242
Views
7
CrossRef citations to date
0
Altmetric
Case Report

A severe case of olanzapine overdose with analytical data

, Ph.D. , M.D., , Ph.D. , M.S., , M.D., , Ph.D. & , M.D.
Pages 412-415 | Received 15 Jun 2006, Accepted 05 Jul 2006, Published online: 07 Oct 2008

References

  • Stip E. Novel antipsychotics: Issues and controversies. Typicality of atypical antipsychotics. J Psychiatry Neurosci 2000; 25: 137–153
  • Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. J Toxicol Clin Toxicol 2001; 39: 1–14
  • 3. Drugdex® ( Product Index and Martindale Product Index. 1974–2005 Thomson Micromedex, Micromedex® Healthcare Series, vol. 127, exp. 3/2006.
  • Cohen LG, Fatalo A, Thompson BT. Olanzapine overdose with serum concentrations. Ann Emerg Med 1999; 34: 275–278
  • Martínez MA, Ballesteros S, Sánchez de la Torre C, Almarza E. Investigation of a fatality due to trazodone poisoning: Case report and literature review. J Anal Toxicol 2005; 29: 262–268
  • Sánchez de la Torre C, Martínez MA, Almarza E. Determination of several psychiatric drugs in whole blood using capillary gas-liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures. Forensic Sci Int 2005; 155: 193–204
  • Shrestha M, Hendrickson RG, Henretig FM. Striking extrapyramidal movements seen in large olanzapine overdoses. J Toxicol Clin Toxicol 2001; 39: 282
  • Palenzona S, Meier PJ, Kupferschmidt H, Rauber-Luethy C. The clinical picture of olanzapine poisoning with special reference to fluctuating mental status. J Toxicol Clin Toxicol 2004; 42: 27–32
  • O'Malley GF, Seifert S, Heard K. Olanzapine overdose mimicking opioid intoxication. Ann Emerg Med 1999; 34: 279–281
  • Bond GR, Thompson JD. Prolonged CNS depression following ingestion of a single dose of olanzapine 10 mg by a 17 kg child. J Tox Clin Tox 1998; 36: 522
  • Bond GR, Thompson JD. Olanzapine pediatric overdose. Ann Emerg Med 1999; 34: 292–293
  • Catalano G, Cooper DS, Catalano MC, Butera AS. Olanzapine overdose in an 18-month-old child. J Child Adolesc Psychopharmacol 1999; 9: 267–271
  • Horak EL, Jenkins AJ. Postmortem tissue distribution of olanzapine and citalopram in a drug intoxication. J Forensic Sci 2005; 50: 679–681
  • Yip L, Graham K. Olanzapine toxicity in a toddler. Pediatrics 1998; 103: 1494
  • Bosch RF, Baumbach A, Bitzer M. Intoxication with olanzapine. Am J Psychiatry 2000; 157: 304–305
  • Isbister GK, Whyte IM, Smith AJ. Olanzapine overdose. Anaesthesia 2001; 56: 400–401
  • Roefaro J, Mukherjee SM. Olanzapine-induced hyperglycemic nonketonic coma. Ann Pharmacother 2001; 35: 300–302
  • Meatherall R, Younes J. Fatality from olanzapine induced hyperglycemia. J Forensic Sci 2002; 47: 893–896
  • Avella J, Wetli CV, Wilson JC, Katz M, Hahn T. Fatal olanzapine-induced hyperglycemic ketoacidosis. Am J Forensic Med Pathol 2004; 25: 172–175
  • Fogel J, Diaz JE. Olanzapine overdose. Ann Emerg Med 1998; 32: 275–276
  • O'Malley GF, Seifert S, Heard K. Pupillary effects of olanzapine overdose mimic opiate and alpha-2 agonists. J Toxicol Clin Toxicol 1998; 36: 523
  • Robertson MD, McMullin MM. Olanzapine concentrations in clinical serum and postmortem blood specimens - when does therapeutic become toxic?. J Forensic Sci 2000; 45: 418–421
  • Davis LE, Becher MW, Tlomak W, Benson BE, Lee RR, Fisher EC. Persistent choreoathetosis in a fatal olanzapine overdose: Drug kinetics, neuroimaging, and neuropathology. Am J Psychiatry 2005; 162: 28–33
  • Bogusz MJ, Kruger KD, Maier RD. Monitoring of olanzapine in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Chromatogr B Biomed Appl 1999; 732: 257–269
  • Catlow JT, Barton RD, Clemens M, Gillespie TA, Goodwin M, Swanson SP. Analysis of olanzapine in human plasma utilizing reversed-phase high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl 1995; 668: 85–90
  • Elian AA. Fatal overdose of olanzepine. Forensic Sci Int 1998; 91: 231–235
  • Stephens BG, Coleman DE, Baselt RC. Olanzapine-related fatality. J Forensic Sci 1998; 43: 1252–1253
  • Bonin MM, Burkhart KK. Olanzapine overdose in a 1-year-old male. Ped Emerg Care 1999; 15: 266–267
  • Gerber JE, Cawthon B. Overdose and death with olanzapine. Two case reports. Am J Forensic Med Pathol 2000; 21: 249–251
  • Kochhar S, Nwokike JN, Jankowitz B, Sholevar EH, Abed T, Baron DA. Olanzapine overdose: A pediatric case report. J Child Adolesc Psychopharmacol 2002; 12: 351–353
  • Miñambres E, Burón J, Rodríguez-Borregán JC, González C, Tejerían E, Ballesteros MA. Intoxicación grave por olanzapina. Investig Clin 2003; 6: 173–174

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.