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Research Article

Pulmonary Immunotoxicology of Select Metals: Aluminum, Arsenic, Cadmium, Chromium, Copper, Manganese, Nickel, Vanadium, and Zinc

Pages 39-69 | Published online: 29 Sep 2008

References

  • Abramson, M. J., Wlodarczyk, J. H., Saunders, N. A., and Hensley, M. J. 1989. Does aluminum smelting cause lung disease? Am. Rev. Respir. Dis. 139:1042–1057.
  • Adamson, I. Y., Prieditis, H., Hedgecock, C., and Vincent, R. 2000. Zinc is the toxic factor in the lung response to an atmospheric particulate sample. Toxicol. Appl. Pharmacol. 166:111–119.
  • Adkins, B., Luginbuhl, G. H., and Gardner, D. E. 1980a. Acute exposure of laboratory mice to manganese oxide. Am. Ind. Hyg. Assoc. J. 41:494–500.
  • Adkins, B., Luginbuhl, G. H., and Gardner, D. E. 1980b. Biochemical changes in pulmonary cells following manganese oxide inhalation. J. Toxicol. Environ. Health 6:445–454.
  • Adkins, B., Luginbuhl, G. H., Miller, F. J., and Gardner, D. E. 1980c. Increased pulmonary susceptibility to streptococcal infection following inhalation of manganese oxide. Environ. Res. 23:110–120.
  • Adkins, B., Richards, J. H., and Gardner, D. E. 1979. Enhancement of experimental respiratory infection following nickel inhalation. Environ. Res. 20: 33-42.Al-Bayati, M. A., Raabe, O. G., and Teague, S. V. 1992. Effect of inhaled dimethylselenide in the Fischer 344 male rat. J. Toxicol. Environ. Health 37:549–557.
  • Al-Laith, M., and Pearce, F. L. 1989. Some further characteristics of histamine secretion from rat mast cells stimulated with sodium orthovanadate. Agents Action 27:65–67.
  • Anderson, W. L., and Tomasi, T. B. 1984. Suppression of lymphocyte proliferation by copper-albumin chelates. J. Biol. Chem. 259: 7602-7606.Aposhian, H. V. 1989. Biochemical toxicology of arsenic. Rev. Biochem. Toxicol. 10:265–299.
  • Aranyi, C., Bradof, J. N., and O’Shea, W. J. 1985. Effects of arsenic trioxide inhalation exposure on pulmonary antibacterial defenses in mice. J. Toxicol. Environ. Health 15:163–172.
  • Arfsten, D. P., Aylward, L. L., and Karch, N. J. 1998. “Chromium.” In Immunotoxicology of Environmental and Occupational Metals. J. T. Zelikoff and P. T. Thomas, eds. pp. 63–92. London: Taylor and Francis.
  • ATSDR: Agency for Toxic Substances and Disease Registry. 1987. Toxicological Profile for Nickel. U.S. Environmental Protection Agency, Atlanta.
  • ATSDR. 1992. Toxicological Profile for Vanadium, U.S. Department of Public Heealth and Human Services, Atlanta.
  • ATSDR. 1994. Toxicological Profile for Zinc, U.S. Department of Public Health and Human Services, Atlanta.
  • ATSDR. 1997. Toxicological Profile for Nickel, (Updated), U.S. Environmental Protection Agency, Atlanta.
  • ATSDR. 1999a. Toxicological Profile for Aluminum, U.S. Department of Public Health and Human Services, Atlanta.
  • ATSDR. 1999b. Toxicological Profile for Cadmium, U.S. Department of Public Health and Human Services, Atlanta.
  • ATSDR. 2000a. Toxicological Profile for Arsenic (Update), U.S. Department of Public Health and Human Services, Atlanta.
  • ATSDR. 2000b. Toxicological Profile for Chromium (Update), U.S. Department of Public Health and Human Services, Atlanta.
  • ATSDR. 2000c. Toxicological Profile for Manganese (Update), U.S. Department of Public Health and Human Services, Atlanta.
  • ATSDR. 2002. Toxicological Profile for Copper (Update), U.S. Department of Public Health and Human Services, Atlanta.
  • Bagchi, D., Bagchi, M., Balmoori, J., Ye, X., and Stohs, S. J. 1997. Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Res. Comm. Mol. Pathol. Pharmacol. 97:335–345.
  • Barcelaux, G. D. 1999. Vanadium. Clin. Toxicol. 37:265–278.
  • Barrie, L. A., and Hoff, R. M. 1985. Five years of air chemistry in the Canadian Arctic. Atmos. Environ. 19:1995–2010.
  • Beach, R. S., Gershwin, M. E., and Hurley, L. S. 1982. Zinc, copper, and manganese in immune function and experimental oncogenesis. Nutr. Cancer 3:172–191.
  • Bell, R. R., Nonavinakere, V. K., and Soliman, M. 2000. Intratracheal exposure of the guinea pig to cadmium and/or selenium: A histological evaluation. Toxicol. Lett. 114:101–109.
  • Benko, V., and Cikrt, M. 1984. Manganese: A review of occupational and environmental toxicology. J. Hyg. Epidemiol. Microbiol. Immunol. 28:139–148.
  • Benko, V., Wagner, V., Wagnerova, M., and Batora, J. 1988. Immunological profiles in workers of a power plant burning coal rich in arsenic content. J. Hyg. Epidemiol. Microbiol. Immunol. 32:137–146.
  • Benko, V., Wagner, V., Wagnerova, M., and Reichrtova, E. 1983. Immuno-biochemical findings in groups of individuals occupationally and non-occupationally exposed to emissions containing nickel and cobalt. J. Hyg. Epidemiol. Microbiol. Immunol. 27:387–394.
  • Bennett, P. A., Dixon, R. J., and Kellie, S. 1993. The phosphotyrosine phosphatase inhibitor vanadyl hydroperoxide induces morphological alterations, cytoskeletal rearrangements, and increased adhesiveness in rat neutrophil leukocytes. J. Cell Sci. 106:891–901.
  • Benova, D., Hadjidekova, V., Hristova, R., Nikolova, T., Boulanova, M., Georgieva, I., Grigorova, M., Popov, T., Panev, T., Georgieva, R., Natarajan, A., Darroudi, F., and Nilsson, R. 2002. Cytogenetic effects of hexavalent chromium in Bulgarian chromium platers. Mutat. Res. 514:29–38.
  • Benson, J. M., Burt, D. G., and Carpenter, R. L. 1988a. Comparative inhalation toxicity of nickel sulfate to F344/N rats and B6C3F1 mice exposed for twelve days. Fundam. Appl. Toxicol. 10:164–178.
  • Benson, J. M., Burt, D. G., Cheng, Y. S., Hahan, F. F., Haley, P. H., Henderson, R. F., Hobbs, C. H., Pickrell, J. A., and Dunnick, J. K. 1989. Biochemical responses of rat and mouse lung to inhaled nickel compounds.Toxicology 57:255–266.
  • Benson, J. M., Carpenter, R. L., Hahn, F. F., Haley, P. J., Hanson, R. L., Hobbs, C. H., Pickrell, J. A., and Dunnick, J. K. 1987. Comparative inhalation toxicity of nickel subsulfide to F344/N rats and B6C3F1 mice exposed for twelve days. Fundam. Appl. Toxicol. 9:251–265.
  • Benson, J. M., Chang, I., Cheng, Y., Hahn, F. F., Kennedy, C. H., Barr, E. B., Maples, K. R., and Snipes, M. B. 1995a. Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate. Fundam. Appl. Toxicol. 28:232–244.
  • Benson, J. M., Cheng, Y. S., Eidson, A. F., Hahn, F. F., Henderson, R. F., and Pickrell, J. A. 1995b. Pulmonary toxicity of nickel subsulfide in F344/N rats exposed for 1-22 days.Toxicology 103:9–22.
  • Benson, J. M., Henderson, R. F., and Pickrell, J. A. 1988b. Comparative in vitro cytotoxicity of nickel oxides and nickel-copper oxides to rat, mouse, and dog pulmonary alveolar macrophages. J. Toxicol. Environ. Health 24:373–383.
  • Benson, J. M., Holmes, A. M., Barr, E., Nikula, K., and March, T. 2000. Particle clearance and histopathology in lungs of C3H/HeJ mice administered beryl-lium/copper alloy by intratracheal instillation. Inhal. Toxicol. 12: 733-749.Benson, J. M., and Zelikoff, J. T. 1996. Respiratory Toxicology of Metals. In Toxicology of Metals. L. W. Chang, ed., pp. 929-938. CRC Press, Boca Raton. Bergstrom, R. 1977. Acute pulmonary toxicity of manganese dioxide. Scand. J. Work Environ. Health 3(Suppl. 1):7-41.
  • Berry, J. P., Meignan, M., Escaig, F., and Galle, P. 1988. Inhaled soluble aerosols insolubilised by lysosomes of alveolar cells. Application to some toxic compounds: Electron microprobe and ion microprobe studies. Toxicology 52:127–139.
  • Blanc, P. D., Boushey, H. A., Wong, H., Wintermeyer, S. F., and Bernstein, M. S. 1993. Cytokines in metal fume fever. Am. Rev. Respir. Dis. 147: 134-138.Blanchard, K. T., Clay, R. J., and Morris, J. B. 1996. Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl. Toxicol. Appl. Pharmacol. 136:280–288.
  • Bonner, J. C., Rice, A. B., Ingram, J. L., Moonmaw, C. R., Nyska, A., Bradbury, A., Sessoms, A. R., Chulada, P. C., Morgan, D. L., Zeldin, D. C., and Langenbach, R. 2002. Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. Am. J. Pathol. 161:459–470.
  • Bonner, J. C., Rice, A. B., Moonmaw, C. R., and Morgan, D. L. 2000. Airway fibrosis in rats induced by vanadium pentoxide. Am. J. Physiol. 278:L209–L216.
  • Borak, J., Cohen, H., and Hethmon, T. A. 2000. Copper exposure and metal fume fever: Lack of evidence for causal relationship? AIHAJ. 61: 832-836.Borella, P., and Bargellini, A. 1993. Effects of trace elements on immune system: Results in cultured human lymphocytes. J. Trace Elem. Electrolytes Health Dis. 7:231–233.
  • Borella, P., Manni, S., and Giardino, A. 1990. Cadmium, nickel, chromium, and lead accummulate in human lymphocytes and interfere with PHA-induced proliferation. J. Trace Elem. Electrolytes Health Dis. 4:87–95.
  • Boscolo, P., Di Gioacchino, M., Cervone, M., Di Giacomo, F., Bavazzano, P., and Builiano, G. 1995. Lymphocyte subpopulations of workers in a plant producing plastic materials (preliminary study). G. Ital. Med. Lav. 17: 27–31.
  • Briggs, T. M., and Owens, T. W. 1980. Industrial Hygiene Characterization of the Photovoltaic Cell Industry. NIOSH Technical Report, DHEW (NIOSH) Publication, pp. 80-112. U.S. Department of Health, Education and Welfare, Cincinnati.
  • Broeckaert, F., Buchet, J. P., Delos, M., Yager, J. W., and Lison, D. 1999. Coal fly ash-and copper smelter dust-induced modulation of ex vivo production of TNF α by murine macrophages: Effects of metals and overload. J. Toxicol. Environ. Health 56:343–360.
