Naloxone reversal of clonidine toxicity: dose, dose, dose

References

• Ahmad SA, Scolnik D, Snehal V, et al. Use of naloxone for clonidine intoxication in the pediatric age group: case report and review of the literature. Am J Ther. 2015;22:e14–e16.
   PubMed Web of Science ®Google Scholar
• Sinha Y, Cranswick NE. Clonidine poisoning in children: a recent experience. J Paediatr Child Health. 2004;40:678–680.
   PubMed Web of Science ®Google Scholar
• Banner W, Lund ME, Clawson L. Failure of naloxone to reverse clonidine toxic effect. Am J Dis Child. 1983;137:1170–1171.
   PubMedGoogle Scholar
• Wiley JF, Wiley CC, Torrey SB, et al. Clonidine poisoning in young children. J Pediatr. 1990;116:654–658.
   PubMed Web of Science ®Google Scholar
• Heidemann SM, Sarnaik AP. Clonidine poisoning in children. Crit Care Med. 1990;18:618–620.
   PubMed Web of Science ®Google Scholar
• Wedin GP, Edwards JL. Clonidine poisoning treated with naloxone. Am J Emerg Med. 1989;7:343–344.
   PubMed Web of Science ®Google Scholar
• North DS, Wieland MJ, Peterson CD. Naloxone administration in clonidine overdosage. Ann Emerg Med. 1981;10:397
   PubMed Web of Science ®Google Scholar
• Gremse D, Artman M, Boerth R. Hypertension associated with naloxone treatment for clonidine poisoning. J Pediatr. 1986;108:776–778.
   PubMed Web of Science ®Google Scholar
• American Association of Poison Control Centers National Poison Data System. [cited 2017 Jun 6]; Available from: www.aapcc.org/data-system/
   Google Scholar
• Dempsey DA. Pediatric vital signs [Table]. In: Olson KR, editor. Poisoning & drug overdose (6th ed.). New York (NY): McGraw-Hill Companies.
   Google Scholar
• Beauchamp GA, Giffin SL, Horowitz BZ. Poisonings associated with intubation: US National Poison Data System exposures 2000-2013. J Med Toxicol. 2016;12:157–164.
   PubMed Web of Science ®Google Scholar
• Lee JH, Turner DA, Kamat P, et al. The number of tracheal intubation attempts matters! A prospective multi-institutional pediatric observational study. BMC Pediatr. 2016;16:58.
   PubMed Web of Science ®Google Scholar
• Pallin DJ, Dwyer RC, Walls RM, et al. Techniques and trends, success rates, and adverse events in Emergency Department pediatric intubations: a report from the National Emergency Airway Registry. Annals Emerg Med. 2016;67:610–615.e1.
   PubMedGoogle Scholar
• Easley R, Segeleon J, Haun S, et al. Prospective study of airway management of children requiring endotracheal intubation before admission to a pediatric intensive care unit. Crit Care Med. 2000;28:2058–2063.
   PubMed Web of Science ®Google Scholar
• Long E, Sabato S, Babl F. Endotracheal intubation in the pediatric emergency department. Ped Anest. 2014;24:1204–1211.
   PubMed Web of Science ®Google Scholar
• Carroll C, Spinella P, Dorsi J, et al. Emergent endotracheal intubations in children: be careful if its late when you intubate. Ped Crit Care Med. 2010;11:343–348.
   PubMed Web of Science ®Google Scholar
• Lowry J, Brown J. Significance of the imidazoline receptors in toxicology. Clin Toxicol. 2014;52:454–469.
   Web of Science ®Google Scholar
• Goldstein D, Levinson P, Simlichman R, et al. Clonidine suppression testing in essential hypertension. Ann Intern Med. 1985;102:42–49.
   PubMed Web of Science ®Google Scholar
• Head GA. Central Imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents. Annals Ny Acad Sci. 1999;881:279–286.
