New Perspectives on Retinoblastoma Family Functions in Differentiation

References

• Yan Z, DeGregori J, Shobet R, Leone G, Stillman B, Nevins J R, Williams R S. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci USA 1998; 95: 3603–3608
   PubMed Web of Science ®Google Scholar
• Krek W, Xu G, Livingston D M. Cyclin A-kinase regulation of E2F-1 binding function underlies suppression of an S-phase checkpoint. Cell 1995; 83: 1149–1158
   PubMed Web of Science ®Google Scholar
• Dynlacht B, Flores O, Lees J A, Harlow E. Differential regulation of E2F trans-activation by cyclin/cdk2 complexes. Genes and Dev 1994; 8: 1772–1786
   PubMed Web of Science ®Google Scholar
• Xu M, Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol 1994; 14: 8420–8431
   PubMed Web of Science ®Google Scholar
• Farnham P J. Transcriptional Control of Cell Growth: the E2F Family. Springer Verlag, New York 1996; vol. 208
   Google Scholar
• Nevins J R, Leone G, DeGregori J, Jakoi L. Role of the Rb/E2F pathway in cell growth control. J Cell Physiol 1997; 173: 233–236
   PubMed Web of Science ®Google Scholar
• Mayol X, Grana X. The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions. Front Biosci 1998; 3: d11–24, http://www.bioscience.org/1998v3dmayollist.htm
   PubMedGoogle Scholar
• Johnson D G, Schneider-Broussard R. The role of E2F in the cell cycle and cancer. Front Biosci 1998; 3: d447–448, http://www.bioScience.org/1998v3djohnsonlist.htm
   PubMedGoogle Scholar
• Campanero M, Flemington E K. Regulation of E2F through ubiquitin-proteosome dependent degradation: stabilization by the pRB tumor suppressor protein. Proc Natl Acad Sci USA 1997; 94: 2221–2226
   PubMed Web of Science ®Google Scholar
• Hateboer G, Kerkhoven R M, Shvarts A, Bernards R, Beijersbergen R L. Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes and Dev 1996; 10: 2960–2970
   PubMed Web of Science ®Google Scholar
• Hoffmann F, Martelli F, Livingston D M, Wang Z. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes and Dev 1996; 10: 2949–2959
   Google Scholar
• Helin K, Holm K, Niebuhr A, Eiberg H, Tommerup N, Hougaard S, Poulsen H S, Spang-Thomsen M, Norgaard P. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. Proc Natl Acad Sci USA 1997; 94: 6933–6938
   PubMed Web of Science ®Google Scholar
• Shan B, Durfee T, Lee W H. Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. Proc. Natl Acad Sci USA 1996; 93: 679–684
   PubMed Web of Science ®Google Scholar
• Wang J YJ, Knudsen E S, Welch P J. The retinoblastoma tumor suppressor gene. Adv in Cancer Res 1994; 64: 25–85
   PubMed Web of Science ®Google Scholar
• Woo M S, Sanchez I, Dynlacht B D. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol Cell Biol 1997; 17: 3566–3579
   PubMed Web of Science ®Google Scholar
• Adams P D, Sellers W R, Sharma S K, Wu A D, Nalin C M, Kaelin W GJ. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol 1996; 16: 6623–6633
   PubMed Web of Science ®Google Scholar
• Paggi M G, Baldi A, Bonetto F, Giordano A. Retinoblastoma protein family in cell cycle and cancer: a review. Cell Biochem 1996; 62: 418–430
   PubMed Web of Science ®Google Scholar
• Lin S C, Skapek S X, Lee E Y. Genes in the RB pathway and their knockout in mice. Seminars Cancer Biol 1996; 7: 279–289
   PubMedGoogle Scholar
• Jacks T, Fazeli E M, Schmitt E, Bronson R T, Goodell M A, Weinberg R A. Effects of an Rb mutation in mice. Nature (London) 1992; 359: 295–300
   PubMed Web of Science ®Google Scholar
• Lee EY-HP, Hu N, Yuan S-SF, Cox L, Bradley A, Lee W-H, Herrup K. Dual roles of the retinoblastoma proteins in cell cycle regulation and neuron differentiation. Genes and Dev 1994; 8: 2008–2021
