Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis

References

• Abd El-Lateef SM, El-Sayed E-SM, Mansour AM, Salama SA. 2019. The protective role of estrogen and its receptors in gentamicin-induced acute kidney injury in rats. Life Sci. 239:117082. doi:10.1016/j.lfs.2019.117082.
   PubMed Web of Science ®Google Scholar
• Adil M, Kandhare AD, Dalvi G, Ghosh P, Venkata S, Raygude KS, Bodhankar SL. 2016. Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Ren Fail. 38(6):996–1006. doi:10.3109/0886022X.2016.1165120.
   PubMed Web of Science ®Google Scholar
• Aebi H. 1984. Catalase in vitro. Methods Enzymol. 105:121–126. doi:10.1016/s0076-6879(84)05016-3.
   Google Scholar
• Akcakavak G, Kazak F, Yilmaz Deveci MZ (2023) Eucalyptol protects against cisplatin-ınduced liver ınjury in rats. Biol Bull Russ Acad Sci. 50(5):987–994. doi:10.1080/01480545.2022.2156530.
   Web of Science ®Google Scholar
• Akcakavak G, Ozdemır O. 2023. Effect of Tarantula cubensis alcoholic extract on tumour pathways in azoxymethane-induced colorectal cancer in rats. Acta Vet Brno. 92(1):79–88. doi:10.2754/avb202392010079.
   Web of Science ®Google Scholar
• Akyüz E, Makav M, Mushap K, et al. 2021. The effect of Tarantula cubensis extract on gentamicin-induced acute kidney injury in ovariectomized rats. Kafkas Üniv Vet Fak Derg. 27(5):559–566. doi:10.9775/kvfd.2021.25390.
   Web of Science ®Google Scholar
• Aladaileh SH, Hussein OE, Abukhalil MH, Saghir SAM, Bin-Jumah M, Alfwuaires MA, Germoush MO, Almaiman AA, Mahmoud AM. 2019. Formononetin upregulates Nrf2/HO-1 signaling and prevents oxidative stress, inflammation, and kidney injury in methotrexate-induced rats. Antioxidants. 8(10):430. doi:10.3390/antiox8100430.
   Web of Science ®Google Scholar
• Althunibat OY, Abukhalil MH, Aladaileh SH, Qaralleh H, Al-Amarat W, Alfwuaires MA, Algefare AI, Namazi NI, Melebary SJ, Babalghith AO, et al. 2022. Formononetin ameliorates renal dysfunction, oxidative stress, ınflammation, and apoptosis and upregulates Nrf2/HO-1 signaling in a rat model of gentamicin-ınduced nephrotoxicity. Front Pharmacol. 13:916732. doi:10.3389/fphar.2022.916732.
   PubMed Web of Science ®Google Scholar
• Amini FG, Rafieian-Kopaei M, Nematbakhsh M, et al. 2012. Ameliorative effects of metformin on renal histologic and biochemical alterations of gentamicin-induced renal toxicity in Wistar rats. J Res Med Sci. 17(7):621–625.
   PubMed Web of Science ®Google Scholar
• Aurelien-Cabezas NS, Paz-Michel BA, Jacinto-Cortes I, Delgado-Enciso OG, Montes-Galindo DA, Cabrera-Licona A, Zaizar-Fregoso SA, Paz-Garcia J, Ceja-Espiritu G, Melnikov V, et al. 2023. Protective effect of neutral electrolyzed saline on gentamicin-ınduced nephrotoxicity: evaluation of histopathologic parameters in a murine model. Medicina. 59(2):397. doi:10.3390/medicina59020397.
   PubMedGoogle Scholar
• Balaha MF, Alamer AA, Eisa AA, Aljohani HM. 2023. Shikonin alleviates gentamicin-ınduced renal ınjury in rats by targeting renal endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt cascades. Antibiotics. 12(5):826. doi:10.3390/antibiotics12050826.
   Google Scholar
• Balakumar P, Rohilla A, Thangathirupathi A. 2010. Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it? Pharmacol Res. 62(3):179–186. doi:10.1016/j.phrs.2010.04.004.
