Oral isotretinoin in the treatment of juvenile acne and psychiatric adverse effects – a systematic review

References

• Natsuaki MN, Yates TM. Adolescent acne and disparities in mental health. Child Dev Perspect. 2021;15(1):37–43. doi: 10.1111/cdep.12397.
   Web of Science ®Google Scholar
• Dessinioti C, Zouboulis CC, Bettoli V, et al. Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin. J Eur Acad Dermatol Venereol. 2020;34(10):2229–2240. doi: 10.1111/jdv.16430.
   PubMed Web of Science ®Google Scholar
• Jones M, Armstrong AW, Baldwin H, et al. ARTICLE: advances in oral isotretinoin therapy. J Drugs Dermatol. 2021;20(5):s5–s11. doi: 10.36849/JDD.s072A.
   PubMed Web of Science ®Google Scholar
• ClinCalc. Isotretinoin - drug usage statistics: clinical tools and calculators for medical professionals - ClinCalc; 2021. https://clincalc.com/DrugStats/Drugs/Isotretinoin
   Google Scholar
• Pile HD, Sadiq NM. Isotretinoin. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.
   Google Scholar
• Kovitwanichkanont T, Driscoll T. A comparative review of the isotretinoin pregnancy risk management programs across four continents. Int J Dermatol. 2018;57(9):1035–1046. doi: 10.1111/ijd.13950.
   PubMed Web of Science ®Google Scholar
• Lueck S. Congressman blames accutane, an acne drug, for son’s suicide: the wall street journal. 2000. https://www.wsj.com/articles/SB970758911174948349
   Google Scholar
• Isotretinoin Capsule Information U.S. Food and Drug Administration 2021. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/isotretinoin-capsule-information
   Google Scholar
• Edwards J. Roche’s accutane: suit over death of congressman’s son nixed CBS news. 2009. https://www.cbsnews.com/news/roches-accutane-suit-over-death-of-congressmans-son-nixed/
   Google Scholar
• Kurhan F, Kamiş GZ. Isotretinoin induced psychotic mania: a case report. Turk Psikiyatri Derg. 2021;32(3):214–218.
   Web of Science ®Google Scholar
• DeLuca M, Nuñez MB, Rodriguez E, et al. Isotretinoin in acne vulgaris complicated by underlying major depression: a case report and review of literature. Case Rep Psychiatry. 2021;2021:9942327. doi: 10.1155/2021/9942327.
   PubMedGoogle Scholar
• Jensen KV, Abba-Aji A. Isotretinoin-Induced delusional disorder, somatic subtype. Case Rep Dermatol Med. 2020;2020:8853167. doi: 10.1155/2020/8853167.
   PubMedGoogle Scholar
• Hanna KJ, Agnieszka KP, Michal D, et al. Affective disorders as potential complication of anti-acne treatment with isotretinoin: a case series. J Affect Disord. 2016;204:154–158. doi: 10.1016/j.jad.2016.06.048.
   PubMed Web of Science ®Google Scholar
• Revuz J, Pawin H, Poli F, et al. The advantage of establishing homogeneous patient groups: is it worth isolating ‘juvenile acne of the face’? J Eur Acad Dermatol Venereol. 2008;22(12):1429–1434. doi: 10.1111/j.1468-3083.2008.02889.x.
   PubMed Web of Science ®Google Scholar
• Benli SÖBS. Self-esteem and depression in adolescents. J Child Psychol. 2022;6(2):15–17.
   Google Scholar
• Samuels DV, Rosenthal R, Lin R, et al. Acne vulgaris and risk of depression and anxiety: a meta-analytic review. J Am Acad Dermatol. 2020;83(2):532–541. doi: 10.1016/j.jaad.2020.02.040.
   PubMed Web of Science ®Google Scholar
• Özyay Eroğlu F, Aktepe E, Erturan İ. The evaluation of psychiatric comorbidity, self-injurious behavior, suicide probability, and other associated psychiatric factors (lonileness, self-esteem, life satisfaction) in adolescents with acne: a clinical pilot study. J Cosmet Dermatol. 2019;18(3):916–921. doi: 10.1111/jocd.12708.
   PubMed Web of Science ®Google Scholar
• Fallah H, Rademaker M. Isotretinoin in the management of acne vulgaris: practical prescribing. Int J Dermatol. 2021;60(4):451–460. doi: 10.1111/ijd.15089.
