Toxicity of simultaneous intrastromal and intracameral injection of voriconazole on corneal endothelium in a rabbit model

References

• Srinivasan M. Fungal keratitis. Curr Opin Ophthalmol. 2004;15(4):321–327. doi: 10.1097/00055735-200408000-00008.
   PubMedGoogle Scholar
• Garg P, Roy A, Roy S. Update on fungal keratitis. Curr Opin Ophthalmol. 2016;27(4):333–339. doi: 10.1097/ICU.0000000000000272.
   PubMed Web of Science ®Google Scholar
• Manikandan P, Abdel-Hadi A, Randhir Babu Singh Y, et al. Fungal Keratitis: epidemiology, rapid detection, and antifungal susceptibilities of Fusarium and Aspergillus isolates from corneal scrapings. Biomed Res Int. 2019;2019:6395840. doi: 10.1155/2019/6395840.
   PubMed Web of Science ®Google Scholar
• Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79(3):214–221.
   PubMed Web of Science ®Google Scholar
• Brown L, Leck AK, Gichangi M, et al. The global incidence and diagnosis of fungal keratitis. Lancet Infect Dis. 2021;21(3):e49–e57. doi: 10.1016/S1473-3099(20)30448-5.
   PubMed Web of Science ®Google Scholar
• Bongomin F, Gago S, Oladele RO, et al. Global and multi-national prevalence of fungal diseases-estimate precision. J Fungi. 2017;3(4):57.
   Web of Science ®Google Scholar
• Sharma N, Bagga B, Singhal D, et al. Fungal keratitis: a review of clinical presentations, treatment strategies and outcomes. Ocul Surf. 2022;24:22–30. doi: 10.1016/j.jtos.2021.12.001.
   PubMed Web of Science ®Google Scholar
• Raj N, Vanathi M, Ahmed NH, et al. Recent perspectives in the management of Fungal Keratitis. J Fungi. 2021;7(11):907.
   Web of Science ®Google Scholar
• Manzouri B, Vafidis GC, Wyse RK. Pharmacotherapy of fungal eye infections. Expert Opin Pharmacother. 2001;2(11):1849–1857. doi: 10.1517/14656566.2.11.1849.
   PubMedGoogle Scholar
• Awwad S, Mohamed Ahmed AHA, Sharma G, et al. Principles of pharmacology in the eye. Br J Pharmacol. 2017;174(23):4205–4223. doi: 10.1111/bph.14024.
   PubMed Web of Science ®Google Scholar
• Hariprasad SM, Mieler WF, Holz ER, et al. Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans. Arch Ophthalmol. 2004;122(1):42–47. doi: 10.1001/archopht.122.1.42.
   PubMedGoogle Scholar
• Chandrasekar PH, Manavathu E. Voriconazole: a second-generation triazole. Drugs Today. 2001;37(2):135–148.
   PubMed Web of Science ®Google Scholar
• Rasoanirina BNV, Lassoued MA, Kamoun A, et al. Voriconazole-loaded self-nanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability. Pharm Dev Technol. 2020;25(6):694–703. doi: 10.1080/10837450.2020.1731532.
   PubMed Web of Science ®Google Scholar
• Ghannoum MA, Kuhn DM. Voriconazole – better chances for patients with invasive mycoses. Eur J Med Res. 2002;7(5):242–256.
   PubMed Web of Science ®Google Scholar
• Scott LJ, Simpson D. Voriconazole: a review of its use in the management of invasive fungal infections. Drugs. 2007;67(2):269–298. doi: 10.2165/00003495-200767020-00009.
   PubMed Web of Science ®Google Scholar
• Hariprasad SM, Mieler WF, Lin TK, et al. Voriconazole in the treatment of fungal eye infections: a review of current literature. Br J Ophthalmol. 2008;92(7):871–878. doi: 10.1136/bjo.2007.136515.
   PubMed Web of Science ®Google Scholar
• Prajna NV, Krishnan T, Rajaraman R, et al. Adjunctive oral voriconazole treatment of Fusarium keratitis: a secondary analysis from the mycotic ulcer treatment trial II. JAMA Ophthalmol. 2017;135(6):520–525. doi: 10.1001/jamaophthalmol.2017.0616.
   PubMed Web of Science ®Google Scholar
• Li C, Pang K, Du L, et al. Efficacy of voriconazole corneal intrastromal injection for the treatment of Fungal Keratitis. J Ophthalmol. 2021;2021:5597003. doi: 10.1155/2021/5597003.