   PubMed Web of Science ®Google Scholar
• Banday AA, Farooq N, Priyamvada S, Yusufi ANK, Khan F. 2008. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci. 82(9–10):450–459. doi:10.1016/j.lfs.2007.11.014.
   PubMed Web of Science ®Google Scholar
• Bencheikh N, Bouhrim M, Kharchoufa L, Al Kamaly OM, Mechchate H, Es-Safi I, Dahmani A, Ouahhoud S, El Assri S, Eto B, et al. 2021. The nephroprotective effect of Zizyphus lotus L.(desf.) fruits in a gentamicin-induced acute kidney injury model in rats: a biochemical and histopathological investigation. Molecules. 26(16):4806. doi:10.3390/molecules26164806.
   PubMed Web of Science ®Google Scholar
• Beutler E. 1971. Red cell metabolism manual of biochemical methods. London: Academic Press, p. 68–70.
   Google Scholar
• Bustos PS, Deza-Ponzio R, Páez PL, Albesa I, Cabrera JL, Virgolini MB, Ortega MG. 2016. Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells. Effect on gentamicin antimicrobial activity. Environ Toxicol Pharmacol. 48:253–264. doi:10.1016/j.etap.2016.11.004.
   PubMed Web of Science ®Google Scholar
• Cai Z-M, Peng J-Q, Chen Y, Tao L, Zhang Y-Y, Fu L-Y, Long Q-D, Shen X-C. 2021. 1, 8-Cineole: a review of source, biological activities, and application. J Asian Nat Prod Res. 23(10):938–954. doi:10.1080/10286020.2020.1839432.
   PubMed Web of Science ®Google Scholar
• Chen Y-C, Chen C-H, Hsu Y-H, Chen T-H, Sue Y-M, Cheng C-Y, Chen T-W. 2011. Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway. Eur J Pharmacol. 658(2–3):213–218. doi:10.1016/j.ejphar.2011.02.025.
   PubMed Web of Science ®Google Scholar
• de Cássia da Silveira e Sá R, Andrade LN, de Sousa DP. 2013. A review on anti-inflammatory activity of monoterpenes. Molecules. 18(1):1227–1254. doi:10.3390/molecules18011227.
   PubMed Web of Science ®Google Scholar
• Edelstein CL, Faubel S. 2011. Chapter 5 - Biomarkers in Acute Kidney Injury. Biomarkers of Kidney Disease, Academic Press, Elsevier; p. 177–232. doi:10.1016/B978-0-12-375672-5.10005-2.
   Google Scholar
• El-Sayed RM, Gheit E, Badawi RA. 2021. Vincamine protects against cisplatin-induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/IFN-γ/CD44 cells inflammatory cascade. Life Sci. 272:119224. doi:10.1016/j.lfs.2021.119224.
   PubMed Web of Science ®Google Scholar
• Erseçkin V, Mert H, İrak K, Yildirim S, Mert N. 2022. Nephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats. Drug Chem Toxicol. 45(2):663–669. doi:10.1080/01480545.2020.1759620.
   PubMed Web of Science ®Google Scholar
• Förstermann U, Sessa WC. 2012. Nitric oxide synthases: regulation and function. Eur Heart J. 33(7):829–837. doi:10.1093/eurheartj/ehr304.
   PubMed Web of Science ®Google Scholar
• Garneau-Tsodikova S, Labby KJ. 2016. Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives. Medchemcomm. 7(1):11–27. doi:10.1039/C5MD00344J.
   PubMed Web of Science ®Google Scholar
• Geshnigani SSH, Mahdavinia M, Kalantar M, Goudarzi M, Khorsandi L, Kalantar H. 2023. Diosmin prophylaxis reduces gentamicin- induced kidney damage in rats. Naunyn Schmiedebergs Arch Pharmacol. 396(1):63–71. doi:10.1007/s00210-022-02295-3.
   PubMed Web of Science ®Google Scholar
• Ghaznavi R, Kadkhodaee M. 2007. Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity. Arch Toxicol. 81(6):453–457. doi:10.1007/s00204-006-0157-2.
