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An overview on cyanobacterial blooms and toxins production: their occurrence and influencing factors

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Pages 326-346 | Received 26 Jan 2020, Accepted 24 Oct 2020, Published online: 05 Nov 2020

References

  • Abreu, V.A.C., et al., 2018. Genomic and genotypic characterization of cylindrospermopsis raciborskii: toward an intraspecific phylogenetic evaluation by comparative genomics. Frontiers in Microbiology, 9, 306.
  • Abu, A.M., et al., 2016. Influence of environmental parameters on toxic cyanobacterial bloom occurrence in a Lake of Bangladesh. Rendiconti Lincei-Scienze Fisiche E Naturali, 27 (3), 473–481.
  • Adesalu, T., and Ikegwu, N.D., 2010. Cyanobacteria of a Tropical Lagoon, Nigeria. Nature and science, 8, 77–82.
  • Affan, A., et al., 2015. Effect of environmental factors on cyanobacterial abundance and cyanotoxins production in natural and drinking water, bangladesh. Pakistan journal of biological sciences, 18 (2), 50–58.
  • Affan, M., et al., 2016. Influence of environmental parameters on toxic cyanobacterial bloom occurrence in a Lake of Bangladesh. Rendiconti Lincei-Scienze Fisiche E Naturali, 27 (3), 473–481. doi: https://doi.org/10.1007/s12210-016-0502-1
  • Ahmed, M.S., Hiller, S., and Luckas, B., 2008. Microcystis aeruginosa bloom and the occurrence of microcystins (heptapeptides hepatotoxins) from an aquaculture pond in Gazipur. Bangladesh. Turkish journal of fisheries and aquatic sciences, 8 (1), 37–41.
  • Ajuzie, C., 2012. A first survey of phytoplankton community richness in lamingo reservoir, jos, Igeria: a wake-up call for the continuous monitoring of microalgae in surface waters serving as drinking water sources in Igeria. New York science journal 1554-0200, 5, 1–8.
  • Akcaalan, R., et al., 2014. First report of cylindrospermopsin production by two cyanobacteria (dolichospermum mendotae and chrysosporum ovalisporum) in Lake Iznik, Turkey. Toxins, 6 (11), 3173–3186.
  • Albay, M., et al., 2003. Depth profiles of cyanobacterial hepatotoxins (microcystins) in three Turkish freshwater lakes. Hydrobiologia, 505 (1-3), 89–95.
  • Albay, M., Matthiensen, A., and Codd, G.A., 2005. Occurrence of toxic blue-green algae in the Kucukcekmece Lagoon (Istanbul, Turkey). Environmental Toxicology, 20 (3), 277–284.
  • Almanza, V., et al., 2016. Occurrence of toxic blooms of Microcystis aeruginosa in a central Chilean (36 degrees Lat. S) urban lake. Revista chilena de historia natural, 89 (1), 8.
  • Alosman, M., et al., 2020. The lethal effects and determinants of microcystin-LR on heart: a mini review. Toxin reviews, 1 –10.
  • Anderson, D.M., 1994. Red tides. Scientific American, 271 (2), 62–68.
  • Andrinolo, D., et al., 2007. Occurrence of Microcystis aeruginosa and microcystins in Río de la Plata river (Argentina). Acta Toxicológica argentina, 15 (1), 8–14.
  • Antunes, J.T., Leão, P.N., and Vasconcelos, V.M., 2015. Cylindrospermopsis raciborskii: review of the distribution, phylogeography, and ecophysiology of a global invasive species. Frontiers in Microbiology, 6, 473.
  • Azevedo, S.M.F.O., et al., 2002. Human intoxication by microcystins during renal dialysis treatment in Caruaru-Brazil. Toxicology, 181-182, 441–446.
  • Bakker, E.S., and Hilt, S., 2016. Impact of water-level fluctuations on cyanobacterial blooms: options for management. Aquatic Ecology, 50 (3), 485–498.
  • Baldia, S.F., et al., 2003. Microcystin production during algal bloom occurrence in Laguna de Bay, the Philippines. Fisheries Science, 69 (1), 110–116.
  • Ballot, A., et al., 2014. Diversity of cyanobacteria and cyanotoxins in Hartbeespoort Dam. Marine and Freshwater Research, 65 (2), 175–189.
  • Bartlett, S.L., et al., 2018. Spatial analysis of toxic or otherwise bioactive cyanobacterial peptides in Green Bay, Lake Michigan. Journal of great lakes research, 44 (5), 924–933.
  • Beattie, K.A., Kaya, K., and Codd, G.A., 2000. The cyanobacterium Nodularia in PCC 7804, of freshwater origin, produces L-Har(2) nodularin. Phytochemistry, 54 (1), 57–61.
  • Berry, J.P., and Lind, O., 2010. First evidence of "paralytic shellfish toxins" and cylindrospermopsin in a Mexican freshwater system, Lago Catemaco, and apparent bioaccumulation of the toxins in "tegogolo" snails (Pomacea patula catemacensis). Toxicon, 55 (5), 930–938.
  • Bishop, C.T., Anet, E.F., and Gorham, P.R., 1959. Isolation and identification of the fast-death factor in Microcystis aeruginosa NRC-1. Canadian journal of biochemistry and physiology, 37 (3), 453–471.
  • Bittencourt-Oliveira, M.D., et al., 2014. Cyanobacteria, microcystins and cylindrospermopsin in public drinking supply reservoirs of Brazil. Anais da academia brasileira de ciencias, 86 (1), 297–309.
  • Bormans, M., Ford, P.W., and Fabbro, L., 2004. Spatial and temporal variability in cyanobacterial populations controlled by physical processes. Journal of plankton research, 27 (1), 61–70.
  • Bouaicha, N., et al., 2019. Structural diversity, characterization and toxicology of microcystins. Toxins, 11 (12), 714.
  • Bouma-Gregson, K., Kudela, R.M., and Power, M.E., 2018. Widespread anatoxin-a detection in benthic cyanobacterial mats throughout a river network. PLoS ONE, 13 (5), e0197669.
  • Bouvy, M., et al., 2000. Occurrence of cylindrospermopsis (Cyanobacteria) in 39 Brazilian tropical reservoirs during the 1998 drought. Aquatic microbial ecology, 23 (1), 13–27.