   PubMed Web of Science ®Google Scholar
• Davies DS, Wing LMH, Reid JL, et al. Pharmacokinetics and concentration-effect relationships of intravenous and oral clonidine. Clin Pharmacol Ther. 1977;21:593–601.
   PubMed Web of Science ®Google Scholar
• Westfall T, Westfall D, Catecholamines and Sympatheomimetic Drugs. In: Brunton L, Chabner G, Knollman B, editors. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw Hill; 2011. p. 275–333.
   Google Scholar
• Kunos G, Farsang C, Ramirez-Gonzales M. Beta-endorphin: possible involvement in the anti-hypertensive effect of central alpha-receptor activation. Science. 1981;211:82–84.
   PubMed Web of Science ®Google Scholar
• Ramirez-gonzalez M, Tchakarov L, Garcia R, et al. β-endorphin acting on the brainsem is involved in the antihypertensive action of clonidine and α-methyldopa in rats. Circ Res. 1983;53:150–157.
   PubMed Web of Science ®Google Scholar
• Farsang C, Vajda L, Kapocsi J, et al. Diurnal rhythm of beta endorphin in normotensive and hypertensive patients: the effect of clonidine. J Clin Endocrinol Metab. 1983;56:865–867.
   PubMed Web of Science ®Google Scholar
• Farsang C, Kunos G. Naloxone reverses the antihypertensive effect of clonidine. Br J Pharmacol. 1979;67:161–164.
   PubMed Web of Science ®Google Scholar
• Farsang C, Kapocsi J, Juhasz I, et al. Possible involvement of an endogenous opioid in the antihypertensive effect of clonidine in patients with essential hypertension. Circulation. 1982;66: 1268–1272.
   PubMed Web of Science ®Google Scholar
• Farsang C, Kapocsi J, Vajda L, et al. Reversal by naloxone of the antihypertensive action of clonidine: involvement of the sympathetic nervous system. Circulation. 1984;69:461–467.
   PubMed Web of Science ®Google Scholar
• Przewłocki R, Höllt V, Voigt KH, et al. Clonidine releases immunoreactive β-endorphin from the separate lobes of the rat pituitary. Life Sci. 1979;24:1601.
   PubMed Web of Science ®Google Scholar
• Erickson SJ, Duncan A. Clonidine poisoning-an emerging problem: Epidemiology, clinical features, management and preventative strategies. J Paediatr Child Health. 1984;42:280–282.
   Google Scholar
• Isbister G, Heppell S, page C, Ryan N. Adult clonidine overdose: prolonged bradycardia and central nervous system depression, but no severe toxicity. Clin Tox. 2017;55:187092.
   Web of Science ®Google Scholar
• Bamshad M, Wasserman G. Pediatric clonidine intoxications. Vet Hum Toxicol. 1990;32:220–223.
   PubMedGoogle Scholar
• Cook P. Clonidine-induced unconsciousness: reversal with naloxone. Anaesth Intensive Care. 1987;15:470–471.
   PubMed Web of Science ®Google Scholar
• Kulig K, Duffy J, Rumack B, et al. Naloxone for treatment of clonidine overdose. JAMA. 1982;247:1697
   PubMed Web of Science ®Google Scholar
• Tenenbein M. Naloxone in clonidine toxicity. Am J Dis Child. 1984;138:1084
   PubMedGoogle Scholar
• Knapp J, Fowler M, Wheeler C, et al. Case 01-1995: a two-year-old female with alteration of consciousness. Pediatr Emerg Care. 1995;11:62–65.
   PubMed Web of Science ®Google Scholar
• Moore R, Rumack BH, Conner CS, et al. Naloxone: underdosage after narcotic poisoning. Am J Dis Child. 1980;134:156–158.
   PubMedGoogle Scholar
• Committee on Drugs; Naloxone dosage and route of Administration for Infants and children: addendum to emergency Drug doses for Infants and children. Pediatrics. 1990;86:484.
   PubMed Web of Science ®Google Scholar