Panmasala Chewing Induces Deterioration in Oral Health and Its Implications in Carcinogenesis

REFERENCES

• R. C. Agarwal, A. V. Sarode, and S. V. Bhide. 1986. Histopathology of hamster cheek and liver following topical application of lime. Indian J. Med. Res 84:542–547.
   PubMed Web of Science ®Google Scholar
• C. D. Anuradha, and C. S. S. Devi. 1993. Serum protein, ascorbic acid & iron & tissue collagen in oral submucous fibrosis—a preliminary study. Indian J. Med. Res 98:147–151.
   PubMed Web of Science ®Google Scholar
• C. D. Anuradha, and C. S. S. Devi. 1995. Studies on hematological profile and trace elements in OSMF. J. Clin. Biochem. Nutrit 19:9–17.
   Web of Science ®Google Scholar
• S. Babu, R. V. Bhat, P. U. Kumar, B. Sasikaran, K. V. Rao, P. Aruna, and P. R. Reddy. 1996. A comparative clinico-pathological study of oral submucous fibrosis in habitual chewers of panmasala and betelquid. J. Toxicol. Clin. Toxicol 34:317–322.
   PubMed Web of Science ®Google Scholar
• M. Bagchi, J. Balmoori, D. Bagchi, S. J. Stohs, J. Chakrabarti, and D. K. Das. 2002. Role of reactive oxygen species in the development of cytotoxicity with various forms of chewing tobacco and panmasala. Toxicology 15:247–255.
   Google Scholar
• A. Baker, S. Gormally, R. Saxena, D. Baldwin, B. Drumm, J. Bonahm, B. Portmann, and A. P. Mowat. 1995. Copper associated liver disease in childhood. J. Hepatol 23:538–543.
   PubMed Web of Science ®Google Scholar
• P. Balaram, H. Sridhar, T. Rajkumar, S. Vaccarella, R. Herrero, A. Nandakumar, K. Ravichandran, K. Ramdas, R. Sankaranarayanan, V. Gajalakshmi, N. Munoz, and S. Franceschi. 2002. Oral cancer in southern India: the influence of smoking, drinking, paan-chewing and oral hygiene. Int. J. Cancer 98:440–455.
   PubMed Web of Science ®Google Scholar
• A. Banerjee, A. Pakrashi, S. Chatterjee, S. Ghosh, and S. K. Dutta. 1993. Semen characteristics of tobacco users in India. Arch. Androl 30:35–40.
   PubMed Web of Science ®Google Scholar
• R. A. Bhisey, A. G. Ramachandani, A. V. D'Souza, A. M. Borges, and P. N. Notani. 1999. Long-term carcinogenicity of panmasala in Swiss mice. Int. J. Cancer 83:79–84.
   Web of Science ®Google Scholar
• R. S. Britton. 1996. Metal induced hepatotoxicity. Semin. Liver Dis. 16:3–12.
   PubMed Web of Science ®Google Scholar
• J. P. Canniff, and W. Harvey. 1981. Aetiology of oral submucous fibrosis: the stimulation of collagen synthesis by extracts of arecanut. Int. J. Oral Surg. 10 (suppl 1):163–167.
   PubMedGoogle Scholar
• K. W. Chang, T. C. Lee, W. I. Yeh, M. Y. Chung, C. J. Liu, L. Y. Chi, and S. C. Lin. 2004. Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br. J. Cancer 91:1551–1555.
   PubMed Web of Science ®Google Scholar
• Y. C. Chang, C. C. Hu, Th. Tsang, K. W. Tai, C. K. Lii, and M. Y. Chou. 2001. Synergistic effects of nicotine on arecoline induced cytotoxicity in human buccal mucosal fibroblasts. J. Oral Pathol. Med. 30:458–464.
   PubMed Web of Science ®Google Scholar
• A. Chatterjee, and S. Deb. 1999. Genotoxic effect of arecoline given either by peritoneal or oral route in murine bone marrow cells and the influence of N-acetylcysteine. Cancer Lett. 139:23–31.
   PubMed Web of Science ®Google Scholar
• K. Chaudhry. 1999. Is panmasala-containing tobacco carcinogenic?. Natl. Med. J. India 12:21–27.
