Does caffeine therapy improve cognitive impairments in valproic acid rat model of autism?

References

• Abreu, R.V., et al., 2011. Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains. Pharmacology biochemistry and behavior, 99(4), 659–664.
   PubMed Web of Science ®Google Scholar
• Akhondzadeh, S., et al., 2000. Dipyridamole in the treatment of schizophrenia: adenosine-dopamine receptor interactions. Journal of clinical pharmacy and therapeutics, 25, 131–137.
   PubMed Web of Science ®Google Scholar
• Akhondzadeh, S., et al., 2006. Allopurinol as an adjunct to lithium and haloperidol for treatment of patients with acute mania: a double-blind, randomized, placebo-controlled trial. Bipolar disorders, 8(5p1), 485–489.
   PubMed Web of Science ®Google Scholar
• Alhaider, I.A., et al., 2010a. Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus. European journal of neuroscience, 31(8), 1368–1376.
   PubMed Web of Science ®Google Scholar
• Alhaider, I.A., et al., 2010b. Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity. Sleep, 33(4), 437–444.
   PubMed Web of Science ®Google Scholar
• Alhaider, I.A., et al., 2011. Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. Molecular and cellular neuroscience, 46(4), 742–751.
   PubMed Web of Science ®Google Scholar
• Alzoubi, K.H., et al., 2013. Caffeine prevents cognitive impairment induced by chronic psychosocial stress and/or high fat-high carbohydrate diet. Behavioural brain research, 237, 7–14.
   PubMed Web of Science ®Google Scholar
• Alzoubi, K.H., et al., 2018. Caffeine prevents memory impairment induced by hyperhomocysteinemia. Journal of molecular neuroscience, 66(2), 222–228.
   PubMed Web of Science ®Google Scholar
• Angelucci, M., et al., 2002. Effects of caffeine on learning and memory in rats tested in the Morris water maze. Brazilian journal of medical and biological research, 35(10), 1201–1208.
   PubMed Web of Science ®Google Scholar
• Arendash, G., et al., 2006. Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain β-amyloid production. Neuroscience, 142(4), 941–952.
   PubMed Web of Science ®Google Scholar
• Assis, M.S., et al., 2018. Effects of caffeine on behavioural and cognitive deficits in rats. Basic & clinical pharmacology & toxicology, 123(4), 435–442.
   PubMed Web of Science ®Google Scholar
• Baio, J., 2012. Prevalence of Autism Spectrum Disorders: Autism and Developmental Disabilities Monitoring Network, 14 Sites, United States, 2008. Morbidity and mortality weekly report, 61(3), 1–19.
   Google Scholar
• Banji, D., et al., 2011. Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals. Brain research, 1410, 141–151.
   PubMed Web of Science ®Google Scholar
• Barendse, E.M., et al., 2013. Working memory deficits in high-functioning adolescents with autism spectrum disorders: neuropsychological and neuroimaging correlates. Journal of neurodevelopmental disorders, 5(1), 14.
   PubMed Web of Science ®Google Scholar
• Boison, D., 2005. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. The neuroscientist, 11(1), 25–36.
   PubMed Web of Science ®Google Scholar
• Boison, D., Masino, S.A., and Geiger, J.D., 2011. Homeostatic bioenergetic network regulation – a novel concept to avoid pharmacoresistance in epilepsy. Expert opinion on drug discovery, 6(7), 713–724.
   PubMed Web of Science ®Google Scholar
• Bromley, R.L., et al., 2008. Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology, 71(23), 1923–1924.
   PubMed Web of Science ®Google Scholar
• Brunstein, M.G., et al., 2001. Therapeutic benefit of adjunctive dipyridamole in schizophrenia is probably due to adenosine-glutamate interactions. Journal of clinical pharmacy and therapeutics, 26(2), 155–156.
   PubMed Web of Science ®Google Scholar
• Cezar, L.C., et al., 2018. Zinc as a therapy in a rat model of autism prenatally induced by valproic acid. Progress in neuro-psychopharmacology and biological psychiatry, 84, 173–180.
   PubMed Web of Science ®Google Scholar
• Chau, D.K., et al., 2017. Downregulation of glutamatergic and GABAergic proteins in valproric acid associated social impairment during adolescence in mice. Behavioural brain research, 316, 255–260.
