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Articles

Melatonin pretreatment can improve the therapeutic effect of adipose-derived stem cells on CCl4-induced liver fibrosis

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Pages 559-572 | Received 10 Mar 2022, Accepted 12 Mar 2023, Published online: 28 Mar 2023

References

  • Alfaifi, M., et al., 2018. Mesenchymal stromal cell therapy for liver diseases. Journal of hepatology, 68 (6), 1272–1285.
  • An, S.Y., et al., 2017. Milk fat globule-EGF factor 8, secreted by mesenchymal stem cells, protects against liver fibrosis in mice. Gastroenterology, 152 (5), 1174–1186.
  • Ang, L.T., et al., 2018. A roadmap for human liver differentiation from pluripotent stem cells. Cell reports, 22 (8), 2190–2205.
  • Arthur, M.J., 2000. Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis. American journal of physiology. Gastrointestinal and liver physiology, 279 (2), G245–249.
  • Banas, A., et al., 2008. Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. Journal of gastroenterology and hepatology, 24 (1), 70–77.
  • Bandi, S., Tchaikovskaya, T., and Gupta, S., 2019. Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products. Differentiation; research in biological diversity, 105, 54–70.
  • Bi, Y., et al., 2019a. Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4(+) T cells in mice. Stem cell research & therapy, 10 (1), 22.
  • Bi, Y., et al., 2019b. Transplanted adult human hepatic stem/progenitor cells prevent histogenesis of advanced hepatic fibrosis in mice induced by carbon tetrachloride. American Journal of Translational Research, 11, 2350–2358.
  • Burst, V.R., et al., 2010. Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury. Nephron. Experimental nephrology, 114 (3), e107-116–e116.
  • Cai, P., et al., 2019. The toxicity and safety of traditional Chinese medicines: please treat with rationality. Bioscience trends, 13 (5), 367–373.
  • Cassidy, A., and Minihane, A.M., 2017. The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids. The American journal of clinical nutrition, 105 (1), 10–22.
  • Chandra, S., et al., 2021. Epigenetics and expression of key genes associated with cardiac fibrosis: NLRP3, MMP2, MMP9, CCN2/CTGF and AGT. Epigenomics, 13 (3), 219–234.
  • Chen, D., et al., 2017. Bright polymer dots tracking stem cell engraftment and migration to injured mouse liver. Theranostics, 7 (7), 1820–1834.
  • Chen, Y., et al., 2020. Baihe Wuyao decoction ameliorates CCl(4)-induced chronic liver injury and liver fibrosis in mice through blocking TGF-β1/Smad2/3 signaling, anti-inflammation and anti-oxidation effects. Journal of ethnopharmacology, 263, 113227.
  • Cho, I.J., et al., 2010. E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation. Hepatology, 52 (6), 2053–2064.
  • Cho, Y.A., et al., 2015. Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis. Journal of pineal research, 58 (1), 127–135.
  • Don, C.W., and Murry, C.E., 2013. Improving survival and efficacy of pluripotent stem cell-derived cardiac grafts. Journal of cellular and molecular medicine, 17 (11), 1355–1362.
  • du Souich, P., Roederer, G., and Dufour, R., 2017. Myotoxicity of statins: Mechanism of action. Pharmacology & therapeutics, 175, 1–16.
  • Dudás, J., et al., 2001. Expression of decorin, transforming growth factor-beta 1, tissue inhibitor metalloproteinase 1 and 2, and type IV collagenases in chronic hepatitis. American journal of clinical pathology, 115 (5), 725–735.
  • Eom, Y.W., Shim, K.Y., and Baik, S.K., 2015. Mesenchymal stem cell therapy for liver fibrosis. The Korean journal of internal medicine, 30 (5), 580–589.
  • Fallowfield, J.A., and Iredale, J.P., 2004. Targeted treatments for cirrhosis. Expert opinion on therapeutic targets, 8 (5), 423–435.
  • Fang, J., et al., 2018. Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress. Aging, 10 (10), 2954–2972.
  • Fisher, E.S., and Curry, S.C., 2019. Evaluation and treatment of acetaminophen toxicity. Advances in pharmacology 85, 263–272.
  • Fu, J., et al., 2011. Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. Journal of pineal research, 51 (1), 104–112.
  • Fukazawa, K., and Nishida, S., 2016. Size mismatch in liver transplantation. Journal of hepato-biliary-pancreatic sciences, 23 (8), 457–466.
  • Gage, B.K., et al., 2020. Generation of functional liver sinusoidal endothelial cells from human pluripotent stem-cell-derived venous angioblasts. Cell stem cell, 27 (2), 254–269.e9. e259.