  • Broeckaert, F., Buchet, J. P., Huaux, F., Lardot, C., and Lison, D. 1997. Reduction of the ex vivo production of TNF α by alveolar phagocytes after administration of coal fly ash and copper smelter dust. J. Toxicol. Environ. Health 51:189–202.
  • Brown, R. F., Marrs, T. C., Rice, P., and Masek, L. C. 1990. The histopathology of rat lung following exposure to zinc oxide/hexachloroethane smoke or instillation with zinc chloride followed by treatment with 70% oxygen. Environ. Health Perspect. 85:81–87.
  • Burns, L. A. 1998. Arsenic. In Immunotoxicology of Environmental and Occupational Metals. J. T. Zelikoff and P. T. Thomas, eds., pp. 1-26. Taylor and Francis, London.
  • Burns, L. A., Sikorski, E. E., Saady, J., and Munson, A. E. 1991. Evidence for arsenic as the primary immunosuppressive component of gallium arsenide. Toxicol. Appl. Pharmacol. 110:157–169.
  • Bustamante, J., Dock, L., Vahter, M., Fowler, B., and Orrenius, S. 1997. The semiconductor elements arsenic and indium induce apoptosis in rat thymocytes. Toxicology 118:129–136.
  • Camner, P., Casarett-Bruce, M., Curstedt, T., Jarstrand, C., Wiernikm, A., Johansson, A., Lundborg, M., and Robertson, B. 1984. Toxicology of Nickel. In Nickel in the Human Environment, IARC Scientific Publication No. 53. F. W. Sunderman, Jr., ed., pp. 267–276, International Agency for Research on Cancer, World Health Organization, Lyon.
  • Camner, P., Curstedt, T., Jarstrand, C., Johansson, A., Robertson, B., and Wiernik, A. 1985. Rabbit lung after inhalation of manganese chloride: A comparison with the effects of chlorides of nickel, cadmium, cobalt, and copper. Environ. Res. 38:301–309.
  • Carter, J. D., Ghio, A. J., Samet, J. M., and Devlin, R. B. 1997. Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicol. Appl. Pharmacol. 146: 180-188.Castranova, V., Bowman, L., Miles, P. R., and Reasor, M. J. 1980a. Toxicity of metal ions to alveolar macrophages. Am. J. Ind. Med. 1: 349-357.Castranova, V., Bowman, L., Reason, M. J., and Miles, P. R. 1980b. Effects of heavy metal ions on selected oxidative metabolic processes in rat alveolar macrophages. Toxicol. Appl. Pharmacol. 53:14–23.
  • Castranova, V., Bowman, L., Wright, J. R., Colby, H., and Miles, P. R. 1984. Toxicity of metallic ions in the lung: Effect of alveolar macrophages and alveolar Type II cells. J. Toxicol. Environ. Health 13:845–856.
  • Chan, E. D., and Riches, D. 2001. IFN γ + LPS induction of iNOS in modulated by ERK, JNK/SAPK, and p38mapk in a mouse macrophage cell line. Am. J. Physiol. 280:C441–C450.
  • Chan-Yeung, M., Enarson, D. A., MacLean, L., and Irving, D. 1989. Longitudinal study of workers in an aluminum smelter. Arch. Environ. Health 44:134–139.
  • Chasteen, N.D. 1983. The biochemistry of vanadium. Struct. Bonding 53:105–138.
  • Chaumard, C., Quero, A. M., Bouley, G., Girard, F., Boudene, C., and German, A. 1983. Influence of inhaled cadmium microparticles on mouse influenza pneumonia. Environ. Res. 31:428–439.
  • Chaumard, C., Forestier, F., and Quero, A. M. 1991. Influence of inhaled cadmium on the immune response to influenza virus. Arch. Environ. Health 46:50–56.
  • Chen, L. C., and Gordon, T. 2001. Development of pulmonary tolerance in mice exposed to zinc oxide fumes. Toxicol. Sci. 60:144–151.
  • Chen W. J., Monnat, R., and Chen, M. 1978. Aluminum-induced pulmonary granulomatosis. Human Pathol. 9:705–711.
  • Chong, I., Lin, S., Hwang, J., Huang, M., Wang, T., Tsai, M., You, J., and Paulauskis, J. D. 2000a. Expression and regulation of macrophage inflammatory protein-2 gene by vanadium in mouse macrophages. Inflammation 24:127–139.
  • Chong, I., Shi, M. M., Love, J. A., Christiani, D. C., and Paulauskis, J. D. 2000b. Regulation of chemokine mRNA expression in a rat model of vanadium-induced pulmonary inflammation. Inflammation 24:505–517.
  • Cifone, M. G., Procopio, A., Napolitano, T., Alesse, E., Santoni, G., and Santoni, A. 1990. Cadmium inhibits spontaneous (NK), antibody-mediated (ADCC) and IL-2-stimulated cytotoxic functions of natural killer cells. Immunophamacology 20:73–80.
  • Clay, R. J., and Morris, J. B. 1989. Comparative pneumotoxicity of cyclopentadienyl manganese tricarbonyl and methylcyclopentadienyl manganese tricarbonyl. Toxicol. Appl. Pharmacol. 98:434–443.
  • Cleven, R., Janus, J. A., Annema, J. A., and Sloof, W. 1993. Integrated Criteria Document -Zinc. National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
  • Cohen, M. D. 1998. Vanadium. In Experimental Immunotoxicology. J. T. Zelikoff, and P.T. Thomas, eds., pp. 207-229. Taylor and Francis, London. Cohen, M. D. 2000. Metals. In Pulmonary Immunotoxicology, M. D. Cohen, J. T. Zelikoff, and R. B. Schlesinger, eds., pp. 267-300. Kluwer Academic Publishers, Norwell, MA.
  • Cohen, M. D., Becker, S., Devlin, R., Schlesinger, R. B., and Zelikoff, J. T. 1997a. Effects of vanadium upon polyI:C-induced responses in rat lung and alveolar macrophages. J. Toxicol. Environ. Health 51:591–608.
  • Cohen, M. D., Chen, C. M., and Wei, C. I. 1989. Decreased resistance to Listeria monocytogenes in mice following vanadate exposure: Effects upon the function of macrophages. Int. J. Immunopharmacol. 11:285–292.
  • Cohen, M. D., Chen, L. C., Zelikoff, J. T., and Schlesinger, R. B. 1997b. Pulmonary retention and distribution of inhaled chromium: Effects of particle solubility and ozone co-exposure. Inhal. Toxicol. 9:843–865.
  • Cohen, M. D., and Costa, M. 1998. Chromium. In Environmental and Occupational Medicine, 3rd Edition. W. N. Rom, ed., pp. 1045-1055, Lippincott-Raven Publishers, Philadelphia.
  • Cohen, M. D., Parsons, E., Schlesinger, R. B., and Zelikoff, J. T. 1993. Immunotoxicity of in vitro vanadium exposure: Effects on interleukin-1, tumor necrosis factor, and prostaglandin E2 by WEHI-3 macrophages. Int. J. Immunopharmacol. 15:437–446.
  • Cohen, M. D., and Wei, C. I. 1988. Effects of ammonium metavanadate treatment upon macrophage glutathione redox cycle activity, superoxide production, and intracellular glutathione status. J. Leukocyte Biol. 44:122–129.
  • Cohen, M. D., Wei, C. I., Tan, H., and Kao, K. J. 1986. Effect of ammonium metavana-date on the murine immune response. J. Toxicol. Environ. Health 19:279–298.
  • Cohen, M. D., Yang, Z., Qu, Q., Schelsinger, R. B., and Zelikoff, J. T. 1996a. Vanadium affects macrophage interferon-γ binding and -inducible responses. Toxicol. Appl. Pharmacol. 138:110–120.
  • Cohen, M. D., Yang, Z., Zelikoff, J. T., and Schlesinger, R. B. 1996b. Pulmonary immunotoxicity of inhaled ammonium metavanadate in Fisher 344 rats. Fundam. Appl. Toxicol. 33:254–263.
  • Cohen, M. D., Zelikoff, J. T., Chen, L. C., and Schlesinger, R. B. 1998. Immunotoxicologic effects of inhaled chromium: Role of particle solubility and co-exposure to ozone. Toxicol. Appl. Pharmacol. 152:30–40.
  • Cohen, S. R. 1974. A review of the health hazards from copper exposure. J. Occup. Med. 16:621–624.
  • Conklin, A. W., Skinner, C. S., Felten, T. L., and Sanders, C. L. 1982. Clearance and distribution of intratracheally-instilled vanadium compounds in the rat. Toxicol. Lett. 11:199–203.
  • Conner, M. W., Flood, W. H., Rogers, A. E., and Amdur, M. O. 1988. Lung injury in guinea pigs caused by multiple exposures to ultrafine zinc oxide: Changes in pulmonary lavage fluid. J. Toxicol. Environ. Health 25:57–69.
  • Contreras, G. R., and Chan-Yeung, M. 1997. Bronchial reactions to exposure to welding fumes. Occup. Environ. Med. 54:836–839.
  • Costa, M. 2000. Trace Elements: Aluminum, Arsenic, Cadmium, and Nickel. In Environmental Toxicants, 2nd Edition. M. Lippmann, ed., pp. 811-850. Wiley Interscience, New York.
  • Daisey, J. M. 1987. Chemical Composition of Inhalable Particulate Matter-Seasonal and Intersite Comparisons. In Toxic Air Pollution: A Comprehensive Study of Non-Criteria Air Pollutants. P. J. Lioy, and J. M. Daisey, eds., pp. 47-63. Lewis Publishing Inc., Chelsea, MI.
  • Daniels, M. J., Menache, M. G., Burleson, G. R., Graham, J. A., and Selgrade, M. J. 1987. Effects of NiCl2 and CdCl2 on susceptibility to murine cytomegalovirus and virus-augmented NK cell and interferon responses. Fundam. Appl. Toxicol. 8:443–453.
  • Daum, J. R., Shepherd, D. M., and Noelle, R. J. 1993. Immunotoxicology of cadmium and mercury on B-lymphocytes. I: Effects on lymphocyte function. Int. J. Immunopharmacol. 15:383–394.
  • Davies, D. J., and Bennett, B. G. 1985. Exposure of man to environmental copper-an exposure commitment. Sci. Total Environ. 46: 215-227.Davies, T. A. 1946. Manganese pneumonitis. Br. J. Ind. Med. 3: 111-135.Davis, J. M. 1999. Inhalation health risks of manganese: An EPA perspective. Neurotoxicology 20:511–518.
  • Davis, J. M., Jarabek, A. M., Mage, D. T., and Graham, J. A. 1998. The EPA health risk assessment of methylcyclopentadienyl manganese tricarbonyl (MMT). Risk Anal. 18:57–70.
  • Davis, J. M., Jarabek, A. M., Mage, D. T., and Graham, J. A. 1999. Inhalation risk assessment of MMT. Environ. Res. 80:103–104.
  • Davis, R. L., and Milham, S. 1990. Altered immune status in aluminum reduction plant workers. Am. J. Ind. Med. 18:79–85.
  • DeFlora, S., Camoirano, A., Bagnasco, M., Bennicelli, C., Corbett, G. E., and Kerger, B. D. 1997. Estimates of chromium (VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity. Carcinogenesis 18:531–537.
  • Derelanko, M. J., Rinehart, W. E., Hilaski, R. J., Thompson, R. B., and Loser, E. 1999. Thirteen-week subchronic rat inhalation toxicity study with a recovery phase of trivalent chromium compounds, chromic oxide and basic chromium sulfate. Toxicol. Sci. 52:278–288.
