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Research Article

CpG and Non-CpG Oligodeoxynucleotides Induce Differential Proinflammatory Gene Expression Profiles in Liver and Peripheral Blood Leukocytes in Mice

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Pages 57-68 | Received 27 Jan 2006, Accepted 24 Mar 2006, Published online: 20 Oct 2008

REFERENCES

  • Aderem A., Ulevitch R. J. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406: 782–787, [CSA]
  • Agrawal S. Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochim. Biophys. Acta 1999; 1489: 53–68, [CSA]
  • Asselin-Paturel C., Boonstra A., Dalod M., Durand I., Yessaad N., Dezutter-Dambuyant C., Vicari A., O'Garra A., Biron C., Briere F., Trinchieri G. Mouse Type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2001; 2: 1144–1150, [CSA]
  • Barish C. F. Alicaforsen therapy in inflammatory bowel disease. Expert Opin. Biol. Ther. 2005; 5: 1387–1391, [CSA]
  • Cichy J., Pure E. The liberation of CD44. J. Cell Biol. 2003; 161: 839–843, [CSA]
  • Condon T. P., Flournoy S., Sawyer G. J., Baker B. F., Kishimoto T. K., Bennett C. F. ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes. Antisense Nucl. Acid Drug Dev. 2001; 11: 107–116, [CSA]
  • el-Gabalawy H., Canvin J., Ma G. M., Van der Vieren M., Hoffman P., Gallatin M., Wilkins J. Synovial distribution of alpha d/CD18, a novel leukointegrin. Comparison with other integrins and their ligands. Arthritis Rheum. 1996; 39: 1913–1921, [CSA]
  • Hartmann G., Weiner G. J., Krieg A. M. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 1999; 96: 9305–9310, [CSA]
  • Henry S. P., Bolte H., Auletta C., Kornbrust D. J. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in cynomolgus monkeys. Toxicology 1997a; 120: 145–155, [CSA]
  • Henry S. P., Grillone L. R., Orr J. L., Brunner R. H., Kornbrust J., Kornbrust D. J. Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague–Dawley rats. Toxicology 1997b; 116: 77–88, [CSA]
  • Henry S. P., Stecker K., Brooks D., Monteith D., Conklin B., Bennett C. F. Chemically-modified oligonucleotides exhibit decreased immune stimulation in mice. J. Pharmacol. Exp. Ther. 2000; 292: 468–479, [CSA]
  • Henry S. P., Taylor J., Midgley L., Levin A. A., Kornbrust D. J. Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide in a 4-week study in CD-1 mice. Antisense Nucl. Acid Drug Dev. 1997c; 7: 473–481, [CSA]
  • Henry S. P., Templin M. V., Gillett N., Rojko J., Levin A. A. Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1. Toxicol. Pathol. 1999; 27: 95–100, [CSA]
  • Hoke G. D., Draper K., Freier S., Gonzalez C., Driver V. B., Zounes M. C., Ecker D. J. Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection. Nucl. Acids Res. 1991; 19: 5743–5748, [CSA]
  • Imler J. L., Hoffmann J. A. Toll receptors in innate immunity. Trends Cell Biol. 2001; 11: 304–311, [CSA]
  • Jakob T., Walker P. S., Krieg A. M., Udey M. C., Vogel J. C. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of TH1 responses by immunostimulatory DNA. J. Immunol. 1998; 161: 3042–3049, [CSA]
  • Janatpour M. J., Hudak S., Sathe M., Sedgwick J. D., McEvoy L. M. Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J. Exp. Med. 2001; 194: 1375–1384, [CSA]
  • Jiang G., Li Z., Liu F., Ellsworth K., Dallas-Yang Q., Wu M., Ronan J., Esau C., Murphy C., Szalkowski D., Bergeron R., Doebber T., Zhang B. B. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J. Clin. Invest. 2005; 115: 1030–1038, [CSA]
  • Jinquan T., Quan S., Jacobi H. H., Jing C., Millner A., Jensen B., Madsen H., Ryder L. P., Svejgaard A., Malling H. J., Skov P. S., Poulsen L. K. CXC chemokine receptor 3 expression on CD34(+) hematopoietic progenitors from human cord blood induced by granulocyte-macrophage colony-stimulating factor: Chemotaxis and adhesion induced by its ligands, interferon gamma-inducible protein 10 and monokine induced by interferon gamma. Blood 2000; 96: 1230–1238, [CSA]
  • Kandimalla E. R., Bhagat L., Zhu F., Yu D., Cong Y., Wang D., Tang J. X., Tang J., Knetter C. F., Lien E., Agrawal S. A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif. Proc. Natl. Acad. Sci. USA 2003; 100: 14303–14308, [CSA]
  • Kansas G. S., Muirhead M. J., Dailey M. O. Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans. Blood 1990; 76: 2483–2492, [CSA]