   PubMed Web of Science ®Google Scholar
• Connor, M., 2009. Allopurinol for pain relief: more than just crystal clearance? British journal of pharmacology, 156(1), 4–6.
   PubMed Web of Science ®Google Scholar
• Dall’igna, O.P., et al., 2007. Caffeine and adenosine A2a receptor antagonists prevent β-amyloid (25–35)-induced cognitive deficits in mice. Experimental neurology, 203, 241–245.
   PubMed Web of Science ®Google Scholar
• Dall’igna, O.P., Souza, D.O., and Lara, D.R., 2004. Caffeine as a neuroprotective adenosine receptor antagonist. Annals of pharmacotherapy, 38, 717–718.
   PubMed Web of Science ®Google Scholar
• Demarco, P., and Zagnoni, P., 1986. Allopurinol and severe epilepsy. Neurology, 36(11), 1538–1539.
   PubMed Web of Science ®Google Scholar
• Dickerson, F.B., et al., 2009. A double-blind trial of adjunctive allopurinol for schizophrenia. Schizophrenia research, 109(1–3), 66–69.
   PubMed Web of Science ®Google Scholar
• Emrich, H., et al., 1980. Effect of sodium valproate on mania. Archiv für Psychiatrie Und Nervenkrankheiten, 229(1), 1–16.
   PubMedGoogle Scholar
• Ferré, S., 2008. An update on the mechanisms of the psychostimulant effects of caffeine. Journal of neurochemistry, 105(4), 1067–1079.
   PubMed Web of Science ®Google Scholar
• Filipek, P.A., et al., 2000. Practice parameter: screening and diagnosis of autism: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology, 55(4), 468–479.
   PubMed Web of Science ®Google Scholar
• Foley, A.G., Cassidy, A.W., and Regan, C.M., 2014. Pentyl-4-yn-VPA, a histone deacetylase inhibitor, ameliorates deficits in social behavior and cognition in a rodent model of autism spectrum disorders. European journal of pharmacology, 727, 80–86.
   PubMed Web of Science ®Google Scholar
• Fredholm, B.B., et al., 1999. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological reviews, 51(1), 83–133.
   PubMed Web of Science ®Google Scholar
• Fredholm, B.B., et al., 2005. Adenosine and brain function. International review of neurobiology, 63, 191–270.
   PubMed Web of Science ®Google Scholar
• Gao, J., et al., 2016. Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. International journal of developmental neuroscience, 49, 67–78.
   PubMed Web of Science ®Google Scholar
• Garcez, M.L., et al., 2019. Caffeine neuroprotection decreases A2A adenosine receptor content in aged mice. Neurochemical research, 44(4), 787.
   PubMed Web of Science ®Google Scholar
• Gobbi, G., and Janiri, L., 2006. Sodium-and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex. Psychopharmacology, 185(2), 255–262.
   PubMed Web of Science ®Google Scholar
• Gomes, C.V., et al., 2011. Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochimica et Biophysica Acta (BBA) – biomembranes, 1808(5), 1380–1399.
   PubMed Web of Science ®Google Scholar
• Hughes, R.N., and Hancock, N.J., 2017. Effects of acute caffeine on anxiety-related behavior in rats chronically exposed to the drug, with some evidence of possible withdrawal-reversal. Behavioural brain research, 321, 87–98.
   PubMed Web of Science ®Google Scholar
• Johannessen, C.U., and Johannessen, S.I., 2003. Valproate: past, present, and future. CNS drug reviews, 9(2), 199–216.
   PubMedGoogle Scholar
• Kaidanovich-Beilin, O., et al., 2011. Assessment of social interaction behaviors. Journal of visualized experiments : JoVE, (48), 2473.
   Google Scholar
• Kasimay Cakir, O., et al., 2017. Protective effect of low dose caffeine on psychological stress and cognitive function. Physiology & behavior, 168, 1–10.
   PubMed Web of Science ®Google Scholar
• Kataoka, S., et al., 2013. Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid. International journal of neuropsychopharmacology, 16(1), 91–103.
