Advanced search
Publication Cover
Toxin Reviews Volume 40, 2021 - Issue 4
Submit an article Journal homepage
120
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Impact of bee venom and melittin on apoptosis and biotransformation in colorectal carcinoma cell lines

Danijela D. Nikodijevića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0002-6453-0313View further author information
ORCID Icon,
Milena G. Milutinovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5075-5650View further author information
ORCID Icon,
Danijela M. Cvetkovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0001-7767-1345View further author information
ORCID Icon,
Maja Đ. Ćupurdijaa Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0001-7173-160XView further author information
ORCID Icon,
Milena M. Jovanovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0002-2003-8124View further author information
ORCID Icon,
Ivan V. Mrkićb Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Belgrade, SerbiaORCID Iconhttps://orcid.org/0000-0002-0262-3741View further author information
ORCID Icon,
Marija Đ. Jankulović-Gavrovićb Department of Biochemistry, Faculty of Chemistry, University of Belgrade, Belgrade, SerbiaORCID Iconhttps://orcid.org/0000-0002-8591-4391View further author information
ORCID Icon &
Snežana D. Markovića Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, SerbiaORCID Iconhttps://orcid.org/0000-0002-3892-8977View further author information
ORCID Icon show all
Pages 1272-1279 | Received 13 Feb 2019, Accepted 08 Oct 2019, Published online: 24 Oct 2019

References

  • Adams, J.M. and Cory, S., 2007. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 26(9), 1324–1337.
  • Akhdar, H., et al., 2012. Anticancer drug metabolism: chemotherapy resistance and new therapeutic approaches. In: James Paxton, ed. Topics on drug metabolism. Croatia: InTech, 137–173.
  • Antić, V., 2014. Colorectal cancer incidence variation in Serbian districts. Medical journal (Kragujevac), 48(1), 48–53.
  • Baguley, B., 2010. Multiple drug resistance mechanisms in cancer. Molecular biotechnology, 46(3), 308–316.
  • Bakos, E., et al., 2000. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Molecular pharmacology, 57(4), 760–768.
  • Baskić, D., et al., 2006. Analysis of cyclohexamide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide. Cell biology international, 30(11), 924–932.
  • Bogdanov, S., 2017. Propolis: composition, health, medicine: a review. Bee Product Science. Available from: www.bee-hexagon.net
  • Chomczynski, P. and Sacchi, N., 1987. Single-step method of RNА isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Analytical biochemistry, 162(1), 156–159.
  • Dinić, J., et al., 2015. New approaches with natural product drugs for overcoming multidrug resistance in cancer. Current pharmaceutical design, 21(38), 5589–5604.
  • Evers, R., et al., 2000. Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport. British journal of cancer, 83(3), 366–374.
  • Gajski, G. and Garaj-Vrhovac, V., 2013. Melittin: a lytic peptide with anticancer properties. Environmental toxicology and pharmacology, 36(2), 697–705.
  • Gomes, A., et al., 2010. Anticancer potential of animal venoms and toxins. Indian journal of experimental biology, 48(2), 93–103.
  • Guanti, G., et al., 2000. Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. Human molecular genetics, 9(2), 283–287.
  • Guengerich, F.P., 2007. Cytochrome P450 and chemical toxicology. Chemical research in toxicology, 21(1), 70–83.
  • Higuchi, H., et al., 2001. The bile acid glycochenodeoxycholate induces TRAIL-Receptor 2/DR5 expression and apoptosis. Journal of biological chemistry, 276(42), 38610–38618.
  • Ip, S.W., et al., 2008. The role of mitochondria in bee venom-induced apoptosis in human breast cancer MCF7. In vivo (Athens, Greece), 22(2), 237–246.
  • Jo, M., et al., 2012. Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicology and applied pharmacology, 258(1), 72–81.
  • Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227(5259), 680–685.
  • Lee, H.L., et al., 2015. Bee venom inhibits growth of human cervical tumors in mice. Oncotarget, 6(9), 7280–7292.
  • Mayer, B. and Oberbauer, R., 2003. Mitochondrial regulation of apoptosis. Physiology, 18(3), 89–94.
  • Milutinović, M., et al., 2015. The molecular mechanisms of apoptosis induced by Allium flavum L. and synergistic effects with new-synthesized Pd(II) complex on colon cancer cells. Journal of food biochemistry, 39(3), 238–250.
  • Mosmann, T., 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of immunological methods, 65(1–2), 55–63.
  • Ozoren, N. and El-Deiry, W.S., 2002. Defining characteristics of types I and II apoptotic cells. Neoplasia, 4(6), 551–557.
  • Premratanachai, P. and Chanchao, C., 2014. Review of the anticancer activities of bee products. Asian Pacific Journal of Tropical Biomedicine, 4(5), 337–344.
  • Schmittgen, T.D. and Livak, K.J., 2008. Analyzing real-time PCR data by the comparative C(T) method. Nature protocols, 3(6), 1101–1108.
  • Son, D.J., et al., 2007. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacology and therapeutics, 115, 246–270.
  • Torre, L.A., et al., 2015. Global cancer statistics, 2012. CA: a cancer journal for clinicians, 65(2), 87–108.
  • Zheng, J., et al., 2015. Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B. Oncotarget, 6(42), 44437–44451.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.