  • Gao, W., et al., 2014. Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells. Journal of pineal research, 56 (1), 62–70.
  • Ghosheh, N., et al., 2017. Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue. Physiological genomics, 49 (8), 430–446.
  • Hernandez-Gea, V., and Friedman, S.L., 2011. Pathogenesis of liver fibrosis. Annual review of pathology: mechanisms of disease, 6 (1), 425–456.
  • Jiaqi, C., et al., 2016. Effects of melatonin and its analogues on neural stem cells. Molecular cellular endocrinology, 420, 169–179.
  • Kim, P.H., et al., 2015. Stanniocalcin 2 enhances mesenchymal stem cell survival by suppressing oxidative stress. BMB reports, 48 (12), 702–707.
  • Kirchner, V.A., et al., 2020. Current status of liver transplantation in North America. International Journal of Surgery, 82s, 9–13.
  • Kopp, J.L., Grompe, M., and Sander, M., 2016. Stem cells versus plasticity in liver and pancreas regeneration. Nature cell biology, 18 (3), 238–245.
  • Kränkel, N., et al., 2011. Targeting stem cell niches and trafficking for cardiovascular therapy. Pharmacology & Therapeutics, 129 (1), 62–81.
  • Kumar, A., et al., 2012. Effect of mitotic inducers and retinoic acid blocker on expression of pluripotent genes in ES cells derived from early stage in vitro-produced embryos in buffalo. In vitro cellular & developmental biology. animal, 48 (10), 625–632.
  • Lambrecht, J., van Grunsven, L.A., and Tacke, F., 2020. Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis. Expert opinion on pharmacotherapy, 21 (13), 1637–1650.
  • Lee, J.H., Han, Y.S., and Lee, S.H., 2020a. Melatonin-induced PGC-1α improves angiogenic potential of mesenchymal stem cells in hindlimb ischemia. Biomolecules & therapeutics, 28 (3), 240–249.
  • Lee, J.H., et al., 2020b. Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. Aging cell, 19 (3), e13111.
  • Li, X., et al., 2018. A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins. Phytomedicine : international journal of phytotherapy and phytopharmacology, 50, 73–87.
  • Li, X.M., et al., 2016. Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways. Acta pharmacologica Sinica, 37 (6), 783–793.
  • Liao, N., et al., 2020. Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model. Stem cell research & therapy, 11 (1), 237.
  • Liu, C., et al., 2020. Melatonin protects neural stem cells against tri-ortho-cresyl phosphate-induced autophagy. Frontiers in Molecular Neuroscience, 13, 25.
  • Liu, Y., et al., 2018. Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation. International journal of molecular medicine, 42 (2), 755–768.
  • Loh, K.M., Palaria, A., and Ang, L.T., 2019. Efficient differentiation of human pluripotent stem cells into liver cells. Journal of visualized experiments, (148), e58975.
  • Long, T., et al., 2019. Protective effects of trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-d-glucopyranoside on liver fibrosis and renal injury induced by CCl(4)via down-regulating p-ERK1/2 and p-Smad1/2. Food & function, 10 (8), 5115–5123.
  • Lou, G., et al., 2017. Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases. Experimental & molecular medicine, 49 (6), e346.
  • Ma, J., et al., 2019. Locostatin alleviates liver fibrosis induced by carbon tetrachloride in mice. Digestive diseases and sciences, 64 (9), 2570–2580.
  • Mahmoud, Y.I., and Mahmoud, A.A., 2016. Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: Nicotinamide effect in acetaminophen-damged liver. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 68 (6), 345–354.
  • Margheri, M., et al., 2012. Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: Molecular basis for the anticancer effect of these molecules. European journal of pharmacology, 681 (1-3), 34–43.
  • Marslin, G., Et al., 2018. Oral delivery of curcumin polymeric nanoparticles ameliorates CCl4-induced Subacute hepatotoxicity in Wistar rats. Polymers, 10 (5), 541.
  • Mazo, D.F., et al., 2013. S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis. Drug Design, Development and Therapy, 7, 553–563.
  • Mortezaee, K., 2018. Human hepatocellular carcinoma: protection by melatonin. Journal of cellular physiology, 233 (10), 6486–6508.
  • Mortezaee, K., and Khanlarkhani, N., 2017. Melatonin application in targeting oxidative-induced liver injuries: a review. Journal of cellular physiology, 233 (5), 4015–4032.
  • Mortezaee, K., et al., 2017. Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4. Cell and tissue research, 369 (2), 303–312.
