Advanced search
Publication Cover
Toxin Reviews Volume 40, 2021 - Issue 4
Submit an article Journal homepage
72
Views
4
CrossRef citations to date
0
Altmetric
Research Article

The protective effect of prenatally administered vitamin E on behavioral alterations in an animal model of autism induced by valproic acid

Ahmad Alinaghi Langaria Student Research Committee, Kerman University of Medical Sciences, Kerman, IranView further author information
,
Akram Nezhadib Neuroscience Research Center, Aja University of Medical Sciences, Tehran, IranView further author information
,
Halimeh Kameshkia Student Research Committee, Kerman University of Medical Sciences, Kerman, IranView further author information
,
Sobhan Mohammadi Jorjafkic Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranView further author information
,
Yasamin Mirhosseinic Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranView further author information
,
Mohammad Khaksarid Endocrinology and Metabolism Research, and Physiology Research Centers, Kerman University of Medical Sciences, Kerman, IranView further author information
,
Manzumeh Shamsi Meymandic Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranView further author information
&
Masoumeh Nozarie Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranCorrespondence[email protected] [email protected]
View further author information
 show all
Pages 676-680 | Received 20 Jan 2020, Accepted 22 Mar 2020, Published online: 13 Apr 2020

References

  • Abdella, E.M., et al., 2014. Protective role of vitamin E against valproic acid-induced cytogenotoxicity and hepatotoxicity in mice. The journal of basic & applied zoology, 67 (4), 127–139.
  • Abidi, P., Leers-Sucheta, S., and Azhar, S., 2004. Suppression of steroidogenesis and activator protein-1 transcription factor activity in rat adrenals by vitamin e deficiency-induced chronic oxidative stress. The journal of nutritional biochemistry, 15 (4), 210–219.
  • Adachi, K., Izumi, M., and Mitsuma, T., 1999. Effect of vitamin E deficiency on rat brain monoamine metabolism. Neurochemical research, 24 (10), 1307–1311.
  • Aktaş, A., et al., 2010. The effects of valproic acid on renal corpuscle of pregnant rats and protective role of folic acid and vitamin E. African journal of biotechnology, 9 (34), 5605–5610.
  • Al Deeb, S., et al., 2000. Vitamin E decreases valproic acid induced neural tube defects in mice. Neuroscience letters, 292 (3), 179–182.
  • Bambini-Junior, V., et al., 2011. Animal model of autism induced by prenatal exposure to valproate: behavioral changes and liver parameters. Brain research, 1408, 8–16.
  • Baran, Ö. P., Yıldırım, A., and Akkuş, M., 2004. The Protective Role of Folic Acid and Vitamin E Against Toxical Effects of Valproic Acid on Liver Tissue During Period of Gestation. Dicle. Tip. Dergisi, 31 (4), 17–23.
  • Baran, Ö., Nergiz, Y., and Tuncer, M.C., 2006. The effects of valporic acid, vitamin E and folic acid on ribs of rat fetuses in the prenatal period. Annals of anatomy – anatomischer anzeiger, 188 (2), 117–125.
  • Benger, M., Kinali, M., and Mazarakis, N.D., 2018. Autism spectrum disorder: prospects for treatment using gene therapy. Molecular autism, 9 (1), 39.
  • Bjørklund, G., et al., 2019. The role of vitamins in autism spectrum disorder: what do we know? Journal of molecular neuroscience, 67 (3), 373–387.
  • Gohil, K., et al., 2003. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in α-tocopherol transfer protein. Free radical biology and medicine, 35 (11), 1343–1354.
  • Graf, W., et al., 1998. Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics, 29 (04), 195–201.
  • Hsieh, C.-L., et al., 2014. Resveratrol and vitamin E rescue valproic acid-induced teratogenicity: the mechanism of action. Clinical and experimental pharmacology and physiology, 41 (3), 210–219.
  • Huang, H.S., et al., 1996. Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes. Toxicology, 112 (1), 69–85.
  • Li, X., et al., 2009. Elevated immune response in the brain of autistic patients. Journal of Neuroimmunology, 207 (1–2), 111–116.
  • Mabunga, D.F.N., et al., 2015. Exploring the Validity of Valproic Acid Animal Model of Autism. Experimental neurobiology, Korean society for brain and neural science, 24 (4), 285–300.
  • Mohammadi, S., et al., 2020. Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of NMDA receptor function. Psychopharmacology, springer berlin heidelberg, 237 (1), 199–110.
  • Nazeri, M., et al., 2015. Psychological or physical prenatal stress differentially affects cognition behaviors. Physiology & behavior, 142, 155–160.
  • Okura, Y., et al., 2009. Dietary vitamin E deficiency increases anxiety-related behavior in rats under stress of social isolation. BioFactors, 35 (3), 273–278.
  • Principi, N., and Esposito, S., 2020. Vitamin D deficiency during pregnancy and autism spectrum disorders development. Frontiers in psychiatry, 10, 987.
  • Raghavan, R., et al., 2018. Maternal multivitamin intake, plasma folate and vitamin B 12 levels and autism spectrum disorder risk in offspring. Paediatric and perinatal epidemiology, 32 (1), 100–111.
  • Roullet, F.I., et al., 2013. In utero exposure to valproic acid and autism – a current review of clinical and animal studies. Neurotoxicology and teratology, 36, 47–56.
  • Saeedi Goraghani, M., et al., 2019. Behavioral consequences of simultaneous postnatal exposure to MK-801 and static magnetic field in male wistar rats. Neuroscience letters, 701, 77–83.
  • Schneider, T., and Przewłocki, R., 2005. Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology, 30 (1), 80–89.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.