   PubMed Web of Science ®Google Scholar
• H.-M. Chen, R.-P. Hsieh, H. Yang, Y.-S. Kuo, M. Yen-Ping Kuo, and C.-P. Chiang. 2004. HLA typing in Taiwanese patients with oral submucous fibrosis. J. Oral Pathol. Med. 33:191–199.
   PubMed Web of Science ®Google Scholar
• C.-J. Chiu, M.-L. Chang, C.-P. Chiang, L.-J. Hahn, L.-L. Hsieh, and C.-J. Chen. 2002. Interaction of collagen-related genes and susceptibility to betelquid-induced oral submucous fibrosis. Cancer Epidemiol. Biomarkers Prevent. 11:646–665.
   PubMed Web of Science ®Google Scholar
• A. G. Christen. 1970. The clinical effect of tobacco on oral tissue. J. Am. Dental Assoc. 81:284–286.
   Web of Science ®Google Scholar
• S. Cox. 2000. Oral cancer in Australia—risk factors and disease distribution. Ann. Australas. Coll. Dent. Surg. 15:261–263.
   Google Scholar
• B. J. Dave, A. H. Trivedi, and A. G. Adhvaryu. 1991. Cytogenetic studies reveal increased genomic damage among panmasala consumers. Mutagenesis 6:159–163.
   PubMed Web of Science ®Google Scholar
• R. Doll. 1986. Tobacco: an overview of health effects. IARC Sci. Publ. 74:11–22.
   Google Scholar
• L. J. Dunham, C. S. Muir, and J. J. E. Hamner. 1966. Epithelial atypia in hamster cheek pouches treated repeatedly with calcium hydroxide. Br. J. Cancer 20:588–593.
   PubMed Web of Science ®Google Scholar
• L. J. Dunham, R. H. Shhets, and J. F. Morton. 1974. Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherlands Antilles. J. Natl. Cancer Inst. 53:1259–1269.
   PubMedGoogle Scholar
• P. Farrand, R. M. Rowe, A. Johnson, and H. Murdoch. 2001. Prevalence, age of onset and demographic relationship of different areca nut habit amongst children in Tower Hamlets, London. Br. Dent. J. 190:150–154.
   PubMed Web of Science ®Google Scholar
• C. L. Gaworski, M. M. Dozier, J. M. Gerhart, N. Rajendran, L. H. Brennecke, C. Aranyi, and J. D. Heck. 1997. 13-week inhalation toxicity study of menthol cigarette smoke. Food Chem. Toxicol. 35:683–692.
   PubMed Web of Science ®Google Scholar
• P. C. Gupta, and C. S. Ray. 2003. Smokeless tobacco and health in India and South Asia. Respirology 8:419–431.
   PubMed Web of Science ®Google Scholar
• P. C. Gupta, and C. S. Ray. 2004. Epidemiology of Betel quid usage. Ann. Acad. Med. Singapore 33 (Suppl.):31–36.
   PubMedGoogle Scholar
• W. Harvey, A. Scutt, S. Meghji, and J. P. Caniff. 1986. Stimulation of human buccal mucosa fibroblast in vitro by betel nut alkaloids. Arch. Oral Biol. 3:45–49.
   Google Scholar
• S. Hasim, V. S. Aboobaker, R. Madhubala, R. K. Bhattacharya, and A. R. Rao. 1994. Modulatory effects of essential oils from spices on the formation of DNA adduct by aflatoxin B1 in vitro. Nutr. Cancer 21:169–175.
   PubMed Web of Science ®Google Scholar
• IARC. 1985. Monograph on evaluation of carcinogenic risk of chemical to human: Tobacco habits other than smoking: Betel quid and areca nut chewing and some related nitrosamine. IARC 37:141–200.
   Google Scholar
• IARC. 2004. Monograph on evaluation of carcinogenic risk of chemical to human: Betel quid and areca nut chewing. IARC 85:39–48.
   Google Scholar
• R. J. Jaju, R. K. Patrel, S. R. Bakshi, A. H. Trivedi, B. J. Dave, and S. G. Adhvaryu. 1992. Chromosome damaging effects of panmasala. Cancer Lett. 65:221–226.