  • DeVoto, E., and Yokel, R. A. 1994. The biological speciation and toxicokinetics of aluminum. Environ. Health Perspect. 102:940–951.
  • Dick, C. A., Brown, D. M., Donaldson, K., and Stone, V. 2003. The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types. Inhal. Toxicol. 15:39–52 Dickerson, O. B. 1994. Antimony, Arsenic, and Their Compounds. In Occupational Medicine, Third Edition. C. Zenz, O. B. Dickerson, and E. P. Horvath, Jr., eds., pp. 468-472. Mosby, St. Louis.
  • Dinslage-Schlunz, A., and Rosmanith, J. 1976. The course of dust elimination from the rat lung after long-term inhalation of zinc oxide. Beit. zur Silikoseforsch.-Pneumokon. 28:79–89.
  • Dreher, K. L., Jaskot, R. H., Lehmann, J. R., Richards, J. H., McGee, J. K., Ghio, A. J., and Costa, D. L. 1997. Soluble transition metals mediate residual oil fly ash-induced acute lung injury. J. Toxicol. Environ. Health 50: 285-305.Drinker, P., Thomson, R. M., and Finn, J. L. 1927. Metal fume fever-IV. Threshold doses of zinc oxide, preventive measures, and the chronic effects of repeated exposures. J. Ind. Hyg. 9:331–345.
  • Drown, D. B., Obers, S. G., and Sharma, R. P. 1986. Pulmonary clearance of soluble and insoluble forms of manganese. J. Toxicol. Environ. Health 17:201–212.
  • Drummond, J. G., Aranyi, C., Schiff, L. J., Fenters, J. D., and Graham, J. A. 1986. Comparative study of various methods used for determining health effects of inhaled sulfates. Environ. Res. 41:514–528.
  • Dufresne, A., Loosereewanich, P., Armstrong, B., Theriault, G., and Begin, R. 1996. Inorganic particles in the lungs of five aluminum smelter workers with pleuro-pulmonary cancer. Am. Ind. Hyg. Assoc. J. 57:370–375.
  • Duncan, D. D., and Lawrence, D. A. 1988. Four sulfhydryl-modifying compounds cause different structural damage but similar functional damage in murine lymphocytes. Chem.-Biol. Interact. 68:137–152.
  • Dunnick, J. K., Elwell, M. R., Benson, J. M., Hobbs, C. H., Hahn, F. F., Haley, P. J., Cheng, Y. S., and Edison, A. F. 1989. Lung toxicity after 13-week inhalation exposure to nickel oxide, nickel subsulfide, or nickel sulfate hexahydrate in F344/N rats and B6C3F1 mice. Fundam. Appl. Toxicol. 12:584–594.
  • Dye, J. A., Adler, K. B., Richards, J. H., and Dreher, K. L. 1999. Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression. Am. J. Physiol. 277:L498–L510.
  • Eckert, H., and Jerochin, S. 1982. Copper sulfate-mediated changes of the lung. An experimental contribution to pathogenesis of Vineyard Sprayer’s Lung. Z. Erkrank. Atm. Org. 158:270–276.
  • Edel, J., and Sabbioni, E. 1988. Retention of intratracheally-instilled and ingested tetravalent and pentavalent vanadium in the rat. J. Trace Elem. Electrolytes Health Dis. 2:23–30.
  • Ehrlich, R. 1980. Interactions between environmental pollutants and respiratory infections. Environ. Health Perspect. 35:89–100.
  • Ehrlich, R., Findlay, J. C., and Gardner, D. E. 1978. Susceptibility to bacterial pneumonia of animals exposed to sulfates. Toxicol. Lett. 1: 325-330.Eklund, A., Arns, R., Blaschke, E., Hed, J., Hjertquist, S. O., Larsson, K., Lowgren, H., Nystrom, J., Skold, C. M., and Tornling, G. 1989. Characteristics of alveolar cells and soluble components in bronchoalveolar lavage fluid from non-smoking aluminum potroom workers. Br. J. Ind. Med. 46: 782-786.Ellingsen, D. G., Hetland, S., and Thomassen, Y. 2003. Manganese air exposure assessment and biological monitoring in the manganese alloy production industry. J. Environ. Monitor. 5:84–90.
  • Elliott, G. R., van Batenburg, M. J., and Bonta, I. L. 1987. Copper modulation of macrophage cyclooxygenase metabolite synthesis. Prostaglandins 34:657–667.
  • Ess, S. M., Steinegger, A. F., Ess, H. J., and Schlatter, C. 1993. Experimental study on the fibrogenic properties of different types of alumina. Am. Ind. Hyg. Assoc. J. 54:360–370.
  • Evans, E. F. 1945. Casualties following exposure to zinc chloride. Lancet 2: 368–370.
  • Evans, G. A., Garcia, G. G., Erwin, R., Howard, O. M., and Farrar, W. L. 1994. Pervanadate simulates the effects of interleukin-2 (IL-2) in human T-cells and provides evidence for the activation of two distinct tyrosine kinase pathways by IL-2. J. Biol. Chem. 269:23407–23412.
  • Farmer, J. G., and Johnson, L. R. 1990. Assessment of occupational exposure to inorganic arsenic based on urinary concentration and speciation of arsenic. Br. J. Ind. Med. 47:342–348.
  • Fine, J. M., Gordon, T., Chen, L. C., Kinney, P., Falcone, G., and Beckett, W. S. 1997. Metal fume fever: Characterization of clinical and plasma IL-6 responses in controlled human exposures to zinc oxide fume at and below the threshold limit value. J. Occup. Environ. Med. 39:722–726.
  • Fine, J. M., Gordon, T., Chen, L. C., Kinney, P., Falcone, G., Sparer, J., and
  • Beckett, W. S. 2000. Characterization of clinical tolerance to inhaled zinc oxide in naive subjects and sheet metal workers. J. Occup. Environ. Med. 42:1085–1091.
  • Fishbein, L. 1984. Overview of analysis of carcinogenic and/or mutagenic metals in biological and environmental samples. I. Arsenic, beryllium, cadmium, chromium and selenium. Intl. J. Environ. Anal. Chem. 17: 113-170.Fishburn, C. W., and Zenz, C. 1969. Metal fume fever. A report of a case. J. Occup. Med. 11:142–144.
  • Fisher, G. L., McNeill, K. L., and Democko, C. J. 1986. Trace element interactions affecting pulmonary macrophage cytotoxicity. Environ. Res. 39: 164–171.
  • Fisher, G. L., McNeill, K. L., Whaley, C. B., and Fong, J. 1978. Attachment and phagocytosis studies with murine pulmonary alveolar macrophages. J. Reticuloendothel. Soc. 24:243–252.
  • Flinn, R. H., Neal, P. A., Rinehart, W. H., Dallavalee, J. M., Fulton, W. B., and Dooley, A. E. 1940. Chronic Manganese Poisoning in an Ore-Crushing Mill. Public Health Bulletin No. 247.
  • Flynn, A. 1985. In vitro levels of copper, magnesium, and zinc required for mitogen-stimulated T-lymphocyte proliferation. Nutr. Res. 5: 487-495.Fortoul, T. I., Quan-Torres, A., Sanchez, I., Lopez, I. E., Bizarro, P., Mendoza, M. L., Osorio, L., Espejel-Maya, G., Avila-Casado, C., Avila-Costa, M., Colin-Barenque, L., Villanueva, D. N., and Olaiz-Fernandez, G. 2002. Vanadium in ambient air: Concentrations in lung tissue from autopsies of Mexico City residents in the 1960s and 1990s. Arch. Environ. Health 57:446–449.
  • Funkhouser, S. W., Martinez-Maza, O., and Vredevoe, D. 1994. Cadmium inhibits IL-6 production and IL-6 mRNA expression in a human monocytic cell line, THP-1. Environ. Res. 66:77–86.
  • Gallagher, K. E., Mattarazzo, W. J., and Gray I. 1979. Trace metal modification of immunocompetence: II. Effect of Pb2+,Cd2+, and Cr3+ on RNA turnover, hexokinase activity, and blastogenesis during B-lymphocyte transformation in vitro. Clin. Immunol. Immunopathol. 13:369–377.
  • Gallagher, K. E., and Gray I. 1982. Cadmium inhibition of RNA metabolism in murine lymphocytes. J. Immunopharmacol. 3:339–361.
  • Galvin, J. B., and Oberg, S. G. 1984. Toxicity of hexavalent chromium to the alveolar macrophage in vivo and in vitro. Environ. Res. 33:7–16.
  • Ganrot, P. O. 1986. Metabolism and possible health effects of aluminum. Environ. Health Perspect. 65:363–441.
  • Garcia-Vargas, G. G., and Cebrian, M. E. 1996. Health Effects of Arsenic. In Toxicology of Metals. L. W. Chang, ed., pp. 423-438. CRC Press, Boca Raton. Gardner, D. E., Miller, F. J., Illing, J. W., and Kirtz, J. M. 1977. Alterations in bacterial defense mechanisms of the lung induced by inhalation of cadmium. Bull. Eur. Physiopathol. Respir. 13:157–174.
  • Gavett, S. H., Madison, S. L., Dreher, K. L., Winsett, D. W., McGee, J. K., and Costa, D. L. 1997. Metal and sulfate composition of residual oil fly ash determines airway hyperreactivity and lung injury in rats. Environ. Res. 72:162–172.
  • Geertz, R., Gulyas, H., and Gercken, G. 1994. Cytotoxicity of dust constituents towards alveolar macrophages: Interactions of heavy metal compounds. Toxicology 86:13–27.
  • Gerber, G. B., Leonard, A., and Hantson, P. 2002. Carcinogenicity, mutagenicity, and teratogenicity of manganese compounds. CRC Crit. Rev Oncol.-Hematol. 42:25–34.
  • Gibbs, G. W. 1985. Mortality of aluminum reduction plant workers, 1950 through 1977. J. Occup. Med. 27:761–770.
  • Glaser, U., Hochrainer, D., Kloppel, H., and Kuhmen, H. 1985. Low level chromium(VI) inhalation effects on alveolar macrophages and immune functions in Wistar rats. Arch. Toxicol. 57:250–256.
  • Glaser, U., Hochrainer, D., Kloppel, H., and Oldiges, H. 1986. Carcinogenicity of sodium dichromate and chromium (VI/III) oxide aerosols inhaled by male Wistar rats. Toxicology 42:219–232.
  • Gordon, T., Chen, L. C., Fine, J. M., Schlesinger, R. B., Su, W., Kimmel, T. A., and Amdur, M. O. 1992. Pulmonary effects of inhaled zinc oxide in human subjects, guinea pigs, rats, and rabbits. Am. Ind. Hyg. Assoc. J. 53:503–509.
  • Goren, M. B., Swendsen, S. L., Fiscus, J., and Miranti, C. 1984. Fluorescent markers for studying phagosomelysosome fusion. J. Leukocyte Biol. 36: 273–282.
  • Goutet, M., Ban, M., and Binet, S. 2000. Effects of nickel sulfate on pulmonary natural immunity in Wistar rats. Toxicology 145:15–26.
  • Goyer, R. A. 1996. Toxic Effects of Metals. In Casarett and Doull’s Toxicology: The Basic Science of Poisons. C. D. Klaassen, ed., pp. 691-698. McGraw-Hill, New York.
