Biomonitoring of mycotoxin exposure using urinary biomarker approaches: a review

References

• Abia, W.A., et al., 2013. Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach. Food and chemical toxicology, 62, 927–934.
   PubMed Web of Science ®Google Scholar
• Abrunhosa, L., Calado, T., and Venancio, A., 2011. Incidence of fumonisin B(2) production by Aspergillus niger in Portuguese wine regions. Journal of agricultural and food chemistry, 59 (13), 7514–7518.
   PubMed Web of Science ®Google Scholar
• Akdemir, C., et al., 2010. Estimation of ochratoxin A in some Turkish populations: an analysis in urine as a simple, sensitive and reliable biomarker. Food and chemical toxicology, 48 (3), 877–882.
   PubMed Web of Science ®Google Scholar
• Alassane-Kpembi, I., et al., 2017. Mycotoxins co-contamination: methodological aspects and biological relevance of combined toxicity studies. Critical reviews in food science and nutrition, 57 (16), 3489–3507.
   PubMed Web of Science ®Google Scholar
• Ali, N., Blaszkewicz, M., and Degen, G.H., 2016a. Assessment of deoxynivalenol exposure among Bangladeshi and German adults by a biomarker-based approach. Toxicology letters, 258, 20–28.
   PubMed Web of Science ®Google Scholar
• Ali, N., et al., 2015a. Deoxynivalenol exposure assessment for pregnant women in Bangladesh. Toxins, 7 (10), 3845–3857.
   PubMed Web of Science ®Google Scholar
• Ali, N., et al., 2015b. First results on citrinin biomarkers in urines from rural and urban cohorts in Bangladesh. Mycotoxin research, 31 (1), 9–16.
   PubMed Web of Science ®Google Scholar
• Ali, N., et al., 2016b. Urinary biomarkers of ochratoxin A and citrinin exposure in two Bangladeshi cohorts : follow-up study on regional and seasonal influences. Archives of toxicology, 90 (11), 2683–2697.
   PubMed Web of Science ®Google Scholar
• Ali, N., et al., 2016c. Occurrence of aflatoxin M1 in urines from rural and urban adult cohorts in Bangladesh. Archives of toxicology, 90 (7), 1749–1755.
   PubMed Web of Science ®Google Scholar
• Ali, N., et al., 2017a. Determination of aflatoxin M1 in urine samples indicates frequent dietary exposure to aflatoxin B1 in the Bangladeshi population. International journal of hygiene and environmental health, 220 (2), 271–281.
   PubMed Web of Science ®Google Scholar
• Ali, N., Muñoz, K., and Degen, G.H., 2017b. Ochratoxin A and its metabolites in urines of German adults – An assessment of variables in biomarker analysis. Toxicology letters, 275, 19–26.
   PubMed Web of Science ®Google Scholar
• Amirahmadi, M., et al., 2018. Simultaneous analysis of mycotoxins in corn flour using LC/MS-MS combined with a modified QuEChERS procedure. Toxin reviews, 37 (3), 187–195.
   Web of Science ®Google Scholar
• Amoriello, T. et al. 2018. Behaviour of durum wheat cultivars towards deoxynivalenol content: A multi-year assay in Italy. Italian Journal of Agronomy, 13(1), 12–20.
   Google Scholar
• Assunção, R., et al., 2015. Single-compound and cumulative risk assessment of mycotoxins present in breakfast cereals consumed by children from Lisbon region, Portugal. Food and chemical toxicology, 86, 274–281.
   PubMed Web of Science ®Google Scholar
• Assunção, R., Silva, M.J., and Alvito, P., 2016. Challenges in risk assessment of multiple mycotoxins in food. World mycotoxin journal, 9 (5), 791–811.
   Web of Science ®Google Scholar
• Ayelign, A., et al., 2017. Assessment of aflatoxin exposure among young children in Ethiopia using urinary biomarkers urinary biomarkers. Food additives and contaminants: part A, 34 (9), 1606–1616.
   PubMed Web of Science ®Google Scholar
• Belhassen, H., et al., 2015. Zearalenone and its metabolites in urine and breast cancer risk: a case-control study in Tunisia. Chemosphere, 128, 1–6.
   PubMed Web of Science ®Google Scholar
• Bernhoft, A., et al., 2001. Placental transfer of the estrogenic mycotoxin zearalenone in rats. Reproductive toxicology, 15 (5), 545–550.
   PubMed Web of Science ®Google Scholar
• Berthiller, F., et al., 2009. Formation, determination and significance of masked and other conjugated mycotoxins. Analytical and bioanalytical chemistry, 395 (5), 1243–1252.