   PubMed Web of Science ®Google Scholar
• A. Jayadeep, P. K. Raveendran, S. Kannan, K. R. Nalinakumari, B. Mathew, M. KrishnanNair, and V. P. Menon. 1997. Serum levels of copper, zinc, iron and ceruplasmin in oral leukoplakia and squamous cell carcinoma. J. Exp. Clin. Cancer Res. 16:295–300.
   PubMed Web of Science ®Google Scholar
• P. Jayashankar, P. V. Mohanan, and K. Rathinam. 1997. Hepatoprotective activity of ethyl acetate extract of Acacia catachu. Indian. J. Pharmacol. 29:426–428.
   Google Scholar
• N. W. Johnson, and C. Bain. 2000. Tobacco and oral disease. EU-working group on tobacco and oral health. Br. Dent. J. 189:200–206.
   PubMed Web of Science ®Google Scholar
• A. Kanan, D. Mukul, and S. K. Khanna. 1997. Estimation of menthol in panmasala samples by a specttrophotometric method. Food Addit. Contam. 14:367–371.
   PubMedGoogle Scholar
• R. D. Khrime, Y. N. Mehra, S. B. S. Mann, S. K. Mehta, and R. N. Chakraborty. 1991. Effect of instant preparation of betelnut (panmasala) on the oral mucosa of albino rats. Indian J. Med. Res. 94:119–124.
   PubMedGoogle Scholar
• S. Kumar, and H. N. Saiyed. 1999. Role of betel nut chewing in cancer its toxicity and chemo prevention-an over view. Indian J. Environ. Toxicol. 9:5–11.
   Google Scholar
• S. Kumar, K. Chaudhury, and H. N. Saiyed. 2006a. Occupational cancer. In Cancer Awareness, Prevention and control: Strategies for South Asia-A UICC hand book, UICC in collaboration with Tata Memorial Center, Indian Council of Medical Research and Indian Cancer Society, Geneva, Switzerland. 96–115.
   Google Scholar
• S. Kumar, S. K. Nigam, A. Shagufta, and H. N. Saiyed. 2003. Effect of Pan masala (a chewing material) on sperm morphology of mouse. Bull. Environ. Contam. Toxicol. 70:1184–1188.
   PubMedGoogle Scholar
• S. Kumar, G. Parmar, and H. N. Saiyed. 2004. Nut and tobacco chewing. Br. Dent. J. 197:292.
   PubMed Web of Science ®Google Scholar
• S. Kumar, G. Parmar, and H. N. Saiyed. 2006b. Plenary lecture on Areca nut and tobacco chewing and health effects—a critical appraisal. International symposium on environmental mutagenesis and public health and XXXI Annual session of Environmental Mutagen Society of India, Hyderabad, India, 23–25 February 2006 (abst).
   Google Scholar
• S. Kumar, R. K. Phukan, and M. Chetia. 1993. Annual report, Regional Medical Research Centre, Dibrugarh, India.
   Google Scholar
• K. Kumpawat, and A. Chatterjee. 2003. The usefulness of cytogenetic parameters, level of p53 protein and endogenous glutathione as intermediate end-points in raw betel—nut genotoxicity. Hum. Exp. Toxicol. 22:363–371.
   PubMed Web of Science ®Google Scholar
• K. C. Lai, and T. C. Lee. 2006. Genetic damage in cultured human keratinocytes stressed by long term exposure to areca nut extracts. Mutat. Res. 599:66–75.
   PubMed Web of Science ®Google Scholar
• R. H. Ma, C. C. Tsai, and T. Y. Sheih. 1995. Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan. J. Oral Pathol. Med. 24:407–413.
   PubMed Web of Science ®Google Scholar
• J. M. MacDougall, K. Fandrick, X. Zhang, S. V. Serafin, and J. R. Cashman. 2003. Inhibition of human liver microsomal (S)-nicotine oxidation by (−)-menthol and analogues. Chem. Res. Toxicol. 16:988–993.
   PubMed Web of Science ®Google Scholar
• R. Maher, P. Aga, N. W. Johnson, R. Sankaranaryanan, and S. Warnakulasuriya. 1997. Evaluation of multiple micronutrient supplementations in the management of oral submucous fibrosis in Karachi, Pakistan. Nutr. Cancer 27:41–47.
