Cytological and functional effect of complement 3a on Human Scleral Fibroblasts

References

• Baird PN, Saw SM, Lanca C, et al. Myopia. Nat Rev Dis Primers. 2020;6(1):99. doi: 10.1038/s41572-020-00231-4.
   PubMed Web of Science ®Google Scholar
• Xiang ZY, Zou HD. Recent epidemiology study data of myopia. J Ophthalmol. 2020;2020:4395278. doi: 10.1155/2020/4395278.
   PubMed Web of Science ®Google Scholar
• Ouyang X, Han Y, Xie Y, et al. The collagen metabolism affects the scleral mechanical properties in the different processes of scleral remodeling. Biomed Pharmacother. 2019;118:109294. doi: 10.1016/j.biopha.2019.109294.
   PubMed Web of Science ®Google Scholar
• Pugazhendhi S, Ambati B, Hunter AA. Pathogenesis and prevention of worsening axial elongation in pathological myopia. Clin Ophthalmol. 2020;14:853–873. doi: 10.2147/OPTH.S241435.
   PubMed Web of Science ®Google Scholar
• Zhu C, Chen Q, Yuan Y, et al. Endoplasmic reticulum stress regulates scleral remodeling in a Guinea pig model of form-deprivation myopia. J Ophthalmol. 2020;2020:3264525. doi: 10.1155/2020/3264525.
   PubMed Web of Science ®Google Scholar
• Rada JA, Shelton S, Norton TT. The sclera and myopia. Exp Eye Res. 2006;82(2):185–200. doi: 10.1016/j.exer.2005.08.009.
   PubMed Web of Science ®Google Scholar
• Jiang B, Wu ZY, Zhu ZC, et al. Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in Guinea pigs. Int J Ophthalmol. 2017;10(4):550–554.
   PubMed Web of Science ®Google Scholar
• Yue Y, Hsiao YW, Zhou JB. Association between MMP/TIMP levels in the aqueous humor and plasma with axial lengths in myopia patients. Biomed Res Int. 2020;2020:2961742. doi: 10.1155/2020/2961742.
   PubMed Web of Science ®Google Scholar
• de Almeida LGN, Thode H, Eslambolchi Y, et al. Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology. Pharmacol Rev. 2022;74(3):712–768. doi: 10.1124/pharmrev.121.000349.
   PubMed Web of Science ®Google Scholar
• Deng HW, Tian Y, Zhou XJ, et al. Effect of bilberry extract on development of form-deprivation myopia in the Guinea pig. J Ocul Pharmacol Ther. 2016;32(4):196–202. doi: 10.1089/jop.2015.0053.
   PubMed Web of Science ®Google Scholar
• Kim JW, Lindsey JD, Wang N, et al. Increased human scleral permeability with prostaglandin exposure. Invest Ophthalmol Vis Sci. 2001;42(7):1514–1521.
   PubMed Web of Science ®Google Scholar
• Khan MA, Assiri AM, Broering DC. Complement mediators: key regulators of airway tissue remodeling in asthma. J Transl Med. 2015;13:272. doi: 10.1186/s12967-015-0565-2.
   PubMed Web of Science ®Google Scholar
• Mansoor N, Wahid F, Azam M, et al. Molecular mechanisms of complement system proteins and matrix metalloproteinases in the pathogenesis of age-related macular degeneration. Curr Mol Med. 2019;19(10):705–718. doi: 10.2174/1566524019666190828150625.
   PubMedGoogle Scholar
• Chen L, Fukuda N, Matsumoto T, et al. Role of complement 3 in the pathogenesis of hypertension. Hypertens Res. 2020;43(4):255–262. doi: 10.1038/s41440-019-0371-y.
   PubMed Web of Science ®Google Scholar
• Long Q, Ye J, Li Y, et al. C-reactive protein and complement components in patients with pathological myopia. Optom Vis Sci. 2013;90(5):501–506. doi: 10.1097/OPX.0b013e31828daa6e.
   PubMed Web of Science ®Google Scholar
• Gao TT, Long Q, Yang X. Complement factors C1q, C3 and C5b-9 in the posterior sclera of Guinea pigs with negative lens-defocused myopia. Int J Ophthalmol. 2015;8(4):675–680.
   PubMed Web of Science ®Google Scholar
• Long Q, Cao X, Bian A, et al. C3a increases VEGF and decreases PEDF mRNA levels in human retinal pigment epithelial cells. Biomed Res Int. 2016;2016:6958752. doi: 10.1155/2016/6958752.
   PubMed Web of Science ®Google Scholar
• McBrien NA, Jobling AI, Gentle A. Biomechanics of the sclera in myopia: extracellular and cellular factors. Optom Vis Sci. 2009;86(1):E23–30. doi: 10.1097/OPX.0b013e3181940669.
   PubMed Web of Science ®Google Scholar
• McBrien NA, Gentle A. Role of the sclera in the development and pathological complications of myopia. Prog Retin Eye Res. 2003;22(3):307–338. doi: 10.1016/s1350-9462(02)00063-0.
   PubMed Web of Science ®Google Scholar
• Chen BY, Ma JX, Wang CY, et al. Mechanical behavior of scleral fibroblasts in experimental myopia. Graefes Arch Clin Exp Ophthalmol. 2012;250(3):341–348. doi: 10.1007/s00417-011-1854-y.