  • Grabowski, G. M., Paulauskis, J. D., and Godleski, J. J. 1999. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol. Appl. Pharmacol. 156:170–178.
  • Graham, J. A., Gardner, D. E., Waters, M. D., and Coffin, D. C. 1975. Effect of trace metals on phagocytosis by alveolar macrophages. Infect. Immun. 11:1278–1283.
  • Graham, J. A., Miller, F. J., Daniels, M. J., Payne, E. A., and Gardner, D. E. 1978. Influence of cadmium, nickel, and chromium on primary immunity in mice. Environ. Res. 16:77–87.
  • Grinstein, S., Furuya, W., Lu, D. J., and Mills, G. B. 1990. Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils. J. Biol. Chem. 265:318–327.
  • Gusev, V. A., Danilovskaja, Y. V., Vatolkina, O. Y., Lomonosova, O. S., and Velichkovsky, B. T. 1993. Effect of quartz and alumina dust on generation of superoxide radicals and hydrogen peroxide by alveolar macrophages, granulocytes, and monocytes. Br. J. Ind. Med. 50:732–735.
  • Hadley, J. G., Gardner, D. E., Coffin, D. L., and Menzel, D. B. 1977. Inhibition of antbody-mediated rosette formation by alveolar macrophages: A sensitive assay for metal toxicity. J. Reticuloendothel. Soc. 22:417–422.
  • Hakkinen, P. J., and Haschek, W. M. 1982. Pulmonary toxicity of methylcyclopentadienyl manganese tricarbonyl: Nonciliated bronchiolar epithelial (Clara) cell necrosis and alveolar damage in the mouse, rat, and hamster. Toxicol. Appl. Pharmacol. 65:11–22.
  • Haley, P. J., Bice, D. E., Muggenburg, B. A., Hahn, F. F., and Benjamin, S. A. 1987. Immunopathologic effects of nickel subsulfide on the primate pulmonary immune system. Toxicol. Appl. Pharmacol. 88:1–12.
  • Haley, P. J., Shopp, G. M., Benson, J. M., Cheng, Y. S., Bice, D. E., Luster, M. I., Dunnick, J. K., and Hobbs, C. H. 1990. The immunotoxicity of three nickel compounds following a 13-week inhalation exposure in the mouse. Fundam. Appl. Toxicol. 15:476–487.
  • Hassoun, E. A., and Stohs, S. J. 1995. Chromium-induced production of reactive oxygen species, DNA single-strand breads, nitric oxide production, and lactate dehydrogenase leakage in J774A.1 cell cultures. J. Biochem. Toxicol. 10:315–321.
  • Hatch, G. E., Slade, R., Boykin, E., Hu, P. C., Miller, F. J., and Gardner, D. E. 1981. Correlation of effects of inhaled versus intratracheally-injected metals on susceptibility to respiratory infection in mice. Am. Rev. Respir. Dis. 124:167–173.
  • Hickey, R. J., Schoff, E. P., and Clelland, R. C. 1967. Relationship between air pollution and certain chronic disease death rates. Arch. Environ. Health 15:728–739.
  • Hinderer, R. K. 1979. Toxicity studies of methylcyclopentadienyl manganese tricarbonyl (MMT). Am. Ind. Hyg. Assoc. J. 40:164–167.
  • Hirano, S., Ebihara, H., Sakai, S., Kodama, N., and Suzuki, K. T. 1993. Pulmonary clearance and toxicity of intratracheally-instilled cupric oxide in rats. Arch. Toxicol. 67:312–317.
  • Hirano, S., Sakai, S., Ebihara, H., Kodama, N., and Suzuki, K. T. 1990. Metabolism and pulmonary toxicity of intratracheally-instilled cupric sulfate in rats. Toxicology 64:223–233.
  • Hjortsø, E., Qvist, J., Bud, M. I., Thomsen, J. L., Andersen, J. B., Wiberg-Jorgensen, F., Jensen, N. K., Jones, R., Reid, L. M., and Zapol, W. M. 1988. ARDS after accidental inhalation of zinc chloride smoke. Intensive Care Med. 14:17–24.
  • Hodges, N. J., Adam, B., Lee, A. J., Cross, H. J., and Chipman, J. K. 2001. Induction of DNA strandbreaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: Association with 8-oxo-2-dexyguanosine formation and inter-individual variability. Mutagenesis 16: 467-474.Homma, S., Jones, R., Qvist, J., Zapol, W. M, and Reid, L. 1992. Pulmonary vascular lesions in the adult respiratory distress syndrome caused by inhalation of zinc chloride smoke: A morphometric study. Human Pathol. 23: 45-50.Hopkins, L. L., and Tilton, B. E. 1966. Metabolism of trace amounts of vanadium48 in rat organs and liver subcellular particles. Am. J. Physiol. 211:169–172.
  • Horiguchi, H., Mukaida, N., Okamoto, S., Teranishi, H., Kasuya, M., and Matsushima, K. 1993. Cadmium induces interleukin-8 production in human peripheral blood mononuclear cells with the concomitant generation of su-peroxide radicals. Lymphokine Cytokine Res. 12:421–428.
  • Huaux, F., Lasfargues, G., Lauwerys, R., and Lison, D. 1995. Lung toxicity of hard metal particles and production of interleukin-1, tumor necrosis factor-α, fibronectin, and cyctatin-c by lung phagocytes. Toxicol. Appl. Pharmacol. 132:53–62.
  • Hull, M. J., and Abraham, J. L. 2002. Aluminum welding fume-induced pneumoconiosis. Human Pathol. 33:819–825.
  • IARC: International Agency for Research on Cancer. 1980. Some Metals and Metallic Compounds, Monograph 23, World Health Organization, Lyon. IARC. 1990. Chromium, Nickel, and Welding, Monograph 49, World Health Organization, Lyon.
  • IARC. 1993. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry, Monograph 58, World Health Organization, Lyon.
  • IARC. 1987. Overall Evaluation of Carcinogenicity: An Updating of IARC Monographs 1-42, Supplement 7, World Health Organization, Lyon. Igarishi, K., David, M., Larner, A. C., and Finbloom, D. S. 1993. In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate. Mol. Cell. Biol. 13:3984–3989.
  • Imbert, V., Peyron, J. F., Far, D. F., Mari, B., Auberger, P., and Rossi, B. 1994.
  • Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem. J. 297:163–173.
  • Irsigler, G. B., Visseer, P. J., and Spangenberg, P. 1999. Asthma and chemical bronchitis in vanadium plant workers. Am. J. Ind. Med. 35: 336-374.Ishiguro, S., Miyamoto, A., Tokushima, T., Ueda, A., and Nishio, A. 2000. Low extracellular Mg2+ concentrations suppress phagocytosis in vitro by alveolar macrophages from rats. Magnesium Res. 13:11–18.
  • Ishihara, Y., Kyono, H., Serita, F., Toya, T., Kawashima, H., and Miyasaka, M. 2002. Inflammatory responses and mucus secretion in rats with acute broncheolitis induced by nickel chloride. Inhal. Toxicol. 14: 417-430.Ishiyama, H., Ogino, K., Sato, M., Ogura, M., Dan, S., and Hobara, T. 1997. Histopathological changes induced by zinc hydroxide in rat lungs. Exp. Toxic. Pathol. 49:261–266.
  • Jaramillo, M., and Olivier, M. 2002. Hydrogen peroxide induces murine macrophage chemokine gene transcription via extracellular signal-regulated kinase-and cAMP-dependent pathways: Involvement of NF-κ B, activator protein 1, and cAMP response element binding protein. J. Immunol. 169:7026–7038.
  • Johansson, A., and Camner, P. 1980. Effects of nickel dust on rabbit alveolar epithelium. Environ. Res. 22:510–516.
  • Johansson, A., and Camner, P. 1986. Adverse effects of metals on the alveolar part of the lung. Scan. Electron Microsc. II:631-637.
  • Johansson, A., Camner, P., Jarstrand, C., and Wiernik, A. 1983. Rabbit alveolar macrophages after inhalation of soluble cadmium, cobalt, and copper: A comparison with the effects of soluble nickel. Environ. Res. 31: 340-354.Johansson, A., Camner, P., Jarstrand, C., and Wiernik, A. 1983. Rabbit lungs after long-term exposure to low nickel dust concentrations. II. Effects on morphology and function. Environ. Res. 30:142–151.
  • Johansson, A., Curstedt, T., Jarstrand, C., and Camner, P. 1992. Alveolar macrophages and lung lesions after combined exposure to nickel, cobalt, and trivalent chromium. Environ. Health Perspect. 97:215–219.
  • Johansson, A., Curstedt, T., Robertson, B., and Camner, P. 1989. Lung lesions after experimental combined exposure to nickel and trivalent chromium. Environ. Res. 50:103–119.
  • Johansson, A., Robertson, B., Curstedt, T., and Camner, P. 1986b. Rabbit lung after inhalation of hexa-and trivalent chromium. Environ. Res. 41:110–119.
  • Johansson, A., Wiernik, A., Jarstrand, C., and Camner, P. 1986a. Rabbit alveolar macrophages after inhalation of hexa-and trivalent chromium. Environ. Res. 39:372–385.
  • Jones, D. G. 1984. Effects of dietary copper depletion on acute and delayed inflammatory response in mice. Res. Vet. Sci. 37:205–210.
  • Jones, D. G., and Suttle, N. F. 1983. The effect of copper deficiency on the resistance of mice to infection with Pasturella haemolytica. J. Comp. Pathol. 93:143–149.
  • Jones, K. C., and Bennett, B. G. 1986. Exposure of man to environmental aluminum-an exposure commitment assessment. Sci. Total Environ. 52: 65–82.
  • Kacew, S., Parulekar, M. R., and Merali, Z. 1982. Effects of parenteral vanadium administration on pulmonary metabolism of rats. Toxicol. Lett. 11: 119-124.Kadota, S., Fantus, I. G., Deragon, G., Guyda, H. J., and Posner, B. I. 1987. Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2. J. Biol. Chem. 262:8252–8256.
  • Karlsson, N., Cassel, G., Fangmark, I., and Bergman, F. 1986. A comparative study of the acute inhalation toxicity of smoke from TiO2-hexachloroethane and Zn-hexachloroethane pyrotechnic mixtures. Arch. Toxicol. 59:160–166.
  • Kastelan, M., Gerencer, M., Kastelan, A., and Gamulin, S. 1981. Inhibition of mitogen-and specific antigen-induced human proliferation by cadmium. Exp. Cell Biol. 49:15–19.
  • Kennedy, T., Ghio, A. J., Reed, W., Samet, J., Zagorski, J., Quay, J., Carter, J., Dailey, L., Hoidal, J. R., and Devlin, R. B. 1998. Copper-dependent inflammation and nuclear factor-κ B activation by particulate air pollution. Am. J. Respir. Cell Mol. Biol. 19:366–378.
  • Kielkowski, D., and Rees, D. 1997. Report on Exposure and Health Assessment of Vanadium in Workers. National Centre for Occupational Health, Project No. 925242/96, Report No. 3.1997.
  • Kilburn, K. H. 1998. Pulmonary and Neurologic Effects of Aluminum. In Environmental and Occupational Medicine, 3rd ed. W. N. Rom, ed., pp. 1065-1073. Lippincott-Raven Publishers, Philadelphia.
  • Kivuoloto, M. 1980. Observations on the lungs of vanadium workers. Br. J. Ind. Med. 37:363–366.