   PubMed Web of Science ®Google Scholar
• Lee E HYP, Chang C Y, Hu N, Wang Y CJ, Lai C C, Herrup K, Lee W-H, Bradley A. Mice deficient for Rb are nonviable and show defects in neuogenesis and hematopoiesis. Nature (London) 1992; 359: 288–294
   PubMed Web of Science ®Google Scholar
• Riley D J, Lee EY-HP, Lee W-H. The retinoblastoma protein: more than a tumor suppressor. Ann Rev Cell Biol 1994; 10: 1–29
   PubMedGoogle Scholar
• Zackenhaus E, Jiang Z, Chung D, Marth J D, Phillips R A, Gallie B L. pRB controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes and Dev 1996; 10: 3051–3064
   PubMedGoogle Scholar
• Cobrinik D, Lee M H, Hannon G, Mulligan G, Bronson R T, Dyson N, Harlow E, Beach D, Weinberg R A, Jacks T. Shared role of the pRB-related p130 and p107 protein in limb development. Genes and Dev 1996; 10: 1633–1644
   PubMed Web of Science ®Google Scholar
• Lee M H, Williams B O, Mulligan G, Mukai S, Bronson R T, Dyson N, Harlow E, Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes and Dev 1996; 10: 1621–1632
   PubMed Web of Science ®Google Scholar
• Hurford R K, Cobrinik D, Lee M H, Dyson N. pRb and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes and Dev 1997; 11: 1447–1463
   PubMed Web of Science ®Google Scholar
• Mulligan G J, Wong J, Jacks T. p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol 1998; 18: 206–220
   PubMed Web of Science ®Google Scholar
• Tevosian S G, Shih H, Mendelson K G, Sheppard K A, Paulson K E, Yee A S. HBP-1: A new transcriptional repressor that is targeted of the retinoblastoma family. Genes and Dev 1997; 11: 383–396
   PubMedGoogle Scholar
• Maione R, Fimia G, Holman P, Schaffhausen B, Amati P. Retinoblastoma antioncogene is involved in the inhibition of myogenesis by polyomavirus large T antigen. Cell Growth Diff 1994; 5: 231–237
   PubMedGoogle Scholar
• Corbeil H, Whyte P, Branton P E. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene 1995; 11: 909–920
   PubMedGoogle Scholar
• Schneider J W, Gu W, Zhu L, Mahdavi V, Nadal-Ginard B. Reversal of terminal differentiation mediated by p107 in Rb – / – muscle cells. Science 1994; 264: 1467–1470
   PubMed Web of Science ®Google Scholar
• Maione R, Amati P. Interdependence between muscle differentiation and cell cycle control. Biochim Biophys Acta 1997; 1332: M19–M30
   PubMed Web of Science ®Google Scholar
• Mayol X, Garriga J, Grana X. G1 cyclin/CDK independent phosphorylation and accumulation of p130 during the transition from G1 to G0 lead to its association with p130. Oncogene 1996; 13: 237–246
   PubMedGoogle Scholar
• Smith E J, Leone G, DeGregori J, Jakoi L, Nevins J R. The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state. Mol Cell Biol 1996; 16: 6965–6976
   PubMed Web of Science ®Google Scholar
• Shin E, Shin A, Paulding C, Schaffhausen B, Yee A S. Multiple changes in E2F transcription factor function occur upon muscle differentiation. Mol Cell Biol 1995; 15: 2252–2262
   PubMedGoogle Scholar
• Cobrinik D, Whyte P, Peeper D, Jacks T, Weinberg R. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes and Dev 1993; 7: 2392–2404
   PubMed Web of Science ®Google Scholar
• Altiok S, Xu M, Spiegelman B M. PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes and Dev 1997; 11: 1987–1998
   PubMed Web of Science ®Google Scholar
• Sellers W R, Kaelin W GJ. RB [corrected] as a modulator of transcription. Biochim Biophys Acta 1996; 1288(1)M1–M5
   Google Scholar
• Kaelin W G, Krek W, Sellers W R, DeCaprio J A, Ajchanbaum F, Fuchs C S, Chittenden T, Li Y, Farnham P J, Blanar M A, Livingston D M, Flemington E K. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 1992; 70: 351–364