  • Briand, J.F., et al., 2002. Environmental context of Cylindrospermopsis raciborskii (Cyanobacteria) blooms in a shallow pond in France. Water research, 36 (13), 3183–3192.
  • Brient, L., et al., 2009. First Occurrence of Cylindrospermopsin in Freshwater in France. Environmental toxicology, 24 (4), 415–420.
  • Bryant, D. A., 1994. The molecular biology of cyanobacteria. Dordrecht, Kluwer Academic Publishers.
  • Buratti, F.M., et al., 2017. Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation. Archives of toxicology, 91 (3), 1049–1130.
  • Caldwell, D.E., and Caldwell, S.J., 1978. A Zoogloea sp. associated with blooms of Anabaena flos-aquae. Canadian journal of microbiology, 24 (8), 922–931.
  • Campos, V., et al., 1999. Microcystin in cyanobacterial blooms in a Chilean lake. Systematic and applied microbiology, 22 (2), 169–173.
  • Cao, L., et al., 2019a. Effects of microcystin-LR on the microstructure and inflammation-related factors of jejunum in mice. Toxins, 11 (9), 482.
  • Cao, L., et al., 2019b. A review of cardiovascular toxicity of microcystins. Toxins, 11 (9), 507.
  • Carmichael, W.W., 2001. Health effects of toxin-producing cyanobacteria: the CyanoHABs. Human & ecological risk assessment., 7 (5), 1393–1407.
  • Carmichael, W.W., et al., 1988. Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green algae). Toxicon, 26 (11), 971–973.
  • Carmichael, W.W., et al., 2001. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environmental health perspectives, 109 (7), 663–668.
  • Carmichael, W.W., and Boyer, G.L., 2016. Health impacts from cyanobacteria harmful algae blooms: Implications for the North American Great Lakes. Harmful algae, 54, 194–212.
  • Carmichael, W.W., and Li, R., 2006. Cyanobacteria toxins in the Salton Sea. Saline systems, 2, 5.
  • Carneiro, R.L., et al., 2012. Co-occurrence of microcystin and microginin congeners in Brazilian strains of Microcystis sp. FEMS microbiology ecology, 82 (3), 692–702.
  • Cazenave, J., et al., 2005. Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis: A field and laboratory study. Aquatic toxicology, 75 (2), 178–190. doi:
  • Chaffin, J.D., et al., 2018. Accuracy of data buoys for measurement of cyanobacteria, chlorophyll, and turbidity in a large lake (Lake Erie, North America): implications for estimation of cyanobacterial bloom parameters from water quality sonde measurements. Environmental science and pollution research, 25 (25), 25175–25189.
  • Chen, K., Allen, J., and Lu, J., 2017. Community structures of phytoplankton with emphasis on toxic cyanobacteria in an ohio inland lake during bloom season. Journal of water resource and protection, 09 (11), 1229–1299.
  • Chen, Y., Shen, D.F., and Fang, D.J., 2013. Nodularins in poisoning. Clinica chimica acta, 425, 18–29.
  • Chia, A.M., et al., 2009. A survey for the presence of microcystins in aquaculture ponds in Zaria, Northern-Nigeria: Possible public health implication. African journal of biotechnology, 8 (22), 6282–6289.
  • Chiswell, R.K., et al., 1999. Stability of cylindrospermopsin, the toxin from the cyanobacterium, Cylindrospermopsis raciborskii: Effect of pH, temperature, and sunlight on decomposition. Environmental toxicology, 14 (1), 155–161.
  • Chorus, I., 1999. and., and Bartram, J., Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management. London: F & FN Spon.
  • Costa, I.A., et al., 2006. Occurrence of toxin-producing cyanobacteria blooms in a Brazilian semiarid reservoir. Brazilian journal of biology, 66 (1B), 211–219.
  • Davis, T.W., et al., 2009. The effects of temperature and nutrients on the growth and dynamics of toxic and non-toxic strains of Microcystis during cyanobacteria blooms. Harmful algae, 8 (5), 715–725.
  • Dawah, A., et al., 2015. Influence of alum on cyanobacterial blooms and water quality of earthen fish ponds. Environmental science and pollution research international, 22 (21), 16502–16513.
  • Dawson, R.M., 1998. The toxicology of microcystins. Toxicon , 36 (7), 953–962.
  • de la Escalera, G.M., et al., 2017. Dynamics of toxic genotypes of Microcystis aeruginosa complex (MAC) through a wide freshwater to marine environmental gradient. Harmful algae, 62, 73–83.
  • Dillenberg, H.O., and Dehnel, M.K., 1960. Toxic waterbloom in Saskatchewan, 1959. Canadian medical association journal, 83, 1151–1154.
  • Dokulil, M.T., and Teubner, K., 2000. Cyanobacterial dominance in lakes. Hydrobiologia, 438 (1/3), 1–12.
  • Dolman, A.M., et al., 2012. Cyanobacteria and cyanotoxins: the influence of nitrogen versus phosphorus. PloS ONE, 7 (6), e38757.
  • Donald, D.B., et al., 2011. Comparative effects of urea, ammonium, and nitrate on phytoplankton abundance, community composition, and toxicity in hypereutrophic freshwaters. Limnology and oceanography, 56 (6), 2161–2175.
  • Donati, C., et al., 1994. Microcystin-LR adsorption by powdered activated carbon. Water research, 28 (8), 1735–1742. doi: https://doi.org/http://dx.doi.org/10.1016/0043-1354(94)90245-3
  • Drobac, D., et al., 2017. Microcystin accumulation and potential effects on antioxidant capacity of leaves and fruits of Capsicum annuum. Journal of toxicology and environmental health, Part A, 80 (3), 145–154.
  • Echenique-Subiabre, I., et al., 2018. Spatial and temporal variability in the development and potential toxicity of phormidium biofilms in the Tarn River, France. Toxins, 10 (10), 418.
  • Edwards, L.J., Wilson, K., and Veitch, M.G., 2018. An outbreak of paralytic shellfish poisoning in Tasmania. Communicable diseases intelligence 42, S2209-6051(18)00004–0.
  • Ehrenhaus, C., and Susana, V.M., 2006. Changes in the phytoplankton of lake planetario after a restoration process. Darwiniana, 44 (2), 319–328.
  • Elizabet, F.M., et al., 2016. Occurrence and toxicity of Microcystis aeruginosa (Cyanobacteria) in the Parana River, downstream of the Yacyreta dam (Argentina). Revista de biologia tropical, 64 (1), 203–211.
