173
Views
0
CrossRef citations to date
0
Altmetric
Case Reports

Polypharmacy and Reversible Drug Induced QT Prolongation in a Patient with Advanced Cancer: Case Report

, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 33-37 | Received 31 Mar 2023, Accepted 15 Dec 2023, Published online: 05 Jan 2024

References

  • Al-Khatib SM, LaPointe NMA, Kramer JM, Califf RM. What clinicians should know about the QT interval.JAMA. 2003;289(16):2120–7. doi:10.1001/jama.289.16.2120.
  • Vandenberk B, Vandael E, Robyns T. Which QT correction formulae to use for QT monitoring? J Am Heart Assoc. 2016;5(6):1–10. doi:10.1161/JAHA.116.003264.
  • Khatib R, Sabir FRN, Omari C, Pepper C, Tayebjee MH. Managing drug-induced QT prolongation in clinical practice. Postgrad Med J. 2021;97(1149):452–8. doi:10.1136/postgradmedj-2020-138661.
  • Gavioli EM, Guardado N, Haniff F, Deiab N, Vider E. The risk of QTc prolongation with antiemetics in the palliative care setting: a narrative review. J Pain Palliat Care Pharmacother. 2021;35(2):125–35. doi:10.1080/15360288.2021.1900491.
  • Mason JW, Moon TE. Use and cardiovascular safety of transdermal and other granisetron preparations in cancer management. Cancer Manag Res. 2013;5(1):179–85. doi:10.2147/CMAR.S34352.
  • Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC. QTc prolongation, torsades de pointes, and psychotropic medications. Psychosomatics. 2013;54(1):1–13. doi:10.1016/j.psym.2012.11.001.
  • Giraud EL, Ferrier KRM, Lankheet NAG, Desar IME, Steeghs N, Beukema RJ, van Erp NP, Smolders EJ. The QT interval prolongation potential of anticancer and supportive drugs: a comprehensive overview. Lancet Oncol. 2022;23(9):e406–e415. doi:10.1016/S1470-2045(22)00221-2.
  • Kim P, Masha L, Olson A, Iliescu C, Karimzad K, Hassan S, Palaskas N, Durand J-B, Leung CH, Lopez-Mattei J, et al. QT prolongation in cancer patients. Front Cardiovasc Med. 2021;8:613625. doi:10.3389/fcvm.2021.613625.
  • Roden DM. Clinical practice. Long-QT syndrome. N Engl J Med. 2008;358(2):169–76. doi:10.1056/NEJMcp0706513.
  • Hardy JR, Bundock D, Cross J, Gibbons K, Pinkerton R, Kindl K, Good P, Philip J. Prevalence of QTc prolongation in patients with advanced cancer receiving palliative care—a cause for concern? J Pain Symptom Manage. 2020;59(4):856–63. doi:10.1016/j.jpainsymman.2019.12.356.
  • Grindrod KA, Nagge J. Simplifying QT prolongation for busy clinicians. Can Fam Physician. 2019;65(4):268–70.
  • Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W, American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the American College of Cardiology Foundation. Prevention of torsade de pointes in hospital settings: A scientific statement from the American heart association and the American college of cardiology foundation. Circulation. 2010;121(8):1047–60. doi:10.1161/CIRCULATIONAHA.109.192704.
  • Cheng JJ, Azizoddin AM, Maranzano MJ, Sargsyan N, Shen J. J. Polypharmacy in Oncology. Clin Geriatr Med. 2022;38(4):705–14. doi:10.1016/j.cger.2022.05.010.
  • Turcotte A, Achi S, Mamlouk O, Mandayam S. Electrolytes disturbances in cancer patients. Curr Opin Nephrol Hypertens. 2022;31(5):425–34. doi:10.1097/MNH.0000000000000819.
  • Fujiki A, Sakabe M. Differences in the slope of the QT-RR relation based on 24-hour Holter ECG recordings between cardioembolic and atherosclerotic stroke. Intern Med. 2016;55(20):2927–32. doi:10.2169/internalmedicine.55.6702.
  • McLean SL, Blenkinsopp A, Bennett MI. Using haloperidol as an antiemetic in palliative care: informing practice through evidence from cancer treatment and postoperative contexts. J Pain Palliat Care Pharmacother. 2013;27(2):132–5. doi:10.3109/15360288.2013.782937.
  • Ozeki Y, Fujii K, Kurimoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Ishida N, Horie M, Kunugi H, et al. QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):401–5. doi:10.1016/j.pnpbp.2010.01.008.
  • Jackson CW, Sheehan AH, Reddan JG. Evidence-based review of the black-box warning for droperidol. Am J Health Syst Pharm. 2007;64(11):1174–86. doi:10.2146/ajhp060505.
  • Nykamp DL, Blackmon CL, Schmidt PE, Roberson AG. QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine. Ann Pharmacother. 2005;39(3):543–6. doi:10.1345/aph.1E513.
  • Leppert W. The role of methadone in cancer pain treatment - A review. Int J Clin Pract. 2009;63(7):1095–109. doi:10.1111/j.1742-1241.2008.01990.x.
  • Kreutzwiser D, Tawfic QA. Methadone for pain management: a pharmacotherapeutic review. CNS Drugs. 2020;34(8):827–39. doi:10.1007/s40263-020-00743-3.
  • Yamanaka E, Chino S, Takasusuki T, Hamaguchi S, Yamaguchi S. Effect of Methadone on cardiac repolarization in Japanese cancer patients: A longitudinal study. Cardiol Ther. 2020;9(1):119–26. doi:10.1007/s40119-019-00156-4.
  • Lovell AG, Protus BM, Saphire ML, Kale SS, Lehman A, Hartman A. Evaluation of QTc interval prolongation among patients with cancer using enteral methadone. Am J Hosp Palliat Care. 2019;36(3):177–84. doi:10.1177/1049909118811904.
  • McCance-Katz EF. (R)-methadone versus racemic methadone : what is best for patient care? Addiction. 2011;106(4):687–8. doi:10.1111/j.1360-0443.2011.03374.x.
  • Ansermort N, Albayrak O, Schlapfer J. Substitution of (R,S)-methadone by (R)-methadone: impact on QTc interval. Arch Intern Med. 2010;170(6):529–36.
  • McPherson ML, Walker KA, Davis MP, Bruera E, Reddy A, Paice J, Malotte K, Lockman DK, Wellman C, Salpeter S, et al. Safe and appropriate use of methadone in hospice and palliative care: expert consensus white paper. J Pain Symptom Manage. 2019;57(3):635–45.e4. doi:10.1016/j.jpainsymman.2018.12.001.
  • Bertschy G, Eap CB, Powell K, Baumann P. Fluoxetin addition to methadone in addicts: pharmacokinetics aspects. Ther Drug Monit. 1996;18(5):570–2. doi:10.1097/00007691-199610000-00008.
  • Deodhar M, Rihani SBA, Darakjian L, Turgeon J, Michaud V. Assessing the mechanisms of fluoxetine-mediated CYP2D6 inhibition. Pharmaceutics. 2021;13(2):148. doi:10.3390/pharmaceutics13020148.
  • Woosley RL, Heise CW, Gallo T, et al. www.CredibleMeds.org., QTdrugs List; 2023. [last accessed March 13, 2023].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.