1,709
Views
0
CrossRef citations to date
0
Altmetric
Review Article

Understanding the Gaps in the Reporting of COPD Exacerbations by Patients: A Review

, , ORCID Icon, , , , , , & show all
Article: 2316594 | Received 01 Dec 2023, Accepted 05 Feb 2024, Published online: 29 Feb 2024

References

  • Spencer S, Jones PW, . Time course of recovery of health status following an infective exacerbation of chronic bronchitis. Thorax. 2003;58(7):1–9. doi: 10.1136/thorax.58.7.589.
  • Cote CG, Dordelly LJ, Celli BR. Impact of COPD exacerbations on patient-centered outcomes. Chest. 2007;131(3):696–704. doi: 10.1378/chest.06-1610.
  • Celli BR, Thomas NE, Anderson JA, et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am J Respir Crit Care Med. 2008;178(4):332–338. doi: 10.1164/rccm.200712-1869OC.
  • Whittaker H, Rubino A, Müllerová H, et al. Frequency and severity of exacerbations of COPD associated with future risk of exacerbations and mortality: a UK routine health care data study. Int J Chron Obstruct Pulmon Dis. 2022;17:427–437. doi: 10.2147/copd.s346591.
  • Rothnie KJ, Müllerová H, Smeeth L, et al. Natural history of chronic obstructive pulmonary disease exacerbations in a general practice-based population with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;198(4):464–471. doi: 10.1164/rccm.201710-2029OC.
  • Press VG, Konetzka RT, White SR. Insights about the economic impact of chronic obstructive pulmonary disease readmissions post implementation of the hospital readmission reduction program. Curr Opin Pulm Med. 2018;24(2):138–146. doi: 10.1097/mcp.0000000000000454.
  • Mittmann N, Kuramoto L, Seung SJ, et al. The cost of moderate and severe COPD exacerbations to the Canadian healthcare system. Respir Med. 2008;102(3):413–421. doi: 10.1016/j.rmed.2007.10.010.
  • Perera PN, Armstrong EP, Sherrill DL, et al. Acute exacerbations of COPD in the United States: inpatient burden and predictors of costs and mortality. COPD. 2012;9(2):131–141. doi: 10.3109/15412555.2011.650239.
  • Simoens S, Decramer M, De Coster S, et al. Clinical and economic analysis of antimicrobial therapy of chronic obstructive pulmonary disease exacerbations: clinical and economic analysis of COPD exacerbations. Int J Clin Pract. 2007;61(2):200–206. doi: 10.1111/j.1742-1241.2006.01240.x.
  • O’Reilly JF, Williams AE, Rice L. Health status impairment and costs associated with COPD exacerbation managed in hospital. Int J Clin Pract. 2007;61(7):1112–1120. doi: 10.1111/j.1742-1241.2007.01424.x.
  • Geitona M, Hatzikou M, Steiropoulos P, et al. The cost of COPD exacerbations: a university hospital–based study in Greece. Respir Med. 2011;105(3):402–409. doi: 10.1016/j.rmed.2010.09.020.
  • Blasi F, Cesana G, Conti S, et al. The clinical and economic impact of exacerbations of chronic obstructive pulmonary disease: a cohort of hospitalized patients. PLOS One. 2014;9(6):e101228. doi: 10.1371/journal.pone.0101228.
  • Jahnz-Różyk K, Targowski T, From S. Comparison of outpatient and inpatient costs of moderate and severe exacerbations of chronic obstructive pulmonary disease in Poland. Adv Respir Med. 2008;76(6):426–430. doi: 10.5603/ARM.27861.
  • Polatli M, Öksüz E, Malhan S. Economic burden and key cost drivers of managing hospitalized chronic obstructive pulmonary disease patients admitted with an exacerbation in Türkiye: a cost of illness study from payer perspective. Turkiye Klinikleri Arch Lung. 2022; 21(2):39–50. doi: 10.5336/archlung.2022-88430.
  • 2023 GOLD Report - Global Initiative for Chronic Obstructive Lung Disease - GOLD. [Internet]. [cited 2023 May 29]. Available from: https://goldcopd.org/2023-gold-report-2/.
  • Kim V, Aaron SD. What is a COPD exacerbation? Current definitions, pitfalls, challenges and opportunities for improvement. [internet]. Eur Respir J. 2018; [cited 2023 May 2952(5):1801261. Available fromhttps://erj.ersjournals.com/content/52/5/1801261
  • Anthonisen NR, Manfreda J, Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106(2):196–204. doi: 10.7326/0003-4819-106-2-196.
