An extensive review of experimental ochratoxicosis in poultry: II. Hemato-biochemical and immunological alterations along with other health issues

References

• Abidin, Z., et al., 2013. Ameliorative effects of L-carnitine and vitamin E upon OTA induced haematological and serum biochemical alterations in white Leghorn cockerels. British poultry science, 54 (4), 471–477.
   PubMed Web of Science ®Google Scholar
• Abidin, Z., Khatoon, A., and Numan, M., 2011. Mycotoxins in broilers: pathological alterations induced by aflatoxins and ochratoxins, diagnosis and determination, treatment and control of mycotoxicosis. World's poultry science journal, 67 (3), 485–496.
   Web of Science ®Google Scholar
• Agawane, S.B., and Lonkar, P.S., 2004. Effect of probiotic containing Saccharomyces boulardii on experimental ochratoxicosis in broilers: hematobiochemical studies. Journal of veterinary science, 5 (4), 359–367.
   PubMedGoogle Scholar
• Aleksandrov, M., and Dzhurov, A., 1987. Effect of ochratoxin on the health status of broilers. Veterinarno-medicinski nauki, 24 (5), 38–43.
   PubMedGoogle Scholar
• Bailey, C.A., et al., 1989. Ochratoxin A and dietary protein. 2. Effects on hematology and various clinical chemistry measurements. Poultry science, 68 (12), 1664–1671.
   PubMed Web of Science ®Google Scholar
• Beg, M.U., et al., 2006. Mycotoxins in poultry feed in Kuwait. Archives of environmental contamination and toxicology, 50 (4), 594–602.
   PubMed Web of Science ®Google Scholar
• Bennett, J.W., and Klich, M., 2003. Mycotoxins. Clinical microbiology reviews, 16 (3), 497–516.
   PubMed Web of Science ®Google Scholar
• Betina, V., 1989. Mycotoxins. Chemical, biological and environmental aspects. Elsevier.
   Google Scholar
• Bhatti, S.A., et al., 2018. Dietary L-carnitine and vitamin-E; a strategy to combat ochratoxin-A induced immunosuppression. Toxicon: official journal of the international society on toxinology, 153, 62–71.
   PubMed Web of Science ®Google Scholar
• Bhatti, S.A., et al., 2017. Protective role of bentonite against aflatoxin B1-and ochratoxin A-induced immunotoxicity in broilers. Journal of immunotoxicology, 14 (1), 66–76.
   PubMed Web of Science ®Google Scholar
• Biro, K., et al., 2002. Tissue distribution of ochratoxin A as determined by HPLC and ELISA and histopathological effects in chickens. Avian Pathology, 31 (2), 141–148.
   PubMed Web of Science ®Google Scholar
• Bullerman, L.B., and Bianchini, A., 2007. Stability of mycotoxins during food processing. International journal of food microbiology, 119 (1–2), 140–146.
   PubMed Web of Science ®Google Scholar
• Campbell, M.L., JR., et al., 1983. Evaluation of immunity of young broiler chickens during simultaneous aflatoxicosis and ochratoxicosis. Poultry science, 62 (11), 2138–2144.
   PubMed Web of Science ®Google Scholar
• Chang, C.F., Doerr, J.A., and Hamilton, P.B., 1981. Experimental ochratoxicosis in turkey poults. Poultry science, 60 (1), 114–119.
   PubMed Web of Science ®Google Scholar
• Chang, C.F., and Hamilton, P.B., 1980. Impairment of phagocytosis by heterophils from chickens during ochratoxicosis. Applied and environmental microbiology, 39 (3), 572–575.
   PubMed Web of Science ®Google Scholar
• Chang, C.F., and Hamilton, P.B., 1982. Increased severity and new symptoms of infectious bursal disease during aflatoxicosis in broiler chickens 1, 2. Poultry science, 61 (6), 1061–1068.
   PubMed Web of Science ®Google Scholar
• Chang, C.F., Huff, W.E., and Hamilton, P.B., 1979. A leucocytopenia induced in chickens by dietary ochratoxin A. Poultry science, 58 (3), 555–558.
