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REVIEW ARTICLE

Pulmonary Hypertension in COPD: A Review and Consideration of the Role of Arterial Vasodilators

Pages 137-144 | Published online: 02 Jul 2009

REFERENCES

  • Girgis R E, Mathai S C. Pulmonary hypertension associated with chronic respiratory disease. Clin Chest Med 2007; 28: 219–232; x
  • Simonneau G, Galie N, Rubin L J, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004; 43: 5S–12S
  • Rich S, Dantzker D R, Ayres S M, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216–223
  • Thabut G, Dauriat G, Stern J B, et al. Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation. Chest 2005; 127: 1531–1536
  • Chaouat A, Bugnet A S, Kadaoui N, et al. Severe pulmonary hypertension and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 172: 189–194
  • Fishman A P. State of the art: chronic cor pulmonale. Am Rev Respir Dis 1976; 114: 775–794
  • Scharf S M, Iqbal M, Keller C, et al. Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med 2002; 166: 314–322
  • McGoon M, Gutterman D, Steen V, et al. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004; 126: 14S–34S
  • Kessler R, Faller M, Weitzenblum E, et al. “Natural history” of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease. Am J Respir Crit Care Med 2001; 164: 219–224
  • Weitzenblum E, Sautegeau A, Ehrhart M, et al. Long-term course of pulmonary arterial pressure in chronic obstructive pulmonary disease. Am Rev Respir Dis 1984; 130: 993–998
  • Kessler R, Faller M, Fourgaut G, et al. Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 159: 158–164
  • Oswald-Mammosser M, Weitzenblum E, Quoix E, et al. Prognostic factors in COPD patients receiving long-term oxygen therapy. Importance of pulmonary artery pressure. Chest 1995; 107: 1193–1198
  • Hospital Stays Involving Chronic Pulmonary Heart Disease. 2005, Available at: www.hcup-us.ahrq.gov/reports/stat-briefs/sb43.pdf Accessed March 8, 2008
  • Lee-Chiong T, Matthay R. Pulmonary hypertension and cor pulmonale in COPD. Sem Respir Crit Care Med 2003; 24: 263–272
  • West J B. Respiratory Physiology: The Essentials, 7th edn. Lippincott, Williams and Wilkins, Philadelphia 2004
  • Grant B J, Davies E E, Jones H A, et al. Local regulation of pulmonary blood flow and ventilation-perfusion ratios in the coatimundi. J Appl Physiol 1976; 40: 216–228
  • Voelkel N F. Mechanisms of hypoxic pulmonary vasoconstriction. Am Rev Respir Dis 1986; 133: 1186–1195
  • Hida W, Tun Y, Kikuchi Y, et al. Pulmonary hypertension in patients with chronic obstructive pulmonary disease: recent advances in pathophysiology and management. Respirology 2002; 7: 3–13
  • Presberg K W, Dincer H E. Pathophysiology of pulmonary hypertension due to lung disease. Curr Opin Pulm Med 2003; 9: 131–138
  • Shimoda L A, Sham J S, Sylvester J T. Altered pulmonary vasoreactivity in the chronically hypoxic lung. Physiol Res 2000; 49: 549–560
  • Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995; 333: 214–221
  • Eddahibi S, Chaouat A, Morrell N, et al. Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease. Circulation 2003; 108: 1839–1844
  • Weitzenblum E, Chaouat A. Severe pulmonary hypertension in COPD: is it a distinct disease?. Chest 2005; 127: 1480–1482
  • Santos S, Peinado V I, Ramirez J, et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 2002; 19: 632–638
  • Santos S, Peinado V I, Ramirez J, et al. Enhanced expression of vascular endothelial growth factor in pulmonary arteries of smokers and patients with moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 167: 1250–1256
  • Higenbottam T. Pulmonary hypertension and chronic obstructive pulmonary disease: a case for treatment. Proc Am Thorac Soc 2005; 2: 12–19
  • Peinado V I, Barbera J A, Abate P, et al. Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 159: 1605–1611
  • Hale K A, Niewoehner D E, Cosio M G. Morphologic changes in the muscular pulmonary arteries: relationship to cigarette smoking, airway disease, and emphysema. Am Rev Respir Dis 1980; 122: 273–278