   PubMed Web of Science ®Google Scholar
• Kerr, D.M., et al., 2013. Alterations in the endocannabinoid system in the rat valproic acid model of autism. Behavioural brain research, 249, 124–132.
   PubMed Web of Science ®Google Scholar
• Kim, J.-W., et al., 2017. Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism. Neuropharmacology, 113, 71–81.
   PubMed Web of Science ®Google Scholar
• Kim, P., et al., 2013. Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. Food and chemical toxicology, 51, 288–296.
   PubMed Web of Science ®Google Scholar
• Kopf, S.R., et al., 1999. Adenosine and memory storage. Psychopharmacology, 146(2), 214–219.
   PubMed Web of Science ®Google Scholar
• Kumar, H., and Sharma, B., 2016. Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats. Brain research, 1630, 83–97.
   PubMed Web of Science ®Google Scholar
• Lambert, P., et al., 1975. Dipropylacetamide in the treatment of manic-depressive psychosis. L’Encephale, 1(1), 25–31.
   PubMedGoogle Scholar
• Löscher, W., 1999. Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Progress in neurobiology, 58(1), 31–59.
   PubMed Web of Science ®Google Scholar
• Löscher, W., 2002. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS drugs, 16(10), 669–694.
   PubMed Web of Science ®Google Scholar
• Lovatt, D., et al., 2012. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proceedings of the national academy of sciences U S A, 109(16), 6265–6270.
   PubMed Web of Science ®Google Scholar
• Mahdi, S., et al., 2019. Effect of chronic administration and withdrawal of caffeine on motor function, cognitive functions, anxiety, and the social behavior of BLC57 mice. International journal of health sciences (Qassim), 13(2), 10–16.
   PubMed Web of Science ®Google Scholar
• Markram, K., et al., 2008. Abnormal fear conditioning and amygdala processing in an animal model of autism. Neuropsychopharmacology, 33(4), 901–912.
   PubMed Web of Science ®Google Scholar
• Marshad, R.A., et al., 2018. Streptozotocin-induced diabetes mellitus affects the NMDA receptors: Role of caffeine administration in enhancing learning, memory and locomotor deficits. International journal of health sciences (Qassim), 12(3), 10–17.
   PubMed Web of Science ®Google Scholar
• Masino, S.A., et al., 2013. Adenosine and autism: a spectrum of opportunities. Neuropharmacology, 68, 116–121.
   PubMed Web of Science ®Google Scholar
• Meador, K.J., et al., 2009. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. New England journal of medicine, 360(16), 1597–1605.
   PubMed Web of Science ®Google Scholar
• Moldrich, R.X., et al., 2013. Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. Behavioural brain research, 257, 253–264.
   PubMed Web of Science ®Google Scholar
• Moy, S., et al., 2004. Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice. Genes, brain and behavior, 3(5), 287–302.
   PubMed Web of Science ®Google Scholar
• Nadebaum, C., et al., 2011. The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy. Journal of the international neuropsychological society, 17(01), 133–142.
   PubMed Web of Science ®Google Scholar
• Nau, H., Hauck, R.S., and Ehlers, K., 1991. Valproic acid‐induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms. Pharmacology & toxicology, 69, 310–321.
   PubMedGoogle Scholar
• Nazeri, M., et al., 2015. Psychological or physical prenatal stress differentially affects cognition behaviors. Physiology & behavior, 142, 155–160.
   PubMed Web of Science ®Google Scholar
• Nehlig, A., Daval, J.-L., and Debry, G., 1992. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain research reviews, 17(2), 139–170.
   PubMed Web of Science ®Google Scholar
• Newbury, D., et al., 2011. Investigation of dyslexia and SLI risk variants in reading-and language-impaired subjects. Behavior genetics, 41(1), 90–104.
   PubMed Web of Science ®Google Scholar
• Nicholson, A., and Stone, B.M., 1980. Heterocyclic amphetamine derivatives and caffeine on sleep in man. British journal of clinical pharmacology, 9(2), 195–203.
   PubMed Web of Science ®Google Scholar
• Nicolini, C., and Fahnestock, M., 2018. The valproic acid-induced rodent model of autism. Experimental neurology, 299, 217–217.
