Lack of “Hemichannel” Activity in Insulin-Producing Cells

REFERENCES

• Ashcroft F M. Ion Channels and Disease. Academic Press, San Diego 2000
   Google Scholar
• Bao L, Locovei S, Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett 2004; 572: 65–68
   PubMed Web of Science ®Google Scholar
• Bröer S, Wagner C A. Membrane Transporter Diseases. Kluwer Academic, New York 2003
   Google Scholar
• Bruzzone R, Barbe M T, Jakob N J, Monyer H. Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem 2005; 92: 1033–1043
   PubMed Web of Science ®Google Scholar
• Bruzzone R, Hormuzdi S G, Barbe M T, Herb A, Monyer H. Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci U S A 2003; 100: 13644–13649
   PubMed Web of Science ®Google Scholar
• Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 2007; 87: 659–797
   PubMed Web of Science ®Google Scholar
• Bukauskas F F, Verselis V K. Gap junction channel gating. Biochim Biophys Acta 2004; 1662: 42–60
   PubMed Web of Science ®Google Scholar
• Calabrese A, Zhang M, Serre-Beinier V, Caton D, Mas C, Satin L S, et al. Connexin36 controls synchronization of Ca2 + oscillations and insulin secretion in MIN6 cells. Diabetes 2003; 52: 417–424
   PubMed Web of Science ®Google Scholar
• Charpantier E, Cancela J, Meda P. Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels. Diabetologia 2007; 50: 2332–2341
   PubMed Web of Science ®Google Scholar
• Detimary P, Jonas J C, Henquin J C. Stable and diffusible pools of nucleotides in pancreatic islet cells. Endocrinology 1996; 137: 4671–4676
   Google Scholar
• DeVries S H, Schwartz E A. Hemi-gap-junction channels in solitary horizontal cells of the catfish retina. J Physiol 1992; 445: 201–230
   PubMed Web of Science ®Google Scholar
• Goodenough D A, Paul D L. Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol 2003; 4: 285–294
   PubMed Web of Science ®Google Scholar
• Harris A L. Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys 2001; 34: 325–472
   PubMed Web of Science ®Google Scholar
• Hofer A, Dermietzel R. Visualization and functional blocking of gap junction hemichannels (connexons) with antibodies against external loop domains in astrocytes. Glia 1998; 24: 141–154
   PubMed Web of Science ®Google Scholar
• Kondo R P, Wang S Y, John S A, Weiss J N, Goldhaber J I. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J Mol Cell Cardiol. 2000; 32: 1859–1872
   PubMed Web of Science ®Google Scholar
• Li H, Liu T F, Lazrak A, Peracchia C, Goldberg G S, Lampe P D, Johnson R G. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J Cell Biol 1996; 134: 1019–1030
   PubMed Web of Science ®Google Scholar
• Liu T F, Li H Y, Atkinson M M, Johnson R G. Comparison of lucifer yellow leakage and cell-to-cell transfer following intracellular injection in normal and antisense Novikoff cells under treatment with low extracellular Ca2 +. Methods Find Exp Clin Pharmacol 1996; 18: 493–497
   PubMed Web of Science ®Google Scholar
• Locovei S, Bao L, Dahl G. Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A 2006a; 103: 7655–7659
   PubMed Web of Science ®Google Scholar
• Locovei S, Scemes E, Qiu F, Spray D C, Dahl G. Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex. FEBS Lett 2007; 581: 483–488
   PubMed Web of Science ®Google Scholar
• Locovei S, Wang J, Dahl G. Activation of pannexin1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett 2006b; 580: 239–244
   PubMed Web of Science ®Google Scholar
• Musil L S, Goodenough D A. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J Cell Biol 1991; 115: 1357–1374
   PubMed Web of Science ®Google Scholar
• Panchin Y, Kelmanso I, Matz M, Lukyanov K, Usman N, Lukyanov S. A ubiquitous family of putative gap junction molecules. Curr Biol 2000; 10: R473–R474
   PubMed Web of Science ®Google Scholar
• Paul D L, Ebihara L, Takemoto L J, Swenson K I, Goodenough D A. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol 1991; 115: 1077–1089
   PubMed Web of Science ®Google Scholar
• Pelegrin P, Surprenant A. Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor. EMBO J 2006; 25: 5071–5082
   PubMed Web of Science ®Google Scholar
• Purpura V, Scemes E, Spray D C. Mechanisms of glutamate release from astrocytes: Gap junction “hemichannels”, purinergic receptors and exocytotic release. Neurochem Int 2004; 45: 259–264
   PubMed Web of Science ®Google Scholar
• Quist A P, Rhee S K, Lin H, Lal R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J Cell Biol 2000; 148: 1063–1074
   PubMed Web of Science ®Google Scholar
• Ravier M A, Guldenagel M, Charollais A, Gjinovci A, Caille D, Sohl G, et al. Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2 + and insulin oscillations, and basal insulin release. Diabetes 2005; 54: 1798–1807
   PubMed Web of Science ®Google Scholar
• Saez J C, Retamal M A, Basilio D, Bukauskas F F, Bennett M V. Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta 2005; 1711: 215–224
   PubMed Web of Science ®Google Scholar
• Speier S, Gjinovci A, Charollais A, Meda P, Rupnik M. Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics. Diabetes 2007; 56: 1078–1086
   PubMed Web of Science ®Google Scholar
• Spray D C, YE Z C, Ramson B R. Functional connexin “hemichannels”: A critical appraisal. Glia 2006; 54: 758–773
   PubMed Web of Science ®Google Scholar
• Srinivas M, Rozental R, Kojima T, Dermietzel R, Mehler M, Condorelli D F, Kessler J A, Spray D C. Functional properties of channels formed by the neuronal gap junction protein connexin36. J Neurosci 1999; 19: 9848–9855
   PubMed Web of Science ®Google Scholar
• Stout C, Goodenough D A, Paul D L. Connexins: Functions without junctions. Curr Opin Cell Biol 2004; 16: 507–512
   PubMed Web of Science ®Google Scholar
• Striedinger K, Meda P, Scemes E. Exocytosis of ATP from astrocyte progenitors modulates spontaneous Ca2 + oscillations and cell migration. Glia 2007; 55: 652–662
   PubMed Web of Science ®Google Scholar
• Wellershaus K, Degen J, Deuchars J, Theis M, Charollais A, Caille D, Gauthier B, Janssen-Bienhold U, Meda P, Willecke K. A conditional mouse mutant with cyan fluorescent reporter protein reveals specific expression and functions of connexin36 in cerebral neurons and pancreatic beta-cells. Exp Cell Res 2008; 314: 997–1012
   PubMed Web of Science ®Google Scholar