   PubMed Web of Science ®Google Scholar
• Biehl, M.L., et al., 1993. Biliary excretion and enterohepatic cycling of zearalenone in immature pigs. Toxicology and applied pharmacology, 121 (1), 152–159.
   PubMed Web of Science ®Google Scholar
• Borchers, A., et al., 2010. Food Safety. Clinical reviews in allergy and immunology, 39 (2), 95–141.
   PubMed Web of Science ®Google Scholar
• Borutova, R., et al., 2012. Co-prevalence and statistical correlations between mycotoxins in feedstuffs collected in the Asia-Oceania in 2010. Animal feed science and technology, 178 (3–4), 190–197.
   Web of Science ®Google Scholar
• Bottalico A., Perrone G., 2002. Toxigenic Fusarium species and mycotoxins associated with head blight in small-grain cereals in Europe. In: Logrieco A., Bailey J.A., Corazza L., Cooke B.M. (eds) Mycotoxins in Plant Disease, 611–624.
   Google Scholar
• Bryden, W.L., 2007. Mycotoxins in the food chain: human health implications. Asia pacific journal of clinical nutrition, 16 (1), 95–101.
   PubMedGoogle Scholar
• Campagnollo, F.B., et al., 2016. The prevalence and effect of unit operations for dairy products processing on the fate of aflatoxin M1: a review. Food control, 68, 310–329.
   Web of Science ®Google Scholar
• Cano-Sancho, G., et al., 2010. Biomonitoring of Fusarium spp. Mycotoxins: perspectives for an individual exposure assessment tool. Food science and technology international, 16 (3), 266–276.
   PubMed Web of Science ®Google Scholar
• Coronel, M.B., et al., 2011. Ochratoxin A and its metabolite ochratoxin alpha in urine and assessment of the exposure of inhabitants of Lleida, Spain. Food and chemical toxicology, 49 (6), 1436–1442.
   PubMed Web of Science ®Google Scholar
• Delongchamp, R.R., and Young, J.F., 2001. Tissue sphinganine as a biomarker of fumonisin-induced apoptosis. Food additives and contaminants, 18 (3), 255–261.
   PubMed Web of Science ®Google Scholar
• Deng, C., et al., 2018. Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method. Scientific reports, 8 (1), 3901.
   PubMedGoogle Scholar
• Diaz, D. E., 2005. The mycotoxin blue book. Nottingham, UK: Nottingham University Press.
   Google Scholar
• Dietrich, D.R., Heussner, A.H., and O’Brien, E. 2005. Ochratoxin A: comparative pharmacokinetics and toxicological implications (experimental and domestic animals and humans). Food additives and contaminants, 22 (sup1), 45–52.
   PubMed Web of Science ®Google Scholar
• Domijan, A., et al., 2009. Urine ochratoxin A and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. Arhiv za higijenu rada i toksikologiju, 60 (4), 387–393.
   PubMed Web of Science ®Google Scholar
• Duarte, S., et al., 2010. Monitoring of ochratoxin A exposure of the Portuguese population through a nationwide urine survey-Winter 2007. The science of the total environment, 408 (5), 1195–1198.
   PubMed Web of Science ®Google Scholar
• Duarte, S.C., et al., 2009. Ochratoxin A exposure assessment of the inhabitants of Lisbon during winter 2007/2008 through bread and urine analysis. Food additives and contaminants, 26 (10), 1411–1420.
   Web of Science ®Google Scholar
• Duarte, S.C., et al., 2012. Determinants of ochratoxin A exposure – A one year follow-up study of urine levels. International journal of hygiene and environmental health, 215 (3), 360–367.
   PubMed Web of Science ®Google Scholar
• Ediage, E.N., et al., 2012. A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry. Analytica chimica acta, 741, 58–69.
   PubMed Web of Science ®Google Scholar
• Ediage, E.N., et al., 2013. Multimycotoxin analysis in urines to assess infant exposure: a case study in Cameroon. Environment international, 57–58, 50–59.
   PubMed Web of Science ®Google Scholar
• European Commission, 2000. Opinion of the scientific committee on food on Fusarium- toxins part 2: Zearalenone (ZEA). Scientific Committee on Food, 22 june, 1–12.
   Google Scholar
• European Commission, 2006. Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Oj L364, 5–24.
   Google Scholar
• European Food Safety Authority, 2016. Appropriateness to set a group health-based guidance value for zearalenone and its modified forms. EFSA journal, 14 (4), 4425, 17–36.
   Web of Science ®Google Scholar
• Ezekiel, C.N., et al., 2014. Mycotoxin exposure in rural residents in northern Nigeria: a pilot study using multi-urinary biomarkers. Environment international, 66, 138–145.