   PubMed Web of Science ®Google Scholar
• Sellers W R, Rodgers J W, Kaelin W GJ. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci USA 1995; 92: 11544–11548
   PubMed Web of Science ®Google Scholar
• Chow K N, Dean D C. Domains A and B in the RB pocket interact to form a transcriptional repressor motif. Mol Cell Biol 1996; 16: 4862–4868
   PubMedGoogle Scholar
• Brehm A, Miska E A, McCance D J, Reid J L, Bannister A J, Kouzarides T. Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature (London) 1998; 391: 597–600
   PubMed Web of Science ®Google Scholar
• Luo R, Postigio A, Dean D C. RB interacts with histone deacetylase to repress transcription. Cell 1998; 92: 642–473
   Google Scholar
• Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Villain J P, Troalen F, Trouche D, Harel-Bellan A. Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature (London) 1998; 391: 601–604
   PubMed Web of Science ®Google Scholar
• Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes and Dev 1998; 12: 599–606
   PubMed Web of Science ®Google Scholar
• Yee A S, Raychaudhuri P, Jakoi L, Nevins J R. The adenovirus-inducible factor E2F stimulates transcription following specific DNA binding. Mol Cell Biol 1989; 9: 578–585
   PubMedGoogle Scholar
• Singh P, Coe J, Hong W. A role for the retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature (London) 1995; 374: 562–565
   PubMedGoogle Scholar
• Defeo-Jones D, Huang P, Jones R, Haskell K, Vuocolo G, Hanobik M, Huber H, Oliff A. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. Nature (London) 1991; 352: 251–253
   PubMed Web of Science ®Google Scholar
• Dowdy S F, Hinds P W, Louie P, Reed S I, Weinberg R A. Physical interaction of the retinoblastoma protein with D-type cyclins. Cell 1993; 73: 499–511
   PubMed Web of Science ®Google Scholar
• Ewen M, Sluss H K, Sherr C J, Matsuhime H, Kato J, Livingston D M. Functional interactions of retinoblastoma and D-type cyclins. Cell 1993; 73: 487–497
   PubMed Web of Science ®Google Scholar
• Buyse I, Shao G, Huang S. The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus EIA protein. Proc Natl Acad Sci USA 1995; 92: 4467–4471
   PubMed Web of Science ®Google Scholar
• Dunaief J L, Strober B E, Guha S, Khavari P A, Alin K, Luban J, Begemann M, Crabtree G, Goff S. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 1994; 79: 119–130
   PubMed Web of Science ®Google Scholar
• Wang C Y, Petryniak B, Thompson C B, Kaelin W G, Leiden J M. Regulation of the Ets-related transcription factor Elf-I by binding to the retinoblastoma protein. Science 1993; 1330–1335
   Google Scholar
• Lavender P, Vandel L, Bannister A J, Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. Oncogene 1997; 14: 2721–2728
   PubMedGoogle Scholar
• Lesage F, Hugnot J P, Amri E Z, Grimaldi P, Barhanin J, Lazdunski M. Expression cloning in the K + transport-defective yeast and regulation of HBP1, a new putative HMG transcriptional regulator. Nucl Acids Res 1994; 22: 3685–3688
   PubMedGoogle Scholar
• Love J J, Li X, Case D A, Giese K, Grosschedl R, Wright P E. Structural basis for DNA bending by the architectual transcription factor Lef-1. Nature (London) 1995; 376: 791–795
   PubMed Web of Science ®Google Scholar
• Grosschedl R. Higher order nucleoprotein complexes in transcription: analogies with site-specific recombination. Current Opin Cell Biol 1995; 7: 362–370
   PubMedGoogle Scholar
• Hunter T. Oncoprotein Networks. Cell 1997; 88: 333–346
   PubMed Web of Science ®Google Scholar
• Mudryj M, Hiebert S, Nevins J R. A role for the adenovirus-inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J 1990; 9: 2179–2184