  • El-Kassas, H.Y., Nassar, M.Z.A., and Gharib, S.M., 2016. Study of phytoplankton in a natural hypersaline lagoon in a desert area (Bardawil Lagoon in Northern Sinai, Egypt). Rendiconti lincei, 27 (3), 483–493.
  • El-Shehawy, R., et al., 2012. Global warming and hepatotoxin production by cyanobacteria: what can we learn from experiments? Water research, 46 (5), 1420–1429.
  • EPA 2006., Toxicological reviews of cyanobacterial toxins: cylindrospermopsin (external review draft). Washington: United States Environmental Protection Agency.
  • Fahnenstiel, G.L., et al., 2008. Microcystin concentrations and cell quotas in Saginaw Bay, Lake Huron. Aquatic ecosystem health & management, 11 (2), 190–195.
  • Falconer, I.R., 1999. An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water. Environmental toxicology, 14 (1), 5–12.
  • Falconer, I. R., 2005. Cyanobacterial toxins of drinking water supplies: cylindrospermopsins and microcystins. Boca Raton: CRC.
  • Fastner, J., et al., 1999. Characterization and diversity of microcystins in natural blooms and strains of the genera Microcystis and Planktothrix from German freshwaters. Fundamental and applied limnology, 145 (2), 147–163.
  • Fastner, J., et al., 2018. Fatal Neurotoxicosis in dogs associated with tychoplanktic, anatoxin-a producing tychonema sp. in Mesotrophic Lake Tegel, Berlin. Toxins, 10 (2), 60.
  • Fawell, J., et al., 1993. Blue-green algae and their toxins: analysis, toxicity, treatment, and environmental control. Water supply, 11 (3–4), 109–121.
  • Fawell, J.K., et al., 1999. The toxicity of cyanobacterial toxins in the mouse: II anatoxin-a. Human & experimental toxicology, 18 (3), 168–173.
  • Feng, H., et al., 2019. Identification and characterization of the dominant Microcystis sp. cyanobacteria detected in Lake Dong Ting. Journal of toxicology and environmental health, part A, 82 (22), 1143–1150.
  • Figueredo, C.C., and Giani, A., 2009. Phytoplankton community in the tropical lake of Lagoa Santa (Brazil): Conditions favoring a persistent bloom of Cylindrospermopsis raciborskii. Limnologica, 39 (4), 264–272.
  • Fonseca, J.R., et al., 2015. Cyanobacterial occurrence and detection of microcystins and saxitoxins in reservoirs of the Brazilian semi-arid. Acta limnologica brasiliensia, 27 (1), 78–92.
  • Genuario, D.B., et al., 2013. Characterization of freshwater benthic biofilm-forming hydrocoryne (cyanobacteria) isolates from Antarctica. Journal of phycology, 49 (6), 1142–1153.
  • Ghobrial, M.G., Nassr, H.S., and Kamil, A.W., 2015. Bioactivity effect of two macrophyte extracts on growth performance of two bloom-forming cyanophytes. The Egyptian journal of aquatic research, 41 (1), 69–81. doi:
  • Giannuzzi, L., et al., 2011. An acute case of intoxication with cyanobacteria and cyanotoxins in recreational water in Salto Grande Dam, Argentina. Marine drugs, 9 (11), 2164–2175.
  • Gobler, C.J., et al., 2016. The dual role of nitrogen supply in controlling the growth and toxicity of cyanobacterial blooms. Harmful algae, 54, 87–97.
  • Gomaa, M.N., et al., 2014. Oscillatoria winter bloom in the Nile River. Phykos, 2 (44), 65–71.
  • Gomes, L.N., et al., 2012. Association between biotic and abiotic parameters and the occurrence of cyanobacteria in a Brazilian reservoir. Environmental monitoring and assessment, 184 (8), 4635–4645.
  • Gondwe, M.J., Guildford, S.J., and Hecky, R.E., 2008. Planktonic nitrogen fixation in Lake Malawi/Nyasa. Hydrobiologia, 596 (1), 251–267.
  • Gorham, T., et al., 2017. Ten-year survey of cyanobacterial blooms in Ohio's waterbodies using satellite remote sensing. Harmful algae, 66, 13–19.
  • Greer, B., et al., 2016. A validated UPLC–MS/MS method for the surveillance of ten aquatic biotoxins in European brackish and freshwater systems. Harmful algae, 55, 31–40. doi:
  • Grizzetti, B., Bouraoui, F., and Aloe, A., 2012. Changes of nitrogen and phosphorus loads to European seas. Global change biology, 18 (2), 769–782.
  • Gugger, M., et al., 2005. First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon, 45 (7), 919–928.
  • Haande, S., et al., 2011. Phytoplankton dynamics and cyanobacterial dominance in Murchison Bay of Lake Victoria (Uganda) in relation to environmental conditions. Limnologica, 41 (1), 20–29.
  • Hamill, K.D., 2001. Toxicity in benthic freshwater cyanobacteria (blue-green algae): first observations in New Zealand. New Zealand journal of marine and freshwater research, 35 (5), 1057–1059.
  • Havens, K. E., 2008. Cyanobacteria blooms: effects on aquatic ecosystems. Adv Exp Med Biol, 619, 733–747. doi: https://doi.org/10.1007/978-0-387-75865-7_33. PMID: 18461790.
  • Hawkins, P.R., et al., 1985. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir. Applied and environmental microbiology, 50 (5), 1292–1295.
  • Hitzfeld, B.C., et al., 2000. Toxin production in cyanobacterial mats from ponds on the McMurdo Ice Shelf, Antarctica. Toxicon , 38 (12), 1731–1748.
  • Hoeger, S.J., et al., 2004. Occurrence and elimination of cyanobacterial toxins in two Australian drinking water treatment plants. Toxicon, 43 (6), 639–649.
  • Hu, C., et al., 2016. Relative importance of Microcystis abundance and diversity in determining microcystin dynamics in Lake Erie coastal wetland and downstream beach water. Journal of applied microbiology, 120 (1), 138–151.
  • Humpage, A.R., et al., 2000. Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutation research, 472 (1-2), 155–161.