   PubMed Web of Science ®Google Scholar
• O'Reilly K, Bailey SJ, Lane MA. Retinoid-mediated regulation of mood: possible cellular mechanisms. Exp Biol Med. 2008;233(3):251–258. doi: 10.3181/0706-MR-158.
   Web of Science ®Google Scholar
• Melnik BC. Apoptosis may explain the pharmacological mode of action and adverse effects of isotretinoin, including teratogenicity. Acta Derm Venereol. 2017;97(2):173–181. doi: 10.2340/00015555-2535.
   PubMed Web of Science ®Google Scholar
• Ormerod AD, Thind CK, Rice SA, et al. Influence of isotretinoin on hippocampal-based learning in human subjects. Psychopharmacology. 2012;221(4):667–674. doi: 10.1007/s00213-011-2611-y.
   PubMed Web of Science ®Google Scholar
• Drew CJ, O'Reilly KC, Lane MA, et al. Chronic administration of 13-cis-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei. Neuroscience. 2011;172:66–73. doi: 10.1016/j.neuroscience.2010.10.050.
   PubMed Web of Science ®Google Scholar
• O'Reilly KC, Shumake J, Gonzalez-Lima F, et al. Chronic administration of 13-cis-retinoic acid increases depression-related behavior in mice. Neuropsychopharmacology. 2006;31(9):1919–1927. doi: 10.1038/sj.npp.1300998.
   PubMed Web of Science ®Google Scholar
• Ferguson SA, Cisneros FJ, Gough B, et al. Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. Toxicol Sci. 2005;87(2):451–459. doi: 10.1093/toxsci/kfi262.
   PubMed Web of Science ®Google Scholar
• Singer S, Tkachenko E, Sharma P, et al. Psychiatric adverse events in patients taking isotretinoin as reported in a food and drug administration database From 1997 to 2017. JAMA Dermatol. 2019;155(10):1162–1166. doi: 10.1001/jamadermatol.2019.1416.
   PubMed Web of Science ®Google Scholar
• Hodgkiss-Harlow CJ, Eichenfield LF, Dohil MA. Effective monitoring of isotretinoin safety in a pediatric dermatology population: a novel "patient symptom survey" approach. J Am Acad Dermatol. 2011;65(3):517–524. doi: 10.1016/j.jaad.2010.06.040.
   PubMed Web of Science ®Google Scholar
• Botsali A, Kocyigit PP, Uran P. The effects of isotretinoin on affective and cognitive functions are disparate in adolescent acne vulgaris patients. J Dermatolog Treat. 2020;31(7):734–738. doi: 10.1080/09546634.2019.1606396.
   PubMed Web of Science ®Google Scholar
• Cohen J, Adams S, Patten S. No association found between patients receiving isotretinoin for acne and the development of depression in a Canadian prospective cohort. Can J Clin Pharmacol. 2007;14(2):e227–33.
   PubMedGoogle Scholar
• Erdoğan Y, Erturan İ, Aktepe E, et al. Comparison of quality of life, depression, anxiety, suicide, social anxiety and Obsessive-Compulsive symptoms Between adolescents with acne receiving isotretinoin and antibiotics: a prospective, non-randomised, Open-Label study. Paediatr Drugs. 2019;21(3):195–202. doi: 10.1007/s40272-019-00340-y.
   PubMed Web of Science ®Google Scholar
• Šimić D, Penavić JZ, Babić D, et al. Psychological status and quality of life in acne patients treated with oral isotretinoin. Psychiatr Danub. 2017;29(Suppl 2):104–110.
   PubMedGoogle Scholar
• Suarez B, Serrano A, Cova Y, et al. Isotretinoin was not associated with depression or anxiety: a twelve-week study. World J Psychiatry. 2016;6(1):136–142. doi: 10.5498/wjp.v6.i1.136.
   PubMedGoogle Scholar
• Simić D, Situm M, Letica E, et al. Psychological impact of isotretinoin treatment in patients with moderate and severe acne. Coll Antropol. 2009;33(Suppl 2):15–19.
   PubMedGoogle Scholar
• Chia CY, Lane W, Chibnall J, et al. Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study. Arch Dermatol. 2005;141(5):557–560. doi: 10.1001/archderm.141.5.557.
   PubMedGoogle Scholar
• Hersom K, Neary MP, Levaux HP, et al. Isotretinoin and antidepressant pharmacotherapy: a prescription sequence symmetry analysis. J Am Acad Dermatol. 2003;49(3):424–432. doi: 10.1067/s0190-9622(03)02087-5.