   PubMed Web of Science ®Google Scholar
• S. Meghji, J. P. Caniff, W. Harvey, A. Scott, and D. Phillipson. 1982. Inhibition of collagenase activity by areca nut tannins: a mechanism of collagen accumulation in oral submucous fibrosis (abstract no 89). J. Dent. Res. 61:545.
   Web of Science ®Google Scholar
• S. P. Misra, V. Misra, M. Dwivedi, and S. C. Gupta. 1998. Oesophageal subepithelial fibrosis: an extension of oral submucosal fibrosis. Postgrad. Med. J. 74:733–736.
   PubMed Web of Science ®Google Scholar
• A. Mukherjee, and A. K. Giri. 1991. Sister chromatid exchange induced by ‘panmasala (a betel quid ingredient) in male mice in vivo. Food Chem. Toxicol. 29:401–403.
   PubMed Web of Science ®Google Scholar
• A. Mukherjee, J. Chakraborti, A. Chakraborti, J. Banerjee, and A. Sharma. 1991. Effect of panmasala on the germ cells of male mice. Cancer Lett. 58:161–165.
   PubMed Web of Science ®Google Scholar
• M. Nagabhushan, and S. V. Bhide. 1988. Anti-mutagenicity of catechin against environmental mutagens. Mutagenesis 3:293–296.
   PubMed Web of Science ®Google Scholar
• U. Nair, H. Bartsch, and J. Nair. 2004. Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and panmasala: a review of agents and causative mechanisms. Mutagenesis 19:251–262.
   PubMed Web of Science ®Google Scholar
• U. Nair, M. Friesen, I. Richard, R. Maclennan, S. Thomas, and H. Bartsch. 1990. Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro. Carcinogenesis 11:2145–2148.
   PubMed Web of Science ®Google Scholar
• U. Nair, H. Ohshima, C. Malaveille, M. Friesen, I. K. O'Neill, A. Hautefeuille, and H. Bartsch. 1986. Identificatioin, occurrence and mutagenicity in Salmonella typhimurium of two synthetic nitroarenes, musk ambrette and musk xylene, in Indian chewing tobacco and betel quid. Food Chem. Toxicol. 24:27–31.
   PubMed Web of Science ®Google Scholar
• B. S. Nelson, and B. Heischober. 1999. Betel nut: a common drug used bynaturalized citizens from India, Far East Asia and the South Pacific Islands. Ann. Emerg. Med. 34:238–243.
   PubMed Web of Science ®Google Scholar
• S. K. Nigam, A. Kumar, S. A. Sheikh, and H. N. Saiyed. 2001. Toxicological evaluation of panmasala in pure inbred Swiss mice a preliminary report on long exposure study. Curr. Sci. 80:1306–1309.
   Web of Science ®Google Scholar
• S. R. Pai, A. J. Shirke, and S. V. Gothoskar. 1981. Long term feeding study in C 17 mice administered Saccharia coat betel-nut and 1,4 dinitrosopiperazine in combination. Carcinogenesis 2:175–177.
   PubMed Web of Science ®Google Scholar
• G. B. Panigrahi, and A. R. Rao. 1982. Chromosome breaking ability of arecoline, a major betel nut alkaloid, in mouse bone marrow cells in vivo. Mutat. Res. 122:347–353.
   Google Scholar
• G. B. Panigrahi, and A. R. Rao. 1983. Influence of caffeine on arecoline induced SCE in bone-marrow cells in vivo. Mutat. Res. 103:347–353.
   Google Scholar
• G. B. Panigrahi, and A. R. Rao. 1984. Induction of in vivo sister chromatid exchange by arecaidine a betel nut alkaloid, in mouse bone marrow cells. Cancer Lett. 23:189–192.
   PubMed Web of Science ®Google Scholar
• G. Parmar. 2005. Role of areca nut and panmasala chewing in causation of oral disease in human. PhD thesis, Gujarat University, Ahmedabad.
   Google Scholar
• R. K. Patel, R. J. Jaju, S. R. Bakshi, A. H. Trivedi, B. J. Dave, and S. G. Adhvaryu. 1994a. Panmasala—a genotoxic menace. Mutat. Res. 320:245–249.