  • Moya, A., et al., 2018. Human mesenchymal stem cell failure to adapt to glucose shortage and rapidly use intracellular energy reserves through glycolysis explains poor cell survival after implantation. Stem cells, 36 (3), 363–376.
  • Nazhvani, F.D., et al., 2020. Regenerative effect of mesenteric fat stem cells on ccl4-induced liver cirrhosis, an experimental study. Annals of medicine and surgery (2012), 60, 135–139.
  • Pedroza, M., et al., 2019. Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride. PLOS One, 14 (7), e0218971.
  • Piek, E., Heldin, C.H., and Ten Dijke, P., 1999. Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB journal : official publication of the Federation of American societies for experimental biology, 13 (15), 2105–2124.
  • Ping, J., et al., 2018. Effect of bone marrow mesenchymal stem cell transplantation on CCl4-induced liver injury in rats and intervention effects of Yiguanjian. . Zhongguo Zhong Yao Za Zhi, 43, 3905–3912.
  • Povero, D., et al., 2019. Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis. JCI Insight, 4 (14), e125652.
  • Radio, N.M., Doctor, J.S., and Witt-Enderby, P.A., 2006. Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. Journal of pineal research, 40 (4), 332–342.
  • Regmi, S., et al., 2019. Intraportally delivered stem cell spheroids localize in the liver and protect hepatocytes against GalN/LPS-induced fulminant hepatic toxicity. Stem cell research & therapy, 10 (1), 230.
  • Rong, X., et al., 2019. Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway. Stem cell research & therapy, 10 (1), 98.
  • Saberi, K., et al., 2019. Melatonin preconditioning of bone marrow-derived mesenchymal stem cells promotes their engraftment and improves renal regeneration in a rat model of chronic kidney disease. Journal of molecular histology, 50 (2), 129–140.
  • Shibo, L., et al., 2017. Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma. Journal of pineal research, 62 (3), e12398.
  • Strem, B.M., et al., 2005. Multipotential differentiation of adipose tissue-derived stem cells. The Keio journal of medicine, 54 (3), 132–141.
  • Sun, M., and Kisseleva, T., 2015. Reversibility of liver fibrosis. Clinics and research in hepatology and gastroenterology, 39 (Suppl 1), S60–S63.
  • Tang, W.P., et al., 2018. [Effect of adipose tissue-derived mesenchymal stem cell transplantation in treatment of liver fibrosis and possible mechanism]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 26 (1), 28–33.
  • Tang, Y., et al., 2014. Melatonin pretreatment improves the survival and function of transplanted mesenchymal stem cells after focal cerebral ischemia. Cell transplantation, 23 (10), 1279–1291.
  • Wang, Q., et al., 2019. Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9. Molecular medicine reports, 20, 5239–5248.
  • Wang, X., et al., 2021. Anti-inflammatory, antioxidant, and antifibrotic effects of gingival-derived mscs on bleomycin-induced pulmonary fibrosis in mice. International Journal of Molecular Sciences, 23 (1), 99.
  • Watanabe, Y., et al., 2019. Mesenchymal stem cells and induced bone marrow-derived macrophages synergistically improve liver fibrosis in mice. Stem cells translational medicine, 8 (3), 271–284.
  • Wu, H., et al., 2016. Research progress on potential liver toxic components in traditional Chinese medicine. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi =. China journal of Chinese materia medica, 41, 3209–3217.
  • Xu, Y., et al., 2014. Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases. European journal of pharmacology, 744, 1–9.
  • Yang, F., et al., 2017. Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence. Journal of pineal research, 63 (3), e12422.
  • Yu, S., et al., 2019. Melatonin promotes proliferation of neural stem cells from adult mouse spinal cord via the PI3K/AKT signaling pathway. FEBS letters, 593 (14), 1751–1762.
  • Zhang, Y., et al., 2020. Melatonin Rescues the Ti Particle-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells via the SIRT1/SOD2 Signaling Pathway. Calcified tissue international, 107 (5), 474–488.
  • Zhang, Z., and Wang, F.S., 2013. Stem cell therapies for liver failure and cirrhosis. Journal of hepatology, 59 (1), 183–185.
  • Zhao, L., et al., 2019. Preconditioning strategies for improving the survival rate and paracrine ability of mesenchymal stem cells in acute kidney injury. Journal of cellular and molecular medicine, 23 (2), 720–730.
  • Zuk, P.A., et al., 2001. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue engineering Part engineering A, 7 (2), 211–228.

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