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Research Article

Bacterial and Viral Infection in Patients Hospitalized for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Implication for Antimicrobial Management and Clinical Outcome

, , , , , , , , , , , & ORCID Icon show all
Pages 53-61 | Received 15 Jan 2020, Accepted 15 Nov 2020, Published online: 23 Dec 2020

References

  • Global initiative for chronic obstructive lung disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2020 report) [cited 2019 Dec 31]. Available from: https://goldcopd.org/gold-reports/
  • McManus TE, Marley AM, Baxter N, et al. Respiratory viral infection in exacerbations of COPD. Resp Med. 2008;102(11):1575–1580. DOI:10.1016/j.rmed.2008.06.006
  • Niewoehner DE. The impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary disease. Am J Med. 2006;119(10 Suppl 1):38–45. DOI:10.1016/j.amjmed.2006.08.006
  • Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805–1812. DOI:10.1172/JCI18921
  • Fendrick AM, Saint S, Brook I, et al. Diagnosis and treatment of upper respiratory tract infections in the primary care setting. Clin Ther. 2001;23(10):1683–1706.
  • Sethi S. Infectious etiology of acute exacerbations of chronic bronchitis. Chest. 2000;117(5):380S–385S.
  • Mohan A, Chandra S, Agarwal D, et al. Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: a systematic review. Respirology. 2010;15(3):536–542. DOI:10.1111/j.1440-1843.2010.01722.x
  • Zwaans WAR, Mallia P, van Winden MEC, et al. The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—a systematic review. J Clin Virol. 2014;61(2):181–188. DOI:10.1016/j.jcv.2014.06.025
  • Templeton KE, Scheltinga SA, van den Eeden WC, et al. Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction. Clin Infect Dis. 2005;41(3):345–351.
  • Perotin JM, Dury S, Renois F, et al. Detection of multiple viral and bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: a pilot prospective study. J Med Virol. 2013;85(5):866–873. DOI:10.1002/jmv.23495
  • Kwak HJ, Park DW, Kim JE, et al. Prevalence and risk factors of respiratory viral infections in exacerbations of chronic obstructive pulmonary disease. Tohoku J Exp Med. 2016;240(2):131–139. DOI:10.1620/tjem.240.131
  • Pozzetto B, Grattard F, Pillet S. Multiplex PCR theranostics of severe respiratory infections. Expert Rev Anti Infect Ther. 2010;8(3):251–253. DOI:10.1586/eri.09.131
  • Nouira S, Marghli S, Belghith M, et al. Once daily oral ofloxacin in chronic obstructive pulmonary disease exacerbation requiring mechanical ventilation: a randomised placebo-control trial. Lancet. 2001;358(9298):2020–2025.
  • Weiszhar Z, Horvath I. Induced sputum analysis: step by step. Breathe. 2013;9(4):300–306.
  • Freymuth F, Leven M, Wallet F. Lower respiratory tract infections. In: Cornaglia G, Courcol R, Herrmann JL, et al., editors. European manual of clinical microbiology. 1st ed. France: Epernay; 2012. p. 153–161.
  • Botterel F, Cattoen C, Pozzetto B. Infections broncho-pulmonaires. REMIC Société Française de Microbiologie Ed. 2018;19:199–212.
  • Wedzicha JA, Seemungal TA. COPD exacerbations: defining their cause and prevention. Lancet. 2007;370(9589):786–796. DOI:10.1016/S0140-6736(07)61382-8
  • Ko FW, Chan KP, Hui DS, et al. Acute exacerbation of COPD. Respirology. 2016;21(7):1152–1165. DOI:10.1111/resp.12780
  • Hewitt R, Farne H, Ritchie A, et al. The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma. Ther Adv Respir Dis. 2016;10(2):158–174. DOI:10.1177/1753465815618113
  • Moghoofei M, Azimzadeh Jamalkandi S, Moein M, et al. Bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Infection. 2020;48(1):19–35.
