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Article

Preparation of crotaline F-ab antivenom (CroFab®) with automated mixing methods: in vitro observations

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Pages 69-71 | Received 25 May 2007, Accepted 31 Mar 2008, Published online: 03 Feb 2009

References

  • CroFab package insert. Savage Laboratories, Protherics Inc., Brentwood, TN, USA, (2006).
  • RC Dart, SA Seifert, L Carroll, RF Clark, E Hall, LV Boyer-Hassen, SC Curry, CS Kitchens, and RA Garcia. (1997). Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning. Ann Emerg Med 30 (1):33–39.
  • RC Dart, SA Seifert, LV Boyer, RF Clark, E Hall, P McKinney, J McNally, CS Kitchens, SC Curry, GM Bogdam, SB Ward, and RS Porter. (2001). A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States. Arch Intern Med 161 (16):2030–2036.
  • RE Hill, GM Bogdan, and RC Dart. (2001). Time to reconstitution: purified Fab antivenom vs. unpurified IgG antivenom. Toxicon 39 (5):729–731.
  • AD Kanavage, LV Boyer, J McNally, and JJ Osterhout. (2006). Resistance of antivenom proteins to foaming-induced denaturation. Toxicon 47 (4):445–452.
  • WW Decker, GM Bogdan, RA Garcia, P Wollen, and RC Dart. (1998). Heat and motion stability of polyvalent Crotalidae antivenin, ovine Fab. Toxicon 36 (2):377–382.

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