  • Klinman D. M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 2004; 4: 249–258, [CSA]
  • Krieg A. M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002; 20: 709–760, [CSA]
  • Krieg A. M., Yi A., Matson S., Waldschmidt T. J., Bishop G. A., Teasdale R., Koretzky G. A., Klinman D. M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995; 374: 546–549, [CSA]
  • Lalor P. F., Shields P., Grant A., Adams D. H. Recruitment of lymphocytes to the human liver. Immunol. Cell. Biol. 2002; 80: 52–64, [CSA]
  • Levin A. A. A review of issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta 1999; 1489: 69–84, [CSA]
  • Levin A. A., Henry S. P., Monteith D., Templin M. Toxicity of Antisense Oligonucleotides. Antisense Drug Technology, S. T. Crooke. Marcel Dekker, Inc., New York 2001
  • Levin A. A., Monteith D. K., Leeds J. M., Nicklin P. L., Geary R. S., Butler M., Templin M. V., Henry S. P. Toxicity of oligodeoxynucleotide therapeutic agents. Antisense Research and Application, S. T. Crooke. Springer, Heidelberg 1998
  • Lipford G. B., Sparwasser T., Bauer M., Zimmermann S., Koch E., Heeg K., Wagner H. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 1997; 27: 3420–3426, [CSA]
  • McQueen C. A., Rosado R. R., Williams G. M. Effect of nalidixic acid on DNA repair in rat hepatocytes. Cell Biol. Toxicol. 1989; 5: 201–206, [CSA]
  • Muller W. A. New mechanisms and pathways for monocyte recruitment. J. Exp. Med. 2001; 194: F47–51, [CSA]
  • Nakano H., Yanagita M., Gunn M. D. CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 2001; 194: 1171–1178, [CSA]
  • Peng S. L. Signaling in B-cells via Toll-like receptors. Curr. Opin. Immunol. 2005; 17: 230–236, [CSA]
  • Pisetsky D. S., Reich C. F. The influence of base sequence on the immunological properties of defined oligonucleotides. Immunopharmacology 1998; 40: 199–208, 3rd.[CSA]
  • Scheule R. K. The role of CpG motifs in immunostimulation and gene therapy. Adv. Drug Delivery Rev. 2000; 44: 119–134, [CSA]
  • Schnare M., Holt A. C., Takeda K., Akira S., Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 2000; 10: 1139–1142, [CSA]
  • Senn J. J., Burel S., Henry S. P. Non-CpG-containing antisense 2′ MOE oligonucleotides activate a proinflammatory response independent of TLR-9 or MyD88. J. Pharmacol. Exp. Ther. 2005; 314: 972–979, [CSA]
  • Short M. L., Nickel J., Schmitz A., Renkawitz R. Lysozyme gene expression and regulation. Cell Growth Differ. 1996; 75: 243–257, [CSA]
  • Tan J., Quan S., Jacobi H. H., Jing C., Millner A., Jensen B., Madsen H. O., Ryder L. P., Svejgaard A., Malling H. J., Skov P. S., Poulsen L. K. CXC chemokine receptor 3 expression on CD34(+) hematopoietic progenitors from human cord blood induced by granulocyte-macrophage colony-stimulating factor: Chemotaxis and adhesion induced by its ligands, interferon gamma-inducible protein 10 and monokine induced by interferon gamma. Blood 2000; 96: 1230–1238, [CSA]
  • Uhlmann E., Vollmer J. Recent advances in the development of immunostimulatory oligonucleotides. Curr. Opin. Drug Discov. Devel. 2003; 6: 204–217, [CSA]
  • Ulbrich H., Eriksson E. E., Lindbom L. Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol. Sci. 2003; 24: 640–647, [CSA]
  • Wagner H. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr. Opin. Microbiol. 2002; 5: 62–69, [CSA]
  • Wang H., Rayburn E., Zhang R., Zhang R. Synthetic oligodeoxynucleotides containing deoxycytidyl-deoxyguanosine dinucleotides (CpG ODNs) and modified analogs as novel anticancer therapeutics. Curr. Pharm. Des. 2005; 11: 2889–2907, [CSA]
  • Wild J. S., Sur S. CpG oligonucleotide modulation of allergic inflammation. Allergy 2001; 56: 365–376, [CSA]
  • Zhang Y., Shoda L. K., Brayton K. A., Estes D. M., Palmer G. H., Brown W. C. Induction of interleukin-6 and interleukin-12 in bovine B-lymphocytes, monocytes, and macrophages by a CpG oligodeoxynucleotide (ODN 2059) containing the GTCGTT motif. J. Interferon Cytokine Res. 2001; 21: 871–81, [CSA]
  • Zhao Q., Temsamani J., Zhou R., Agrawal S. Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice. Antisense Nucl. Acid Drug Dev. 1997; 7: 495–502, [CSA]

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