  • Kivuoloto, M., Pakarinen, A., and Pyy, L. 1980. Clinical laboratory results of vanadium-exposed workers. Arch. Environ. Health 36: 109-1130.Kivuoloto, M., Rasanen, O., Rinne, A., and Rissanen, M. 1981. Intracellular immunoglobulin in plasma cells of nasal biopsies taken from vanadium-exposed workers. Annt. Anz. Jena 149:446–450.
  • Kivuoloto, M., Rasanen, O., Rinne, A., and Rissanen, M. 1979. Effects of vanadium on the upper respiratory tract of workers in a vanadium factory. A macroscopic and microscopic study. Scand. J. Work Environ. Health 5: 50–58.
  • Klarlund, J. K., Latini, S., and Forchhammer, J. 1988. Numerous proteins phosphorylated on tyrosine and enhanced tyrosine kinase activities in vanadate-treated NIH 3T3 fibroblasts. Biochim. Biophys. Acta 971:112–120.
  • Knecht, E. A., Moorman, W. J., Clark, J. C., Hull, R. D., Biagini, R. E., Lynch, D. W., Boyle, T. J., and Simon, S. D. 1992. Pulmonary reactivity to vanadium pentoxide following subchronic inhalation exposure in a non-human primate animal model. J. Appl. Toxicol. 12:427–434.
  • Knecht, E. A., Moorman, W. J., Clark, J. C., Lynch, D. W., and Lewis, T. R. 1985. Pulmonary effects of acute vanadium pentoxide inhalation in monkeys. Am. Rev. Respir. Dis. 132:1181–1185.
  • Kodavanti, U. P., Hauser, R., Christiani, D. C., Meng, Z., McGee, J., Ledbetter, A., Richards, J., and Costa, D. L. 1998. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol. Sci. 43:204–212.
  • Kodovanti, U. P., Schladweiler, M. C., Ledbetter, A. D., Hauser, R., Christiani, D. C., Samet, J. M., McGee, J., Richards, J. H., and Costa, D. L. 2002. Pulmonary and systemic effects of zinc-containing emission particles in three rat strains: Multiple exposure scenarios. Toxicol. Sci. 70:73–85.
  • Koller, L. D. 1998. Cadmium. In Immunotoxicology of Environmental and Occupational Metals. J. T. Zelikoff and P. T. Thomas, eds., pp. 41-61. Taylor and Francis, London.
  • Koller, L. D., and Brauner, J. A. 1977. Decreased B-cell response after exposure to lead and cadmium. Toxicol. Appl. Pharmacol. 42:621–624.
  • Kramer, C. M., Coles, R. B., and Carchman, R. A. 1990. In vitro effects of cadmium chloride on calcium metabolism in guinea pig alveolar macrophages: Lack of correlation with superoxide anion release or phagocytosis. In Vitro Toxicol. 3:153–160.
  • Kraus, T., Quidenus, G., and Schaller, K.H. 2000. Normal values for arsenic and selenium concentrations in human lung tissue. Arch. Environ. Contam. Toxicol. 38:384–389.
  • Krzystyniak, K., Fournier, M., Trotter, B., Nadieu, B., and Chevalier, G. 1987. Immunosuppression in mice after inhalation of cadmium aerosol. Toxicol. Lett. 38:1–12.
  • Kudo, N., Nakagawa, Y., and Waku, K. 1996. Biphasic effect of cadmium ions on the secretion of leukotriene B4 in rabbit alveolar macrophages. Arch. Toxicol. 70:801–808.
  • Kuratsune, M., Tokudome, S., Shirakusa, T., Yoshida, M., Tokumitsu, Y., Hayano, T., and Seita, M. 1974. Occupational lung cancer among copper smelters. Int. J. Cancer 13:552–558.
  • Kurosaka, K., Takahashi, M., and Kobayashi, Y. 2003. Activation of extracellular signal-regulated kinase 1/2 is involved in production of CXC-chemokine by macrophages during phagocytosis of late apoptotic cells. Biochem. Biophys. Res. Commun. 306:1070–1074.
  • Kuschner, W. G., D’Alessandro, A., Wintermeyer, S. F., Wong, H., Boushey, H. A., and Blanc, P. D. 1995. Pulmonary responses to purified zinc oxide fume. J. Invest. Med. 43:371–378.
  • Kuschner, W. G., D’Alessandro, A., Wong, H., and Blanc, P. D. 1997. Early pulmonary cytokine responses to zinc oxide fume inhalation. Environ. Res. 75:7–11.
  • La Dou, J. 1986. Health issues in the microelectronics industry. Ocup. Med. 1:1–11.
  • Labedzka, M., Gulyas, H., Schmidt, N., and Gercken, G. 1989. Toxicity of metallic ions and oxides to rabbit alveolar macrophages. Environ. Res. 48:255–274. Landrigan, P. J. 1992. Arsenic. In Environmental and Occupational Medicine, 2nd Edition. W. N. Rom, ed., pp. 773-779. Little, Brown, and Company, Toronto.
  • Landsberger, S., and Wu, D. 1995. The impact of heavy metals from environmental tobacco smoke on indoor air quality as determined by Compton suppression neu-tron activation analyses. Sci. Total Environ. 173-174:323–337.
  • Lantz, R. C., Parliman, G., Chen, G. J., Barber, D., Winski, S., and Carter, D. E. 1995. Effect of arsenic exposure on alveolar macrophage function II. Effect of slightly soluble forms of As(III) and As(V). Environ. Res. 68:59–67.
  • Lantz, R. C., Parliman, G., Chen, G. J., and Carter, D. E. 1994. Effect of arsenic exposure on alveolar macrophage function I. Effect of soluble As(III) and As(V). Environ. Res. 67:183–195.
  • Larsson, K., Eklund, A., Arns, R., Lowgren, H., Nystrom, J., Sundstrom, G., and Tornling, G. 1989. Lung function and bronchial reactivity in aluminum potroom workers. Scand. J. Work Environ. Health 15:296–301.
  • Lauwerys, R. R. 1994. Cadmium and Its Compounds. In Occupational Medicine, Third Edition. C. Zenz, O. B. Dickerson, and E. P. Horvath, Jr., eds., pp. 481-486. Mosby, St. Louis.
  • Lawrence, D. A. 1981. Heavy metal modulation of lymphocyte activities. I. In vitro effects of heavy metals on primary humoral immune response. Toxicol. Appl. Pharmacol. 57:439–451.
  • Lee, D. N., Yen, H. T., Shen, T. F., and Chen, B. J. 2000. Chromium-induced glucose uptake, superoxide anion production, and phagocytosis in cultured pulmonary alveolar macrophages of weanling pigs. Biol. Trace Elem. Res. 77:53–64.
  • Lees, R. E. 1980. Changes in lung function after exposure to vanadium compounds in fuel oil ash. Br. J. Ind. Med. 37:253–256.
  • Lehman, K. B. 1910. Study of technically and hygienically important gases and steams. XIV. Foundry or zinc fever. Arch. Hyg. 72:358–381.
  • Levy, B. S., Hoffman, L., and Gottsegen, S. 1984. Boilermakers’ bronchitis. Respiratory tract irritation associated with vanadium pentoxide during oil-to-coal conversion of a power plant. J. Occup. Med. 26:567–570.
  • Lewis, A. J. 1982. The role of copper in inflammatory disorders. Agents Actions 15:513–519.
  • Lindenschmidt, R. C., Driscoll, K. E., Perkins, M. A., Higgins, J. M., Maurer, J. K., and Belfiore, K. A. 1990. The comparison of a fibrogenic and two nonfibrogenic dusts by bronchoalveolar lavage. Toxicol. Appl. Pharmacol. 102:268–281.
  • Lipsky, P. E. 1981. Modulation of T-lymphocyte function by copper and thiols. Agents Actions 8 (Suppl.):85-102.
  • Lipsky, P. E. 1984. Immunosuppression by D-penicillamine in vitro: Inhibition of human T-lymphocyte proliferation by copper-or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes. J. Clin. Invest. 73:53–654.
  • Lipsky, P. E., and Ziff, M. 1980. Inhibition of human helper T-cell function in vitro by D-penicillamine and CuSO4. J. Clin. Invest. 65:1069–1076.
  • Lison, D., Lardot, C., Huaux, F., Zanetti, G., and Fubini, B. 1997. Influence of particle surface area on the toxicity of insoluble manganese dioxide dusts. Arch. Toxicol. 71:725–729.
  • Ljunggren, K. G., Lidums, V., and Sjogren, B. 1991. Blood and urine concentrations of aluminum among workers exposed to aluminum flake powders. Br. J. Ind. Med. 48:106–109.
  • Loose, S. D., Silkworth, J. B., and Simpson, D. W. 1978a. Influence of cadmium on the phagocytic and microbial activity of murine peritoneal macrophages, pulmonary alveolar macrophages, and polymorphonuclear neutrophils. Infect. Immun. 22:378–381.
  • Loose, S. D., Silkworth, J. B., and Warrington, D. 1977. Cadmium-induced depression of respiratory burst in mouse pulmonary alveolar macrophages, peritoneal macrophages, and polymorphonuclear neutrophils. Biochem. Biophys. Res. Commun. 79:326–332.
  • Loose, S. D., Silkworth, J. B., and Warrington, D. 1978b. Cadmium-induced phagocyte cytotoxicity. Bull. Environ. Contam. Toxicol. 20: 582-588.Loranger, S., and Zayed, J. 1995. Environmental and occupational exposure to manganese: A multimedia assessment. Int. Arch. Occup. Environ. Health 67:101–110.
  • Loranger, S., and Zayed, J. 1997. Environmental contamination and human exposure to airborne total and respirable manganese in Montreal. J. Air Waste Man. Assoc. 47:983–989.
  • Ludwig, J. C., and Chvapil, M. 1981. Effects of Metal Ions on Lysosomes. In Trace Elements in the Pathogenesis and Treatment of Inflammation, Agents and Actions, Supplement Vol. 8. K. D. Rainsford, K. Brune, and M. W. Whitehouse, eds., pp. 65–84. Birkhauser-Verlag, Basel.
  • Lukasewycz, O. A., and Prohaska, J. R. 1983. Lymphocytes from copper-deficient mice exhibit decreased mitogen reactivity. Nutr. Res. 3: 335-341.Lukasewycz, O. A., and Prohaska, J. R. 1990. The immune response in copper deficiency. Ann. N.Y. Acad. Sci. 587:147–159.
  • Lukasewycz, O. A., Prohaska, J. R., Meyer, S. G., Schmidtke, J. R., Hatfield, S. M., and Marder, P. 1985. Alterations in lymphocyte subpopulations in copper-deficient mice. Infect. Immun. 48:644–647.
  • Lundborg, M., and Camner, P. 1984. Lysozyme levels in rabbit lung after inhalation of nickel, cadmium, cobalt, and copper chlorides. Environ. Res. 34:335–342.
  • Lundborg, M., Johnansson, A., and Camner, P. 1987. Morphology and release of lysozyme following exposure of rabbit lung macrophages to nickel or cadmium in vitro. Toxicology 46:191–202.
  • Lundborg, M., Lind, B., and Camner, P. 1984. Ability of rabbit alveolar macrophages to dissolve metals. Exp. Lung Res. 7:11–22.
