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Clinical Toxicology Volume 56, 2018 - Issue 5
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2-Methyl-4-chlorophenoxyacetic acid (MCPA) and bromoxynil herbicide ingestion

Angela L. ChiewNSW Poisons Information Centre, Children’s Hospital, Westmead, NSW, Australia; ;Clinical and Experimental Toxicology Unit, Department of Emergency Medicine, Prince of Wales Hospital, Randwick, NSW, Australia; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-0079-5056View further author information
ORCID Icon,
Colin B. PageClinical Toxicology Unit, Princess Alexandra Hospital, Brisbane, Queensland, Australia; ;Clinical Toxicology Research Group, University of Newcastle, Callaghan, NSW, Australia; View further author information
,
David ClancyIntensive Care Unit, Nepean Hospital, Kingswood, NSW, Australia; View further author information
,
Ahmed MostafaSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; View further author information
,
Michael S. RobertsSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia; ;Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, AustraliaView further author information
&
Geoffrey K. IsbisterNSW Poisons Information Centre, Children’s Hospital, Westmead, NSW, Australia; ;Clinical Toxicology Research Group, University of Newcastle, Callaghan, NSW, Australia; View further author information
Pages 377-380 | Received 02 Aug 2017, Accepted 23 Sep 2017, Published online: 09 Oct 2017

References

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  • Flanagan RJ, Meredith TJ, Ruprah M, et al. Alkaline diuresis for acute poisoning with chlorophenoxy herbicides and ioxynil. Lancet. 1990;335:454–458.
  • Berling I, Buckley NA, Mostafa A, et al. 2-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death. Clin Toxicol. 2015;53:486–488.
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  • Roberts DM, Dawson AH, Senarathna L, et al. Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning. Toxicol Lett. 2011;201:270–276.
  • U.S. Environmental Protection Agency. Bromoxynil: Reregistration Eligibility Decision (RED). US EPA; 1998. [cited 2017 Sep]. Available from: https://archive.epa.gov/pesticides/reregistration/web/pdf/2070red.pdf.
  • Salama A, Osman K, El-Bakary A, et al. Tissue distribution and pharmacokinetics of bromoxynil in rat. Int J Curr Pharm Rev Res. 2016;8:54–60.
  • Lavergne V, Nolin TD, Hoffman RS, et al. The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology. Clin Toxicol. 2012;50:403–413.
  • Tucker GT. Measurement of the renal clearance of drugs. Br J Clin Pharmacol. 1981;12:761–770.

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