   PubMed Web of Science ®Google Scholar
• Fakhri, Y., et al., 2019a. Concentration and prevalence of aflatoxin M1 in human breast milk in Iran: systematic review, meta-analysis, and carcinogenic risk assessment: a review. Journal of food protection, 82 (5), 785–795.
   PubMed Web of Science ®Google Scholar
• Fakhri, Y., et al., 2019b. Aflatoxin M1 in human breast milk: a global systematic review, meta-analysis, and risk assessment study (Monte Carlo simulation). Trends in food science and technology, 88, 333–342.
   Web of Science ®Google Scholar
• Flajs, D., and Peraica, M., 2009. Toxicological properties of citrinin. Archives of industrial hygiene and toxicology, 60 (4), 457–464.
   PubMed Web of Science ®Google Scholar
• Fleck, S.C., et al., 2016. Urine and serum biomonitoring of exposure to environmental estrogens II: soy isoflavones and zearalenone in pregnant women. Food and chemical toxicology, 95, 19–27.
   PubMed Web of Science ®Google Scholar
• Föllmann, W., et al., 2016. Biomonitoring of mycotoxins in urine: pilot study in mill workers. Journal of toxicology and environmental health – part A: current issues, 79 (22-23), 1015–1025.
   PubMed Web of Science ®Google Scholar
• Food and Agriculture Organization of the United Nations – FAO; World Health Organization – WHO, 2011a. Evaluation of certain food additives and contaminants: seventy-fourth report of the Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives and contaminantes. WHO Technical Report Series, 966, 55–70.
   Google Scholar
• Food and Agriculture Organization of the United Nations – FAO; World Health Organization – WHO, 2011b. Evaluation of certain contaminants in food: seventy-second report of the Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain contaminants in food. WHO Technical Report Series, 959, 1–105.
   Google Scholar
• Franco, L.T., et al., 2019. Assessment of mycotoxin exposure and risk characterization using occurrence data in foods and urinary biomarkers in Brazil. Food and chemical toxicology, 128, 21–34.
   PubMed Web of Science ®Google Scholar
• Fredlund, E. et al. 2013. Deoxynivalenol and other selected Fusarium toxins in Swedish oats — Occurrence and correlation to specific Fusarium species. International Journal of Food Microbiology, 167 (2), 276–283.
   Google Scholar
• Gambacorta, S., et al., 2013. Validation study on urinary biomarkers of exposure for aflatoxin B1, ochratoxin A, fumonisin B1, deoxynivalenol and zearalenone in piglets. World mycotoxin journal, 6 (3), 299–308.
   Web of Science ®Google Scholar
• Gerding, J., Cramer, B., and Humpf, H.U., 2014. Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. Molecular nutrition and food research, 58 (12), 2358–2368.
   PubMed Web of Science ®Google Scholar
• Gerding, J., et al., 2015. A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach. Mycotoxin research, 31 (3), 127–136.
   PubMed Web of Science ®Google Scholar
• Gonçalves, B.L., et al., 2018. Mycotoxins in fruits and fruit-based products: occurrence and methods for decontamination. Toxin reviews, 38. DOI:https://doi.org/10.1080/15569543.2018.1457056
   Google Scholar
• Goyarts, T., and Dänicke, S., 2006. Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. Toxicology letters, 163 (3), 171–182.
   PubMed Web of Science ®Google Scholar
• Gratz, S.W., Duncan, G., and Richardson, A.J., 2013. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol. Applied and environmental microbiology, 79 (6), 1821–1825.
   PubMed Web of Science ®Google Scholar
• Grenier, B., and Applegate, T.J., 2013. Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals. Toxins, 5 (2), 396–430.
   PubMed Web of Science ®Google Scholar
• Groopman, J.D., and Kensler, T.W., 1999. The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenesis, 20 (1), 1–11.
   PubMed Web of Science ®Google Scholar
• Groopman, J.D., et al., 1992a. Molecular dosimetry of aflatoxin-N7-guanine in human urine obtained in The Gambia, West Africa. Cancer epidemiology, biomarkers and prevention, 1, 221–227.
   PubMed Web of Science ®Google Scholar
• Groopman, J.D., et al., 1992b. Molecular dosimetry in rat urine of aflatoxin- N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography. Cancer research, 52, 267–274.
   PubMed Web of Science ®Google Scholar
• Groopman, J.D., et al., 1992c. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi autonomous region, People’s Republic of China. Cancer research, 52, 45–52.
   PubMed Web of Science ®Google Scholar
• Groves, C.E., Morales, M., and Wright, S.H., 1998. Peritubular transport of ochratoxin A in rabbit renal proximal tubules. Journal of pharmacology and experimental therapeutics, 284, 943–948.