  • Lutsenko, L. A., Borisenkova, R. V., Gvozdeva, L. L., Skriabin, S., and Ivanova, L. G. 1997. Fibrogenic and general toxic effects of copper and nickel sulfide ore dust. Med. Truda Prom. Ekol. 5:38–43.
  • Lyle, W. H., Payton, J. E., and Hui, M., 1976. Haemodialysis and copper fever. Lancet 2:1324–1325.
  • Mabuchi, K., Lilienfeld, A. M., and Snell, L. M. 1979. Lung cancer among pesticide workers exposed to inorganic arsenicals. Arch. Environ. Health 34:312–320.
  • Maier, L. A. 2002. Clinical approach to chronic beryllium disease and other nonpneumoconiotic interstitial lung diseases. J. Thor. Imaging 17: 273-284.Maigetter, R. Z., Ehrlich, R., Fenters, J. D., and Gardner, D. E. 1976. Potentiating effects of manganese dioxide on experimental respiratory infections. Environ. Res. 11:386–391.
  • Mali, J. L., and Carter, A. 1987. Occupational asthma due to fumes of galvanised metal. Chest 92:375–376.
  • Mali, J. L., Carter, A., and Dolovich, J. 1993. Occupational asthma due to zinc. Eur. Respir. J. 6:447–450.
  • Malo, J. L., Cartier, A., Doepner, M., Nieboer, E., Evans, S., and Dolovich, J. 1982. Occupational asthma caused by nickel sulfate. J. Allergy Clin. Immunol. 69:55–59.
  • Malo, J. L., Cartier, A., Gagnon, G., Evans, S., and Dolovich, J. 1985. Isolated late asthmatic reaction due to nickel antibody. Clin. Allergy 15: 95-99.Maloney, M. E. 1996. Arsenic in dermatology. Dermatol. Surg. 22:301–304.
  • Marrs, T. C., Clifford, W. E., and Colgrave, H. F. 1983. Pathological changes produced by exposure of rabbits and rats to smokes from mixtures of hexachloroethane and zinc oxide. Toxicol. Lett. 19:247–252.
  • Mastromatteo, E. 1994. Nickel and Its Compounds. In Occupational Medicine, Third Edition. C. Zenz, O. B. Dickerson, and E. P. Horvath, Jr., eds., pp. 558-571. Mosby, St. Louis.
  • Matarese, S. L., and Matthews, J. I. 1986. Zinc chloride (smoke bomb) inhalational lung injury. Chest 89:308–309.
  • McCord CP. 1960. Metal fume fever as an immunological disease. Ind. Med. Surg. 29:101–106.
  • McDowell, S. A., Gammon, K., Zingarelli, B., Bachurski, C. J., Aronow, B. J., Prows, D. R., and Leikauf, G. D. 2003. Inhibition of nitric oxide restores surfactant gene expression following nickel-induced lung injury. Am. J. Respir. Cell Mol. Biol. 28:188–198.
  • McKenna, I. M., Waalkes, M. P., Chen, L. C., and Gordon, T. 1997. Comparison of inflammatory lung responses in Wistar rats and C57 and DBA mice following acute exposure to cadmium oxide fumes. Toxicol. Appl. Pharmacol. 146:196–206.
  • Migally, N., Murthy, R. C., Doye, A., and Zambernard, J. 1982. Changes in pulmonary alveolar macrophages in rats exposed to oxides of zinc and nickel. J. Submicrosc. Cytol. 14:621–626.
  • Montero, M. R., Guerri, C., Ribelles, M., and Grisoia, S. 1981. Inhibition of protein synthesis in cell cultures by vanadate and in brain homogenates of rats fed vanadate. Physiol. Chem. Phys. 13:281–287.
  • Morgan, D. L., Shines, C. J., Jeter, S. P., Blazka, M. E., Elwell, M. R., Wilson, R. E., Ward, S. M., Price, H. C, and Moskowitz, P. D. 1997. Comparative pulmonary absorption, distribution, and toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride in Sprague-Dawley rats. Toxicol. Appl. Pharmacol. 147:399–410.
  • Morgan, D. L., Shines, C. J., Jeter, S. P., Wilson, R. E., Elwell, M. R., Price, H. C., and Moskowitz, P. D. 1995. Acute pulmonary toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride intratracheallyinstilled into rats. Environ. Res. 71:16–24.
  • Morgan, L. G., and Usher, V. 1994. Health problems associated with nickel refining and use. Ann. Occup. Hyg. 38:189–198.
  • Morrow, P. E., Gibb, F. R., and Gazioglu, K. M. 1967. A study of particulate clearance from the human lungs. Am. Rev. Respir. Dis. 96:1209–1221.
  • Morrow, P. E., Gibb, F. R., and Johnson, L. 1964. Clearance of insoluble dust from the lower respiratory tract. Health Phys. 10:543–555.
  • Murthy, R. C., Migally, N., Doye, A., and Zambernard, J. 1982. Ultrastructural changes in rat alveolar macrophages exposed to oxides of copper and cadmium., J. Submicrosc. Cytol. 14:347–353.
  • Musk, A. W., and Tees, J. G. 1982. Asthma caused by occupational exposure to vanadium compounds. Med. J. Aust. 1:183–184.
  • NAS: National Academy of Sciences. 1973. Committee on Biologic Effects of Atmospheric Pollutants, Division of Medical Sciences, National Research Council: Manganese, pp. 101-113, National Academy of Sciences, Washington, D.C.
  • Nechay, B. R., Nanninga, L. B., Nechay, P. E., Post, R. L., Grantham, J. J., Macara, I. G., Kubena, L. F., Phillips, T. D., and Nielsen, F. H. 1986. Role of vanadium in biology. Fed. Proc. 45:123–132.
  • Nemery, B. 1990. Metal toxicity and the respiratory tract. Eur. Respir. J. 3: 202–219.
  • Newberne, P. M., Hurt, C. E., and Young, V. R. 1968. The role of diet and the reticuloendothelial system in the response of rats to Salmonella typhimurium infection. Br. J. Exp. Pathol. 49:448–457.
  • Newhook, R., Hirtle, H., Byrne, K., and Meek, M. E. 2003. Releases from copper smelters and refineries and zinc plants in Canada: Human health exposure and risk characterization. Sci. Total Environ. 301:23–41.
  • Newman-Taylor, A. J. 1992. Cadmium. In Environmental and Occupational Medicine, 2nd Edition. W. N. Rom, ed., pp. 767-772. Little, Brown, and Company, Toronto.
  • Nieboer, E., Evans, S. L., and Dolovich, J. 1984. Occupational asthma from nickel sensitivity. II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity. Br. J. Ind. Med. 41:56–63.
  • Niitsuya, M., Watanabe, M., Okada, M., Shinji, H., Satoh, T., Aizawa, Y., Cho, Y. C., and Kotani, M. 2003. Magnetometric evaluation of cadmium oxide-induced toxicity to pulmonary alveolar macrophages of Syrian golden hamsters. J. Toxicol. Environ. Health 66:365–378.
  • Nilsen, A. M., Mylius, E. A., and Gullvag, B. M. 1987. Alveolar macrophages from expectorates as indicators of pulmonary irritation in primary aluminum reduction plant workers. Am. J. Ind. Med. 12:101–112.
  • NIOSH: National Institute for Occupational Safety and Health. 1984. National Occupational Exposure Survey (1980-1983), United States Department of Health and Human Services, Washington, D.C.
  • NIOSH. 1985. Pocket Guide to Chemical Hazards: Fifth Edition, United States Department of Health and Human Services, Washington, DC, 1985, pp. 234–235.
  • NIOSH. 1990. National Occupational Exposure Survey, pp. 89-103, U.S. Department of Health and Human Services, PHS, CDC, NIOSH, Cincinnati. Nriagu, J. O., and Pacyna, J. M. 1988. Quantitative assessment of worldwide contamination of air, waiter, and soils by trace metals. Nature 333:134–139.
  • Oberg, S. G., Parker, R. D., and Sharma, R. P. 1978. Distribution and elimination of intratracheally-administered vanadium compound in the rat. Toxicology 11:315–323.
  • Obone, E., Chakrabarti, S. K., Bai, C., Malick, M. A., Lamontagne, L., and Subramanian, K. S. 1999. Toxicity and bioaccumulation of nickel sulfate in Sprague-Dawley rats following 13 weeks of subchronic exposure. J. Toxicol. Environ. Health 57:379–401.
  • Ohsawa, M., and Kawai, K. 1981. Cytological shift in lymphocytes induced by cadmium in mice and rats. Environ. Res. 24:192–200.
  • Ohyama, S., Ishihishi, N., Hisanaga, A., and Yamamoto, A. 1988. Chronic toxicity, including tumorigenicity of gallium arsenide to the lung of hamsters. Appl. Organomet. Chem. 2:333–337.
  • OSHA: Occupational Safety and Health Agency. 1997. Occupational Safety and Health Standards. Code of Federal Regulations, Part 1910.100, Subpart Z-Toxic and Hazardous Substances. 1997. U.S. Government Printing Office, Washington, D.C.
  • OSHA. 1999. U.S. Department of Labor. Occupational Safety and Health Administration Code of Federal Regulations. U.S. Government Printing Office, Washington, D.C., 29 CFR 1910.0000.
  • Ostiguy, G., Vaillancourt, C., and Begin, R. 1995. Respiratory health of workers exposed to metal dusts and foundry fumes in a copper refinery. Occup. Environ. Med. 52:204–210.
  • Paschoa, A. S., Wrenn, M. E., Singh, M. P., Bruenger, F. W., Miller, S. C., Cholewa, M., and Jones, K. W. 1987. Localization of vanadium-containing particles in the lungs of uranium/vanadium miners. Biol. Trace Elem. Res. 13:275–282.
  • Peoples, S. M., McCarthy, J. F., Chen, L. C., Eppelsheimer, D., and Amdur, M. O. 1988. Copper oxide aerosol: Generation and characterization. Am. Ind. Hyg. Assoc. J. 49:271–276.
  • Pierce, L. M., Alessandrini, F., Godleski, J. J., and Paulauskis, J. D. 1996. Vanadium-induced chemokine mRNA expression and pulmonary inflammation. Toxicol. Appl. Pharmacol. 138:1–11.
  • Pimentel, J. C., and Marques, F. 1969. Vineyard sprayer’s lung: A new occupational disease. Thorax 24:678–688.
  • Piscator, M. 1976. Health hazards from inhalation of metal fumes. Environ. Res. 11:268–270.
  • Pistelli, R., Pupp, N., Forastiere, F., Agabit, N., Corbo, G. M., Tidel, F., and Perucci, C. A. 1991. Increase in non-specific bronchial responsiveness following occupational exposure to vanadium. Med. Lav. 82:270–275.
  • Port, C. D., Fenters, J. D., Ehrlich, R., Coffin, D. L., and Gardner, D. 1975. Interaction of nickel oxide and influenza infection in the hamster. Environ. Health Perspect. 10:268.
  • Prieditis, H., and Adamson, I. 2002. Comparative pulmonary toxicity of various soluble metals found in urban particulate dusts. Exp. Lung Res. 28:563–576.