  • MacNee W. Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Part two. Am J Respir Crit Care Med 1994; 150: 1158–1168
  • McDonald I G, Butler J. Distribution of vascular resistance in the isolated perfused dog lung. J Appl Physiol 1967; 23: 463–474
  • Naeije R, Barbera J A. Pulmonary hypertension associated with COPD. Crit Care 2001; 5: 286–289
  • Mal H. Prevalence and diagnosis of severe pulmonary hypertension in patients with chronic obstructive pulmonary disease. Curr Opin Pulm Med 2007; 13: 114–119
  • Biernacki W, Flenley D C, Muir A L, et al. Pulmonary hypertension and right ventricular function in patients with COPD. Chest 1988; 94: 1169–1175
  • Barbera J A, Peinado V I, Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur Respir J 2003; 21: 892–905
  • Bardsley P, Evely R, Howard P. Hypoxic cor pulmonale: a review. Herz 1986; 11: 155–168
  • Hill N S. The cardiac exam in lung disease. Clin Chest Med 1987; 8: 273–285
  • Matthay R A, Schwarz M I, Ellis J H, Jr., et al. Pulmonary artery hypertension in chronic obstructive pulmonary disease: determination by chest radiography. Invest Radiol 1981; 16: 95–100
  • Kilcoyne M M, Davis A L, Ferrer M I. A dynamic electrocardiographic concept useful in the diagnosis of cor pulmonale. Result of a survey of 200 patients with chronic obstructive pulmonary disease. Circulation 1970; 42: 903–924
  • Incalzi R A, Fuso L, De Rosa M, et al. Electrocardiographic signs of chronic cor pulmonale: A negative prognostic finding in chronic obstructive pulmonary disease. Circulation 1999; 99: 1600–1605
  • Leuchte H H, Baumgartner R A, Nounou M E, et al. Brain natriuretic peptide is a prognostic parameter in chronic lung disease. Am J Respir Crit Care Med 2006; 173: 744–750
  • Arcasoy S M, Christie J D, Ferrari V A, et al. Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med 2003; 167: 735–740
  • Fisher M R, Criner G J, Fishman A P, et al. Estimating pulmonary artery pressures by echocardiography in patients with emphysema. Eur Respir J 2007; 30: 914–921
  • Aduen J, Lozano M, Burger C, et al. A new echocardiographic method to estimate the mean pulmonary pressure: correlation with right heart catheterization. Amer J Respir Crit Care Med 2007; 175: A715
  • Badesch D B, Abman S H, Simonneau G, et al. Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines. Chest 2007; 131: 1917–1928
  • Li J H, Safford R E, Aduen J F, et al. Pulmonary hypertension and thyroid disease. Chest 2007; 132: 793–797
  • Tunariu N, Gibbs S J, Win Z, et al. Ventilation-perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease as a treatable cause of pulmonary hypertension. J Nucl Med 2007; 48: 680–684
  • Turnbull L W, Ridgway J P, Biernacki W, et al. Assessment of the right ventricle by magnetic resonance imaging in chronic obstructive lung disease. Thorax 1990; 45: 597–601
  • Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 1980; 93: 391–398
  • Timms R M, Khaja F U, Williams G W. Hemodynamic response to oxygen therapy in chronic obstructive pulmonary disease. Ann Intern Med 1985; 102: 29–36
  • Weitzenblum E, Sautegeau A, Ehrhart M, et al. Long-term oxygen therapy can reverse the progression of pulmonary hypertension in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1985; 131: 493–498
  • Gorecka D, Bednarek M, Nowinski A, et al. Diagnosis of airflow limitation combined with smoking cessation advice increases stop-smoking rate. Chest 2003; 123: 1916–1923
  • Zielinski J, Tobiasz M, Hawrylkiewicz I, et al. Effects of long-term oxygen therapy on pulmonary hemodynamics in COPD patients: a 6-year prospective study. Chest 1998; 113: 65–70
  • Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 1981; 1: 681–686
  • Ashutosh K, Mead G, Dunsky M. Early effects of oxygen administration and prognosis in chronic obstructive pulmonary disease and cor pulmonale. Am Rev Respir Dis 1983; 127: 399–404
  • Vaz Fragoso C A, Miller M A. Review of the clinical efficacy of theophylline in the treatment of chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 147: S40–47