  • Huszar, V.L.M., et al., 2000. Cyanoprokaryote assemblages in eight productive tropical Brazilian waters. Hydrobiologia, 424 (1), 67–77.,
  • IARC 2010. Ingested nitrate and nitrite, and Cyanobacterial peptide toxins. World Health Organization, International agency for research on cancer. Lyon, France: IARC.
  • Jacoby, J.M., et al., 2000. Environmental factors associated with a toxic bloom of Microcystis aeruginosa. Canadian journal of fisheries and aquatic sciences, 57 (1), 231–240.
  • Jahan, R., et al., 2010. Study of harmful algal blooms in a eutrophic pond, Bangladesh. Environmental monitoring and assessment, 170 (1-4), 7–21.
  • Jankowiak, J., et al., 2019. Deciphering the effects of nitrogen, phosphorus, and temperature on cyanobacterial bloom intensification, diversity, and toxicity in western Lake Erie. Limnology and oceanography, 64 (3), 1347–1370.
  • Ji, X., et al., 2017. Competition between cyanobacteria and green algae at low versus elevated CO2: who will win, and why? Journal of experimental botany, 68 (14), 3815–3828.
  • Jia, Y., et al., 2018. Heavy metal migration and risk transference associated with cyanobacterial blooms in eutrophic freshwater. Science of the total environment., 613-614, 1324–1330.
  • Jochimsen, E.M., et al., 1998. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. New England journal of medicine, 338 (13), 873–878.
  • Johnk, K.D., et al., 2008. Summer heatwaves promote blooms of harmful cyanobacteria. Global change biology, 14 (3), 495–512.
  • Joung, S.H., et al., 2002. Water Quality and Cyanobacterial Anatoxin-a Concentration in Daechung Reservoir. Korean journal of ecology and environment, 35 (5), 257–265.
  • Joung, S.H., et al., 2011. Correlations between environmental factors and toxic and non-toxic Microcystis dynamics during bloom in Daechung Reservoir, Korea. Harmful algae, 10 (2), 188–193.
  • Jungblut, A.D., et al., 2006. Characterization of microcystin production in an Antarctic cyanobacterial mat community. Toxicon, 47 (3), 271–278.
  • Kaneko, T., et al., 1996. Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA research, 3 (3), 109–136.
  • Kanoshina, I., Lips, U., and Leppänen, J.-M., 2003. The influence of weather conditions (temperature and wind) on cyanobacterial bloom development in the Gulf of Finland (Baltic Sea). Harmful algae, 2 (1), 29–41.
  • Kiss, T., et al., 2002. Membrane effects of toxins isolated from a cyanobacterium, Cylindrospermopsis raciborskii, on identified molluscan neurones. Comparative biochemistry and physiology part C: toxicology & pharmacology, 131 (2), 167–176.
  • Kleinteich, J., et al., 2012. Temperature-related changes in polar cyanobacterial mat diversity and toxin production. Nature climate change, 2 (5), 356–360.
  • Kleinteich, J., et al., 2014. Diversity of toxin and non-toxin containing cyanobacterial mats of meltwater ponds on the Antarctic Peninsula: a pyrosequencing approach. Antarctic science, 26 (5), 521–532.
  • Koker, L., et al., 2017. Distribution of toxic cyanobacteria and cyanotoxins in turkish waterbodies. Journal of environmental protection and ecology, 18 (2), 425–432.
  • Konst, H., et al., 1965. Symptoms and pathology produced by toxic Microcystis aeruginosa NRC-1 in laboratory and domestic animals. Canadian journal of comparative medicine and veterinary science, 29 (9), 221–228.
  • Lapointe, B.E., Herren, L.W., and Paule, A.L., 2017. Septic systems contribute to nutrient pollution and harmful algal blooms in the St. Lucie Estuary, Southeast Florida, USA. Harmful algae, 70, 1–22.
  • Ledreux, A., et al., 2010. Evidence for saxitoxins production by the cyanobacterium Aphanizomenon gracile in a French recreational water body. Harmful algae, 10 (1), 88–97.
  • Lee, C., et al., 2015. Associations among Human-Associated Fecal Contamination, Microcystis aeruginosa, and Microcystin at Lake Erie Beaches. International journal of environmental research and public health, 12 (9), 11466–11485.
  • Lei, L.M., et al., 2014. Occurrence and dominance of Cylindrospermopsis raciborskii and dissolved cylindrospermopsin in urban reservoirs used for drinking water supply, South China. Environmental monitoring and assessment, 186 (5), 3079–3090.
  • Leon-Munoz, J., et al., 2018. Hydroclimatic conditions trigger record harmful algal bloom in western Patagonia (summer 2016). Scientific reports, 8, 1330.
  • Levesque, B., et al., 2014. Prospective study of acute health effects in relation to exposure to cyanobacteria. Science of the total environment, 466, 397–403.
  • Li, H., et al., 2019. High-throughput DNA sequencing reveals the dominance of pico- and other filamentous cyanobacteria in an urban freshwater Lake. Science of the total environment, 661, 465–480.
  • Li, X.Y., and Ma, J.G., 2017. Mitochondria and lysosomes play a key role in HepG2 cell apoptosis induced by microcystin-LR. Toxin reviews, 36 (1), 63–72.
  • Liu, P., et al., 2018. Isolation, molecular identification, and characterization of a unique toxic cyanobacterium Microcystis sp. found in Hunan Province. Journal of toxicology and environmental health. Part A, 81 (21), 1142–1149.
  • Llewellyn, L.E., 2006. Saxitoxin, a toxic marine natural product that targets a multitude of receptors. Natural product reports, 23 (2), 200–222.
  • Low-Décarie, E., Fussmann, G.F., and Bell, G., 2011. The effect of elevated CO2 on growth and competition in experimental phytoplankton communities. Global change biology, 17 (8), 2525–2535.
  • Lu, J., et al., 2019. Nitrogen-phosphorus-associated metabolic activities during the development of a cyanobacterial bloom revealed by metatranscriptomics. Scientific reports, 9 (1), 2480.
  • Lu, L., et al., 2018. Contribution of heterotrophic bacterioplankton to cyanobacterial bloom formation in a tributary backwater area of the Three Gorges Reservoir, China. Environmental science and pollution research, 25 (27), 27402–27412.
  • Lukac, M., and Aegerter, R., 1993. Influence of trace metals on growth and toxin production of Microcystis aeruginosa. Toxicon , 31 (3), 293–305.