  • Priest, N. D., Newton, D., Talbot, B., McAughey, J., Day, P., and Fifield, K. 1998. Industry-Sponsored Studies on the Biokinetics and Bioavailability of Aluminum in Man. In Health in the Aluminum Industry. N. D. Priest and T. V. O’Donnell, eds., pp. 105-129. Middlesex University Press, London. Pritchard, R. J., Ghio, A. J., Lehmann, J. R., Winsett, D. W., Tepper, J. S., Park, P., Gilmour, M. I., Dreher, K. L., and Costa, D. L. 1996. Oxidant generation and lung injury after particulate air pollutant exposure increase with the concentrations of associated metals. Inhal. Toxicol. 8:457–477.
  • Prohaska, J. R., and Lukasewycz, O. A. 1981. Copper deficiency suppresses the immune response of mice. Science 213:559–561.
  • Prows, D. R., Biswas, P., Willeke, K., Bingham, E., and Leikauf, G. D. 2000. Genetic susceptibility to irritant-induced acute lung injury in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 279:L575–L582.
  • Pumiglia, K. M., Lau, L., Huang, C., Burroughs, S., and Feinstein, M. B. 1992. Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem. J. 286:441–449. Purves, D. 1977. Trace Element Contamination of the Atmosphere. In Trace Element Contamination of the Environment. D. Purves, ed., pp. 62-72. Elsevier, New York.
  • Ramirez, P., Eastmond, D. A., and Laclette, J. P. 1997. Disruption of micro-tubule assembly and spindle cell formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat. Res. 386:291–298.
  • Rehder, D. 1995. Inorganic Considerations on the Function of Vanadium in Biological Systems. In Vanadium and Its Role in Life; Metal Ions in Biological Systems, Vol. 31. H. Sigel and A. Sigel, eds., pp. 1–44. Marcel Dekker, Inc., New York.
  • Rhoads, K., and Sanders, C. L 1985. Lung clearance, translocation, and acute toxicity of arsenic, beryllium, cadmium, cobalt, lead, selenium, vanadium, and ytterbium oxides following desposition in rat lung. Environ. Res. 36: 359-378.Rifat, S. L., Eastwood, M. R., Crapper McLachlan, D. R., and Corey, P. N. 1990. Effect of exposure of miners to aluminum powder. Lancet 336: 1162-1165.Rollin, H. B., Theodorou, P., and Kilroe-Smith, T. A. 1991. Deposition of aluminum in tissues of rabbits exposed to inhalation of low concentrations of Al2O3. Br. J. Ind. Med. 48:389–391.
  • Romundstad, P., Andersen, A., and Haldorsen, T. 2000. Cancer incidence among workers in six Norwegian aluminum plants. Scand. J. Work. Environ. Health 26:461–469.
  • Roussin, A., Cabec, V. L., Lonchampt, M., De Nadai, J., Canet, E., and Maridonneau-Parini, I. 1997. Neutrophil-associated inflammatory responses in rats are inhibited by phenylarsince oxide. Eur. J. Pharmacol. 322: 91-96.Sagripanti, J. L., Goering, P. L., and Lamanna, A. 1991. Interaction of copper with DNA and antagonism by other metals. Toxicol. Appl. Pharmacol. 110:477–485.
  • Saldiva, P., Clarke, R. W., Coull, B. A., Stearns, R. C., Lawrence, J., Krishna Murthy, G. G., Diaz, E., Koutrakis, P., Suh, H., Tsuda, A., and Godleski, J. J. 2002. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am. J. Respir. Crit. Care Med. 165: 1610–1617.
  • Samet, J. M., Graves, L. M., Quay, L., Dailey, L. A., Devlin, R. B., Ghio, A. J., Wu, W., Bromberg, P. A., and Reed, W. 1998. Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am. J. Physiol. 275:L551–L558.
  • Saric, M. 1992. Occupational and environmental exposures and nonspecific lung disease-A review of selected studies. Isr. J. Med. Sci. 28:509–512.
  • Saric, M., Holetic, A., and Ofner, E. 1977. Acute respiratory diseases in a manganese contaminated area. Proc. Intl. Conf. Heavy Metals Environ. 3:389–398.
  • Sawyer, H. J. 1994. Chromium and Its Compounds. In Occupational Medicine, Third Edition. C. Zenz, O. B. Dickerson, and E. P. Horvath, Jr., eds., pp. 487-495. Mosby, St. Louis.
  • Schaller, K. H., and Angerer, J. 1992. Biological monitoring in the occupational setting-relationship to cadmium exposure. IARC Sci. Pub. 118: 53-63.Schiff, L. J., and Graham, J. A. 1984. Cytotoxic effect of vanadium and oil-fired fly ash on hamster tracheal epithelium. Environ. Res. 34: 390-402.Schlesinger, R. B., Snyder, C. A., Chen, L. C., Gorczynski, J. E., and Menache, M. 2000. Clearance and translocation of aluminum oxide (alumina) from the lungs. Inhal. Toxicol. 12:927–939.
  • Schroeder, W. H., Dobson, M., and Kane, D. M. 1987. Toxic trace elements associated with airborne particulate matter: A review. J. Air Pollut. Control Assoc. 37:1267–1285.
  • Schwarz, Y. A., Kivity, S., Fischbein, A., Ribak, Y., Fireman, E., Struhar, D., Topilsky, M., and Greif, J. 1994. Eosinophilic lung reaction to aluminum and hard metal. Chest 105:1261–1263.
  • Seglen, P. O., and Gordon, P. B. 1981. Vanadate inhibits protein degradation in isolated rat hepatocytes, J. Biol. Chem. 256:7699–7703.
  • Serita, F., Kyono, H., and Seki, Y. 1999. Pulmonary clearance and lesions in rats after a single inhalation of ultrafine metallic nickel at dose levels comparable to the threshold limit value. Ind. Health 37:353–363.
  • Sharma, R. P., Flora, S. J., Brown, D. B., and Oberg, S. G. 1987. Persistence of vanadium compounds in lungs after intratracheal instillation in rats. Toxicol. Indust. Health 3:321–329.
  • Shenker, B. J., Matarazzo, W. J., Hirsch, R. L., and Gray, I. 1977. Trace metal modification of immunocompetence. I. Effect of trace metals in cultures on in vitro transformation of B-lymphocytes. Cell. Immunol. 34:19–24.
  • Sikorski, E. E., McCay, J. A., White, K. L., Jr, Bradley, S. G., and Munson, A. E. 1989. Immunotoxicity of the semiconductor gallium arsenide in female B6C3F1 mice. Fundam. Appl. Toxicol. 13:843–858.
  • Singh, J., Kaw, J. L., and Zaidi, S. H. 1977. Early biochemical response of pulmonary tissues to manganese dioxide. Toxicology 8:177–184.
  • Sjogren, B., Elinder, C., Lidums, V., and Chang, G. 1988. Uptake and urinary excretion of aluminum among welders. Int. Arch. Occup. Environ. Health 60:77–79.
  • Sjogren, B., Lidums, V., Hakansson, M., Hedstrom, L. 1985. Exposure and uri-nary excretion of aluminum during welding. Scand. J. Work Environ. Health 11:39–43.
  • Skornik, W. A., and Brain, J. D. 1983. Relative toxicity of inhaled metal sulfate salts for pulmonary macrophages. Am. Rev. Respir. Dis. 128:297–303.
  • Smialowicz, R. J. 1998. Nickel. In Immunotoxicology of Environmental and Occupational Metals. J. T. Zelikoff and P. T. Thomas, eds., pp. 163-194. Taylor and Francis, London.
  • Smialowicz, R. J., Rogers, R. R., Riddle, M. M., Garner, R. J., Rowe, D. G., and Leubke, R. W. 1985. Immunologic effects of nickel. II. Suppression of natural killer (NK) activity. Environ. Res. 36:56–66.
  • Smialowicz, R. J., Rogers, R. R., Riddle, M. M., Leubke, R. W., Fogelson, L. D., and Rowe, D. G. 1987. Effects of manganese, calcium, magnesium, and zinc on nickel-induced suppression of murine natural killer cell activity. J. Toxicol. Environ. Health 20:67–80.
  • Smialowicz, R. J., Rogers, R. R., Riddle, M. M., and Stott, G. A. 1984. Immunologic effects of nickel. I. Suppression of cellular and humoral immunity. Environ. Res. 3:413–427.
  • Smith, C. J., Livingston, S. D., and Doolittle, D. J. 1997. An international survey of IARC Group I carcinogens reported in mainstream cigarette smoke. Food Chem. Toxicol. 35:1107–1130.
  • Smith, K. L., and Lawrence, D. A. 1988. Immunomodulation of in vitro antigen presentation by cations. Toxicol. Appl. Pharmacol. 96:476–484.
  • Smyth, L. T., Ruhf, R. C., Whitman, N. E., and Dugan, T. 1973. Clinical manganism and exposure to manganese in the production and processing of ferromanganese alloy. J. Occup. Med. 15:101–109.
  • Snella, M. 1985. Manganese dioxide induces alveolar macrophage chemotaxis for neutrophils in vitro. Toxicology 34:153–159.
  • Snow, E. T., and Costa, M. 1992. Nickel Toxicity and Carcinogenesis. In Environmental and Occupational Medicine, 2nd Edition. W. N. Rom, ed., pp. 807-813. Little, Brown, and Company, Toronto.
  • Snyder, C. A. 1991. Immune function assays as indicators of chromate exposure. Environ. Health Perspect. 92:83–86.
  • Sorahan, T., Lister, A., Gilthorpe, M. S., and Harrington, J. M. 1995. Mortality of copper cadmium alloy workers with special reference to lung cancer and non-malignant diseases of the respiratory system, 1946-1992. Occup. Environ. Med. 52:804–812.
  • Sorgdrager, B., de Looff, A. J., de Monchy, J. G., Pal, T. M., Dubois, A. E., and Rijcken, B. 1998. Occurrence of occupational asthma in aluminum potroom workers in relation to preventive measures. Int. Arch. Occup. Environ. Health 71:53–59.
  • Sorgdrager, B., Pal, T. M., de Looff, A. J., Dubois, A. E., and de Monchy, J. G. 1995. Occupational asthma in aluminum potroom workers related to pre-employment eosinophil count. Eur. Resp. J. 8:1520–1524.
  • Søyseth, V., Kongerud, J., Aalen, O. O., Botten, G., and Boe, J. 1995. Bronchial responsiveness decreases in relocated aluminum potroom workers compared with workers who continue their potroom exposure. Int. Arch. Occup. Environ. Health 67:53–57.
  • Spiegelberg, T., Kordel, W., and Hichrainer, D. 1984. Effects of NiO inhalation on alveolar macrophages and the humoral immune system of rats. Ecotoxicol. Environ. Safety 8:516–525.
  • Squibb, K. S., and Fowler, B. A. 1983. The Toxicity of Arsenic and Its Compounds. In Biological and Environmental Effects of Arsenic. B. A. Fowler, ed., pp. 233-269. Elsevier Biomedical Press, Amsterdam.
  • Steenland, K., Loomis, D., Shy, C., and Simonsen, N. 1996. Review of occupational lung carcinogens. Am. J. Ind. Med. 29:474–490.
  • Stocks, P. 1960. On the relations between atmospheric pollution in urban and rural localities and mortality from cancer, bronchitis, pneumonia, with particular reference to 3,4-benzopyrene, beryllium, molybdenum, vanadium, and arsenic. Br. J. Cancer 14:397–418.
  • Stokinger, H. E. 1981. The Metals: Manganese. In Patty’s Industrial Hygiene and Toxicology, 3rd Ed. G. Clayton and F. Clayton, eds., pp. 1749-1769. Wiley and Sons, New York.