  • Jones PW, Wang C, Chen P, et al. The development of a COPD exacerbation recognition tool (CERT) to help patients recognize when to seek medical advice. Int J Chron Obstruct Pulmon Dis. 2022;17:213–222. doi: 10.2147/copd.s337644.
  • Jones P, Hataji O, Suzukamo Y, et al. Development of a communication tool between patients and physicians global initiative for recognizing COPD exacerbations in Japan. COPD. 2023;20(1):216–223. doi: 10.1080/15412555.2023.2219742.
  • Calverley PMA, Martinez FJ, Vestbo J, et al. International differences in the frequency of chronic obstructive pulmonary disease exacerbations reported in three clinical trials. Am J Respir Crit Care Med. 2022;206(1):25–33. doi: 10.1164/rccm.202111-2630oc.
  • Celli BR, Fabbri LM, Aaron SD, et al. An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal. Am J Respir Crit Care Med. 2021;204(11):1251–1258. doi: 10.1164/rccm.202108-1819pp.
  • Jones PW, Lamarca R, Chuecos F, et al. Characterisation and impact of reported and unreported exacerbations: results from ATTAIN. Eur Respir J. 2014;44(5):1156–1165. doi: 10.1183/09031936.00038814.
  • Betsuyaku T, Kato M, Fujimoto K, et al. A randomized trial of symptom-based management in Japanese patients with COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:2409–2423. doi: 10.2147/copd.s152723.
  • Xu W, Collet JP, Shapiro S, et al. Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year. Eur Respir J. 2010;35(5):1022–1030. doi: 10.1183/09031936.00079409.
  • Langsetmo L, Platt RW, Ernst P, et al. Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort. Am J Respir Crit Care Med. 2008;177(4):396–401. doi: 10.1164/rccm.200708-1290oc.
  • Wilkinson TMA, Donaldson GC, Hurst JR, et al. Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;169(12):1298–1303. doi: 10.1164/rccm.200310-1443oc.
  • Chandra D, Tsai CL, Camargo CA. Acute exacerbations of COPD: delay in presentation and the risk of hospitalization. COPD. 2009;6(2):95–103. doi: 10.1080/15412550902751746.
  • Barnes N, Calverley PM, Kaplan A, et al. Chronic obstructive pulmonary disease and exacerbations: patient insights from the global hidden depths of COPD survey. BMC Pulm Med. 2013;13(1):54. doi: 10.1186/1471-2466-13-54.
  • Miravitlles M, Acharya S, Aggarwal B, et al. Clinical concepts for triple therapy use in patients with COPD: a delphi consensus. Int J Chron Obstruct Pulmon Dis. 2023;18:1853–1866. doi: 10.2147/copd.s424128.
  • Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(11):925–931. doi: 10.1136/thx.2005.040527.
  • Sadatsafavi M, Sin DD, Zafari Z, et al. The association between rate and severity of exacerbations in chronic obstructive pulmonary disease: an application of a joint frailty-logistic model. Am J Epidemiol. 2016;184(9):681–689. doi: 10.1093/aje/kww085.
  • Hernandez P,Balter MS,Bourbeau J, et al. Canadian practice assessment in chronic obstructive pulmonary disease: respiratory specialist physician perception versus patient reality. Can Respir J. 2013;20(2):97–105. doi: 10.1155/2013/369019.
  • Trappenburg JC, Schaap D, Monninkhof EM, et al. How do COPD patients respond to exacerbations? BMC Pulm Med. 2011;11(1):43. doi: 10.1186/1471-2466-11-43.
  • Donaldson GC, Seemungal TAR, Bhowmik A, et al. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57(10):847–852. doi: 10.1136/thorax.57.10.847.
  • Seemungal TA, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(5 Pt 1):1418–1422. doi: 10.1164/ajrccm.157.5.9709032.
  • Calderazzo MA, Trujillo-Torralbo MB, Finney LJ, et al. Inflammation and infections in unreported chronic obstructive pulmonary disease exacerbations. Int J Chron Obstruct Pulmon Dis. 2019;14:823–832. doi: 10.2147/copd.s191946.
  • Leidy NK, Murray LT, Jones P, et al. Performance of the exacerbations of chronic pulmonary disease tool patient-reported outcome measure in three clinical trials of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014; Mar [cited 2023 Apr 11(3):316–325. doi: 10.1513/AnnalsATS.201309-305OC.
  • Ryrsø CK, Godtfredsen NS, Kofod LM, et al. Lower mortality after early supervised pulmonary rehabilitation following COPD-exacerbations: a systematic review and meta-analysis. BMC Pulm Med. 2018;18(1):154. doi: 10.1186/s12890-018-0718-1.