   PubMed Web of Science ®Google Scholar
• Hagelberg, S., Hult, K., and Fuchs, R., 1989. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. Journal of applied toxicology, 9 (2), 91–96.
   PubMed Web of Science ®Google Scholar
• Haschek, W.M., et al., 1992. Characterization of fumonisin toxicity in orally and intravenously dosed swine. Mycopathologia, 117 (1-2), 83–96.
   PubMed Web of Science ®Google Scholar
• Heshmati, A., et al., 2017. Co-occurrence of aflatoxins and ochratoxin A in dried fruits in Iran: dietary exposure risk assessment. Food and chemical toxicology: an international journal published for the British industrial biological research association, 106 (Pt A), 202–208.
   PubMedGoogle Scholar
• Heshmati, A., et al., 2019. Changes in aflatoxins content during processing of pekmez as a traditional product of grape. Lebensmittel-wissenschaft and technologie, 103, 178–185.
   Web of Science ®Google Scholar
• Heyndrickx, E., et al., 2015. Human biomonitoring of multiple mycotoxins in the Belgian population: results of the BIOMYCO study. Environment international, 84, 82–89.
   PubMed Web of Science ®Google Scholar
• Hsieh, D.P., and Atkinson, D.N., 1991. Bisfuranoid mycotoxins: their genotoxicity and carcinogenicity. Advances in experimental medicine and biology, 283, 525–532.
   PubMedGoogle Scholar
• Hussein, H., and Brasel, J., 2001. Toxicity, metabolism and impact of mycotoxins on human and animals. Toxicology, 167 (2), 101–134.
   PubMed Web of Science ®Google Scholar
• Huybrechts, B., et al., 2015. Fast and sensitive LC – MS/MS method measuring human mycotoxin exposure using biomarkers in urine. Archives of toxicology, 89 (11), 1993–2005.
   PubMed Web of Science ®Google Scholar
• International Agency for Research on Cancer. 2002. IARC Monograph on the Evaluation of Carcinogenic Risk to Humans. 82, 171. Available at: http://monographs.iarc.fr/ENG/Monographs/vol82/mono82.pdf. Accessed 17 October 18.
   Google Scholar
• Jager, A.V., et al., 2016. Assessment of aflatoxin exposure using serum and urinary biomarkers in São Paulo, Brazil: a pilot study. International journal of hygiene and environmental health, 219 (3), 294–300.
   PubMed Web of Science ®Google Scholar
• Johnson, N.M., et al., 2010. Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma. Science of the total environment, 408 (23), 6027–6031.
   PubMed Web of Science ®Google Scholar
• Jørgensen, K., 1998. Survey of pork, poultry, coffee, beer and pulses for ochratoxin A. Food additives and contaminants, 15 (5), 550–554.
   PubMedGoogle Scholar
• Karbancioglu-Güler, F., and Heperkan, D., 2009. Natural occurrence of fumonisin B1 in dried figs as an unexpected hazard. Food and chemical toxicology : an international journal published for the British industrial biological research association, 47 (2), 289–292.
   PubMed Web of Science ®Google Scholar
• Khaldi, N., and Wolfe, K.H., 2011. Evolutionary origins of the fumonisin secondary metabolite gene cluster in Fusarium verticillioides and Aspergillus niger. International journal of evolutionary biology, 2011, 1.
   Google Scholar
• Khaneghah, A M., et al., 2018a. Prevalence and concentration of ochratoxin A, zearalenone, deoxynivalenol and total aflatoxin in cereal-based products: a systematic review and meta-analysis. Food chemical and toxicology, 118, 830–848.
   PubMed Web of Science ®Google Scholar
• Khaneghah, A.M., et al., 2018b. Impact of unit operations during processing of cereal-based products on the levels of deoxynivalenol, total aflatoxin, ochratoxin A, and zearalenone: a systematic review and meta-analysis. Food chemistry, 268, 611–624.
   PubMed Web of Science ®Google Scholar
• Khaneghah, A.M., et al., 2018c. Deoxynivalenol and its masked forms: Characteristics, incidence, control and fate during wheat and wheat based products processing – A review. Trends in food science and technology, 71, 13–24.
   Web of Science ®Google Scholar
• Kiessling, K.H., and Pettersson, H., 1978. Metabolism of zearalenone in rat liver. Acta pharmacologica et toxicologica, 43 (4), 285–290.
   PubMedGoogle Scholar
• Klapec, T., et al., 2012. Urinary ochratoxin A and ochratoxin alpha in pregnant women. Food and chemical toxicology : an international journal published for the British industrial biological research association, 50 (12), 4487–4492.