   PubMed Web of Science ®Google Scholar
• Gorgulho R, Jacinto R, Lopes SS, Pereira SA, Tranfield EM, Martins GG, Gualda EJ, Derks RJE, Correia AC, Steenvoorden E, et al. 2018. Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations. Arch Toxicol. 92(1):411–423. doi:10.1007/s00204-017-2063-1.
   PubMed Web of Science ®Google Scholar
• Graille M, Wild P, Sauvain J-J, Hemmendinger M, Guseva Canu I, Hopf NB. 2020. Urinary 8-OHdG as a biomarker for oxidative stress: a systematic literature review and meta-analysis. Int J Mol Sci. 21(11):3743. doi:10.3390/ijms21113743.
   PubMed Web of Science ®Google Scholar
• Hakyemez IN, Cevizci MN, Aksoz E, Yilmaz K, Uysal S, Altun E. 2022. Protective effects of p-coumaric acid against gentamicin- induced nephrotoxicity in rats. Drug Chem Toxicol. 45(6):2825–2832. doi:10.1080/01480545.2021.1993703.
   PubMed Web of Science ®Google Scholar
• Hussein MM, Althagafi HA, Alharthi F, Albrakati A, Alsharif KF, Theyab A, Kassab RB, Mufti AH, Algahtani M, Oyouni AAA, et al. 2022. Apigenin attenuates molecular, biochemical, and histopathological changes associated with renal impairments induced by gentamicin exposure in rats. Environ Sci Pollut Res Int. 29(43):65276–65288. doi:10.1007/s11356-022-20235-9.
   PubMed Web of Science ®Google Scholar
• Ince S, Kucukkurt I, Demirel HH, Arslan-Acaroz D, Varol N. 2020. Boron, a trace mineral, alleviates gentamicin-induced nephrotoxicity in rats. Biol Trace Elem Res. 195(2):515–524. doi:10.1007/s12011-019-01875-4.
   PubMed Web of Science ®Google Scholar
• Javed S, Khan JA, Khaliq T, et al. 2015. Experimental evaluation of nephroprotective potential of Calotropis procera (Ait) flowers against gentamicin-induced toxicity in albino rabbits. Pak Vet J. 35(2):222–226.
   Web of Science ®Google Scholar
• Juergens UR, Engelen T, Racké K, Stöber M, Gillissen A, Vetter H. 2004. Inhibitory activity of 1, 8-cineol (eucalyptol) on cytokine production in human mononuclear phagocytes in vitro. Pulm Pharmacol Ther. 17(5):281–287. doi:10.1016/j.pupt.2004.06.002.
   PubMed Web of Science ®Google Scholar
• Kandemir FM, Ozkaraca M, Yildirim BA, Hanedan B, Kirbas A, Kilic K, Aktas E, Benzer F. 2015. Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats. Ren Fail. 37(3):518–525. doi:10.3109/0886022X.2015.1006100.
   PubMed Web of Science ®Google Scholar
• Kang S, Chen T, Hao Z, Yang X, Wang M, Zhang Z, Hao S, Lang F, Hao H. 2022. Oxymatrine alleviates gentamicin-induced renal injury in rats. Molecules. 27(19):6209. doi:10.3390/molecules27196209.
   PubMed Web of Science ®Google Scholar
• Kazak F. 2022. A bioactive compound: eucalyptol. Functional foods and nutraceuticals: bioactive compounds. Lyon, France: Livre de Lyon, p. 125–138.
   Google Scholar
• Kazak F, Deveci MZY, Akçakavak G. 2022. Eucalyptol alleviates cisplatin-induced kidney damage in rats. Drug Chem Toxicol. 1–8. doi:10.1080/01480545.2022.2156530.
   PubMed Web of Science ®Google Scholar
• Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders H-J. 2021. Acute kidney injury. Nat Rev Dis Primers. 7(1):52. doi:10.1038/s41572-021-00284-z.
   PubMed Web of Science ®Google Scholar
• Klaassen CD, Reisman SA. 2010. Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol. 244(1):57–65. doi:10.1016/j.taap.2010.01.013.