  • Singh D, Litewka D, Páramo R, et al. Delaying disease progression in COPD with early initiation of dual bronchodilator or triple inhaled pharmacotherapy (DEPICT): a predictive modelling approach. Adv Ther. 2023;40(10):4689–4690. doi: 10.1007/s12325-023-02583-1.
  • Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363(12):1128–1138. doi: 10.1056/nejmoa0909883.
  • Williams V, Hardinge M, Ryan S, et al. Patients’ experience of identifying and managing exacerbations in COPD: a qualitative study. NPJ Prim Care Respir Med. 2014;24(1):14062. doi: 10.1038/npjpcrm.2014.62.
  • Understanding-COPD-Exacerbations-Survey-Report.pdf [Internet]. [cited 2023 Jul 4]. Available from: https://www.copdfoundation.org/Downloads/Understanding-COPD-Exacerbations-Survey-Report.pdf.
  • Choate R, Sandhaus RA, Holm KE, et al. Patient-reported pulmonary symptoms, exacerbations, and management in a cohort of patients with alpha-1 antitrypsin deficiency. Chronic Obstr Pulm Dis. 2022;9(4):549–561. doi: 10.15326/jcopdf.2022.0317.
  • Locke ER, Young JP, Battaglia C, et al. Care-seeking and delay of care during COPD exacerbations. NPJ Prim Care Respir Med. 2022;32(1):7. doi: 10.1038/s41533-022-00269-9.
  • Jiang M, Ma JF. Comprehension and recognition of acute exacerbation among chronic obstructive pulmonary disease patients. Zhonghua Liu Xing Bing Xue Za Zhi. 2013;34(10):1030–1034.
  • Celli B, Vestbo J, Jenkins CR, et al. Sex differences in mortality and clinical expressions of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;183(3):317–322. doi: 10.1164/rccm.201004-0665oc.
  • Kamil F, Pinzon I, Foreman MG. Sex and race factors in early-onset COPD. Curr Opin Pulm Med. 2013;19(2):140–144. doi: 10.1097/mcp.0b013e32835d903b.
  • Kowalczyk A, Kosiek K, Godycki-Cwirko M, et al. Community determinants of COPD exacerbations in elderly patients in Lodz province, Poland: a retrospective observational big data cohort study. BMJ Open. 2022;12(10):e060247. doi: 10.1136/bmjopen-2021-060247.
  • Galiatsatos P, Woo H, Paulin LM, et al. The association between neighborhood socioeconomic disadvantage and chronic obstructive pulmonary disease: a retrospective cohort study of SPIROMICS. In. A26 ENVIRONMENTAL MODIFIERS OF LUNG DISEASE [Internet]. ATS Sch. 2019 [cited 2023 May 29]. p. A1178–A1178. (American Thoracic Society International Conference Abstracts). doi: 10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A1178.
  • Au DH,Bryson CL,Chien JW, et al. The effects of smoking cessation on the risk of chronic obstructive pulmonary disease exacerbations. J Gen Intern Med. 2009;24(4):457–463. doi: 10.1007/s11606-009-0907-y.
  • Williams PJ,Cumella A,Philip KEJ, et al. Smoking and socioeconomic factors linked to acute exacerbations of COPD: analysis from an asthma + lung UK survey. BMJ Open Resp Res. 2022;9(1):e001290. doi: 10.1136/bmjresp-2022-001290.
  • Kilic H,Kokturk N,Sari G, et al. Do females behave differently in COPD exacerbation?. Int J Chron Obstruct Pulmon Dis. 2015;10:823–830. doi: 10.2147/COPD.S78952.
  • Cardoso J,Ferreira AJ,Guimarães M, et al. Treatable traits in COPD- A proposed approach. Int J Chron Obstruct Pulmon Dis. 2021;16:3167–3182. doi: 10.2147/COPD.S330817.
  • Philip KEJ,Lonergan B,Cumella A, et al. COVID-19 related concerns of people with long-term respiratory conditions: A qualitative study. BMC Pulm Med. 2020;20(1):319. doi: 10.1186/s12890-020-01363-9.
  • Kessler R, Ståhl E, Vogelmeier C, et al. Patient understanding, detection, and experience of COPD exacerbations: an observational, interview-based study. Chest. 2006;130(1):133–142. doi: 10.1378/chest.130.1.133.
  • Machado A, Almeida S, Burtin C, et al. Giving voice to people - experiences during mild to moderate acute exacerbations of COPD. Chronic Obstr Pulm Dis. 2022;9(3):336–348. doi: 10.15326/jcopdf.2022.0283.