   PubMed Web of Science ®Google Scholar
• Kongkapan, J., et al., 2015. A Brief overview of our current understanding of nivalenol: a growing potential danger vet to be fully investigated. Israel journal of veterinary medicine, 71, 1–7.
   Web of Science ®Google Scholar
• Kostelanska, M. et al. 2009. Occurrence of deoxynivalenol and its major conjugate, deoxynivalenol-3-glucoside, in beer and some brewing intermediates. Journal of Agricultural and Food Chemistry, 57, 3187–3194.
   Google Scholar
• Kuiper-Goodman, T., Scott, P.M., and Watanabe, H., 1987. Risk assessment of the mycotoxin zearalenone. Regulatory toxicology and pharmacology, 7, 253–306.
   PubMed Web of Science ®Google Scholar
• Lei, Y., et al., 2013. Estimation of urinary concentration of aflatoxin M1 in Chinese pregnant women. Journal of food science78 (11), T1835–T1838.
   PubMed Web of Science ®Google Scholar
• Magan, N., and Olsen, M., 2006. Mycotoxins in food, Boca Raton: CRC Press.
   Google Scholar
• Mahmood Fashandi, H., Abbasi, R., and Mousavi Khaneghah, A., 2018. The detoxification of aflatoxin M1 by Lactobacillus acidophilus and Bifidobacterium spp.: a review. Journal of food processing and preservation, 42 (9), e13704.
   Web of Science ®Google Scholar
• Marasas, W.F., 2001. Discovery and occurrence of the fumonisins: a historical perspective. Environmental health perspectives, 2, 239–243.
   Google Scholar
• Marasas, W.F., et al., 1988. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort journal of veterinary research, 55, 197–203.
   PubMed Web of Science ®Google Scholar
• Martinez-Larranaga, M.R., et al., 1999. Toxicokinetics and oral bioavailability of fumonisin B1. Veterinary and human toxicology, 41 (6), 357–362.
   PubMedGoogle Scholar
• Mason, S., et al., 2015. A survey on relationship between diet and urinary excretion of aflatoxin M1 : a screening pilot study on Iranian population. Journal of food quality and hazards control, 2, 66–70.
   Google Scholar
• Maul, R., et al., 2015. In vitro glucuronidation kinetics of deoxynivalenol by human and animal microsomes and recombinant human UGT enzymes. Archives of toxicology, 89 (6), 949–960.
   PubMed Web of Science ®Google Scholar
• Meky, F.A., et al., 2001. Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production. Food and chemical toxicology, 39 (8), 827–836.
   PubMed Web of Science ®Google Scholar
• Meky, F.A., et. al., 2003. Development of a urinary biomarker of human exposure to deoxynivalenol. Food and chemical toxicology, 41 (2), 265–273.
   PubMed Web of Science ®Google Scholar
• Minervini, F., et. al., 2004. Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. Toxicology in vitro, 18 (1), 21–28.
   PubMed Web of Science ®Google Scholar
• Missmer, S.A., et al., 2006. Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border. Environmental health perspectives, 114 (2), 237–241.
   PubMed Web of Science ®Google Scholar
• Mousavi Khaneghah, A., D Chaves, R., and Akbarirad, H., 2017. Detoxification of aflatoxin M1 (AFM1) in dairy base beverages (acidophilus milk) by using different types of lactic acid bacteria – mini review. Current nutrition and food science, 13 (2), 78–81.
   Web of Science ®Google Scholar
• Mousavi Khaneghah, A., et al., 2018. Aflatoxins in cereals: state of the art. Journal of food safety, 38 (6), e12532.
   Web of Science ®Google Scholar
• Muñoz, K., Blaszkewicz, M., and Degen, H., 2010. Simultaneous analysis of ochratoxin A and its major metabolite ochratoxin alpha in plasma and urine for an advanced biomonitoring of the mycotoxin. Journal of chromatography b, 878 (27), 2623–2629.
   PubMed Web of Science ®Google Scholar
• Olsen, M., Pettersson, H., and Kiessling, K.H., 1981. Reduction of zearalenone to zearalenol in female rat liver by 3 α-hydroxy-steroid dehydrogenase. Acta pharmacologica et toxicologica, 48 (2), 157–161.
   PubMedGoogle Scholar
• Olsen, M.E., et al., 1985. Quantitative liquid chromatographic method using fluorescence detection for determining zearalenone and its metabolites in blood plasma and urine. Journal association of official analytical chemists, 68, 632–635.
   PubMedGoogle Scholar
• Ostry, V., et al., 2017. Mycotoxins as human carcinogens – The IARC monographs classification. Mycotoxin research, 33 (1), 65–73.
   PubMed Web of Science ®Google Scholar
• Oteiza, J.M., et al., 2017. Influence of production on the presence of patulin and ochratoxin A in fruit juices and wines of Argentina. LWT-Food Science and Technology, 80, 200–207.