  • Ma, J.G., and Li, X.Y., 2017. MicroRNAs are involved in the toxicity of microcystins. Toxin reviews, 36 (2), 165–175.
  • Ma, J.G., and Li, X.Y., 2018. High-throughput sequencing provides an insight into the hepatotoxicity mechanism of MC-LR in HepG2 cells. Toxin Reviews, 37 (1), 1–10.
  • MacKintosh, C., et al., 1990. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS letters, 264 (2), 187–192.
  • Mancini, M., et al., 2010. Cianobacterial bloom and animal mass mortality in a reservoir from Central Argentina. Brazilian journal of biology, 70 (3 suppl), 841–845.
  • Masango, M.G., et al., 2010. Assessment of microcystis bloom toxicity associated with wildlife mortality in the Kruger National Park, South Africa. Journal of Wildlife diseases, 46 (1), 95–102.
  • Massey, I.Y., et al., 2018a. Exposure routes and health effects of microcystins on animals and humans: A mini-review. Toxicon, 151, 156–162.
  • Massey, I.Y., et al., 2020a. A mini-review on detection methods of microcystins. Toxins, 12 (10), 641.
  • Massey, I.Y., and Yang, F., 2020b. A mini review on microcystins and bacterial degradation. Toxins, 12 (4), 268.
  • Massey, I.Y., Zhang, X., and Yang, F., 2018b. Importance of bacterial biodegradation and detoxification processes of microcystins for environmental health. Journal of toxicology and environmental health, part B, 21 (6-8), 313–357.
  • McGregor, G.B., et al., 2012. First report of a toxic Nodularia spumigena (Nostocales/ Cyanobacteria) bloom in sub-tropical Australia. I. Phycological and public health investigations. International journal of environmental research and public health, 9 (7), 2396–2411.
  • McGregor, G.B., and Fabbro, L.D., 2000. Dominance of Cylindrospermopsis raciborskii (Nostocales, Cyanoprokaryota) in Queensland tropical and subtropical reservoirs: Implications for monitoring and management. Lakes and reservoirs: research and management, 5 (3), 195–205.
  • McGregor, G.B., and Sendall, B.C., 2017. Iningainema pulvinus gen nov., sp nov (Cyanobacteria, Scytonemataceae) a new nodularin producer from Edgbaston Reserve, north-eastern Australia. Harmful algae, 62, 10–19.
  • Meriluoto, J., et al., 2017. Toxic cyanobacteria and cyanotoxins in European waters - recent progress achieved through the CYANOCOST Action and challenges for further research. Advances in oceanography and limnology, 8 (1), 161–178.
  • Merino-Ibarra, M., et al., 2008. Physical and chemical limnology of a wind-swept tropical highland reservoir. Aquatic ecology, 42 (3), 335–345.
  • Metcalf, J.S., et al., 2012. Cyanotoxins in desert environments may present a risk to human health. Science of the total environment., 421-422, 118–123.
  • Mohamed, Z.A., 2001. Accumulation of cyanobacterial hepatotoxins by Daphnia in some Egyptian irrigation canals. Ecotoxicology and environmental safety, 50 (1), 4–8.
  • Mohamed, Z.A., 2002. Allelopathic activity of Spirogyra sp.: stimulating bloom formation and toxin production by Oscillatoria agardhii in some irrigation canals, Egypt. Journal of plankton research, 24 (2), 137–141.
  • Mohamed, Z.A., 2007. First report of toxic Cylindrospermopsis raciborskii and Raphidiopsis mediterranea (Cyanoprokaryota) in Egyptian fresh waters. FEMS microbiology ecology, 59 (3), 749–761.
  • Mohamed, Z.A., et al., 2015. Occurrence of cyanobacteria and microcystin toxins in raw and treated waters of the Nile River, Egypt: implication for water treatment and human health. Environmental science and pollution research, 22 (15), 11716–11727.
  • Mohamed, Z.A., El-Sharouny, H.M., and Ali, W.S.M., 2006. Microcystin production in benthic mats of cyanobacteria in the Nile River and irrigation canals, Egypt. Toxicon , 47 (5), 584–590.
  • Mohamed, Z.A., and Hussein, A.A., 2006. Depuration of microcystins in tilapia fish exposed to natural populations of toxic cyanobacteria: a laboratory study. Ecotoxicology and environmental safety, 63 (3), 424–429.
  • Moisander, P.H., McClinton, E., and Paerl, H.W., 2002. Salinity effects on growth, photosynthetic parameters, and nitrogenase activity in estuarine planktonic cyanobacteria. Microbial ecology, 43 (4), 432–442.
  • Molot, L.A., et al., 2014. A novel model for cyanobacteria bloom formation: the critical role of anoxia and ferrous iron. Freshwater biology, 59 (6), 1323–1340.
  • Moreno-Ostos, E., et al., 2009. The influence of wind-induced mixing on the vertical distribution of buoyant and sinking phytoplankton species. Aquatic ecology, 43 (2), 271–284.
  • Mowe, M.A.D., et al., 2015. Tropical cyanobacterial blooms: a review of prevalence, problem taxa, toxins and influencing environmental factors. Journal of limnology, 73 (AoP), 205–224.
  • Murray, S.A., Mihali, T.K., and Neilan, B.A., 2011. Extraordinary conservation, gene loss, and positive selection in the evolution of an ancient neurotoxin. Molecular biology and evolution, 28 (3), 1173–1182.
  • Nchabeleng, T., et al., 2014. Microcystin-LR equivalent concentrations in fish tissue during a post-bloom Microcystis exposure in Loskop Dam. African journal of aquatic science, 39 (4), 459–466.
  • Ndlela, L.L., et al., 2016. An overview of cyanobacterial bloom occurrences and research in Africa over the last decade. Harmful algae, 60, 11–26.
  • Nicholson, B.C., and Burch, M.D., 2001. Evaluation of analytical methods for detection and quantification of cyanotoxins in relation to Australian drinking water guidelines. Available from http://www.health.gov.au/nhmrc/publications/synopses/eh19syn.htm [accessed 14 January 2004].
  • Oberholster, P.J., et al., 2015. First report of an Anabaena Bory strain containing microcystin-LR in a freshwater body in Africa. African journal of aquatic science, 40 (1), 21–36.
  • Oberholster, P.J., and Botha, A.M., 2007. Use of PCR based technologies for risk assessment of a winter cyanobacterial bloom in Lake Midmar, South Africa. African journal of biotechnology, 6 (15), 1794–1805.
