 . Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin . Biochem Biophys. Res. Commun. , 211 : 396 – 403 .
  • Muller , G. , Ayoub , M. , Storz , P. , Rennecke , J. , Rabbro , D. and Pfizenmaier , K. 1995 . PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid . EMBO J. , 14 : 1961 – 1969 .
  • Olivera , A. and Spiegel , S. 1993 . Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens . Nature , 365 : 557 – 560. .
  • Riley , R. T. , Voss , K. A. , Yoo , H. S. , Gelderbiom , W. C. A. and Merrill , A. H. Jr. 1994 . Mechanism of fumonisin toxicity and carcinogenesis . J. Food Protect. , 57 : 638 – 645 .
  • Shier. , W. T. , Abbas , H. K. and Mirocha , C. J. 1991 . Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternate f. sp. lycopersici toxin (AAL) in cultured mammalian cells . Mycopathologia , 116 : 97 – 104 .
  • Smith , P. K. , Krohn , R. I. , Hermanson , G. T. , Mallia , A. K. , Gartner , F. H. , Provenzano , M. D. , Fujimoto , E. K. , Goeke , N. M. , Olson , B. J. and Klenk , D. C. 1985 . Measurement of protein using bicinchoninic acid . Anal. Biochem. , 150 : 76 – 85 .
  • Wolff , R. A. , Dobrowsky , R. T. , Bielawska , A. , Obeid , L. M. and Hannun , Y. A. 1994 . Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction . J. Biol. Chem. , 269 : 19605 – 19609 .
  • Yoo , H. S. , Norred , W. P. , Wang , E. , Merrill , A. H. Jr. and Riley , R. T. 1992 . Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells . Toxicol. Appl. Pharmacol. , 114 : 9 – 15 .
  • Yoo , H. S. , Norred , W. P. and Riley , R. T. 1996a . A rapid method for quantifying free sphingoid bases and complex sphingolipids in microgram amounts of cultures cells (LLC-PK1) following exposure to fumonisin B1. . Toxicol. In Vitro. , 10 : 77 – 84 .
  • Yoo , H. S. , Norred , W. P. , Showker , J. and Riley , R. T. 1996b . Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. . Toxicol. Appl. Pharmacol. , 138 : 211 – 218 .
  • Zhang , H. , Desai , N. N. , Olivera , A. , Seki , T. , Brooker , G. and Spiegel , S. 1991 . Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation . J. Cell. Biol. , 114 : 155 – 167 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.