   Web of Science ®Google Scholar
• Papageorgiou, M., et al., 2018a. Assessment of urinary deoxynivalenol biomarkers in UK children and adolescents. Toxins, 10 (2), 1–13.
   Web of Science ®Google Scholar
• Papageorgiou, M., et al., 2018b. Occurrence of deoxynivalenol in an elderly cohort in the UK: a biomonitoring approach approach. Food additives and contaminants: part A, 49, 2032–2044.
   Google Scholar
• Paustenbach, D., and Galbraith, D., 2006. Biomonitoring and bio-markers: exposure assessment will never be the same. Environmental health perspectives, 114 (8), 1143–1149.
   PubMed Web of Science ®Google Scholar
• Pestka, J.J., and Smolinski, A.T., 2005. Deoxynivalenol: toxicology and potential effects on humans. Journal of toxicology and environmental health – part B critical reviews, 8 (1), 39–69.
   PubMed Web of Science ®Google Scholar
• Pestka, J.J., et al., 2017. Sex is a determinant for deoxynivalenol metabolism and elimination in the mouse. Toxins (Basel), 9, 1–12.
   Web of Science ®Google Scholar
• Petzinger, E., and Ziegler, K., 2000. Ochratoxin A from a toxicological perspective. Journal of veterinary pharmacology and therapeutics, 23, 91–98.
   PubMed Web of Science ®Google Scholar
• Piekkola, S., et al., 2012. Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women. Food additives and contaminants: part A chemistry, 29 (6), 962–971.
   PubMed Web of Science ®Google Scholar
• Polychronaki, N., et al., 2008. Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea. Food and chemical toxicology : an international journal published for the British industrial biological research association, 46 (2), 519–526.
   PubMed Web of Science ®Google Scholar
• Poór, M., et al., 2017. Interaction of mycotoxin zearalenone with human serum albumin. Journal of photochemistry and photobiology B, biology, 170, 16–24.
   PubMed Web of Science ®Google Scholar
• Qian, G.-S., et al., 1994. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer epidemiology, biomarkers and prevention, 3, 3–10.
   PubMed Web of Science ®Google Scholar
• Rahmani, J., et al., 2018. The prevalence of aflatoxin M1 in milk of Middle East region: a systematic review, meta-analysis and probabilistic health risk assessment. Food and chemical toxicology, 118, 653–666.
   PubMed Web of Science ®Google Scholar
• Rastegar, H., et al., 2017. Removal of aflatoxin B1 by roasting with lemon juice and/or citric acid in contaminated pistachio nuts. Food control, 71, 279–284.
   Web of Science ®Google Scholar
• Redzwan, S.M., et al., 2012. Association between aflatoxin M1 excreted in human urine samples with the consumption of milk and dairy products. Bulletin of environmental contamination and toxicology, 89 (6), 1115–1119.
   PubMed Web of Science ®Google Scholar
• Riley, R. T., and Voss, K. A., 2011. Developing mechanism-based and exposure biomarkers for mycotoxins in animals. In: S. De Saeger, ed. Determining mycotoxins and mycotoxigenic fungi in food and feed. Cambridge, UK: Woodhead Publishing Limited, 245–275.
   Google Scholar
• Riley, R.T., et al., 2012. The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. Molecular nutrition and food research, 56, 1445–1455.
   PubMed Web of Science ®Google Scholar
• Ringot, D., et al., 2006. Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chemico-biological interactions, 159 (1), 18–46.
   PubMed Web of Science ®Google Scholar
• Rizzo, A., Eskola, M., and Atroshi, F., 2002. Ochratoxin A in cereals, foodstuffs and human plasma. European journal of plant pathology, 108 (7), 631–637.
   Web of Science ®Google Scholar
• Rodríguez-Carrasco, Y., et al., 2014. Exposure assessment approach through mycotoxin/creatinine ratio in urine by GC-MS/MS. Food and chemical toxicology, 72, 69–75.
   PubMed Web of Science ®Google Scholar
• Romero, A.C., et al., 2010. Occurrence of AFM1 in urine samples of a Brazilian population and association with food consumption. Food control, 21 (4), 554–558.
   Web of Science ®Google Scholar
• Sabbioni, G., 1990. Chemical and physical properties of the major serum albumin adduct of aflatoxin B1 and their implications for the quantification in biological samples. Chemico-biological interactions, 75 (1), 1–15.
   PubMed Web of Science ®Google Scholar
• Sarkanj, B., et al., 2013. Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia. Food and chemical toxicology journal, 62, 231–237.
