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Clinical Toxicology Volume 59, 2021 - Issue 4
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Trends in adverse events and related health-care facility utilization from cough and cold medication exposures in children

George Sam Wanga Department of Pediatrics, Children’s Hospital Colorado, Aurora, CO, USA;b Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, CO, USAView further author information
,
Jody L. Greenb Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, CO, USAView further author information
,
Kate M. Reynoldsb Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, CO, USACorrespondence[email protected]
View further author information
,
William Bannerc Oklahoma Center for Poison and Drug Information, Oklahoma University College of Pharmacy, Oklahoma City, OK, USAView further author information
,
G. Randall Bondd Faculté de Médecine, Hope Africa University, Bujumbura, BurundiView further author information
,
Ralph E. Kauffmane Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USAView further author information
,
Robert B. Palmerb Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, CO, USAView further author information
,
Ian M. Paulf Pediatrics & Public Health Sciences, Penn State College of Medicine, Hershey, PA, USAView further author information
,
Malin Rapp-Olssonb Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, CO, USAView further author information
&
Richard C. Dartb Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, Denver, CO, USAView further author information
 show all
Pages 351-354 | Received 18 Jun 2020, Accepted 22 Aug 2020, Published online: 11 Sep 2020

References

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  • Hampton L, Nguyen D, Edwards J, et al. Cough and cold medication adverse events after market withdrawal and labeling revision. Pediatrics. 2013;132(6):1047–1054.
  • Mazer-Amirshahi M, Reid N, van den Anker J, et al. Effect of cough and cold medication restriction and label changes on pediatric ingestions reported to United States poison centers. J Pediatr. 2013;163(5):1372–1376.
  • Green J, Wang G, Reynolds K, et al. Safety profile of cough and cold medication use in pediatrics. Pediatrics. 2017;139(6):e20163070.
  • Green J, Reynolds K, Banner W, et al. Evaluation of the quality and value of data sources for postmarket surveillance of the safety of cough and cold medications in children. BMC Med Res Methodol. 2018;18(1):175.
  • Guideline on detection and management of duplicate individual cases and Individual Case Safety Reports (ICSRs). London, UK: European Medicines Agency; 2009.
  • Paul I, Yoder K, Crowell K, et al. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics. 2004;114(1):e85-90.
  • Horton D, Gerhard T, Strom B. Trends in cough and cold medicine recommendations for children in the United States, 2002-2015. JAMA Pediatr. 2019;173(9):885.
  • Lovegrove M, Hon S, Geller R, et al. Efficacy of flow restrictors in limiting access of liquid medications by young children. J Pediatr. 2013;163(4):1134–1139 e1.
  • Brass E, Reynolds K, Burnham R, et al. Frequency of poison center exposures for pediatric accidental unsupervised ingestions of acetaminophen after the introduction of flow restrictors. J Pediatr. 2018;198:254–259.e1.
  • Restricted delivery systems: flow restrictors for oral liquid drug products. Guidance for industry. Silver Spring, MD: U.S. Department of Health and Human Services Food and Drug Administration; 2020.
  • Heldenbrand S, Martin B, Gubbins P, et al. Assessment of medication adherence app features, functionality, and health literacy level and the creation of a searchable Web-based adherence app resource for health care professionals and patients. J Am Pharm Assoc. 2016;56(3):293–302.
  • Brass E, Reynolds K, Burnham R, et al. Medication errors with pediatric liquid acetaminophen after standardization of concentration and packaging improvements. Acad Pediatr. 2018;18(5):563–568.

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