   PubMed Web of Science ®Google Scholar
• Corrier, D.E., 1990. Comparison of phytohemagglutinin-induced cutaneous hypersensitivity reactions in the interdigital skin of broiler and layer chicks. Avian diseases, 34 (2), 369–373.
   PubMed Web of Science ®Google Scholar
• Corrier, D.E., 1991. Mycotoxins: mechanism of immunosuppression. Veterinary immunology and immunopathology, 30 (1), 73–87.
   PubMed Web of Science ®Google Scholar
• Denli, M., et al., 2008. Efficacy of a new ochratoxin-binding agent (OcraTox) to counteract the deleterious effects of ochratoxin A in laying hens. Poultry science, 87 (11), 2266–2272.
   PubMed Web of Science ®Google Scholar
• Duff, S.R., Burns, R.B., and Dwivedi, P., 1987. Skeletal changes in broiler chicks and turkey poults fed diets containing ochratoxin A. Research in veterinary science, 43 (3), 301–307.
   PubMed Web of Science ®Google Scholar
• Dwivedi, P., and Burns, R.B., 1984. Effect of ochratoxin A on immunoglobulins in broiler chicks. Research in veterinary science, 36 (1), 117–121.
   PubMed Web of Science ®Google Scholar
• Dwivedi, P., and Burns, R.B., 1985. Immunosuppressive effects of ochratoxin A in young turkeys. Avian pathology: journal of the W.V.P.A, 14 (2), 213–225.
   PubMed Web of Science ®Google Scholar
• Elaroussi, M.A., et al., 2006. Experimental ochratoxicosis in broiler chickens. Avian pathology: journal of the W.V.P.A, 35 (4), 263–269.
   PubMed Web of Science ®Google Scholar
• Elaroussi, M.A., et al., 2008. Ochratoxicosis in broiler chickens: functional and histological changes in target organs. International journal of poultry science, 7 (5), 414–422.
   Google Scholar
• Elissalde, M.H., et al., 1994. Effect of ochratoxin A on Salmonella-challenged broiler chicks. Poultry science, 73 (8), 1241–1248.
   PubMed Web of Science ®Google Scholar
• Ezekiel, C.N., et al., 2012. Fungal and bacterial metabolites in commercial poultry feed from Nigeria. Food additives and contaminants. Part A, chemistry, analysis, control, exposure and risk assessment, 29 (8), 1288–1299.
   Google Scholar
• Frye, C.E., and Chu, F.S., 1977. Distribution of ochratoxin A in chicken tissues and eggs. Journal of food safety, 1 (2), 147–159.
   Google Scholar
• Fuchs, R., 1988. Distribution and fate of ochratoxin A in experimental animals, Doctoral thesis, Swedish University of Agricultural Science, Uppsala, 13–41
   Google Scholar
• Fukata, T., et al., 1996. Effect of ochratoxin A on Salmonella typhimurium-challenged layer chickens. Avian diseases, 40 (4), 924–926.
   PubMed Web of Science ®Google Scholar
• Garaleviciene, D., 2003. Effect of antioxidant preparation “oxynil” on health status and productivity of laying hens fed naturally moulded feed. Veterinarija ir zootechnika, 24, 22–29.
   Google Scholar
• Garaleviciene, D., Pettersson, H., and Agnedal, M., 2002. Occurrence of trichothecenes, zearalenone and ochratoxin A in cereals and mixed feed from central Lithuania. Mycotoxin research, 18 (2), 77–89.
   PubMedGoogle Scholar
• Garcia, A.R., et al., 2003. Evaluation of two mycotoxin binders to reduce toxicity of broiler diets containing ochratoxin A and T-2 toxin contaminated grain. Avian diseases, 47 (3), 691–699.
   PubMed Web of Science ®Google Scholar
• Gentles, A., et al., 1999. Toxicological evaluations of cyclopiazonic acid and ochratoxin A in broilers. Poultry science, 78 (10), 1380–1384.