  • Woodruff PG, Barr RG, Bleecker E, et al. Clinical significance of symptoms in smokers with preserved pulmonary function. N Engl J Med. 2016;374(19):1811–1821. doi: 10.1056/nejmoa1505971.
  • Oliveira A, Afreixo V, Marques A. Enhancing our understanding of the time course of acute exacerbations of COPD managed on an outpatient basis. Int J Chron Obstruct Pulmon Dis. 2018;13:3759–3766. doi: 10.2147/copd.s175890.
  • Yawn BP. Early identification of exacerbations in patients with chronic obstructive pulmonary disease. J Prim Care Community Health. 2013;4(1):75–80. doi: 10.1177/2150131912443827.
  • Lee SD, Huang MS, Kang J, et al. The COPD assessment test (CAT) assists prediction of COPD exacerbations in high-risk patients. Respir Med. 2014;108(4):600–608. doi: 10.1016/j.rmed.2013.12.014.
  • Adibi A, Sin DD, Safari A, et al. The acute COPD exacerbation prediction tool (ACCEPT): a modelling study. Lancet Respir Med. 2020;8(10):1013–1021. doi: 10.1016/s2213-2600(19)30397-2.
  • Burgel PR, Nesme-Meyer P, Chanez P, et al. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest. 2009;135(4):975–982. doi: 10.1378/chest.08-2062.
  • Kim V, Han MK, Vance GB, et al. The chronic bronchitic phenotype of COPD: an analysis of the COPD gene study. Chest. 2011;140(3):626–633. doi: 10.1378/chest.10-2948.
  • Miller BE, Tal-Singer R, Rennard SI, et al. Plasma fibrinogen qualification as a drug development tool in chronic obstructive pulmonary disease. perspective of the chronic obstructive pulmonary disease biomarker qualification consortium. Am J Respir Crit Care Med. 2016;193(6):607–613. doi: 10.1164/rccm.201509-1722pp.
  • Henoch I, Löfdahl CG, Ekberg-Jansson A. Influences of patient education on exacerbations and hospital admissions in patients with COPD – a longitudinal national register study. Eur Clin Respir J. 2018;5(1):1500073. doi: 10.1080/20018525.2018.1500073.
  • Rice KL, Dewan N, Bloomfield HE, et al. Disease management program for chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010;182(7):890–896. doi: 10.1164/rccm.200910-1579oc.
  • Song X, Hallensleben C, Shen H, et al. REducing delay through edUcation on eXacerbations for people with chronic lung disease: study protocol of a single-arm pre-post study. J Adv Nurs. 2022;78(8):2656–2663. doi: 10.1111/jan.15311.
  • Howcroft M, Walters EH, Wood-Baker R, et al. Action plans with brief patient education for exacerbations in chronic obstructive pulmonary disease. . Cochrane Database Syst Rev. 2016;12(12):CD005074. doi: 10.1002/14651858.CD005074.pub4.
  • Worth H, Dhein Y. Does patient education modify behaviour in the management of COPD? Patient Educ Couns. 2004;52(3):267–270. doi: 10.1016/S0738-3991(03)00101-0.
  • Cooper CB, Paine R, Curtis JL, et al. Novel respiratory disability score predicts COPD exacerbations and mortality in the SPIROMICS cohort. Int J Chron Obstruct Pulmon Dis. 2020;15:1887–1898. doi: 10.2147/COPD.S250191.
  • Yañez AM, Guerrero D, Pérez de Alejo R, et al. Monitoring breathing rate at home allows early identification of COPD exacerbations. Chest. 2012;142(6):1524–1529. doi: 10.1378/chest.11-2728.
  • Bowler R, Allinder M, Jacobson S, et al. Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD. BMJ Open Respir Res. 2019;6(1):e000350. doi: 10.1136/bmjresp-2018-000350.
  • Matusitz J, Breen GM. Telemedicine: its effects on health com­munication. Health Commun. 2007;21(1):73–83. doi: 10.1080/10410230701283439.
  • Franek J. Home telehealth for patients with chronic obstructive pulmonary disease (COPD): an evidence-based analysis. Ont Health Technol Assess Ser. 2012;12(11):1–58.
  • Rassouli F, Germann A, Baty F, et al. Telehealth mitigates COPD disease progression compared to standard of care: a randomized controlled crossover trial. J Intern Med. 2021;289(3):404–410. doi: 10.1111/joim.13230.
  • Lenferink A, Brusse-Keizer M, Valk PDvd, et al. Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease . Cochrane Database Syst Rev. 2017;8(8):CD011682. doi: 10.1002/14651858.CD011682.pub2.