   PubMed Web of Science ®Google Scholar
• Kumar SK, Mani KP. 2021. Endocan alters nitric oxide production in endothelial cells by targeting AKT/eNOS and NFkB/iNOS signaling. Nitric Oxide. 117:26–33. doi:10.1016/j.niox.2021.09.006.
   PubMed Web of Science ®Google Scholar
• Liu C, Kang Y, Zhou X, Yang Z, Gu J, Han C. 2017. Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation. J Ethnopharmacol. 198:122–130. doi:10.1016/j.jep.2016.12.034.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with pholin phenol reagent. J Biol Chem. 193(1):265–275. doi:10.1016/S0021-9258(19)52451-6.
   PubMed Web of Science ®Google Scholar
• Luna L. 1968. Manual of histological staining methods. Armed Forces Institute of Pathology. New York: McGraw Hill Book Company; p. 33–46.
   Google Scholar
• Metin TO, Bayrak G, Yaman S, Doganer A, Yoldas A, Eser N, Aykan DA, Yilmaz BC, Kurt AH, Ayaz L, et al. 2023. Expression of ER stress markers (GRP78 and PERK) in experimental nephrotoxicity induced by cisplatin and gentamicin: roles of inflammatory response and oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 396(4):789–801. doi:10.1007/s00210-022-02358-5.
   PubMed Web of Science ®Google Scholar
• Mohammed M, Aboulhoda B, Mahmoud R. 2019. Vitamin D attenuates gentamicin-induced acute renal damage via prevention of oxidative stress and DNA damage. Hum Exp Toxicol. 38(3):321–335. doi:10.1177/0960327118812166.
   PubMed Web of Science ®Google Scholar
• Rahimi Monfared S, Valibeik A, Jafaripour L, Eslamifar Z, Veiskarami S, Ahmadvand H. 2023. Role of cineole in alleviation of acute kidney injury and renal function recovery following gentamicin administration in rats. Iran J Basic Med Sci. 26(5):504–510. doi:10.22038/IJBMS.2023.68430.14944.
   PubMed Web of Science ®Google Scholar
• Nguyen T, Nioi P, Pickett CB. 2009. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 284(20):13291–13295. doi:10.1074/jbc.R900010200.
   PubMed Web of Science ®Google Scholar
• Ola OS, Sofolahan TA. 2021. A monoterpene antioxidant, linalool, mitigates benzene-induced oxidative toxicities on hematology and liver of male rats. Egyptian J Basic Appl Sci. 8(1):39–53. doi:10.1080/2314808X.2021.1898141.
   Google Scholar
• Ozdemir O, Akcakavak G, Tuzcu M. 2022. Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis. Rc Fcv-Luz. XXXII(single):1–8. doi:10.52973/rcfcv-e32150.
   Google Scholar
• Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT–PCR. Nucleic Acids Res. 29(9):e45. doi:10.1023/A:1005658330108.
   PubMed Web of Science ®Google Scholar
• Pinar N, Karataş Y, Dağlioğlu YK, Gönlüşen G. 2020. Effects of quercetin and coenzyme Q10 on gentamicin-induced nephrotoxicity in rats. Cukurova Medical Journal. 45(1):251–256. doi:10.17826/cumj.648050.
   Web of Science ®Google Scholar
• Polat A, Parlakpinar H, Tasdemir S, Colak C, Vardi N, Ucar M, Emre MH, Acet A. 2006. Protective role of aminoguanidine on gentamicin- induced acute renal failure in rats. Acta Histochem. 108(5):365–371. doi:10.1016/j.acthis.2006.06.005.
   PubMed Web of Science ®Google Scholar
• Porres-Martínez M, González-Burgos E, Carretero ME, Gómez-Serranillos MP. 2016. In vitro neuroprotective potential of the monoterpenes α-pinene and 1, 8-cineole against H2O2-induced oxidative stress in PC12 cells. Z Naturforsch C J Biosci. 71(7-8):191–199. doi:10.1515/znc-2014-4135.
   PubMed Web of Science ®Google Scholar
• Quiros Y, Vicente-Vicente L, Morales AI, López-Novoa JM, López-Hernández FJ. 2011. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol Sci. 119(2):245–256. doi:10.1093/toxsci/kfq267.