   PubMed Web of Science ®Google Scholar
• Gekle, M. and Silbernagl, S. 1994. The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: toxodynamic and toxokinetic aspects. Kidney and Blood Pressure Research, 17 (1), 40–49.
   Google Scholar
• Gilani, S.H., Bancroft, J., and Reily, M., 1978. Teratogenisity of ochratoxin A in chick embryos. Toxicology and applied pharmacology, 46 (2), 543–546.
   PubMed Web of Science ®Google Scholar
• Glahn, R.P., 1993. Mycotoxins and the avian kidneys: assessment of physiological function. World's poultry science journal, 49 (03), 242–250.
   Google Scholar
• Goliński, P., et al., 1983. Mycotoxins in cereal grain. Part VI. The effect of ochratoxin A on growth and tissue residues of the mycotoxin in broiler chickens. Die nahrung, 27 (3), 251–256.
   PubMedGoogle Scholar
• Hamilton, P.B., et al., 1982. Natural occurrences of ochratoxicosis in poultry. Poultry science, 61 (9), 1832–1841.
   PubMed Web of Science ®Google Scholar
• Hanif, N.Q., et al., 2008. Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix Plus). British poultry science, 49 (5), 632–642.
   PubMed Web of Science ®Google Scholar
• Harvey, R.B., et al., 1987. Immunologic effects of low levels of ochratoxin A in ovo: utilization of a chicken embryo model. Avian diseases, 31 (4), 787–791.
   PubMed Web of Science ®Google Scholar
• Hassan, Z., et al., 2011a. In vivo and ex vivo phagocytic potential of macrophages from progeny of breeder hens kept on ochratoxin A (OTA)-contaminated diet. Journal of immunotoxicology, 9, 401–408.
   Web of Science ®Google Scholar
• Hassan, Z., et al., 2011b. Immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-contaminated feed. Journal of immunotoxicology, 8, 122–130.
   PubMed Web of Science ®Google Scholar
• Hassan, Z., et al., 2011c. Immunological status of White Leghorn chicks hatched from eggs inoculated with ochratoxin A (OTA). Journal of immunotoxicology, 8, 204–209.
   PubMed Web of Science ®Google Scholar
• Hassan, Z., et al., 2011d. Immunological responses of male White Leghorn chicks kept on ochratoxin A (OTA)-contaminated feed. Journal of immunotoxicology, 9, 301–308.
   Web of Science ®Google Scholar
• Hoehler, D., Marquardt, R.R., and Rohlich, A.A.F., 1997. Lipid peroxidation as one mode of action in ochratoxin A toxicity in rats and chicks. Canadian journal of animal science, 77 (2), 287–292.
   Web of Science ®Google Scholar
• Huff, W.E., et al., 1984. The individual and combined effects of aflatoxin and ochratoxin A on various processing parameters of broiler chickens. Poultry science, 63 (11), 2153–2161.
   PubMed Web of Science ®Google Scholar
• Huff, W.E., Kubena, L.F., and Harvey, R.B., 1988. Progression of ochratoxicosis in broiler chickens. Poultry science, 67 (8), 1139–1146.
   PubMed Web of Science ®Google Scholar
• Huff, W.E., Wyatt, R.D., and Hamilton, P.B., 1975. Nephrotoxicity of dietary ochratoxin A in broiler chickens. Applied microbiology, 30 (1), 48–51.
   PubMedGoogle Scholar
• Kalorey, D.R., et al., 2005. Effect of polyherbal feed supplement “Growell” during induced aflatoxicosis, ochratoxicosis and combined mycotoxicoses in broilers. Asian-Australasian journal of animal sciences, 18 (3), 375–383.
