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Letter

All cases of pediatric methotrexate ingestion should be referred to hospital for assessment until more robust evidence suggests the contrary

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Pages 869-870 | Received 02 Jan 2018, Accepted 23 Jan 2018, Published online: 07 Feb 2018

References

  • Hays H, Beuhler MC, Spiller HA, et al. Evaluation of toxicity after acute accidental methotrexate ingestions in children under 6 years old: a 16-year multi-center review. Clin Toxicol. 2018;56:120–125.
  • Hoffman RS. Understanding the limitations of retrospective analyses of poison center data. Clin Toxicol. 2007;45:943–945.
  • Ruha AM. The case report: a tool for the toxicologist. J Med Toxicol. 2009;5:1–2.
  • Stoller RG, Hande KR, Jacobs SA, et al. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. N Engl J Med. 1977;297:630–634.
  • Chabner BA, Young RC. Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues. J Clin Invest. 1973;52:1804–1811.

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