   PubMed Web of Science ®Google Scholar
• Konar P, Joshi S, Mandhare SJ, et al. Intrastromal voriconazole: an adjuvant approach for recalcitrant mycotic keratitis. Indian J Ophthalmol. 2020;68(1):35–38. doi: 10.4103/ijo.IJO_378_19.
   PubMed Web of Science ®Google Scholar
• Nejabat M, Yaqubi N, Khosravi A, et al. Therapeutic effect of intrastromal voriconazole, topical voriconazole, and topical natamycin on Fusarium keratitis in rabbit. J Ophthalmol. 2016;2016:8692830. doi: 10.1155/2016/8692830.
   PubMed Web of Science ®Google Scholar
• Lekhanont K, Nonpassopon M, Nimvorapun N, et al. Treatment with intrastromal and intracameral voriconazole in 2 eyes with Lasiodiplodia theobromae keratitis: case reports. Medicine. 2015;94(6):e541. doi: 10.1097/MD.0000000000000541.
   PubMed Web of Science ®Google Scholar
• Kalaiselvi G, Narayana S, Krishnan T, et al. Intrastromal voriconazole for deep recalcitrant fungal keratitis: a case series. Br J Ophthalmol. 2015;99(2):195–198. doi: 10.1136/bjophthalmol-2014-305412.
   PubMed Web of Science ®Google Scholar
• Mittal V, Mittal R. Intracameral and topical voriconazole for fungal corneal endoexudates. Cornea. 2012;31(4):366–370. doi: 10.1097/ICO.0b013e318233f0a8.
   PubMed Web of Science ®Google Scholar
• Haddad RS, El-Mollayess GM. Combination of intracameral and intrastromal voriconazole in the treatment of recalcitrant Acremonium fungal keratitis. Middle East Afr J Ophthalmol. 2012;19(2):265–268. doi: 10.4103/0974-9233.95271.
   PubMedGoogle Scholar
• Siatiri H, Daneshgar F, Siatiri N, et al. The effects of intrastromal voriconazole injection and topical voriconazole in the treatment of recalcitrant Fusarium keratitis. Cornea. 2011;30(8):872–875. doi: 10.1097/ICO.0b013e3182100993.
   PubMed Web of Science ®Google Scholar
• Sharma N, Agarwal P, Sinha R, et al. Evaluation of intrastromal voriconazole injection in recalcitrant deep fungal keratitis: case series. Br J Ophthalmol. 2011;95(12):1735–1737. doi: 10.1136/bjo.2010.192815.
   PubMed Web of Science ®Google Scholar
• Shen YC, Wang CY, Tsai HY, et al. Intracameral voriconazole injection in the treatment of fungal endophthalmitis resulting from keratitis. Am J Ophthalmol. 2010;149(6):916–921. doi: 10.1016/j.ajo.2010.01.024.
   PubMed Web of Science ®Google Scholar
• Goyal J, Fernandes M, Shah SG. Intracameral voriconazole injection in the treatment of fungal endophthalmitis resulting from keratitis . Am J Ophthalmol . 2010;150(6):939; author reply 939–40. doi: 10.1016/j.ajo.2010.08.009.
   PubMed Web of Science ®Google Scholar
• Tu EY. Alternaria keratitis: clinical presentation and resolution with topical fluconazole or intrastromal voriconazole and topical caspofungin. Cornea. 2009;28(1):116–119. doi: 10.1097/ICO.0b013e31818225f8.
   PubMed Web of Science ®Google Scholar
• Prakash G, Sharma N, Goel M, et al. Evaluation of intrastromal injection of voriconazole as a therapeutic adjunctive for the management of deep recalcitrant fungal keratitis. Am J Ophthalmol. 2008;146(1):56–59. doi: 10.1016/j.ajo.2008.02.023.
   PubMed Web of Science ®Google Scholar
• Park CH, Lee HS, Chung SK. Toxicity of intrastromal voriconazole injection on corneal endothelium in rabbits. Cornea. 2014;33(9):928–934. doi: 10.1097/ICO.0000000000000181.
   PubMed Web of Science ®Google Scholar
• Han SB, Yang HK, Hyon JY, et al. Toxicity of voriconazole on corneal endothelial cells in an animal model. Br J Ophthalmol. 2012;96(6):905–908. doi: 10.1136/bjophthalmol-2011-301129.