   Web of Science ®Google Scholar
• Khatoon, A., and Abidin, Z., 2018. An extensive review of experimental ochratoxicosis in poultry: I. Growth and production parameters along with histopathological alterations. World's poultry science journal, 74, 627–646. doi: 10.1017/S0043933918000685
   PubMed Web of Science ®Google Scholar
• Khatoon, A., et al., 2018. Effects of feeding bentonite clay upon ochratoxin A induced immunosuppression in broiler chicks. Food additives and contaminants, 35 (3), 538–545.
   Google Scholar
• Khatoon, A., et al., 2017. Mitigation potential of distillery sludge (DS) against ochratoxin A induced immunopathological alterations in broiler chicks. World mycotoxin journal, 10 (3), 255–262.
   Web of Science ®Google Scholar
• Khatoon, A., et al., 2013. Amelioration of ochratoxin A-induced immunotoxic effects by silymarin and vitamin E in white Leghorn cockerels. Journal of immunotoxicology, 10 (1), 25–31.
   PubMed Web of Science ®Google Scholar
• Koynarski, V., et al., 2007. Experimental coccidiosis provoked by Eimeria acervulina in chicks simultaneously fed on ochratoxin A contaminated diet. Research in veterinary science, 82 (2), 225–231.
   PubMed Web of Science ®Google Scholar
• Kozaczynski, W., 1994. Experimental ochratoxicosis A in chickens. Histopathological and histochemical study. Archivum veterinarium Polonicum, 34, 205–219.
   PubMedGoogle Scholar
• Kubena, L.F., et al., 1984. Toxicity of ochratoxin A and penicillic acid to chicks. Bulletin of environmental contamination and toxicology, 32 (1), 711–716.
   Google Scholar
• Kubena, L.F., et al., 1994. Influence of ochratoxin A and diacetoxyscirpenol singly and in combination on broiler chickens. Poultry science, 73 (3), 408–415.
   PubMed Web of Science ®Google Scholar
• Kubena, L.F., et al., 1989. Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens. Poultry science, 68 (7), 867–872.
   PubMed Web of Science ®Google Scholar
• Kubena, L.F., et al., 1988. Influence of ochratoxin A and deoxynivalenol on growing broiler chicks. Poultry science, 67 (2), 253–260.
   PubMed Web of Science ®Google Scholar
• Kubena, L.F., et al., 1983. Toxicity of ochratoxin A and tannic acid to growing chicks. Poultry science, 62 (9), 1786–1792.
   PubMed Web of Science ®Google Scholar
• Kumar, A., et al., 2004. Pathological changes in broiler chickens fed ochratoxin A and inoculated with Escherichia coli. Avian Pathology: journal of the W.V.P.A, 33 (4), 413–417.
   PubMed Web of Science ®Google Scholar
• Kumar, A., et al., 2003. Effect of ochratoxin A on Escherichia coli-challenged broiler chicks. Avian diseases, 47 (2), 415–424.
   PubMed Web of Science ®Google Scholar
• Lautert, C., et al., 2014. Individual in vitro effects of ochratoxin A, deoxynivalenol and zearalenone on oxidative stress and acetylcholinesterase in lymphocytes of broiler chickens. Springer plus, 3 (1), 506.
   PubMedGoogle Scholar
• Mally, A., et al., 2005. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicology and applied pharmacology, 206 (1), 43–53.
   PubMed Web of Science ®Google Scholar
• Manning, R.O., and Wyatt, R.D., 1984. Toxicity of Aspergillus ochraceus contaminated wheat and different chemical forms of ochratoxin A in broiler chicks. Poultry science, 63 (3), 458–465.
   PubMed Web of Science ®Google Scholar
• Marquardt, R.R., and Frolich, A.A., 1992. A review of recent advances in understanding ochratoxicosis. Journal of animal science, 70 (12), 3968–3988.
   PubMed Web of Science ®Google Scholar
• Micco, C., et al., 1987. Long-term administration of low doses of mycotoxins in poultry. 1. Residues of ochratoxin A in broilers and laying hens. Poultry science, 66 (1), 47–50.
   PubMed Web of Science ®Google Scholar
• Moura, M.A., et al., 2004. Effects of ochratoxin A on broiler leukocytes. Revista Brasileira de Ciência Avícola, 6 (3), 187–190.