   PubMedGoogle Scholar
• R. K. Patel, A. H. Trivedi, R. J. Jaju, S. G. Adhvaryu, and D. B. Balar. 1994b. Ethanol potentiates the clastogenicity of panmasala—an in vitro experience. Carcinogenesis 15:2017–2021.
   PubMed Web of Science ®Google Scholar
• R. K. Patel, A. H. Trivedi, R. J. Jaju, M. S. Kukreti, J. M. Bhatavdekar, P. M. Shah, and D. D. Patel. 1998a. Protection from panmasdala induced genomic damage by beta-carotene and retionic acid—an in vitro experience. Neoplasma 45:169–175.
   PubMed Web of Science ®Google Scholar
• R. K. Patel, A. H. Trivedi, S. K. Roy, J. M. Bhatavdekar, P. M. Shah, and D. D. Patel. 1998b. Influence of alpha-tocopherol and ascorbic acid on panmasala induced genomic damage. An in vitro experiment. J. Exp. Clin. Cancer Res. 17:419–424.
   PubMed Web of Science ®Google Scholar
• P. E. Peterson. 2003. Tobacco and oral health—the role of World Health Organization. Oral Health Prev. Dent. 1:309–315.
   PubMedGoogle Scholar
• K. Polasa, S. Babu, and I. S. Shenolikar. 1993. Dose-dependent genotoxic effect of panmasala and areca nut in the Salmonella typhimurium assay. Food Chem. Toxicol. 31:439–442.
   PubMed Web of Science ®Google Scholar
• A. G. Ramchandani, A. V. D’ Souza, A. M. Borges, and R. A. Bhisey. 1998. Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, panmasala in mouse skin, stomach and oesophagus. Int. J. Cancer 75:225–232.
   PubMed Web of Science ®Google Scholar
• K. K. Ranadive, S. V. Gothoskar, A. R. Rao, B. U. Tazebwalla, and R. Y. Ambaye. 1976. Experimental studies on betel-nut and tobacco carcinogenicity. Int. J. Cancer 24:835–843.
   Google Scholar
• K. Ranganathan, M. U. Deci, E. Joshua, K. KiranKumar, and T. R. Saraswathi. 2004. Oral submucous fibrosis: a case-control study in Chennai, South India. J. Oral Pathol. Med. 33:274–277.
   PubMed Web of Science ®Google Scholar
• A. R. Rao. 1984. Modifying influences of betel-quidingredients on B(a)P induced carcinogenesis in the buccal pouch of hamster. Int. J. Cancer 33:581–586.
   PubMed Web of Science ®Google Scholar
• A. R. Rao, and P. Das. 1989. Evaluation of the carcinogenicity of different preparations of arecanut in mice. Int. J. Cancer 43:428–432.
   PubMed Web of Science ®Google Scholar
• D. Ray, Kh. Sharatchaandra, and I. S. Thokchom. 2006. Antipyretic, antidiarrhoeal, hypoglycaemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu Willd in albino rats. Indian J. Pharmacol. 38:408–413.
   Google Scholar
• J. Reibel. 2003. Tobacco and oral diseases: an update on the evidence, with recommendations. Med. Princ. Pruct. 12:22–32.
   PubMed Web of Science ®Google Scholar
• P. A. Reichart, and H. P. Philipsen. March, 2006. Oral submucous fibrosis in a 31-year-old Indian woman: first case report from Germany. Mund Kiefer Gesichtschir. 10:192–196. (in German)
   PubMedGoogle Scholar
• A. Rivenson, D. Hoffmann, B. Prolopczyk, S. Amin, and S. S. Hecht. 1988. Induction of lung and exocrine pancreas tumour in F-344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Res. 48:6912–6917.
   PubMed Web of Science ®Google Scholar
• M. P. Rosin. 1984. The influence of pH on the convertogenic activity of plant phenolics. Mutat. Res. 135:109–113.
   PubMedGoogle Scholar
• T. M. Said, G. Ranga, and A. Agarwal. 2005. Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation Fertil. Steril. 84:649–653.
