REFERENCES
- Stout C, Goodenough D A, Paul D L. Connexins: Functions without junctions. Curr Opin Cell Biol 2004; 16: 507–512, [PUBMED], [INFOTRIEVE], [CSA]
- Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Guldenagel M, Deutsch U, Sohl G. Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 2002; 383: 725–737, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Krutovskikh V, Yamasaki H. Connexin gene mutations in human genetic diseases. Mutat Res 2000; 462: 197–207, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Richard G. Connexin disorders of the skin. Adv Dermatol 2001; 17: 243–277, [PUBMED], [INFOTRIEVE], [CSA]
- Lo C W. Genes, gene knockouts, and mutations in the analysis of gap junctions. Dev Genet 1999; 24: 1–4, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Mesnil M. Connexins and cancer. Biol Cell 2002; 94: 493–500, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Trosko J E, Ruch R J. Cell-cell communication in carcinogenesis. Frontiers in Bioscience 1998; 3: 208, [CSA]
- King T J, Fukushima L H, Hieber A D, Shimabukuro K A, Sakr W A, Bertram J S. Reduced levels of connexin43 in cervical dysplasia: Inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis 2000; 21: 1097–1109, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- King T J, Fukushima L H, Yasui Y, Lampe P D, Bertram J S. Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of ht-1080 human fibrosarcoma cells in vitro and in vivo. Mol Carcinog 2002; 35: 29–41, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Mehta P, Perez-Stable C, Nadji M, Mian M, Asotra K, Roos B A. Suppression of human prostate cancer cell growth by forced expression of connexin genes. Developmental Genetics 1999; 24: 91, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Nelles E, Butzler C, Jung D, Temme A, Gabriel H D, Dahl U, Traub O, Stumpel F, Jungermann K, Zielasek J, Toyka K V, Dermietzel R, Willecke K. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 1996; 93: 9565–9570, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Temme A, Stumpel F, Sohl G, Rieber E P, Jungermann K, Willecke K, Ott T. Dilated bile canaliculi and attenuated decrease of nerve-dependent bile secretion in connexin32-deficient mouse liver. Pflugers Arch 2001; 442: 961–966, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Temme A, Buchmann A, Gabriel H D, Nelles E, Schwarz M, Willecke K. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Current Biology 1997; 7: 713–716, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Evert M, Ott T, Temme A, Willecke K, Dombrowski F. Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice. Carcinogenesis 2002; 23: 697–703, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Moennikes O, Buchmann A, Ott T, Willecke K, Schwarz M. The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains. Carcinogenesis 1999; 20: 1379–1382, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- King T J, Lampe P D. Mice deficient for the gap junction protein connexin32 exhibit increased radiation-induced tumorigenesis associated with elevated mitogen-activated protein kinase (p44/erk1, p42/erk2) activation. Carcinogenesis 2004b; 25: 669–680, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- King T J, Lampe P D. The gap junction protein connexin32 is a mouse lung tumor suppressor. Cancer Res 2004a; 64: 7191–7196, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Sherr C J, Roberts J M. Cdk inhibitors: Positive and negative regulators of g1-phase progression. Genes Dev 1999; 13: 1501–1512, [PUBMED], [INFOTRIEVE], [CSA]
- Lloyd R V, Erickson L A, Jin L, Kulig E, Qian X, Cheville J C, Scheithauer B W. P27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 1999; 154: 313–323, [PUBMED], [INFOTRIEVE], [CSA]
- Fero M L, Randel E, Gurley K E, Roberts J MKemp C J. The murine gene p27kip1 is haplo-insufficient for tumour suppression. Nature 1998; 396: 177–180, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Philipp-Staheli J, Payne S R, Kemp C J. P27(kip1): Regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res 2001; 264: 148–168, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Hanna E A, Umhauer S, Roshong S L, Piechocki M P, Fernstrom M J, Fanning J D, Ruch R J. Gap junctional intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro. Carcinogenesis 1999; 20: 1369–1373, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Koffler L, Roshong S, Kyu Park I, Cesen-Cummings K, Thompson D C, Dwyer-Nield L D, Rice P, Mamay C, Malkinson A M, Ruch R J. Growth inhibition in g(1) and altered expression of cyclin d1 and p27(kip-1)after forced connexin expression in lung and liver carcinoma cells. J Cell Biochem 2000; 79: 347–354, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Zhang Y W, Morita I, Ikeda M, Ma K W, Murota S. Connexin43 suppresses proliferation of osteosarcoma u2os cells through post-transcriptional regulation of p27. Oncogene 2001; 20: 4138–4149, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Zhang Y W, Nakayama K, Morita I. A novel route for connexin 43 to inhibit cell proliferation: Negative regulation of s-phase kinase-associated protein (skp 2). Cancer Res 2003; 63: 1623–1630, [PUBMED], [INFOTRIEVE], [CSA]