   PubMed Web of Science ®Google Scholar
• Sarkanj, B., et al., 2018. Ultra-sensitive, stable isotope assisted quantification of multiple urinary mycotoxin exposure biomarkers. Analytica chimica acta, 1019, 84–92.
   PubMed Web of Science ®Google Scholar
• Sass, D.C., et al., 2013. Methods for chemical preparation of aflatoxin B1 adducts, AFB1-N7-guanine and AFB1-lysine. Toxin reviews, 32, 68–74.
   Web of Science ®Google Scholar
• Schlatter, C., StuderRohr, J., and Rasonyi, T., 1996. Carcinogenicity and kinetic aspects of ochratoxin A. Food additives and contaminants, 13, 43–44.
   PubMedGoogle Scholar
• Schoevers, E.J., et al., 2012. Transgenerational toxicity of zearalenone in pigs. Reproductive toxicology (Elmsford, N.Y.), 34 (1), 110–119.
   PubMed Web of Science ®Google Scholar
• Schwartzbord, J., Severe, L., and Brown, D., 2017. Detection of trace aflatoxin M1 in human urine using a commercial ELISA followed by HPLC. Biomarkers, 22 (1), 1–4.
   PubMed Web of Science ®Google Scholar
• Scott, P.M., 2005. Biomarkers of human exposure to ochratoxin A. Food additives and contaminants, 22 (sup1), 99–107.
   PubMed Web of Science ®Google Scholar
• Shephard, G.S., et al., 2013. Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. Food and chemical toxicology, 62, 217–225.
   PubMed Web of Science ®Google Scholar
• Shephard, G.S., van der Westhuizen, L., and Sewram, V., 2007. Biomarkers of exposure to fumonisin mycotoxins: a review. Food additives and contaminants, 24 (10), 1196–1201.
   PubMed Web of Science ®Google Scholar
• Shirima, C.P., et al., 2013. Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers. Molecular nutrition and food research, 1 (57), 1874–1881.
   Google Scholar
• Shirima, C.P., et al., 2015. A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania. Research children’s health, 123 (2), 173–179.
   Google Scholar
• Solfrizzo, M., et al., 2011. Simultaneous LC-MS/MS determination of aflatoxin M1, ochratoxin A, deoxynivalenol, de-epoxydeoxynivalenol, α and β-zearalenols and fumonisin B1 in urine as a multi-biomarker method to assess exposure to mycotoxins. Analytical and bioanalytical chemistry, 401 (9), 2831–2841.
   PubMed Web of Science ®Google Scholar
• Solfrizzo, M., Gambacorta, L., and Visconti, A., 2014. Assessment of multi-mycotoxin exposure in southern Italy by urinary multi-biomarker determination. Toxins, 6 (2), 523–538.
   PubMed Web of Science ®Google Scholar
• Srey, C., et al., 2014. Deoxynivalenol exposure assessment in young children in Tanzania. Molecular nutrition & food research, 58, 1574–1580.
   PubMed Web of Science ®Google Scholar
• Studer-Rohr, I., Schlatter, J., and Dietrich, D.R., 2000. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Archives of toxicology, 74 (9), 499–510.
   PubMed Web of Science ®Google Scholar
• Sun, L.H., et al., 2016. Prevention of aflatoxin B1 hepatoxicity by dietary selenium is associated with inhibition of cytochrome P450 isozymes and up-regulation of 6 selenoprotein genes in chick liver. The journal of nutrition, 146 (4), 655–661.
   Web of Science ®Google Scholar
• Susca, A., et al., 2010. Correlation of mycotoxin fumonisin B2 production and presence of the fumonisin biosynthetic gene fum8 in Aspergillus niger from grape. Journal of agricultural and food chemistry, 58 (16), 9266–9272.
   PubMed Web of Science ®Google Scholar
• Tanaka, T. et al. 1990. A survey of the natural occurrence of Fusarium mycotoxins, deoxynivalenol, nivalenol and zearalenone, in cereals harvested in the Netherlands. Mycopathologia, 110 (1), 19–22.
   Google Scholar
• Torres, O., et al., 2014. Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. Molecular nutrition and food research, 58 (5), 973–983.
   PubMed Web of Science ®Google Scholar
• Tsegaye, W., et al., 2016. Urinary aflatoxin M1 concentrations among pregnant women in Bishoftu, Ethiopia. The FASEB journal, 30, 1149.28.
   Web of Science ®Google Scholar
• Turner, N.W., Subrahmanyam, S., and Piletsky, S.A., 2009. Analytical methods for determination of mycotoxins: a review. Analytica chimica acta, 632 (2), 168–180.
