Cytotoxicity of chlorpyrifos to human liver hepatocellular carcinoma cells: effects on mitochondrial membrane potential and intracellular free Ca²⁺

References

• Bano, D. and Nicotera, P., 2007. Ca2+ signals and neuronal death in brain ischemia. Stroke, 38, 674–676.
   Google Scholar
• Betarbet, R., et al., 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nature neuroscience, 3, 1301–1306.
   Google Scholar
• Caughlan, A., et al., 2004. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicological sciences, 78, 125–134.
   Google Scholar
• Eisner, D.A., Venetucci, L.A., and Trafford, A.W., 2006. Life, sudden death, and intracellular calcium. Circulation research, 99, 223–224.
   Google Scholar
• Farag, A.T., EI Okazy, A.M., and EI-Aswed, A.F., 2003. Developmental toxicity study of chlorpyrifos in rats. Reproductive toxicology (Elmsford, N.Y.), 17, 203–208.
   Google Scholar
• Gasnier, C., et al., 2009. Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology, 262, 184–191.
   Google Scholar
• Guiñazú, N., et al., 2012. Effects of the organophosphate insecticides phosmet and chlorpyrifos on trophoblast JEG-3 cell death, proliferation and inflammatory molecule production. Toxicology in vitro, 26, 406–413.
   Google Scholar
• Hsuan, S.L., Klintworth, H.M., and Xia, Z., 2006. Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. Journal of neuroscience, 26, 4481–4491.
   Google Scholar
• Huang, H.L., et al., 2016. MiR-4673 modulates paclitaxel-induced oxidative stress and loss of mitochondrial membrane potential by targeting 8-oxoguaine-DNA glycosylase-1. Cellular physiology and biochemistry, 42, 889–900.
   Google Scholar
• Huang, W., et al., 2015. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncology letters, 13, 921–929.
   Google Scholar
• Ki, Y.W., et al., 2013. JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis. Toxicology letters, 218, 235–245.
   Google Scholar
• Kuang, C.Y., et al., 2010. Silencing stromal interaction molecule 1 by RNA interference inhibits the proliferation and migration of endothelial progenitor cells. Biochemical and biophysical research communications, 398, 315–320.
   Google Scholar
• Lee, J.E., et al., 2012. Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos. Toxicology and applied pharmacology, 263, 148–162.
   Google Scholar
• Li, D., et al., 2015. The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere, 135, 387–393.
   Google Scholar
• Li, Q., Kobayashi, M., and Kawada, T., 2009. Chlorpyrifos induces apoptosis in human T cells. Toxicology, 255, 53–57.
   Google Scholar
• Li, X.Y., et al., 2012. Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride. Toxicology in vitro, 26, 1087–1092.
   Google Scholar
• Mehta, A., Verma, R.S., and Srivastava, N., 2009. Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver. Pesticide biochemistry and physiology, 94, 55–59.
   Google Scholar
• Mersch-Sundermann, V., et al., 2004. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology, 198, 329–340.
   Google Scholar
• Nakadai, A., Li, Q., and Kawada, T., 2006. Chlorpyrifos induces apoptosis in human monocyte cell line U937. Toxicology, 224, 202–209.
   Google Scholar
• Park, E.K., et al., 2002. Role of Ca(2+) in diallyl disulfide-induced apoptotic cell death of HCT-15 cells. Experimental & molecular medicine, 34, 250–257.
   Google Scholar
• Park, J.H., et al., 2013. Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells. Toxicology and applied pharmacology, 268, 53–57.
   Google Scholar
• Patnaik, R. and Padhy, R.N., 2016. Evaluation of geno-toxicity of methyl parathion and chlorpyrifos to human liver carcinoma cell line (HepG2). Environmental science and pollution research international, 23, 8492–8499.
   Google Scholar
• Plant, N., 2004. Strategies for using in vitro screens in drug metabolism. Drug discovery today, 9, 328–336.
   Google Scholar
• Qiao, D., Seidler, F.J., and Slotkin, T.A., 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicology and applied pharmacology, 206, 17–26.
   Google Scholar
• Rahman, M.F., et al., 2002. Assessment of genotoxic effects of chloropyriphos and acephate by the comet assay in mice leucocytes. Mutation research, 516, 139–147.
   Google Scholar
• Raszewski, G., et al., 2015. Chlorpyrifos and cypermethrin induce apoptosis in human neuroblastoma cell line SH-SY5Y. Basic & clinical pharmacology & toxicology, 116, 158–167.
   Google Scholar
• Verma, R.S., Mehta, A., and Srivastava, N., 2007. In vivo chlorpyrifos oxidative stress: attenuation by antioxidant vitamins. Pesticide biochemistry and physiology, 88, 191–196.
   Google Scholar
• Wang, M., et al., 2010. Curcumin induced HepG2 cell apoptosis-associated mitochondrial membrane potential and intracellular free Ca2+ concentration. European journal of pharmacology, 650, 41–47.
   Google Scholar
• Westerink, W.M. and Schoonen, W.G., 2007. Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicology in vitro, 21, 1581–1591.
   Google Scholar
• Želježić, D., et al., 2016. Cytotoxic, genotoxic and biochemical markers of insecticide toxicity evaluated in human peripheral blood lymphocytes and an HepG2 cell line. Food and chemical toxicology, 96, 90–106.
   Google Scholar