   PubMed Web of Science ®Google Scholar
• R. M. Samarth, M. Panwar, M. Kumar, and A. Kumar. 2006. Protective effects of Mentha piperita Linn on benzo[a]pyrene-induced lung carcinogenicity and mutagenicity in Swiss albino mice. Mutagenesis 21:61–66.
   PubMed Web of Science ®Google Scholar
• A. B. Sarma, J. Chakrabarti, A. Chakrabarti, T. S. Banerjee, D. Roy, D. Mukherjee, and A. Mukherjee. 1992. Evaluation of panmasala for toxic effects on liver and other organs. Food Chem. Toxicol. 30:161–163.
   PubMed Web of Science ®Google Scholar
• S. Sen, G. Talukdar, and A. Sharma. 1988. Unscheduled DNA synthesis in mouse gastric mucosa treated with betel-ingredients. Bionature 8:79–83.
   Google Scholar
• A. Sengupta, S. Ghosh, and S. Bhattacharjee. 2005. Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. Asian Pac. J. Cancer Prev. 6:118–122.
   PubMedGoogle Scholar
• N. Shah, and P. P. Sharma. 1998. Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study. J. Oral Pathol. Med. 27:475–479.
   PubMed Web of Science ®Google Scholar
• R. N. Sharan. 1996. Association of betel nut with carcinogenesis. Cancer J. 9:13–19.
   Web of Science ®Google Scholar
• A. K. Sharma, R. Gupta, H. P. Gupta, and A. K. Singh. 2000. Haemodynamic effects of pan masal a in healthy volunteers. J. Assoc. Physicians India 48:400–401.
   PubMedGoogle Scholar
• L. P. Shirname, M. M. Menon, and S. V. Bhide. 1984. mutagenicity of betel-quid and its ingredients using mammalian test system. Carcinogenesis 5:501–503.
   PubMed Web of Science ®Google Scholar
• L. P. Shirname, M. M. Menon, J. Nair, and S. V. Bhide. 1983. Correlation of mutagenicity and tumorigenicity of betel-quid and its ingredients. Nutr. Cancer 5:87–91.
   PubMedGoogle Scholar
• N. M. Shivapurkar, S. N. Ranadive, S. V. Gothoskar, S. V. Bhide, and K. J. Ranadive. 1980. Tumorigenic effect of aqueous and polyphenolic fractions of betel-nut in Swiss strain mice. Indian J. Exp. Biol. 8:1159–1161.
   Google Scholar
• A. Sinha, and A. R. Rao. 1995. Embryo toxicity of betel nut in mice. Toxicology 37:315–326.
   Google Scholar
• H. F. Stich, and W. Stich. 1982. Chromosome damaging activity of saliva of betel nut and tobacco chewers. Cancer Health 15:193–202.
   Web of Science ®Google Scholar
• H. F. Stich, and S. S. Tsang. 1989. Promoting activity of betel-quid ingredients and their inhibition by retinal. Cancer Lett. 45:71–77.
   PubMed Web of Science ®Google Scholar
• H. F. Stich, A. P. Hornby, B. Mathew, R. Sankaranaryanan, and M. K. Nair. 1988. Response of oral leukoplakia to the administration of vitamin A. Cancer Lett. 40:93–110.
   PubMed Web of Science ®Google Scholar
• K. Sukumaran, and R. Kuttan. 1995. Inhibition of tobacco-induced mutagenesis by eugenol and plant extract. Mutat. Res. 343:25–30.
   PubMed Web of Science ®Google Scholar
• W. J. Suneetha, and T. P. Krishnakantha. 2005. Cardamom extract as inhibitor of human platelet aggregation. Phytother. Res. 19:437–440.
   PubMed Web of Science ®Google Scholar
• C. Sushma, and C. Sharang. 2005. Panmasala advertisements are surrogate for tobacco products. Indian J. Cancer 42:94–98.
   PubMedGoogle Scholar
• T. Tanaka, H. Mori, M. Fujh, M. Takahashi, and I. Hirono. 1983. Carcinogenicity examination of betel quid. 11. Effect of vitamin A deficiency on rats fed semipurified diet containing betel nut and calcium hydroxide. Nutr. Cancer 4:260–266.