  • Linden D, Guo-Parke H, Coyle PV, et al. Respiratory viral infection: a potential "missing link" in the pathogenesis of COPD. Eur Respir Rev. 2019;28(151):180063.
  • Dai MY, Qiao JP, Xu YH, et al. Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD assessment test. Inter J COPD. 2015;10:2257–2263.
  • Biancardi E, Fennell M, Rawlinson W, et al. Viruses are frequently present as the infecting agent in acute exacerbations of chronic obstructive pulmonary disease in patients presenting to hospital. Intern Med J. 2016;46(10):1160–1165.
  • Ko FW, Chan PK, Chan RWY, et al. Molecular detection of respiratory pathogens and typing of human rhinovirus of adults hospitalized for exacerbation of asthma and chronic obstructive pulmonary disease. Respir Res. 2019;20(1):210. DOI:10.1186/s12931-019-1181-0
  • Stolz D, Papakonstantinou E, Grize L, et al. Time-course of upper respiratory tract viral infection and COPD exacerbation. Eur Respir J. 2019;54(4):1900407.
  • Ko FW, Ip M, Chan PK, et al. Viral etiology of acute exacerbations of COPD in Hong Kong. Chest. 2007;132(3):900–908.
  • McManus TE, Marley AM, Baxter N, et al. Respiratory viral infection in exacerbations of COPD. Respir Med. 2008;102(11):1575–1580.
  • Dimopoulos G, Lerikou M, Tsiodras S, et al. Viral epidemiology of acute exacerbations of chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2012;25(1):12–18.
  • Aydemir O, Aydemir Y, Ozdemir M. The role of multiplex PCR test in identification of bacterial pathogens in lower respiratory tract infections. Pak J Med Sci. 2014;30:1011–1016.
  • Gadsby NJ, McHugh MP, Russell CD, et al. Development of two real-time multiplex PCR assays for the detection and quantification of eight key bacterial pathogens in lower respiratory tract infections. Clin Microbiol Infect. 2015;21:788e1–788e13.
  • Lieberman D, Shimoni A, Shleyfer E, et al. Naso- and oropharyngeal potential respiratory pathogens in adult with nonpneumonic lower respiratory tract infection. Diag Microbiol Infect Dis. 2007;58(2):147–151.
  • Shimizu K, Yoshii Y, Morozumi M, et al. Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods. Int J Chron Obstruct Pulmon Dis. 2015;10:2009–2016. DOI:10.2147/COPD.S82752
  • Kim HC, Choi SH, Huh JW, et al. Different pattern of viral infections and clinical outcomes in patient with acute exacerbation of chronic obstructive pulmonary disease and chronic obstructive pulmonary disease with pneumonia. J Med Virol. 2016;88(12):2092–2099.
  • Garrod R, Marshall J, Barley E, et al. The relationship between inflammatory markers and disability in chronic obstructive pulmonary disease (COPD. Prim Care Respir J. 2007;16(4):236–240.
  • Weis N, Almdal T. C-reactive protein: can it be used as a marker of infection in patients with exacerbation of chronic obstructive pulmonary disease? Eur J Intern Med. 2006;17(2):88–91.
  • Papaetis GS, Anastasakou E, Orphanidou D. Chlamydophila pneumoniae infection and COPD: more evidence for lack of evidence? Eur J Intern Med. 2009;20(6):579–585. DOI:10.1016/j.ejim.2009.05.006
  • Nakou A, Papaparaskevas J, Diamantea F, et al. A prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease. Future Microbiol. 2014;9(11):1251–1260. DOI:10.2217/fmb.14.90
  • Brendish NJ, Malachira AK, Armstrong L, et al. Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial. Lancet Respir Med. 2017;5(5):401–411.
  • Brendish NJ, Mills S, Ewings S, et al. Impact of point-of-care testing for respiratory viruses on antibiotic use in adults with exacerbation of airways disease. J Infect. 2019;79(4):357–362.

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