  • Oberholster, P.J., Botha, A.M., and Ashton, P.J., 2009. The influence of a toxic cyanobacterial bloom and water hydrology on algal populations and macroinvertebrate abundance in the upper littoral zone of Lake Krugersdrift, South Africa. Ecotoxicology, 18 (1), 34–46.
  • Oh, H.M., et al., 2000. Microcystin production by Microcystis aeruginosa in a phosphorus-limited chemostat. Applied and environmental microbiology, 66 (1), 176–179.
  • Oh, H.M., et al., 2001. Seasonal variation and indirect monitoring of microcystin concentrations in Daechung Reservoir, Korea. Applied and environmental microbiology, 67 (4), 1484–1489.
  • Ohtani, I., Moore, R.E., and Runnegar, M.T.C., 1992. Cylindrospermopsin - a potent hepatotoxin from the blue-green-alga Cylindrospermopsis-raciborskii. Journal of the American chemical society, 114 (20), 7941–7942.
  • Okogwu, O., and Ugwumba, O.A., 2009. Cyanobacteria abundance and its relationship to water quality in the Mid-Cross River floodplain, Nigeria. Revista de biología tropical, 57 (1-2), 33–43.
  • Omidi, A., Esterhuizen-Londt, M., and Pflugmacher, S., 2018. Still challenging: the ecological function of the cyanobacterial toxin microcystin - What we know so far. Toxin reviews, 37 (2), 87–105.
  • Osswald, J., et al., 2007. Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a. Environment international, 33 (8), 1070–1089.
  • Paerl, H.W., 1988. Nuisance phytoplankton blooms in coastal, estuarine, and inland waters. Limnology and oceanography, 33 (4_part_2), 823–843. 823847.
  • Paerl, H.W., et al., 2001. Harmful freshwater algal blooms, with an emphasis on cyanobacteria. The scientific world journal, 1, 76–113.
  • Paerl, H.W., et al., 2016. Mitigating cyanobacterial harmful algal blooms in aquatic ecosystems impacted by climate change and anthropogenic nutrients. Harmful algae, 54, 213–222. doi:
  • Paerl, H.W., and Huisman, J., 2008. Climate - Blooms like it hot. Science, 320 (5872), 57–58.
  • Paerl, H.W., and Huisman, J., 2009. Climate change: a catalyst for global expansion of harmful cyanobacterial blooms. Environmental microbiology reports, 1 (1), 27–37.
  • Paerl, H.W., and Otten, T.G., 2013. Harmful cyanobacterial blooms: causes, consequences, and controls. Microbial ecology, 65 (4), 995–1010.
  • Park, H., et al., 2001. D-Leu(1) microcystin-LR, a new microcystin isolated from waterbloom in a Canadian prairie lake. Toxicon, 39 (6), 855–862.
  • Park, H.D., et al., 1993. Hepatotoxin (microcystin) and neurotoxin (anatoxin-a) contained in natural blooms and strains of cyanobacteria from Japanese freshwaters. Natural toxins, 1 (6), 353–360.
  • Park, H.K., et al., 2000. Seasonal succession of toxic cyanobacteria and microcystins concentration in paldang reservoir. Algae, 15 (1), 29–35.
  • Park, Y., et al., 2017. Evaluating physico-chemical influences on cyanobacterial blooms using hyperspectral images in inland water, Korea. Water research., 126, 319–328.
  • Pavlova, V., et al., 2006. Contamination of some reservoirs and lakes in Republic of Bulgaria by microcystins. Acta hydrochimica et hydrobiologica, 34 (5), 437–441.
  • Pearson, L., et al., 2010. On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin. Marine drugs, 8 (5), 1650–1680.
  • Penn, K., et al., 2014. Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom. The ISME journal, 8 (9), 1866–1878.
  • Pick, F.R., 2016. Blooming algae: a Canadian perspective on the rise of toxic cyanobacteria. Canadian journal of fisheries and aquatic sciences, 73 (7), 1149–1158.
  • Prakash, S., Lawton, L.A., and Edwards, C., 2009. Stability of toxigenic Microcystis blooms. Harmful algae, 8 (3), 377–384.
  • Puddick, J., et al., 2015. Further characterization of glycine-containing microcystins from the McMurdo Dry Valleys of Antarctica. Toxins, 7 (2), 493–515.
  • Qi, Y., et al., 2015. Seven new microcystin variants discovered from a native Microcystis aeruginosa strain--unambiguous assignment of product ions by tandem mass spectrometry. Rapid communications in mass spectrometry: Rcm, 29 (2), 220–224.
  • Rabalais, N.N., et al., 2010. Dynamics and distribution of natural and human-caused hypoxia. Biogeosciences, 7 (2), 585–619.
  • Rakko, A., and Seppala, J., 2014. Effect of salinity on the growth rate and nutrient stoichiometry of two Baltic Sea filamentous cyanobacterial species. Estonian journal of ecology, 63 (2), 55–70.
  • Rapala, J., et al., 1997. Variation of microcystins, cyanobacterial hepatotoxins, in Anabaena spp. as a function of growth stimuli. Applied and environmental microbiology, 63 (6), 2206–2212.
  • Reichwaldt, E.S., Song, H., and Ghadouani, A., 2013. Effects of the Distribution of a Toxic Microcystis Bloom on the Small Scale Patchiness of Zooplankton. PLoS ONE, 8 (6), e66674.
  • Rejmánková, E., et al., 2011. Cyanobacterial blooms in Lake Atitlan, Guatemala. Limnologica, 41 (4), 296–302. doi:
  • Ren, Y., et al., 2014. Spatiotemporal distribution pattern of cyanobacteria community and its relationship with the environmental factors in Hongze Lake, China. Environmental monitoring and assessment, 186 (10), 6919–6933.
  • Ressom, R., et al., 1994., Health effects of toxic cyanobacteria ( blue-green algae). Canberra: National Health and Medical Research Council, Australian Government Publishing Service.
  • Rogers, R.S., and Rapoport, H., 1980. The pKa’s of saxitoxin. Journal of the American chemical society, 102 (24), 7335–7339.
  • Rucker, J., et al., 2007. Concentrations of particulate and dissolved cylindrospermopsin in 21 Aphanizomenon-dominated temperate lakes. Toxicon, 50 (6), 800–809.