   PubMedGoogle Scholar
• A. Taylor. 1996. Detection and monitoring for disorders of essential trace elements. Ann. Clin. Biochem. 33:486–510.
   PubMed Web of Science ®Google Scholar
• S. Thomas, and J. Kearsley. 1993. Betel quid and oral cancer: a review. Eur. J. Cancer B Oral Oncol. 29B:251–255.
   PubMed Web of Science ®Google Scholar
• W. M. Tilakaratne, M. F. Klinikowski, T. Saku, T. J. Peter, and S. Warankulasuriya. 2006. Oral submucous fibrosis: Review on etiology and pathogenesis. Oral Oncol. 42:561–568.
   PubMed Web of Science ®Google Scholar
• S. L. Tomar, and G. A. Giovino. 1998. Incidence and predictors of smokeless tobacco use among U.S. youth. Am. J. Public Health 88:20–26.
   PubMed Web of Science ®Google Scholar
• A. H. Trivedi, R. K. Patel, U. M. Rawal, S. G. Adhvaryu, and D. B. Balar. 1994. Evaluation of chemopreventive effects of betel leaf on the genotoxicity of panmasala. Neoplasma 41:177–181.
   PubMed Web of Science ®Google Scholar
• C. Trivedy, D. Baldwin, S. Warnakalasuriya, N. Johnson, and T. J. Peters. 1997. Copper content in areca catechu (betel nut) products and oral submucous fibrosis. Lancet 349:1447.
   PubMed Web of Science ®Google Scholar
• C. R. Trivedy, G. Craig, and S. Warnaklsuriya. 2002. Areca nut symposium. The oral health consequences of chewing areca nut. Addict. Biol. 7:115–125.
   PubMed Web of Science ®Google Scholar
• C. Trivedy, S. Meghji, K. A. Warnakulsuriya, N. W. Johnson, and M. Harris. 2001. Copper stimulation in oral fibroblast in vitro: a role in pathogenesis of oral submucous fibrosis. J. Oral Pathol. Med. 30:465–470.
   PubMed Web of Science ®Google Scholar
• C. Trivedy, S. Warnakulasuriya, V. K. Hazarey, and N. W. Johnson. 1999. The role of copper in the aetiopathogenesis of oral submucous fibrosis. In: A. K. Verma. Oral oncology IV. McMillan Press, New Delhi, 7–10.
   Google Scholar
• C. Trivedy, K. A. Warnakulasuriya, T. J. Peters, R. Senkus, V. K. Hazarey, and N. W. Johnson. 2000. Raised copper levels in tissue in oral submucous fibrosis. J. Oral Pathol. Med. 29:241–248.
   PubMed Web of Science ®Google Scholar
• K. K. Wary, and R. N. Sharan. 1998. An aqueous extract of betel nut of northeast India induces DNA-strand breaks and enhances rate of cell proliferation in vitro. J. Cancer Res. Clin. Oncol. 114:579–582.
   Google Scholar
• G. Wenke, and D. Hoffmann. 1983. A study of betel-quid carcinoopgenesis I on the in vitro nitrosation of arecoline. Carcinogenesis 3:169–172.
   Google Scholar
• World Health Organization. 2002. The World Health Report 2002. Reducing risk, promoting healthy life, WHO, Geneva, 1–248.
   Google Scholar
• C. G. Yeh. 1997. Fatigue root fracture: a spontaneous root fracture in non-endodontically treated teeth. Br. Dent. J. 182:261–266.
   PubMed Web of Science ®Google Scholar
• X. M. Yin, J. Y. Peng, and Y. J. Gao. 2003. Clinical study on the relationship between tooth abrasion and the habits of chewing betel nut. Hunan Yi Ke Da Xue Xue Bao 28:171–173. (In Chinese)
   PubMedGoogle Scholar
• R. B. Zain, N. Ikeda, P. C. Gupta, K. A. Warnakulasuriya, C. W. van Wyk, P. Shrestha, and T. Axel. 1999. Oral mucosal lesions associated with betel quid, areca nut and tobacco chewing habits: consensus from a workshop held in Kuala Lampur, Malaysia, November 25–27, 1996. J. Oral Pathol. Med. 28:1–4.
   PubMed Web of Science ®Google Scholar