   Google Scholar
• Munoz, K., Blaszkewicz, M., and Degen, G.H., 2010. Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin alpha in plasma and urine for an advanced biomonitoring of the mycotoxin. Journal of chromatography B, 27, 2623–2629.
   Google Scholar
• Niemiec, J., et al., 1994. The effect of ochratoxin A on egg quality development of embryos and the level of toxin in egg and tissue of hens and chicks. Journal of animal and feed sciences, 3 (4), 309–316.
   Google Scholar
• O’Brien, E., and Dietrich, D.R., 2005. Ochratoxin A: the continuing enigma. Critical reviews in toxicology, 35 (1), 33–60.
   PubMed Web of Science ®Google Scholar
• Osborne, D.J., et al., 1982. Comparison of ochratoxin, aflatoxin, and T-2 toxin for their effects on selected parameters related to digestion and evidence for specific metabolism of carotenoids in chickens. Poultry science, 61 (8), 1646–1652.
   PubMed Web of Science ®Google Scholar
• Page, R.K., et al., 1980. Influence of low levels of ochratoxin A on egg production, egg-shell strains and serum uric acid levels in Leghorn-type hens. Avian diseases, 24 (3), 777–780.
   PubMed Web of Science ®Google Scholar
• Piskorska, P.J., and Juszkiewicz, T., 1990. Tissue deposition and passage into eggs of ochratoxin A in Japanese quail. Journal of environmental pathology, toxicology, and oncology, 10 (1–2), 8–10.
   PubMedGoogle Scholar
• Politis, I., et al., 2005. Use of Trichosporon mycotoxinivorans to suppress the effects of ochratoxicosis on the immune system of broiler chicks. British poultry science, 46 (1), 58–65.
   PubMed Web of Science ®Google Scholar
• Pozzo, L., et al., 2013. Feeding a diet contaminated with ochratoxin A for chickens at the maximum level recommended by the EU for poultry feeds (0.1 mg/kg). 1. Effects on growth and slaughter performance, haematological and serum traits. Journal of animal physiology and animal nutrition, 97, 13–22.
   PubMed Web of Science ®Google Scholar
• Prior, M.G., and Sisodia, C.S., 1978. Ochratoxicosis in white Leghorn hens. Poultry science, 57 (3), 619–623.
   PubMed Web of Science ®Google Scholar
• Rahimtula, A.D., et al., 1988. Lipid peroxidation as a possible cause of ochratoxin A toxicity. Biochemical pharmacology, 37 (23), 4469–4477.
   PubMed Web of Science ®Google Scholar
• Raju, M., and Devegowda, G., 2000. Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). British poultry science, 41 (5), 640–650.
   PubMed Web of Science ®Google Scholar
• Raju, M., and Devegowda, G., 2002. Esterified-glucomannan in broiler chicken diets-contaminated with aflatoxin, ochratoxin and T-2 toxin: Evaluation of its binding ability (in vitro) and efficacy as immunomodulatory. Asian-Australasian journal of animal sciences, 15, 1051–1056.
   Web of Science ®Google Scholar
• Reichmann, K.G., et al., 1982. The significance of aflatoxin and ochratoxin in the diet of Australian chickens. Australian veterinary journal, 58 (5), 211–212.
   PubMed Web of Science ®Google Scholar
• Ruprich, J., et al., 1991. Long-term administration of the mycotoxin, ochratoxin A in chickens and the residues in the meat and animal feed. Veterinární medicína, 36 (11), 685–693.
   PubMed Web of Science ®Google Scholar
• Sakhare, P.S., et al., 2007. Effect of Toxiroak® polyherbal feed supplement during induced aflatoxicosis, ochratoxicosis and combined mycotoxicoses in broilers. Veterinarski arhiv, 77, 126–146.
   Google Scholar
• Sandhu, B.S., Singh, H., and Singh, B., 1995. Pathological studies in broiler chicks fed aflatoxin or ochratoxin and inoculated with inclusion body hepatitis virus singly and in concurrence. Veterinary research communications, 19 (1), 27–37.
