Brugada-like EKG pattern and myocardial effects in a chronic propofol abuser

References

• Vernooy K, Delhaas T, Cremer OL, Di Diego JM, Oliva A, Timmermans C, Volders PG, Prinzen FW, Crijns HJ, Antzelevitch C, Kalkman CJ, Rodriguez LM, Brugada R. Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. Heart Rhythm 2006; 3:131–137.
   PubMed Web of Science ®Google Scholar
• Branca D, Roberti MS, Lorenzin P, Vincenti E, Scutari G. Influence of the anesthetic 2,6-diisopropylphenol on the oxidative phosphorylation of isolated rat liver mitochondria. Biochem Pharmacol 1991; 42:87–90.
   PubMed Web of Science ®Google Scholar
• Schenkman KA, Yan S. Propofol impairment of mitochondrial respiration in isolated perfused guinea pig hearts determined by reflectance spectroscopy. Crit Care Med 2000; 28:172–177.
   PubMed Web of Science ®Google Scholar
• Yamamoto S, Kawana S, Miyamoto A, Ohshika H, Namiki A. Propofol-induced depression of cultured rat ventricular myocytes is related to the M2-acetylcholine receptor-NO-cGMP signalling pathway. Anesthesiology 1999; 91:1712–1719.
   PubMed Web of Science ®Google Scholar
• Kurokawa H, Murray PA, Damron DS. Propofol attenuates beta-adrenoreceptor-mediated signal transduction via a protein kinase C‐dependent pathway in cardiomyocytes. Anesthesiology 2002; 96:688–698.
   PubMed Web of Science ®Google Scholar
• Fineschi V, Neri M, Di Padua M, Fiore C, Riezzo I, Turillazzi E. Morphology, TNFalpha expression and apoptosis in the hearts of patients who died of abdominal compartment syndrome: an immunohistochemical study. Int J Cardiol 2007; 116:236–241.
   PubMed Web of Science ®Google Scholar
• Ernest D, French C. Propofol infusion syndrome – report of an adult fatality. Anaesth Intensive Care 2003; 31:316–319.
   PubMed Web of Science ®Google Scholar
• Eriksen J, Povey HM. A case of suspected non-surgical adult fatal propofol infusion syndrome. Acta Anaesthesiol Scand 2006; 50:117–119.
   PubMed Web of Science ®Google Scholar
• Wysowski DK, Pollock ML. Reports of death with use of protocol (Diprivan) for nonprocedural (long-term) sedation and literature review. Anesthesiology 2006; 105:1047–1051.
   PubMed Web of Science ®Google Scholar
• Iwersen-Bergmann S, Rösner P, Kühnau HC, Junge M, Schmoldt A. Death after excessive propofol abuse. Int J Legal Med 2001; 114:248–251.
   PubMed Web of Science ®Google Scholar
• Kranioti EF, Mavroforou A, Mylonakis P, Michalodimitrakis M. Lethal self administration of propofol (Diprivan). A case report and review of the literature. Forensic Sci Int 2007; 167:56–58.
   PubMed Web of Science ®Google Scholar
• Roussin A, Montastruc JL, Lapeyre-Mestre M. Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature. Fundam Clin Pharmacol 2007; 21:459–466.
   PubMed Web of Science ®Google Scholar
• Cirimele V, Kintz P, Doray S, Ludes B. Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis. Int J Legal Med 2002; 116:54–57.
   PubMed Web of Science ®Google Scholar
• Roussin A, Mirepoix M, Lassabe G, Dumestre-Toulet V, Gardette V, Montastruc JL, Lapeyre-Mestre M. Death related to a recreational abuse of propofol at therapeutic dose range. Br J Anaesth 2006; 97:268.
   PubMed Web of Science ®Google Scholar
• Stelow EB, Johari VP, Smith SA, Crosson JT, Apple FS. Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. Clin Chem 2000; 46:577–581.
   PubMed Web of Science ®Google Scholar
• Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Priori SG, Towbin JA. Study Group on the Molecular Basis of Arrhythmias of the European Society of Cardiology. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation 2002; 106:2514–2519.
   PubMed Web of Science ®Google Scholar
• Lee CJ, Subeq YM, Lee RP, Wu WT, Hsu BG. Low-dose propofol ameliorates haemorrhagic shock-induced organ damage in conscious rats. Clin Exp Pharmacol Physiol 2008; 35:766–774.
   PubMed Web of Science ®Google Scholar
• Taniguchi T, Kanakura H, Yamamoto K. Effects of post-treatment with propofol on mortality and cytokine responses to endotoxin-induced shock in rats. Crit Care Med 2002; 30:904–907.
   PubMed Web of Science ®Google Scholar
• Casserly B, O'Mahony E, Timm EG, Haqqie S, Eisele G, Urizar R. Propofol infusion syndrome: an unusual cause of renal failure. Am J Kidney Dis 2004 E98–E101.
   Google Scholar
• Neri M, Cerretani D, Fiaschi AI, Laghi PF, Lazzerini PE, Maffione AB, Micheli L, Bruni G, Nencini C, Giorgi G, D'Errico S, Fiore C, Pomara C, Riezzo I, Turillazzi E, Fineschi V. Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats. J Cell Mol Med 2007; 11:156–170.
   PubMed Web of Science ®Google Scholar
• Junttila MJ, Gonzalez M, Lizotte E, Benito B, Vernooy K, Sarkozy A, Huikuri HV, Brugada P, Brugada J, Brugada R. Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation 2008; 117:1890–1893.
   PubMed Web of Science ®Google Scholar