   PubMed Web of Science ®Google Scholar
• Turner, P.C., et al., 2008. Deoxynivalenol: rationale for development and application of a urinary biomarker. Food additives and contaminants: part A, chemistry, analysis, control, exposure & risk assessment, 25, 864–871.
   Web of Science ®Google Scholar
• Turner, P.C., et al., 2010a. A comparison of deoxynivalenol intake and urinary deoxynivalenol in UK adults. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 15 (6), 553–562.
   PubMed Web of Science ®Google Scholar
• Turner, P.C., et al., 2010b. Determinants of urinary deoxynivalenol and de-epoxy deoxynivalenol in male farmers from Normandy, France. Journal of agricultural and food chemistry, 58 (8), 5206–5212.
   PubMed Web of Science ®Google Scholar
• Turner, P.C., et al., 2011. A biomarker survey of urinary deoxynivalenol in China: the Shanghai women’s health study. Food additives and contaminants: part A chemistry, 28, 1220–1223.
   Google Scholar
• Turner, P.C., et al., 2012. A pilot survey for Fusarium mycotoxin biomarkers in women from Golestan, northern Iran. World mycotoxin journal, 5 (2), 195–199.
   Web of Science ®Google Scholar
• Ueno, Y., et al., 1977. Fate and mode of action of zearalenone. Annales de la nutrition et de l'alimentation, 31 (4-6), 935–948.
   PubMedGoogle Scholar
• Varga, J., et al., 2010. Fumonisin contamination and fumonisin producing black Aspergilli in dried vine fruits of different origin. International journal of food microbiology, 143 (3), 143–149.
   PubMed Web of Science ®Google Scholar
• Vidal, A., et al., 2018. Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. Scientific reports, 8, 1–11.
   PubMed Web of Science ®Google Scholar
• Videmann, B., et al., 2008. Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells. Food and chemical toxicology, 46 (10), 3279–3286.
   PubMed Web of Science ®Google Scholar
• Wallin, S., et al., 2013. Biomonitoring study of deoxynivalenol exposure and association with typical cereal consumption in Swedish adults. World mycotoxin journal, 6 (4), 439–448.
   Web of Science ®Google Scholar
• Wallin, S., et al., 2015. Biomonitoring of concurrent mycotoxin exposure among adults in Sweden through urinary multi-biomarker analysis. Food and chemical toxicology: an international journal published for the British industrial biological research association, 83, 133–139.
   PubMed Web of Science ®Google Scholar
• Wan Norhasima, W.M., et al., 2009. The health and toxic adverse effects of Fusarium fungal mycotoxin, fumonisins, on human population. American journal of infectious diseases, 4, 273–281.
   Google Scholar
• Warth, B., et al., 2012. Development and validation of a rapid multi-biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins. Rapid communications in mass spectrometry : rcm, 26 (13), 1533–1540.
   PubMed Web of Science ®Google Scholar
• Warth, B., et al., 2013. New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone. Toxicology letters, 220 (1), 88–94.
   PubMed Web of Science ®Google Scholar
• Warth, B., et al., 2014. Utilising an LC-MS/MS-based multi-biomarker approach to assess mycotoxin exposure in the Bangkok metropolitan area and surrounding provinces. Food additives and contaminants – part A chemistry, analysis, control, exposure and risk assessment, 31 (12), 2040–2046.
   Google Scholar
• Wells, L., et al., 2017. Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9 (7), 1–12.
   Web of Science ®Google Scholar
• World Health Organization 1993. International programme on chemical safety, biomarkers and risk assessment: concepts and principles, environmental health criteria 155. Geneva, Switzerland: World Health Organization.
   Google Scholar
• World Health Organization 2000. Fumonisin B1 – Environmental health criteria 219. International programme on chemical safety. Geneva: World Health Organization.
   Google Scholar
• Wu, L., et al., 2015. Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)-challenged growing pigs. BMC veterinary research, 11, 144–154.
   PubMed Web of Science ®Google Scholar
• Wu, Q., et al., 2010. Metabolic pathways of trichothecenes. Drug metabolism reviews, 42 (2), 250–267.
   PubMed Web of Science ®Google Scholar
• Xu, L., et al., 2010. Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China. Food additives and contaminants. part A, chemistry, analysis, control, exposure and risk assessment, 27 (8), 1161–1169.
   Google Scholar
• Zain, M.E., 2011. Impact of mycotoxins on humans and animals. Journal of saudi chemical society, 15 (2), 129–144.
   Web of Science ®Google Scholar
• Zhu, J., et al., 1987. Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer research, 47 (7), 1848–1852.
   PubMed Web of Science ®Google Scholar
• Zinedine, A., et al., 2007. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food and chemical toxicology : an international journal published for the British industrial biological research association, 45 (1), 1–18.
   PubMed Web of Science ®Google Scholar