   PubMed Web of Science ®Google Scholar
• Morgan IG, French AN, Ashby RS, et al. The epidemics of myopia: aetiology and prevention. Prog Retin Eye Res. 2018;62:134–149. doi: 10.1016/j.preteyeres.2017.09.004.
   PubMed Web of Science ®Google Scholar
• García-Gen E, Penadés M, Mérida S, et al. High myopia and the complement system: Factor H Myopic Maculopathy. J Clin Med. 2021;10(12):2600.
   PubMed Web of Science ®Google Scholar
• Riddell N, Crewther SG. Novel evidence for complement system activation in chick myopia and hyperopia models: a meta-analysis of transcriptome datasets. Sci Rep. 2017;7(1):9719. doi: 10.1038/s41598-017-10277-2.
   PubMedGoogle Scholar
• Giummarra L, Crewther SG, Riddell N, et al. Pathway analysis identifies altered mitochondrial metabolism, neurotransmission, structural pathways and complement Cascade in retina/RPE/choroid in chick model of form-deprivation myopia. PeerJ. 2018;6:e5048. doi: 10.7717/peerj.5048.
   PubMed Web of Science ®Google Scholar
• Li C, Cheng D, Xu P, et al. POSTN promotes the proliferation of spermatogonial cells by activating the wnt/β-Catenin signaling pathway. Reprod Sci. 2021;28(10):2906–2915. doi: 10.1007/s43032-021-00596-1.
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhao G, Xing S, et al. Role of bone morphogenetic proteins in form-deprivation myopia sclera. Mol Vis. 2011;17:647–657.
   PubMed Web of Science ®Google Scholar
• Rada JA, Johnson JM, Achen VR, et al. Inhibition of scleral proteoglycan synthesis blocks deprivation-induced axial elongation in chicks. Exp Eye Res. 2002;74(2):205–215. doi: 10.1006/exer.2001.1113.
   PubMed Web of Science ®Google Scholar
• Zhao H, Zhang X, Wang M, et al. Stigmasterol simultaneously induces apoptosis and protective autophagy by inhibiting akt/mTOR pathway in gastric cancer cells. Front Oncol. 2021;11:629008. doi: 10.3389/fonc.2021.629008.
   PubMed Web of Science ®Google Scholar
• Xu D, Zhao H, Jin M, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020;587(7832):133–138. doi: 10.1038/s41586-020-2757-z.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Ye Y, Zhu X, et al. Meisoindigo inhibits cellular proliferation via down-regulation of the PI3K/Akt pathway and induces cellular apoptosis in glioblastoma U87 cells. Acta Biochim Pol. 2021;68(2):309–315.
   PubMed Web of Science ®Google Scholar
• Qin J, Song G, Wang Y, et al. Ultrasound irradiation inhibits proliferation of cervical cancer cells by initiating endoplasmic reticulum stress-mediated apoptosis and triggering phosphorylation of JNK. Adv Clin Exp Med. 2021;30(5):545–554. doi: 10.17219/acem/133488.
   PubMed Web of Science ®Google Scholar
• Wu J, Zhao Y, Fu Y, et al. Effects of lumican expression on the apoptosis of scleral fibroblasts: in vivo and in vitro experiments. Exp Ther Med. 2021;21(5):495. doi: 10.3892/etm.2021.9926.
   PubMed Web of Science ®Google Scholar
• Li B, Gao MH, Chu XM, et al. Identification of a novel short peptide seal specific to CD59 and its effect on HeLa cell growth and apoptosis. Cell Oncol. 2012;35(5):355–365. doi: 10.1007/s13402-012-0096-2.
   Web of Science ®Google Scholar
• Shi H, Williams JA, Guo L, et al. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. Apoptosis. 2015;20(4):433–443. doi: 10.1007/s10495-015-1091-7.
   PubMed Web of Science ®Google Scholar
• Tian XD, Cheng YX, Liu GB, et al. Expressions of type I collagen, α2 integrin and β1 integrin in sclera of Guinea pig with defocus myopia and inhibitory effects of bFGF on the formation of myopia. Int J Ophthalmol. 2013;6(1):54–58.
   PubMed Web of Science ®Google Scholar
• Li M, Yuan Y, Chen Q, et al. Expression of Wnt/β-Catenin signaling pathway and its regulatory role in type I collagen with TGF-β1 in scleral fibroblasts from an experimentally induced myopia Guinea pig model. J Ophthalmol. 2016;2016:5126560. doi: 10.1155/2016/5126560.
   PubMed Web of Science ®Google Scholar
• Li XJ, Yang XP, Wan GM, et al. Effects of hepatocyte growth factor on MMP-2 expression in scleral fibroblasts from a Guinea pig myopia model. Int J Ophthalmol. 2014;7(2):239–244.
   PubMed Web of Science ®Google Scholar
• Zhao F, Wu H, Reinach PS, et al. Up-regulation of matrix metalloproteinase-2 by scleral monocyte-derived macrophages contributes to myopia development. Am J Pathol. 2020;190(9):1888–1908. doi: 10.1016/j.ajpath.2020.06.002.
   PubMed Web of Science ®Google Scholar