   PubMed Web of Science ®Google Scholar
• Jick SS, Kremers HM, Vasilakis-Scaramozza C. Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide. Arch Dermatol. 2000;136(10):1231–1236. doi: 10.1001/archderm.136.10.1231.
   PubMedGoogle Scholar
• AlGhofaili FA. Isotretinoin use and risk of depression in acne vulgaris patients in riyadh, Saudi Arabia. Cureus. 2021;13(3):e13680. doi: 10.7759/cureus.13680.
   PubMed Web of Science ®Google Scholar
• Luvizotto PP, Schmitt JV. Depressive symptoms before and during treatment of acne with isotretinoin and its correlations: a prospective study. An Bras Dermatol. 2020;95(6):760–763. doi: 10.1016/j.abd.2020.04.008.
   PubMed Web of Science ®Google Scholar
• Rubio-García L, Pulido-Díaz N, Jímenez-López JL. [Isotretinoin and depressive symptoms in patiens with severe and recurrent acne]. Rev Med Inst Mex Seguro Soc. 2015;53(Suppl 1):S54–S9.
   PubMedGoogle Scholar
• Kaymak Y, Taner E, Taner Y. Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents. Int J Dermatol. 2009;48(1):41–46. doi: 10.1111/j.1365-4632.2009.03806.x.
   PubMed Web of Science ®Google Scholar
• Ergun T, Seckin D, Ozaydin N, et al. Isotretinoin has no negative effect on attention, executive function and mood. J Eur Acad Dermatol Venereol. 2012;26(4):431–439. doi: 10.1111/j.1468-3083.2011.04089.x.
   PubMed Web of Science ®Google Scholar
• Ferahbas A, Turan MT, Esel E, et al. A pilot study evaluating anxiety and depressive scores in acne patients treated with isotretinoin. J Dermatolog Treat. 2004;15(3):153–157. doi: 10.1080/09546630410027472.
   PubMedGoogle Scholar
• Bachmann S. Epidemiology of suicide and the psychiatric perspective. IJERPH. 2018;15(7):1425. doi: 10.3390/ijerph15071425.
   Web of Science ®Google Scholar
• Droitcourt C, Nowak E, Rault C, et al. Risk of suicide attempt associated with isotretinoin: a nationwide cohort and nested case-time-control study. Int J Epidemiol. 2019;48(5):1623–1635. doi: 10.1093/ije/dyz093.
   PubMed Web of Science ®Google Scholar
• Rehn LM, Meririnne E, Höök-Nikanne J, et al. Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male finnish military conscripts. J Eur Acad Dermatol Venereol. 2009;23(11):1294–1297. doi: 10.1111/j.1468-3083.2009.03313.x.
   PubMed Web of Science ®Google Scholar
• Chandrasekaran S, De Sousa JFM, Paghdar S, et al. Is isotretinoin in acne patients a psychological boon or a bane: a systematic review. Cureus. 2021;13(8):e16834. doi: 10.7759/cureus.16834.
   PubMed Web of Science ®Google Scholar
• Li C, Chen J, Wang W, et al. Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis. BMJ Open. 2019;9(1):e021549. doi: 10.1136/bmjopen-2018-021549.
   PubMed Web of Science ®Google Scholar
• Huang YC, Cheng YC. Isotretinoin treatment for acne and risk of depression: a systematic review and meta-analysis (vol 76, pg 1068, 2017). J Am Acad Dermatol. 2017;76(6):1068–1076.e9. doi: 10.1016/j.jaad.2016.12.028.
   PubMed Web of Science ®Google Scholar
• Oliveira JM, Sobreira G, Velosa J, et al. Association of isotretinoin with depression and suicide: a review of current literature. J Cutan Med Surg. 2018;22(1):58–64. doi: 10.1177/1203475417719052.
   PubMed Web of Science ®Google Scholar
• Rea S, Tucker S, Frittelli V, et al. A feasibility study for a triple-blind randomized controlled trial investigating the effects of oral isotretinoin on mood and quality of life in patients with acne vulgaris. Clin Exp Dermatol. 2018;43(1):54–56. doi: 10.1111/ced.13284.
   PubMed Web of Science ®Google Scholar
• Schaffer LC, Schaffer CB, Hunter S, et al. Psychiatric reactions to isotretinoin in patients with bipolar disorder. J Affect Disord. 2010;122(3):306–308. doi: 10.1016/j.jad.2009.09.005.
   PubMed Web of Science ®Google Scholar