- Scherer S S, Xu Y T, Nelles E, Fischbeck K, Willecke K, Bone L J. Connexin32-null mice develop demyelinating peripheral neuropathy. Glia 1998; 24: 8–20, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Fero M L, Rivkin M, Tasch M, Porter P, Carow C E, Firpo E, Polyak K, Tsai L H, Broudy V, Perlmutter R M, Kaushansky K, Roberts J M. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(kip1)-deficient mice. Cell 1996; 85: 733–744, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- King T J, Gurley K E, Prunty J, Shin J L, Kemp C J, Lampe P D. Deficiency in the gap junction protein connexin32 alters p27kip1 tumor suppression and mapk activation in a tissue-specific manner. Oncogene 2005; 24: 1718–1726, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Nikitin A Y, Alcaraz A, Anver M R, Bronson R T, Cardiff R D, Dixon D, Fraire A E, Gabrielson E W, Gunning W T, Haines D C, Kaufman M H, Linnoila R I, Maronpot R R, Rabson A S, Reddick R L, Rehm S, Rozengurt N, Schuller H M, Shmidt E N, Travis W D, Ward J M, Jacks T. Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium. Cancer Res 2004; 64: 2307–2316, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Hilger R A, Scheulen M E, Strumberg D. The ras-raf-mek-erk pathway in the treatment of cancer. Onkologie 2002; 25: 511–518, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Ito Y, Sasaki Y, Horimoto M, Wada S, Tanaka Y, Kasahara A, Ueki T, Hirano T, Yamamoto H, Fujimoto J, Okamoto E, Hayashi N, Hori M. Activation of mitogen-activated protein kinases/ extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 1998; 27: 951–958, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Ramakrishna G, Perella C, Birely L, Diwan B A, Fornwald L W, Anderson L M. Decrease in k-ras p21 and increase in raf1 and activated erk 1 and 2 in murine lung tumors initiated by n-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 2002; 179: 21–34, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Yano T, Yano Y, Nagashima Y, Yuasa M, Yajima S, Horikawa S, Hagiwara K, Kishimoto M, Ichikawa T, Otani S. Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen. Life Sci 1999; 64: 229–236, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Yao R, Wang Y, Lubet R A, You M. Differential gene expression in chemically induced mouse lung adenomas. Neoplasia 2003; 5: 41–52, [PUBMED], [INFOTRIEVE], [CSA]
- Philipp-Staheli J, Kim K H, Liggitt D, Gurley K E, Longton G, Kemp C J. Distinct roles for p53, p27kip1, and p21cip1 during tumor development. Oncogene 2004; 23: 905–913, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Philipp-Staheli J, Kim K H, Payne S R, Gurley K E, Liggitt D, Longton G, Kemp C J. Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in apc mutant mice, but not in smad3 mutant mice. Cancer Cell 2002; 1: 355–368, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Muraoka R S, Lenferink A E, Simpson J, Brantley D M, Roebuck L R, Yakes F M, Arteaga C L. Cyclin-dependent kinase inhibitor p27(kip1) is required for mouse mammary gland morphogenesis and function. J Cell Biol 2001; 153: 917–932, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Defamie N, Berthaut I, Mograbi B, Chevallier D, Dadoune J P, Fenichel P, Segretain D, Pointis G. Impaired gap junction connexin43 in sertoli cells of patients with secretory azoospermia: A marker of undifferentiated sertoli cells. Lab Invest 2003; 83: 449–456, [PUBMED], [INFOTRIEVE], [CSA]
- Upham B L, Rummel A M, Carbone J M, Trosko J E, Ouyang Y, Crawford R B, Kaminski N E. Cannabinoids inhibit gap junctional intercellular communication and activate erk in a rat liver epithelial cell line. Int J Cancer 2003; 104: 12–18, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Warn-Cramer B J, Cottrell G T, Burt J M, Lau A F. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem 1998; 273: 9188–9196, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Warn-Cramer B J, Lampe P D, Kurata W E, Kanemitsu M Y, Loo L W, Eckhart W, Lau A F. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem 1996; 271: 3779–3786, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Lumniczky K, Antal S, Unger E, Wunderlich L, Hidvegi E J, Safrany G. Carcinogenic alterations in murine liver, lung, and uterine tumors induced by in utero exposure to ionizing radiation. Mol Carcinog 1998; 21: 100–110, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Schwarz M, Wanke I, Wulbrand U, Moennikes O, Buchmann A. Role of connexin32 and beta-catenin in tumor promotion in mouse liver. Toxicol Pathol 2003; 31: 99–102, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]