   PubMed Web of Science ®Google Scholar
• Randjelovic P, Veljkovic S, Stojiljkovic N, Sokolovic D, Ilic I. 2017. Gentamicin nephrotoxicity in animals: current knowledge and future perspectives. Exclı J. 16:388–399. doi:10.17179/excli2017-165.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Barbero A, Lopez-Novoa J, Arevalo M. 1997. Involvement of platelet-activating factor in gentamicin nephrotoxicity in rats. Exp Nephrol. 5(1):47–54.
   PubMedGoogle Scholar
• Seol GH, Kim KY. 2016. Eucalyptol and its role in chronic diseases. Adv Exp Med Biol. 929:389–398. doi:10.1007/978-3-319-41342-6_18.
   PubMed Web of Science ®Google Scholar
• Türk S, Kazak F, Peker P, Kisaçam MA. 2021. Rutin attenuates methotrexate-ınduced hepatic oxidative stress in rats. atatürk üniversitesi vet bil derg. 16(3):291–297. doi:10.17094/ataunivbd.982438.
   Google Scholar
• Tuzcu M, Tuzcu N, Akcakavak G, Celik Z. 2022. Diagnosis of Sarcina ventriculi-derived haemorrhagic abomasitis in lambs by histopathology and real-time PCR. Acta Vet Brno. 91(3):227–233. doi:10.2754/avb202291030227.
   Web of Science ®Google Scholar
• Udupa V, Prakash V. 2019. Gentamicin induced acute renal damage and its evaluation using urinary biomarkers in rats. Toxicol Rep. 6:91–99. doi:10.1016/j.toxrep.2018.11.015.
   PubMed Web of Science ®Google Scholar
• Urata T, Mori N, Fukuwatari T. 2017. Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1, 8-cineole via TRPM8 in mice. Neurosci Lett. 650:65–71. doi:10.1016/j.neulet.2017.04.018.
   PubMed Web of Science ®Google Scholar
• Volpini RA, Balbi APC, Costa RS, Coimbra TM. 2006. Increased expression of p38 mitogen-activated protein kinase is related to the acute renal lesions induced by gentamicin. Braz J Med Biol Res. 39(6):817–823. doi:10.1590/s0100-879x2006000600016.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang X, Fu Y, Fu D, Zhen D, Xing A, Chen Y, Gong G, Wei C. 2021. 1, 8-cineole protects against ISO-induced heart failure by inhibiting oxidative stress and ER stress in vitro and in vivo. Eur J Pharmacol. 910:174472. doi:10.1016/j.ejphar.2021.174472.
   PubMedGoogle Scholar
• Mohamadi Yarijani Z, Najafi H, Shackebaei D, Madani SH, Modarresi M, Jassemi SV. 2019. Amelioration of renal and hepatic function, oxidative stress, inflammation and histopathologic damages by Malva sylvestris extract in gentamicin induced renal toxicity. Biomed Pharmacother. 112:108635. doi:10.1016/j.biopha.2019.108635.
   PubMed Web of Science ®Google Scholar
• Yin C, Liu B, Wang P, Li X, Li Y, Zheng X, Tai Y, Wang C, Liu B. 2020. Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. Br J Pharmacol. 177(9):2042–2057. doi:10.1111/bph.14967.
   PubMed Web of Science ®Google Scholar
• Zengin G, Sarikürkçü C, Aktümsek A. 2016. Antioxidant potential and inhibition of key enzymes linked to Alzheimer’s diseases and diabetes mellitus by monoterpene-rich essential oil from Sideritis galatica Bornm. Endemic to Turkey. Rec Nat Prod. 10(2):195–206.
   Google Scholar
• Zhang J, Zou Y, Cheng-Jing Y, Xiang-Heng L, Wang X-P, Yu X-J, Li G-S, Wang J. 2020. Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria‐mediated apoptosis via SIRT1/p53 signalling. J Cell Mol Med. 24(20):11718–11728. doi:10.1111/jcmm.15782.
   PubMed Web of Science ®Google Scholar