  • Kalra L, Bone M F. Effect of nifedipine on physiologic shunting and oxygenation in chronic obstructive pulmonary disease. Am J Med 1993; 94: 419–423
  • Bratel T, Hedenstierna G, Nyquist O, et al. The use of a vasodilator, felodipine, as an adjuvant to long-term oxygen treatment in COLD patients. Eur Respir J 1990; 3: 46–54
  • Dal Nogare A R, Rubin L J. The effects of hydralazine on exercise capacity in pulmonary hypertension secondary to chronic obstructive pulmonary disease. Am Rev Respir Dis 1986; 133: 385–389
  • Rubin L J, Moser K. Long-term effects of nitrendipine on hemodynamics and oxygen transport in patients with cor pulmonale. Chest 1986; 89: 141–145
  • Miller M J, Chappell T R, Cook W, et al. Effects of oral hydralazine on gas exchange in patients with cor pulmonale. Am J Med 1983; 75: 937–942
  • Sturani C, Bassein L, Schiavina M, et al. Oral nifedipine in chronic cor pulmonale secondary to severe chronic obstructive pulmonary disease (COPD). Chest 1983; 84: 135–142
  • Agostoni P, Doria E, Galli C, et al. Nifedipine reduces pulmonary pressure and vascular tone during short- but not long-term treatment of pulmonary hypertension in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1989; 139: 120–125
  • Melot C, Hallemans R, Naeije R, et al. Deleterious effect of nifedipine on pulmonary gas exchange in chronic obstructive pulmonary disease. Am Rev Respir Dis 1984; 130: 612–616
  • Saadjian A Y, Philip-Joet F F, Vestri R, et al. Long-term treatment of chronic obstructive lung disease by Nifedipine: an 18-month haemodynamic study. Eur Respir J 1988; 1: 716–720
  • Archer S L, Mike D, Crow J, et al. A placebo-controlled trial of prostacyclin in acute respiratory failure in COPD. Chest 1996; 109: 750–755
  • Alp S, Skrygan M, Schmidt W E, et al. Sildenafil improves hemodynamic parameters in COPD—an investigation of six patients. Pulm Pharmacol Ther 2006; 19: 386–390
  • Barbera J A, Roger N, Roca J, et al. Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 1996; 347: 436–440
  • Vonbank K, Ziesche R, Higenbottam T W, et al. Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax 2003; 58: 289–293
  • Stolz D, Rasch H, Linka A, et al. A randomized, controlled trial of bosentan in severe COPD. Eur Respir J 2008; 32: 619–628
  • Madden B P, Allenby M, Loke T K, et al. A potential role for sildenafil in the management of pulmonary hypertension in patients with parenchymal lung disease. Vascul Pharmacol 2006; 44: 372–376
  • Maloney J P. Advances in the treatment of secondary pulmonary hypertension. Curr Opin Pulm Med 2003; 9: 139–143
  • McLaughlin V V, McGoon M D. Pulmonary arterial hypertension. Circulation 2006; 114: 1417–1431
  • Ghofrani H A, Wiedemann R, Rose F, et al. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 2002; 360: 895–900
  • Ambrisentan (Letairis) for pulmonary arterial hypertension. Med Lett Drugs Ther 2007; 49: 87–88
  • King T E, Jr., Behr J, Brown K K, et al. BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008; 177: 75–81
  • Criner G J, Scharf S M, Falk J A, et al. Effect of lung volume reduction surgery on resting pulmonary hemodynamics in severe emphysema. Am J Respir Crit Care Med 2007; 176: 253–260
  • Olsson J K, Zamanian R T, Feinstein J A, et al. Surgical and interventional therapies for pulmonary arterial hypertension. Semin Respir Crit Care Med 2005; 26: 417–428
  • Weitzenblum E, Chaouat A. Sleep and chronic obstructive pulmonary disease. Sleep Med Rev 2004; 8: 281–294
  • Fletcher E C, Luckett R A, Miller T, et al. Pulmonary vascular hemodynamics in chronic lung disease patients with and without oxyhemoglobin desaturation during sleep. Chest 1989; 95: 757–764
  • Arias M A, Garcia-Rio F, Alonso-Fernandez A, et al. Pulmonary hypertension in obstructive sleep apnoea: effects of continuous positive airway pressure: a randomized, controlled cross-over study. Eur Heart J 2006; 27: 1106–1113
  • Rizkallah J, Man S F, Sin D D. Prevalence of pulmonary embolism in acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis. Chest 2008, Epub ahead of print, doi: 10.1378/chest. 08–1516

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