  • Runnegar, M.T., et al., 1994. The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochemical and biophysical research communications, 201 (1), 235–241.
  • Sabart, M., et al., 2015. Co-occurrence of microcystin and anatoxin-a in the freshwater lake Aydat (France): Analytical and molecular approaches during a three-year survey. Harmful algae, 48, 12–20.
  • Sandrini, G., et al., 2016. Rapid adaptation of harmful cyanobacteria to rising CO2. Proceedings of the national academy of sciences of the United States of America, 113 (33), 9315–9320.
  • Schindler, D.W., et al., 2008. Eutrophication of lakes cannot be controlled by reducing nitrogen input: results of a 37-year whole-ecosystem experiment. Proceedings of the national academy of sciences of the United States of America, 105 (32), 11254–11258.
  • Schwabe, W., et al., 1988. Plasmids in toxic and nontoxic strains of the cyanobacterium Microcystis aeruginosa. Current microbiology, 17 (3), 133–137.,
  • Silveira, S.B., and Odebrecht, C., 2019. Effects of salinity and temperature on the growth, toxin production, and akinete germination of the cyanobacterium nodularia spumigena. Frontiers in marine science, 6, 339.
  • Sivonen, K., 1990. Effects of light, temperature, nitrate, orthophosphate, and bacteria on growth of and hepatotoxin production by Oscillatoria agardhii strains. Applied and environmental microbiology, 56 (9), 2658–2666.
  • Sivonen, K., and Jones, G., 1999. Cyanobacterial toxins. In: I. Chorus, J. Bartram, eds. Toxic cyanobacteria in water. A guide to their public health consequences, monitoring and management. London: E and FN Spon, 41–111.
  • Skulberg, O.M., et al., 1992. Investigations of a neurotoxic oscillatorialean strain (Cyanophyceae) and its toxin. Isolation and characterization of homoanatoxin-a. Environmental toxicology and chemistry, 11 (3), 321–329.
  • Spoof, L., and Catherine, A., 2017. Appendix 3. In: Meriluto, J., Spoof, L., Codd, G.A., Eds. Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis. Hoboken, NJ, USA: John Wiley & Sons, Ltd, 526–537.
  • Srivastava, A., et al., 2015. Status, alert system, and prediction of cyanobacterial bloom in South Korea. BioMed research international, 2015, 584696.
  • Srivastava, V.C., et al., 1999. Horizontal and vertical distribution of protein phosphatase inhibitors of microcystin class in the Naktong River. Korea algae, 14 (1), 67–72.
  • Su, M., et al., 2019. Succession and interaction of surface and subsurface cyanobacterial blooms in oligotrophic/mesotrophic reservoirs: a case study in Miyun Reservoir. Science of the total environment., 649, 1553–1562.
  • Suh, M.Y., Kim, B.H., and Han, M.S., 2005. Distribution of cyanotoxin microcystin- LR in Han river system and ecological park in Seoul and Kyunggi Districts. [서울 경기지역의 공원 연못 및 한강 수계내 조류독소 Microcystin- LR의 분포]. Korean journal of ecology and environment, 38 (2), 237–248.
  • Suleiman, M., et al., 2017. Case report: paralytic shellfish poisoning in Sabah, Malaysia. The American journal of tropical medicine and hygiene, 97 (6), 1731–1736.
  • Surosz, W., and Palinska, K.A., 2004. Effects of heavy-metal stress on cyanobacterium Anabaena flos-aquae. Archives of environmental contamination and toxicology, 48 (1), 40–48.
  • Svircev, Z., et al., 2019. Global geographical and historical overview of cyanotoxin distribution and cyanobacterial poisonings. Archives of toxicology, 93 (9), 2429–2481.
  • Szlag, D.C., et al., 2015. Cyanobacteria and cyanotoxins occurrence and removal from five high-risk conventional treatment drinking water plants. Toxins, 7 (6), 2198–2220.
  • Taranu, Z.E., et al., 2015. Acceleration of cyanobacterial dominance in north temperate-subarctic lakes during the Anthropocene. Ecology letters, 18 (4), 375–384.
  • Taranu, Z.E., et al., 2017. Predicting microcystin concentrations in lakes and reservoirs at a continental scale: A new framework for modelling an important health risk factor. Global ecology and biogeography, 26 (6), 625–637.
  • Te, S.H., et al., 2017. Relationship of microbiota and cyanobacterial secondary metabolites in planktothricoides-dominated bloom. Environmental science & technology, 51 (8), 4199–4209.
  • Te, S.H., and Gin, K.Y.H., 2011. The dynamics of cyanobacteria and microcystin production in a tropical reservoir of Singapore. Harmful algae, 10 (3), 319–329.
  • Teneva, I., et al., 2014. Ecological status assessment of Skalenski Lakes (Bulgaria). Biotechnology, biotechnological equipment, 28 (1), 82–95.
  • Terao, K., et al., 1994. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans. Toxicon , 32 (7), 833–843.
  • Tiseer, F.A., Tanimu, Y., and Chia, A.M., 2007. Seasonal occurrence of algae and physicochemical parameters of samaru stream, Zaria, Nigeria. Asian journal of earth sciences, 1 (1), 31–37.
  • Tonk, L., et al., 2007. Salt tolerance of the harmful cyanobacterium Microcystis aeruginosa. Aquatic microbial ecology, 46 (2), 117–123.
  • Van Buynder, P.G., et al., 2001. Nodularin uptake by seafood during a cyanobacterial bloom. Environmental toxicology, 16 (6), 468–471.
  • van Vuuren, S.J., and Kriel, G.P., 2008. Cylindrospermopsis raciborskii, a toxic invasive cyanobacterium in South African fresh waters. African journal of aquatic science, 33 (1), 17–26.
  • Vasconcelos, V., et al., 2010. First report on the occurrence of microcystins in planktonic cyanobacteria from Central Mexico. Toxicon , 56 (3), 425–431.
  • Verspagen, J.M.H., et al., 2014. Rising CO2 levels will intensify phytoplankton blooms in eutrophic and hypertrophic lakes. PloS ONE, 9 (8), e104325.,
  • Vidal, F., et al., 2017. Recreational exposure during algal bloom in Carrasco Beach, Uruguay: a liver failure case report. Toxins, 9 (9), 267.