   PubMedGoogle Scholar
• Sherr C J. Cancer cell cycles. Science 1996; 274: 1672–1677
   PubMed Web of Science ®Google Scholar
• Novitch B G, Mulligan G J, Jacks T, Lassar A B. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol 1996; 135: 441–456
   PubMed Web of Science ®Google Scholar
• Wang J YJ. Retinoblastoma protein in growth suppression and death. Curr Opin Gen & Dev 1997; 7: 39–45
   PubMedGoogle Scholar
• Almasan A, Yin Y, Kelly R E, Lee E YHP, Bradley A, Li W, Bertino J, Wahl G M. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes and apoptosis. Proc Natl Acad Sci USA 1995; 92: 5436–5440
   PubMed Web of Science ®Google Scholar
• Haas-Kogan D A, Kogan S C, Levi D, Dazin P, T'Ang A, Fung Y, Israel M. Inhibition of apoptosis by the retinoblastoma gene. EMBO J 1995; 14: 461–472
   PubMed Web of Science ®Google Scholar
• Tan X, Martin S J, Green D R, Wang J YJ. Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death. J Biol Chem 1997; 272: 9613–9616
   PubMedGoogle Scholar
• Janicke R U, Walker P A, Lin X Y, Porter A G. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J 1996; 15: 6969–6978
   PubMed Web of Science ®Google Scholar
• Dou Q-P, An B. RB and apoptotic cell death. Front/Biosci 1998; 3: d419–430, http://www.bioscience.org/1998v3ddoulist.htm
   Google Scholar
• Walsh K, Perlman H. Cell cycle exit upon myogenic differentiation. Curr Opin Gen & Dev 1997; 7: 597–602
   PubMed Web of Science ®Google Scholar
• Morgenbesser S D, Williams B O, Jacks T L, Depinho R A. p53-dependendent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (London) 1996; 371: 72–74
   Google Scholar
• Macleod K F, Hu Y, Jacks T. Loss of RB activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 1996; 15: 6178–88
   PubMed Web of Science ®Google Scholar
• Wang J, Walsh K. Resistance to apoptosis conferred by cdk inhibitors in myocyte differentiation. Science 1996; 273: 359–361
   PubMedGoogle Scholar
• Guo K, Wang J, Andres V, Smith R C, Walsh K. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Mol Cell Biol 1995; 15: 3823–3829
   PubMed Web of Science ®Google Scholar
• Halavey O, Novitch B, Spicer D B, Skapek S, Rhee J, Hannon G J, Beach D, Lassar A B. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 1995; 267: 1018–1021
   Google Scholar
• Parker S B, Eichele G, Zhang P, Rawls A, Sands A T, Bradley A, Olson E N, Harper J W, Elledge S J. p53-independent expression of p21 cipl in muscle and other terminally differentiated cells. Science 1995; 267: 1024–1026
   PubMed Web of Science ®Google Scholar
• Macleod K F, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation and DNA damage. Genes and Dev 1995; 9: 935–944
   PubMed Web of Science ®Google Scholar
• Wang J, Guo K, Wills K N, Walsh K. RB functions to inhibit apoptosi during myocyte differentiation. Cancer Res 1997; 57: 351–354
   PubMed Web of Science ®Google Scholar
• Molkentin J D, Olson E N. Defining the regulatory networks for muscle development. Curr Opin Genetics Dev 1996; 6: 445–453
   PubMed Web of Science ®Google Scholar
• Molkentinin J, Olson E N. Combinatorial control of muscle development by helix-loop-helix and MADS box transcription factors. Proc Natl Acad Sci USA 1996; 93: 9366–9373
   Google Scholar
• Condorelli G, Giordano A. Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation. J Cell Biochem 1997; 67: 423–431
   PubMedGoogle Scholar
• Olson E N, Klein W H. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes and Dev 1994; 8: 1–8
   PubMed Web of Science ®Google Scholar
• Brun R P, Kim J B, Hu E, Altiok S, Spiegelman B M. Adipocyte differentiation: a transcriptional regulatory cascade. Current Opin Cell Biol 1996; 6: 826
