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Toxicology Mechanisms and Methods Volume 13, 2003 - Issue 3
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Research Article

The Toxicokinetics of Cyanide and Mandelonitrile in the Horse and Their Relevance to the Mare Reproductive Loss Syndrome

Levent Dirikolu Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Charlie Hughes Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Dan Harkins Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Jeff Boyles Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Jeff Bosken Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Fritz Lehner Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Amy Troppmann Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Karen McDowell Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Thomas Tobin Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA
,
Manu M. Sebastian Livestock Disease Diagnostic Center, University of Kentucky, Lexington, Kentucky, USA
,
Lenn Harrison Livestock Disease Diagnostic Center, University of Kentucky, Lexington, Kentucky, USA
,
James Crutchfield Department of Agronomy, University of Kentucky, Lexington, Kentucky, USA
,
Steven I. Baskin Pharmacology Division, U. S. Army Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland, USA
&
Terrence D. Fitzgerald Department of Biological Sciences, State University of New York, Cortland, New York, USA
 show all
Pages 199-211 | Published online: 30 Sep 2008

  • Baud, F. J., Harriot, P., Toffis, V, Riou, B., Vicaut, E., Lecarpentier, Y, Bourdon, R., Astier, A., and Bismuth, C. 1991. Elevated blood cyanide concentrations in victims of smoke inhalation. N. Engl. J. Med. 325:1761-1766.
  • Benet, L. Z., and Zia-Amirhosseini, P. 2002. Basic principles of pharmacoki- netics. Toxicol. Pathol. 23:115-123.
  • Borowitz, J. L., Isom, G. E., and Baskin, S. 1.2001. Acute and chronic cyanide toxicity. In Chemical Warfare Agents: Toxicity at Low Levels, ed. S. Somani and J. Romano, 301-319. CRC Press.
  • Combie, J., Doughtery, J., Nugent, E., and Tobin, T. 1979. The pharmacology of narcotic analgesics in the horse. IV. Dose- and time-response relationships for behavioral responses to morphine, meperidine, pentazocine, anileridine, methadone, and hydromcnphone. J. Equine Med. Surg. 3:377-385.
  • Delaney, K. A. Cyanide 2001. In Clinical Toxicology, ed. M. D. Ford, K. A. Delaney, L. J. Ling, and T. Erickson, 705-711. Philadelphia: W. B. Saunders.
  • Doherty, P. A., Perm, V. H., and Smith, R. P. 1982. Congenital malformations induced by infusion of sodium cyanide in the golden hampster. Toxicol. Appl. Pharmacol. 64:456-464.
  • Dominick, M. A., and Carson, T. L. 1983. Effects of carbon monoxide exposure on pregnant sows and their fetuses. Am. J. Vet. Res. 44:35-40.
  • Fitzgerald, T. D., Jeffers, P. M., and Mantella, D. 2002. Depletion of host-derived cyanide in the gut of the eastern tent caterpillar, Malacosoma americanum. J. Chem. Ecol. 28:257-268.
  • Gibaldi, M., and Perrier, D. 1982. Pharmocokinetics, 281-282,409-417. New York: Marcel Dekker.
  • Hughes, C, Lehner, F., Dirikolu, L., Harkins, D., Boyles, J., McDowell, K., Tobin, T., Crutchfield, J., Sebastian, M., Harrison, L, and Baskin, S. I. 2003. A simple and highly sensitive spectrophotometric method for determination of cyanide in equine blood. Toxicol. Mech. Methods 13:2:129-138.
  • Kage, S., Takeaki, N., and Kudo, K. 1996. Determination of cyanide in biological fluids by micro-diffusion analysis. J. Lab. Clin. Med. 44:166-170.
  • Kane, E., and Kirby, E. 2001. Death in bluegrass. Equus 287:60-68.
  • Martinez, M. N. 1998. Noncompartmental methods of drug characterization: statistical moment theory. J. Amer. Vet. Med. Assoc. 213:974-980.
  • McGorum, B. C., and Kirk, J. 2001. Equine disautonomia (grass sickness) is associated with altered plasma amino acid levels and depletion of plasma sulfur amino acids. Equine Vet. J. 33:473-477.
  • Meiser, H., Hagedorn, H. W., and Schultz, S. 2000. Development of a method for determination of cyanide concentrations in serum and rumen fluid of cattle. Am. J. Vet. Res. 61:658-664.
  • Morse, F. W., and Howard, C. D. 1898. Poisonous properties of wild cherry leaves. New Hampshire College Agriculture Experiment Station 56:112-123.
  • Naulty, J., Cefalo, R. C., and Lewis, P. E. 1981. Fetal toxicity of nitroprusside in the pregnant ewe. Am. J. Obstet. Gynecol. 139:708-711.
  • Riddle, W. T. 2002. Clinical observations associated with early fetal loss in mare reproductive loss syndrome during the 2001 and 2002 breeding seasons. In Proceedings of the First Workshop on Mare Reproductive Loss Syndrome, eds. D. Powell, A. Troppmann, and T. Tobin, 12-14. Kentucky Agricultural Experimental Station: University of Kentucky.
  • Seigler, D. S., and Brinker, A. M. 1993. Characterisation of cyanogenic glycosides, cyanolipids, nitroglycosides, organic nitro compounds and nitrile glucosides from plants. In Methods in Plant Biochemistry, Vol. 8, Alkaloids and Sulphur Compounds, ed. P. G. Waterman, 51-131. London: Academic Press.
  • Smeathers, D. M., Gray, E., and James, J. H. 1975. Hydrocyanic acid potential of black cherry leaves as influenced by aging and drying. Agron. J. 65:775-777.
  • Soliman, T. 1948. A Manual of Pharmacology and its Applications to Therapeutics and Toxicology. 1948 Philadelphia: W. B. Saunders.
  • Suhonen, J., Hartiala, K., Tuominen-Gustafsson, H., and Viljanen, M. K. 2000. Borrelia burgdorferi-indnced oxidative burst, calcium mobilization, and phagocytosis of human neutrophils are complement dependent. J. Infect. Dis. 181:195-202.
  • Vetter, J. 2000. Plant cyanogenic glycosides. Toxicon 38:11-36.
  • Witonsky, S. G., Grubbs, S. T., and Andrews, F. M. 2001. A case of red maple (Acer rubrum) toxicity associated with fallen branches. Equine Vet. Educ. 3:163-167.
  • Way, J. L. 1984. Cyanide intoxication and its mechanism of antagonism. Ann. Rev. Pharmacolo. Toxicol. 24:451-481.
  • Yamaoka, K., Nakagava, T., and Uno, T. 1978. Statistical moments in pharma- cokinetics. J. Pharmacokinet. Biopharmaceut. 6:547-558.

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