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Letter to the Editor

Adverse outcomes after single acute methotrexate exposures in pediatric patients are rare

, & ORCID Icon
Pages 870-871 | Received 29 Jan 2018, Accepted 12 Feb 2018, Published online: 02 Apr 2018

References

  • Benson BE, Spyker DA, Troutman WG. TESS-based dose-response using pediatric clonidine exposures. Toxicol Appl Pharmacol. 2006;213:145–151.
  • Stoller RG, Hande KR, Jacobs SA, et al. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. N Engl J Med. 1977;297:630–634.
  • Chabner BA, Young RC. Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues. J Clin Invest. 1973;52:1804–1811.
  • Chan BS, Dawson AH, Buckley N. What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning? Clin Tox. 2017;55:88–96.
  • Hensley MD, Bebarta VS, Borys DJ. A large case series of acute pediatric methotrexate ingestions: significant clinical effects are rare. Ped Emerg Care. 2016;32:682–684.

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