   Google Scholar
• Peterson C, Gordon H, Hall Z, Paterson B, Blau H. Negative control of the helix-loop-helix family of myogenic regulators in the NFB mutant. Cell 1990; 62: 493–502
   PubMedGoogle Scholar
• Puri P L, Balsano C, Burgio V L, Chirillo P, Natoli G, Ricci L, Mattei E, Graessmann A, Levrero M. MyoD prevents cyclinA/cdk2 containing E2F complexes formation in terminally differentiated myocytes. Oncogene 1997; 14: 1171–1184
   PubMedGoogle Scholar
• Gu W, Schneider J W, Condorelli G, Kaushal S, Mahdavi V, Nadai-Ginard B. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 1993; 72: 309–324
   PubMed Web of Science ®Google Scholar
• Yeh W C, Cao Z, Classon M, McKnight S L. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes and Dev 1995; 9: 168–181
   PubMed Web of Science ®Google Scholar
• Chen P L, Riley D J, Chen Y, Lee W H. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes and Dev 1996; 10: 2794–2804
   PubMedGoogle Scholar
• Sellers W R, Novitch B G, Miyake S, Heith A, Otterson G A, Kaye F J, Lasser A B, Kaelin W GJ. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation and suppress tumor cell growth. Genes and Dev 1998; 12: 95–106
   PubMed Web of Science ®Google Scholar
• Riley D J, Liu C Y, Lee W H. Mutations of N-terminal regions render the retinoblastoma protein insufficient for functions in development and tumor suppression. Mol Cell Biol 1997; 17: 7342–7352
   PubMedGoogle Scholar
• Batchvarova N, Wang X Z, Ron D. Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J 1995; 14: 4654–4661
   PubMed Web of Science ®Google Scholar
• Shih H, Tevosian S G, Yee A S. Regulation of Differentiation by HBP1, a Target of the Retinoblastoma Protein. Mol Cell Biol 1998; 18: 4732–43
   PubMedGoogle Scholar
• Datta B, Min W, Burma S, Lengyel P. Increase in p202 expression during skeletal muscle differentiation: Inhibition of MyoD protein expression and activity of p202. Mol Cell Biol 1998; 18: 1074–1083
   PubMedGoogle Scholar
• Classon M, Gorka C, Kennedy B K, Dyson N, Harlow E. Opposing roles for pRB and p107/p130 in adipocyte differentiation, submitted
   Google Scholar
• Choubey D, Lengyel P. Binding of an interferon-inducible protein (p202) to the retinoblastoma protein. J Biol Chem 1995; 270: 6134–6140
   PubMed Web of Science ®Google Scholar
• Choubey D, Li S-J, Datta B, Gutterman J U, Lengyel P. Inhibition of E2F-mediated transcription by p202. EMBO J 1996; 15: 5668–5678
   PubMedGoogle Scholar
• Ron D, Habener J F. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes and Dev 1992; 6: 439–453
   PubMed Web of Science ®Google Scholar
• Crozat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature (London) 1993; 363: 640–644
   PubMed Web of Science ®Google Scholar
• Barone M V, Crozat A, Tabaee A, Philipson L, Ron D. CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest. Genes Dev 1994; 8: 453–464
   PubMed Web of Science ®Google Scholar
• Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth P K, Dotto G P. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse kerati-nocytes independent of cell cycle control. Science 1998; 280: 1069–1072
   PubMed Web of Science ®Google Scholar
• Sugiyama A, Miyagi Y, Shirasawa Y, Kuchino T. Different usage of two polyadenylation signals in transcription of the N-Myc gene in rat tumor cells. Oncogene 1991; 11: 2027–2032
   Google Scholar
• Watanabe G, Howe A, Lee R J, Albanese C, Shu I W, Karnezis A N, Zon L, Kyriakis J, Rundell K, Pestell R G. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc Natl Acad Sci USA 1995; 23: 12861
   Google Scholar