   PubMed Web of Science ®Google Scholar
• Ornoy, A., 2009. Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reproductive toxicology, 28(1), 1–10.
   PubMed Web of Science ®Google Scholar
• Owens, M.J., and Nemeroff, C.B., 2003. Pharmacology of valproate. Psychopharmacology bulletin, 37(Suppl 2), 17–24.
   PubMedGoogle Scholar
• Phiel, C.J., et al., 2001. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. Journal of biological chemistry, 276(39), 36734–36741.
   PubMed Web of Science ®Google Scholar
• Pragnya, B., Kameshwari, J.S., and Veeresh, B., 2014. Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB/C mice. Behavioural brain research, 270, 86–94.
   PubMed Web of Science ®Google Scholar
• Prediger, R.D., et al., 2005. Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder (ADHD) – the spontaneously hypertensive rat (SHR). The international journal of neuropsychopharmacology, 8(04), 583–594.
   PubMed Web of Science ®Google Scholar
• Quarta, D., et al., 2004. Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure. Journal of neurochemistry, 88(5), 1151–1158.
   PubMed Web of Science ®Google Scholar
• Rajizadeh, M.A., et al., 2018. Voluntary exercise impact on cognitive impairments in sleep-deprived intact female rats. Physiology & behavior, 188, 58–66.
   PubMed Web of Science ®Google Scholar
• Rasalam, A.D., et al., 2005. Characteristics of fetal anticonvulsant syndrome associated autistic disorder. Developmental medicine & child neurology, 47(8), 551–555.
   PubMed Web of Science ®Google Scholar
• Sandhya, T., Sowjanya, J., and Veeresh, B., 2012. Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats. Neurochemical research, 37(5), 1121–1131.
   PubMed Web of Science ®Google Scholar
• Santiago, A.R., et al., 2014. Role of microglia adenosine A2A receptors in retinal and brain neurodegenerative diseases. Mediators of inflammation, 2014, 465694.
   PubMed Web of Science ®Google Scholar
• Schneider, T., Turczak, J., and Przewłocki, R., 2006. Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism. Neuropsychopharmacology, 31(1), 36–46.
   PubMed Web of Science ®Google Scholar
• Shallcross, R., et al., 2014. In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. Neurology, 82(3), 213–221.
   PubMed Web of Science ®Google Scholar
• Stockwell, J., Jakova, E., and Cayabyab, F., 2017. Adenosine A1 and A2A receptors in the brain: current research and their role in neurodegeneration. Molecules, 22, 676.
   Web of Science ®Google Scholar
• Takuma, K., et al., 2014. Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism. Pharmacology biochemistry and behavior, 126, 43–49.
   PubMed Web of Science ®Google Scholar
• Tian, Y., et al., 2014. Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism. Journal of pineal research, 56(1), 1–11.
   PubMed Web of Science ®Google Scholar
• Togha, M., et al., 2007. Allopurinol as adjunctive therapy in intractable epilepsy: a double-blind and placebo-controlled trial. Archives of medical research, 38(3), 313–316.
   PubMed Web of Science ®Google Scholar
• Wu, H., et al., 2017. Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism. Life sciences, 173, 43–54.
   PubMed Web of Science ®Google Scholar
• Yang, E.-J., et al., 2016. Early behavioral abnormalities and perinatal alterations of PTEN/AKT pathway in valproic acid autism model mice. PloS one, 11(4), e0153298.
   PubMed Web of Science ®Google Scholar
• Yochum, C.L., et al., 2008. VPA-induced apoptosis and behavioral deficits in neonatal mice. Brain research, 1203, 126–132.
   PubMed Web of Science ®Google Scholar
• Zagnoni, P.G., et al., 1994. Allopurinol as add-on therapy in refractory epilepsy: a double-blind placebo-controlled randomized study. Epilepsia, 35(1), 107–112.
   PubMed Web of Science ®Google Scholar
• Zhao, G., et al., 2015. Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model. International journal of developmental neuroscience, 44, 14–21.
   PubMed Web of Science ®Google Scholar
• Zoghbi, H.Y., and Bear, M.F., 2012. Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold spring harbor perspectives in biology, 4(3), a009886.
   PubMed Web of Science ®Google Scholar