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LetterToEditor

Hypertonic saline: An alternative therapy in TCA overdoses failed to respond sodium bicarbonate

Page 488 | Published online: 20 Jan 2009

References

  • Bebarta VS, Waksman JC. Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate. Clinical Toxicology. 2007; 45: 186–188
  • Wrenn K, Smith BA, Slovis CM. Profound alkelemia during treatment of tricyclic antidepressant overdose: a potential hazard of combined hyperventilation and intravenous bicarbonate. Am J Emerg Med. 1992; 10: 553–555
  • Nattel S, Mittleman M. Treatment of ventricular tachyarrhythmias resulting from amitriptyline toxicity in dogs. J Pharmacol Exp Ther. 1984; 231: 430–5
  • McCabe JL, Menegazzi JJ, Cobaugh DJ, Auble TE. Recovery from severe cyclic antidepressant overdose with hypertonic saline/dextran in a swine model. Acad Emerg Med. 1994; 1(2)111–5
  • McCabe JL, Cobaugh DJ, Menegazzi JJ, Fata J. Experimental Tricyclic Antidepressant Toxicity: A Randomized, Controlled Comparison of Hypertonic Saline Solution, Sodium Bicarbonate, and Hyperventilation. Ann Emerg Med 1998; 32: 329–333
  • McKinney PE, Rasmussen R. Reversal of Severe Tricyclic Antidepressant-Induced Cardiotoxicity with intravenous hypertonic saline solution. Ann Emerg Med. 2003; 42: 20–34
  • Nattel S, Keable H, Sasyniuk BI. Experimental amitriptyline intoxication: electrophysiologic manifestations and management. J Cardiovasc Pharmacol. 1984; 6: 83–9
  • Sasyniuk BI, Jhamandas V. Mechanisms of reversal of toxic effects of amitriptyline on cardiac Purkinje fibers by sodium bicarbonate. J Pharmacol Exp Ther 1984; 231(2)387–94

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