  • Stone, C. J., McLaurin, D. A., Steinhagen, W. H., Cavender, F. L., and Haseman, J. K. 1979. Tissue deposition patters after chronic inhalation exposures of rats and guinea pigs to aluminum chlorhydrate. Toxicol. Appl. Pharmacol. 49:71–76.
  • Sunderman, F. W., Jr., Hopfer, S. M., Lin, S. M., Plowman, M. C., Stojanivic, T., Wong, S. H., Zaharia, O., and Ziebka, L. 1989. Toxicity ot alveolar macrophages in rats following parenteral injection of nickel chloride. Toxicol. Appl. Pharmacol. 100:107–118.
  • Suzuki, Y., Fujii, N., Yano, H., Ohkita, T., Ichikawa, A., and Nishiyama, K. 1978. Effects of the inhalation of manganese dioxide dust on monkey lungs. Tokushima J. Exp. Med. 25:119–125.
  • Swarup, G., Cohen, S., and Garbers, D. L. 1982. Inhibition of membrane phospho-tyrosyl-protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun. 107:1104–1109.
  • Sweet, C. W., and Vermette, S. J. 1993. Sources of toxic trace elements in urban air in Illinois. Environ. Sci. Technol. 27:2502–2510.
  • Tanaka, A., Hirata, M., Omura, M., Zhao, M., Makita, Y., Yamazaki, K., Inoue, N., and Gotoh, K. 2000. Comparative studies of the toxic effects of gallium arsenide, indium arsenide, and arsenic trioxide following intratracheal instillations to the lung of Syrian golden hamsters. Fukuoka Igak. Zass.-Fukuoka Acta Med. 91:21–33.
  • Tanaka, A., Hisanaga, A., Hirata, M., Omura, M., Makita, Y., Inoue, N., and Ishinishi, N. 1996. Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters. Fukuoka Acta Med. 87:108–115.
  • Ter Haar, G. L., Griffing, M. E., Brandt, M., Oberding, D. G., and Kapron, M. 1975. Methylcyclopentadienyl manganese tricarbonyl as an antiknock: Composition and fate of manganese exhaust products. J. Air Pollut. Control Assoc. 25:858–860.
  • Theocharis, S. E., Souliotis, T., and Panayiotisid, P. 1994. Suppression of IL-1 β and TNF α biosynthesis by cadmium in in vitro activated human peripheral blood mono-nuclear cells. Arch. Toxicol. 69:132–136.
  • Thomassen, Y., Ellingsen, D. G., Hetland, S., and Sand, G. 2001. Chemical speciation and sequential extraction of Mn in workroom aerosols: Analytical methodology and results from a field study in Mn alloy plants. J. Environ. Monitor. 3:555–559.
  • Tian, L., and Lawrence, D. A. 1996. Metal-induced modulation of nitric oxide production in vitro by murine macrophages: Lead, nickel, and cobalt utilize different mechanisms. Toxicol. Appl. Pharmacol. 141:540–547.
  • Tipton, I. H., and Shafer, J. J. 1964. Statistical analysis of lung trace element levels. Arch. Environ. Health 8:56–67.
  • Tokudome, S., and Kuratsune, M. 1976. A cohort study on mortality from cancer and other causes among workers at a metal refinery. Int. J. Cancer 17:310–317.
  • Tornling, G., Blaschke, E., and Eklund, A. 1993. Long-term effects of alumina on components of bronchoalveolar lavage fluid from rats. Br. J. Ind. Med. 50:172–175.
  • Torossian, K., Freedman, D., and Fantus, I. G. 1988. Vanadate down-regulates cell surface insulin and growth hormone receptor and inhibits insulin receptor degradation in cultured human lymphocytes. J. Biol. Chem. 263:9353–9359.
  • Torres, M., and Forman, H. J. 2002. Vanadate inhibition of protein tyrosine phosphatase mimics hydrogen peroxide in the activation of the ERK pathway in alveolar macrophages. Ann. N. Y. Acad. Sci. 973:345–348.
  • Toya, T., Fukuda, K., Kohyama, N., Kyono, H., and Arito, H. 1999. Hexavalent chromium responsible for lung lesions induced by intratracheal instillation of chromium fumes in rats. Ind. Health 37:36–46.
  • Toya, T., Fukuda, K., Takaya, M., and Arito, H. 2001. Lung lesions induced by intratracheal instillation of vanadium pentoxide powder in rats. Ind. Health 39:8–15.
  • Trudel, S., Paquet, M. R., and Grinstein, S. 1986. Mechanism of vanadate-induced activation of tyrosine phosphorylation and of the respiratory burst in HL-60 cells. Biochem. J. 276:611–619.
  • Trudel, S., Paquet, M. R., and Grinstein, S. 1991. Mechanism of vanadate-induced activation of tyrosine phosphorylation and of the respiratory burst in HL-60 cells. Biochem. J. 276:611–619.
  • Tsuchiyama, F., Hisanaga, N., Shibata, E., Aoki, T., Takagi, H., Ando, T., and Takeuchi, Y. 1997. Pulmonary metal distribution in urban dwellers. Int. Arch. Occup. Environ. Health 70:77–84.
  • Ulrich, C. E., Rinehart, W., Busey, W., and Doratom, M. A. 1979. Evaluation of the chronic inhalation toxicity of a manganese oxide aerosol. II. Clinical obesrvations, hematology, clinical chemistry, and histopathology. Am. Ind. Hyg. Assoc. J. 40:322–329.
  • Utter, M. F. 1976. The biochemistry of manganese. Med. Clin. N. Amer. 60: 713–727.
  • Vaddi, K., and Wei, C. I. 1991a. Effect of ammonium metavanadate on the mouse peritoneal macrophage lysosomal enzymes. J. Toxicol. Environ. Health 33:65–78.
  • Vaddi, K., and Wei, C. I. 1991b. Modulation of Fc receptor expression and function in mouse peritoneal macrophages by ammonium metavanadate. Int. J. Immunopharmacol. 13:1167–1176.
  • Vaddi, K., and Wei, C. I. 1996. Modulation of macrophage activation by ammonium metavanadate. J. Toxicol. Environ. Health 49:631–645.
  • Vandenplas, O., Binard-van Cangh, F., Gregoire, J., Brumagne, A., and Larbanois, A. 2002. Fever and neutrophilic alveolitis caused by a vanadium-based catalyst. Occup. Environ. Med. 59: 785-787.van Netten, C., Teschke, K. E., and Souter, F. 1990. Occupational exposure to elemental constituents in fingerprint powders. Arch. Environ. Health 45: 123–127.
  • Vega, L., Ostrosky-Wegman, P., Fortoul, T. I., Diaz, C., Madrid, V., and Saavedra, R. 1999. Sodium arsenite reduces proliferation of human activated T-cells by inhibition of secretion of interleukin-2. Immunopharmacol. Immunotoxicol. 21:203–220.
  • Villar, T. G. 1974. Vineyard sprayer’s lung: Clinical aspects. Am. Rev. Respir. Dis. 110:545–555.
  • Vitarella, D., Moss, O., and Dorman, D. C. 2000. Pulmonary clearance of manganese phosphate, manganese sulfate, and manganese tetraoxide by CD rats following intratracheal instillation. Inhal. Toxicol. 12:941–957.
  • Vyas, D., and Chandra, R. K. 1983. Thymic factor activity, lymphocyte stimulation response, and antibody producing cell in copper deficiency. Nutr. Res. 3:343–349.
  • Wang, E., and Choppin, P. W. 1981. Effect of vanadate on intracellular distribution and function of 10 nm microfilaments. Proc. Natl. Acad. Sci. USA 78:2363–2367.
  • Wang, J. Y., Wicklund, B. H., Gustile, R. B., and Tsukayama, D. T. 1996. Titanium, chromium, and cobalt ions modulate the release of bone-associated cytokines by human monocytes/macrophages in vitro. Biomaterials 17: 2223–2240.
  • Wang, Y., and Bonner, J. 2000. Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibro-blasts. Am. J. Respir. Cell Mol. Biol. 22:590–596.
  • Warshawsky, D., Reilman, R., Cheu, J., Radike, M., and Rice, C. 1994. Influence of particle dose on the cytotoxicity of hamster and rat pulmonary alveolar macrophage in vitro. J. Toxicol. Environ. Health 42:407–421.
  • Waters, M. D., Gardner, D. E., and Coffin, D. L. 1974. Cytotoxic effects of vanadium on rabbit alveolar macrophages in vitro. Toxicol. Appl. Pharmacol. 28:253–263.
  • Waters, M. D., Gardner, D. E., Aranyi, C., and Coffin, D. L. 1975. Metal toxicity for rabbit alveolar macrophages in vitro. Environ. Res. 9:32–47.
  • Webb, D. R., Sipes, I. G., and Carter, D. E. 1984. In vitro solubility and in vivo toxicity of gallium arsenide. Toxicol. Appl. Pharmacol. 76:96–104.
  • Webb, D. R., Wilson, S. E, and Carter, D. E. 1986. Comparative pulmonary toxicity of gallium arsenide, gallium (III) oxide, or arsenic (III) oxide intratracheally-instilled into rats. Toxicol. Appl. Pharmacol. 82:405–416.
  • Weir, D., Robertson, A., Jones, S., and Burge, P. 1989. Occupational asthma due to soft corrosive soldering fluxes containing zinc chloride and ammonium chloride. Thorax 44:220–223.
  • White, L. R., Steinegger, A. F., and Schlatter, C. 1987. Pulmonary response following intratracheal instillation of potroom dust from an aluminum reduction plant into rat lung. Environ. Res. 42:534–545.
  • WHO: (World Health Organization). 1988. Vanadium. Environmental Health Criteria No. 81. World Health Organization, Geneva.
  • WHO. 1991. International Programme on Chemical Safety (IPCS). Vanadium Pentoxide and Other Inorganic Vanadium Compounds. IPCS CICAD No. 29, WHO, Geneva.
  • WHO. 2001. Zinc. Environmental Health Criteria No. 221. World Health Organization, Geneva.
  • Wiernik, A., Johansson, A., Jarstrand, C., and Camner, P. 1983. Rabbit lung after inhalation of soluble nickel. I. Effects on alveolar macrophages. Environ. Res. 30:129–141.
  • Woodin, M. A., Liu, Y., Neuberg, D., Hauser, R., Smith, T., and Christiani, D. C. 2000. Acute respiratory symptoms in workers exposed to vanadium-rich fuel-oil ash. Am. J. Ind. Med. 37:353–363.
  • Yokel, R. A., and McNamara, P. J. 2001. Aluminum toxicokinetics: An updated minireview. Pharmacol. Toxicol. 88:159–167.
  • Zayed, J., Mikhail, M., and Loranger, S. 1996. Exposure of taxi drivers and office workers to total respirable manganese in an urban environment. Am. Ind. Hyg. Assoc. J. 57:376–380.
  • Zelikoff, J. T., and Cohen, M. D. 1995. Immunotoxicity of Inorganic Metal Compounds. In Experimental Immunotoxicology. R. J. Smialowicz and M. P. Holsapple, eds., pp. 189-228. CRC Press, Boca Raton.
  • Zhao, Z. T., Zhongjia, T., Diltz, C., You, M., and Fischer, E. 1996. Activation of mitogen-activated protein (MAP) kinase pathway by pervanadate, a potent inhibitor of tyrosine phosphatases. J. Biol. Chem. 271:22251–22255.

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