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Letter to the Editor

Perampanel overdose causing a prolonged coma

, , &
Pages 677-678 | Received 13 Sep 2017, Accepted 26 Dec 2017, Published online: 04 Jan 2018

References

  • Fycompa (perampanel) [package insert]. Woodcliff Lake (NJ): Eisai Inc; 2012.
  • Steinhoff BJ, Ben-Menachem E, Ryvlin P, et al. Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pool analysis of three phase III studies. Epilepsia. 2013;54:1481–1489.
  • Di L, Kerns EH. Blood-brain barrier in drug discovery: optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs. New York: John Wiley & Sons; 2015. Chapter 22. The discovery and development of perampanel. p. 483–504.
  • Craig JJ, Parrett M, Lawthom C, et al. Making a difference for patients with uncontrolled epilepsy. Adv Clin Neurosci Rehabil. 2013;13:1–12.

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