   PubMed Web of Science ®Google Scholar
• Han SB, Shin YJ, Hyon JY, et al. Cytotoxicity of voriconazole on cultured human corneal endothelial cells. Antimicrob Agents Chemother. 2011;55(10):4519–4523. doi: 10.1128/AAC.00569-11.
   PubMed Web of Science ®Google Scholar
• Kernt M, Kampik A. Intracameral voriconazole: in vitro safety for human ocular cells. Toxicology. 2009;258(2–3):84–93. doi: 10.1016/j.tox.2009.01.008.
   PubMed Web of Science ®Google Scholar
• Rossi M, Di Censo F, Di Censo M, et al. Changes in aqueous humor pH after femtosecond laser-assisted cataract surgery. J Refract Surg. 2015;31(7):462–465. doi: 10.3928/1081597X-20150623-04.
   PubMed Web of Science ®Google Scholar
• Podrazky O, Mrazek J, Probostova J, et al. Ex-vivo measurement of the pH in aqueous humor samples by a tapered Fiber-Optic sensor. Sensors. 2021;21(15):5075. doi: 10.3390/s21155075.
   PubMed Web of Science ®Google Scholar
• Yavas GF, Ozturk F, Kusbeci T, et al. Antifungal efficacy of voriconazole, itraconazole and amphotericin b in experimental fusarium solani keratitis. Graefes Arch Clin Exp Ophthalmol. 2008;246(2):275–279. doi: 10.1007/s00417-007-0687-1.
   PubMed Web of Science ®Google Scholar
• Qu L, Li L, Xie H. Toxicity and pharmacokinetics of intrastromal injection of amphotericin B in a rabbit model. Curr Eye Res. 2014;39(4):340–347. doi: 10.3109/02713683.2013.847961.
   PubMed Web of Science ®Google Scholar
• Nett JE, Andes DR. Antifungal agents: spectrum of activity, pharmacology, and clinical indications. Infect Dis Clin North Am. 2016;30(1):51–83. doi: 10.1016/j.idc.2015.10.012.
   PubMed Web of Science ®Google Scholar
• Jones A, Muhtaseb M. Use of voriconazole in fungal keratitis. J Cataract Refract Surg. 2008;34(2):183–184. doi: 10.1016/j.jcrs.2007.09.031.
   PubMed Web of Science ®Google Scholar
• Marangon FB, Miller D, Giaconi JA, et al. In vitro investigation of voriconazole susceptibility for keratitis and endophthalmitis fungal pathogens. Am J Ophthalmol. 2004;137(5):820–825. doi: 10.1016/j.ajo.2003.11.078.
   PubMed Web of Science ®Google Scholar
• Malani AN, Aronoff DM. Voriconazole-induced photosensitivity. Clin Med Res. 2008;6(2):83–85. doi: 10.3121/cmr.2008.806.
   PubMedGoogle Scholar
• Hulin A, Dailly E, Le Guellec C. [Level of evidence for therapeutic drug monitoring of voriconazole]. Therapie. 2011;66(2):109–114. doi: 10.2515/therapie/2011009.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Lee JJ, Kim SD. Topical and oral voriconazole in the treatment of fungal keratitis. Korean J Ophthalmol. 2009;23(1):46–48. doi: 10.3341/kjo.2009.23.1.46.
   PubMedGoogle Scholar
• Vemulakonda GA, Hariprasad SM, Mieler WF, et al. Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans. Arch Ophthalmol. 2008;126(1):18–22. doi: 10.1001/archophthalmol.2007.8.
   PubMedGoogle Scholar
• Gao H, Pennesi M, Shah K, et al. Safety of intravitreal voriconazole: electroretinographic and histopathologic studies. Trans Am Ophthalmol Soc. 2003;101:183–189. discussion 189.
   PubMedGoogle Scholar
• Kramer M, Kramer MR, Blau H, et al. Intravitreal voriconazole for the treatment of endogenous Aspergillus endophthalmitis. Ophthalmology. 2006;113(7):1184–1186. doi: 10.1016/j.ophtha.2006.01.059.
   PubMed Web of Science ®Google Scholar
• Olsen EG, Davanger M. The healing of rabbit corneal endothelium. Acta Ophthalmol (Copenh)). 1984;62(5):796–807. doi: 10.1111/j.1755-3768.1984.tb05808.x.
   PubMed Web of Science ®Google Scholar
• Olsen EG, Davanger M. The healing of human corneal endothelium. An in vitro study. Acta Ophthalmol. 1984;62(6):885–892. doi: 10.1111/j.1755-3768.1984.tb08439.x.
   Web of Science ®Google Scholar