  • Vidal, L., and Kruk, C., 2008. Cylindrospermopsis raciborskii (Cyanobacteria) extends its distribution to Latitude 34°53'S: Taxonomical and ecological features in Uruguayan eutrophic lakes. Pan-American journal of aquatic sciences, 3 (2), 142–151.
  • Walter, J.M., et al., 2018. Occurrence of harmful cyanobacteria in drinking water from a severely drought-impacted semi-arid region. Frontiers in microbiology, 9, 176.
  • Wang, J.H., et al., 2019. Meteorological factors and water quality changes of Plateau Lake Dianchi in China (1990-2015) and their joint influences on cyanobacterial blooms. The science of the total environment, 665, 406–418.
  • Wang, L.P., Liu, L.S., and Zheng, B.H., 2013. Eutrophication development and its key regulating factors in a water-supply reservoir in North China. Journal of environmental sciences, 25 (5), 962–970.
  • Wang, S., et al., 2015. Distribution and population dynamics of potential anatoxin-a-producing cyanobacteria in Lake Dianchi, China. Harmful algae, 48, 63–68.
  • Wei, J., et al., 2020. Simultaneous Microcystis algicidal and microcystin synthesis inhibition by a red pigment prodigiosin. Environmental pollution, 256, 113444.
  • White, S.H., Fabbro, L.D., and Duivenvoorden, L.J., 2003. Changes in cyanoprokaryote populations, Microcystis morphology, and microcystin concentrations in Lake Elphinstone (Central Queensland, Australia).Environmental toxicology, 18 (6), 403–412.
  • Whitton, B. A., and Potts, M., 2000. The ecology of cyanobacteria: their diversity in time and space. Dordrecht: Kluwer Academic Publishers.
  • WHO 1998. Cyanobacterial toxins: Microcystin-LR. Guidelines for drinking water quality. Geneva: World Health Organization.
  • WHO 2003. Coastal and fresh waters, guidelines for safe recreational water environments. Geneva, Switzerland: World Health Organization.
  • WHO 2011. Technical brief technical management of cyanobacteria in drinkingwater supplies: information for regulators and water Suppliers. Geneva, Switzerland: World Health Organization.
  • Wood, S.A., et al., 2006. Changes in concentrations of microcystins in rainbow trout, freshwater mussels, and cyanobacteria in Lakes Rotoiti and Rotoehu. Environmental toxicology, 21 (3), 205–222.
  • Wood, S.A., et al., 2007. First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand. Toxicon, 50 (2), 292–301.
  • Wood, S.A., et al., 2008. Widespread distribution and identification of eight novel microcystins in antarctic cyanobacterial mats. Applied and environmental microbiology, 74 (23), 7243–7251.
  • Wood, S.A., et al., 2010. Identification of a benthic microcystin-producing filamentous cyanobacterium (Oscillatoriales) associated with a dog poisoning in New Zealand. Toxicon, 55 (4), 897–903.
  • Wood, S.A., and Dietrich, D.R., 2011. Quantitative assessment of aerosolized cyanobacterial toxins at two New Zealand lakes. Journal of environmental monitoring , 13 (6), 1617–1624.
  • Wu, T.F., et al., 2013. Dynamics of cyanobacterial bloom formation during short-term hydrodynamic fluctuation in a large shallow, eutrophic, and wind-exposed Lake Taihu, China. Environmental science and pollution research, 20 (12), 8546–8556.
  • Wu, T., et al., 2015. The influence of changes in wind patterns on the areal extension of surface cyanobacterial blooms in a large shallow lake in China. Science of the total environment., 518-519, 24–30.
  • Xu, Y., et al., 2010. Dynamics of the water bloom-forming Microcystis and its relationship with physicochemical factors in Lake Xuanwu (China). Environmental science and pollution research international, 17 (9), 1581–1590.
  • Xu, Y., et al., 2011. Genetic diversity of Microcystis populations in a bloom and its relationship to the environmental factors in Qinhuai River, China. Microbiological research., 167 (1), 20–26.
  • Yang, F., et al., 2018a. Removal of Microcystin-LR by a Novel Native Effective Bacterial Community Designated as YFMCD4 Isolated from Lake Taihu. Toxins, 10 (9), 363.
  • Yang, F., et al., 2018b. Microcystin-LR degradation utilizing a novel effective indigenous bacterial community YFMCD1 from Lake Taihu. Journal of toxicology environmental health part A, 81 (7), 184–193.
  • Yang, F., et al., 2020. A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium. Water research, 174, 115638. doi:
  • Yang, S., et al., 2018. MicroRNA expression profiling involved in MC-LR-induced hepatotoxicity using high-throughput sequencing analysis. Journal of toxicology and environmental health. Part A, 81 (5), 89–97.
  • Yang, Z., et al., 2016. Nutrient reduction magnifies the impact of extreme weather on cyanobacterial bloom formation in large shallow Lake Taihu (China). Water research, 103, 302–310.
  • Yi, X.P., et al., 2019. Effects of chronic exposure to microcystin-LR on kidney in mice. International journal of environmental research and public health, 16 (24), 5030.
  • Yu, G., et al., 2014. Variation of Microcystis and microcystins coupling nitrogen and phosphorus nutrients in Lake Erhai, a drinking-water source in Southwest Plateau, China. Environmental science and pollution research international, 21 (16), 9887–9898.
  • Zeng, J., et al., 2012. Comparison of heavy metal accumulation by a bloom-forming cyanobacterium, Microcystis aeruginosa. Chinese science bulletin, 57 (28-29), 3790–3797.
  • Zhang, C., et al., 2019. Identification and characterization of a novel indigenous algicidal bacterium Chryseobacterium species against Microcystis aeruginosa. Journal of toxicology and environmental health. Part A, 82 (15), 845–853.
  • Zhang, X.J., et al., 2010. The 2007 water crisis in Wuxi, China: analysis of the origin. Journal of hazardous materials, 182 (1-3), 130–135.
  • Zhou, Q., et al., 2014. Influence of sunlight on the proliferation of cyanobacterial blooms and its potential applications in Lake Taihu, China. Journal of environmental sciences, 26 (3), 626–635.
  • Zhu, L., et al., 2014. Ecological dynamics of toxic Microcystis spp. and microcystin-degrading bacteria in Dianchi Lake. Applied and environmental microbiology, 80 (6), 1874–1881.

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