   PubMed Web of Science ®Google Scholar
• Sandhu, B.S., Singh, B. and Brar, R.S., 1998. Haematological and biochemical studies in broiler chicks fed ochratoxin and inoculated with inclusion body hepatitis virus, singly and in concurrence. Veterinary research communications, 22 (5), 335–346.
   Google Scholar
• Santin, E., et al., 2002. The effects of ochratoxin/aluminosilicate interaction on the tissues and humoral immune response of broilers. Avian pathology: journal of the W.V.P.A, 31 (1), 73–79.
   PubMed Web of Science ®Google Scholar
• Sawale, G.K., et al., 2009. Experimental mycotoxicosis in layer induced by ochratoxin A and its amelioration with herbomineral toxin binder ‘Toxiroak. International journal of poultry science, 8, 798–803.
   Google Scholar
• Singh, G.S., et al., 1990. Immunosuppression due to chronic ochratoxicosis in broiler chicks. Journal of comparative pathology, 103 (4), 399–410.
   PubMed Web of Science ®Google Scholar
• Stoev, S.D., et al., 2000. Influence of ochratoxin A and an extract of artichoke on the vaccinal immunity and health in broiler chicks. Experimental and toxicologic pathology: official journal of the Gesellschaft Fur Toxikologische Pathologie, 52 (1), 43–55.
   PubMed Web of Science ®Google Scholar
• Stoev, S.D., et al., 2002a. Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology. Veterinary research, 33 (1), 83–93.
   PubMed Web of Science ®Google Scholar
• Stoev, S.D., et al., 2002b. Studies on some feed additives giving partial protection against ochratoxin A toxicity in chicks. Toxicology letters, 135 (1–2), 33–50.
   PubMed Web of Science ®Google Scholar
• Stoev, S.D., et al., 2004. Experimental mycotoxicosis in chickens induced by ochratoxin A and penicillic acid and intervention with natural plant extracts. Veterinary research communications, 28 (8), 727–746.
   PubMed Web of Science ®Google Scholar
• Streit, E., et al., 2013. Multi-mycotoxin screening reveals the occurrence of 139 different secondary metabolites in feed and feed ingredients. Toxins, 5 (3), 504–523.
   PubMed Web of Science ®Google Scholar
• Surai, P.F., 2000. Effect of selenium and vitamin E content of the maternal diet on the antioxidant system of the yolk and the developing chick. British poultry science, 41 (2), 235–243.
   PubMed Web of Science ®Google Scholar
• Surai, P., and Fisinin, V.I., 2012. The modern anti-stress technologies in poultry: from antioxidants to vitagenes. Sel'skokhozyaistvennaya Biologiya, 4, 3–13.
   Google Scholar
• Umar, S., et al., 2012. Clinico biochemical and haematological changes in broilers induced by concurrent exposure to aflatoxin B1 and ochratoxin A. Science journal of public health, 1, 79–85.
   Google Scholar
• Verma, J., et al., 2004. Effect of graded levels of aflatoxin, ochratoxin and their combinations on the performance and immune response of broilers. British poultry science, 45 (4), 512–518.
   PubMed Web of Science ®Google Scholar
• Voljc, M., et al., 2011. Evaluation of different vitamin E recommendations and bioactivity of α-tocopherol isomers in broiler nutrition by measuring oxidative stress in vivo and the oxidative stability of meat. Poultry science, 90 (7), 1478–1488.
   PubMed Web of Science ®Google Scholar
• Wang, G.H., et al., 2009. Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler chickens. Poultry science, 88 (3), 504–510.
   PubMed Web of Science ®Google Scholar
• Warren, M.F., and Hamilton, P.B., 1980. Intestinal fragility during ochratoxicosis and aflatoxicosis in broiler chickens. Applied and environmental microbiology, 40 (3), 641–645.
   PubMed Web of Science ®Google Scholar