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Research Article

New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate Paraoxon

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Pages 401-408 | Received 01 Jul 2006, Accepted 01 Nov 2006, Published online: 09 Oct 2008

REFERENCES

  • Alston T. A. Pralidoxime rescues both muscarinic and nicotinic systems. Anesth. Analg. 2005; 101: 926–927
  • Bajgar J. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv. Clin. Chem. 2004; 38: 151–216
  • Buckley N., Eddleston M., Szinicz L. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst. Rev. 2005; 1: CD005085
  • Cox D. R. Regression models and life tables. J.R. Statist. Soc. B 1972; 34: 189–220
  • Dart R. C., Goldfrank L. R., Chyka P. A., Lotzer D., Woolf A. D., McNally J., Snodgrass W. R., Olson K. R., Scharman E., Geller R. J., Spyker D., Kraft M., Lipsy R. Combined evidence-based literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann. Emerg. Med. 2000; 36: 126–132
  • Eddleston M., Szinicz L., Eyer P., Buckley N. Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. QJM. 2002; 95: 275–283
  • Hagedorn I. US Patent. 1974; 3852294
  • Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J. Toxicol. Clin. Toxicol. 2002; 6: 803–816
  • Kuča K., Bielavský J., Cabal J., Bielavska M. Synthesis of a potential reactivator of acetylcholinesterase–1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium)-propane dibromide. Tetrahedron Lett. 2003a; 44: 3123–3125
  • Kuča K., Bielavský J., Cabal J., Kassa J. Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase. Bioorg. Med. Chem. Lett. 2003b; 13: 3545–3547
  • Kuča K., Cabal J., Patočka J., Kassa J. Synthesis of bisquaternary symmetric bis (2-hydroxyiminomethylpyridinium) alkane dibromides and their reactivation of cyclosarin-inhibited acetylcholinesterase. Lett. Org. Chem. 2004; 1: 84–86
  • Kuča K., Jun D., Musilek K. Structural requirements for acetylcholinesterase reactivators. Mini Rev. Med. Chem. 2006; 6: 269–277
  • Levine R. Recognized and possible effects of pesticides in humans. Handbook of Pesticide Toxicology, General Principles 1991; 1: 275–360, Hayes, W. J., and Laws, E. R. (Eds.), Academic Press, San Diego
  • Luettringhaus A., Hagedorn I. Quaternary hydroxy-iminomethylpyridinium salts. The dischloride of bis-(4-hydroxyiminomethyl-1-pyridinium-methyl)-ether (lueh6), a new reactivator of acetylcholinesterase inhibited by organic phosphoric acid esters. Arzneimittelforschung 1964; 14: 1–5
  • Musilek K., Holas O., Kuka K., Jun D., Dohnal V., Dolezal M. Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorg. Med. Chem. Lett. 2006; 16(21)5673–5676, Nov 1
  • Namba T. Cholinesterase inhibition by organophosphorus compounds, and its clinical effects. Bull. WHO 1971; 44: 289–307
  • Namba T., Nolte C. T., Jackrel J., Grob D. Poisoning due to organophosphate insecticides: acute and chronic manifestations. Am. J. Med. 1971; 50: 457–492
  • Peter J. V., Cherian A. M. Organic insecticides. Anaesth. Intensive Care 2000; 28: 11–21
  • Peter V., Moran J. L., Graham P. Oxime therapy and outcomes in human organophosphate poisoning: An evaluation using meta-analytic techniques. Crit. Care Med. 2006; 34: 502–510
  • Petroianu G., Hardt F., Toomes M., Bergler W., Rüfer R. High-dose intravenous paraoxon exposure does not cause organophosphate induced delayed neuropathy (OPIDN) in mini pigs. J. Appl. Toxicol 2001; 21: 263–268
  • Petroianu G., Toomes L. M., Petroianu A., Bergeler W., Rüfer R. Control of blood pressure, heart rate and haematocrit during high-dose intravenous paraoxon exposure in mini pigs. J. Appl. Toxicol. 1998; 18: 293–298
  • Petroianu G. A., Nurulain S. M., Nagelkerke N., Al-Sultan M. A., Kuca K., Kassa J. Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon. J. Appl. Toxicol. 2006; 26: 262–268
  • Poziomek E. J., Hackley B. E., Steinberg G. M. Pyridinium aldoximes. J. Organic Chem. 1958; 23: 714–717
  • Thompson C. M., Richardson R. J. Anticholinesterase insecticides. Pesticide Toxicology and International Regulation (Current Toxicology Series), T. C. Marrs, B. Ballantyne. John Wiley & Sons Ltd, Chichester 1970; 89–127
  • Wiener S. W., Hoffman R. S. Nerve agents: a comprehensive review. J. Intensive Care Med. 2004; 19: 22–37
  • Wilson I. B., Ginsburg S. A powerful reactivator of alkylphosphate. Biochim. Biophys. Acta. 1955; 18: 168–170
  • Zoch E. Die Wirkung organischer Phosphorsäureester bzw. Phosphorsäureesterauf versch. Enzyme. Arzneim. Forschung 1971; 21: 181–187

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