129
Views
15
CrossRef citations to date
0
Altmetric
REVIEW

Clinical trials of PUFAs in depression: State of the art

, &
Pages 223-230 | Received 26 Apr 2006, Published online: 12 Jul 2009

References

  • Bhatnagar D, Durrington PN. Omega-3 fatty acids: Their role in the prevention and treatment of atherosclerosis related risk factors and complications. Int J Clin Pract 2003; 57: 305–314
  • Delarue J, Matzinger O, Binnert C, Schneiter P, Chiolero R, Tappy L. Fish oil prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab 2003; 29: 289–295
  • Fontani G, Corradeschi F, Felici A, Alfatti F, Migliorini S, Lodi L. Cognitive and physiological effects of omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest 2005; 35: 691–699
  • Frangou S, Lewis M, McCrone P. Efficacy of EPA in bipolar depression: randomized double-blind placebo controlled study. Br J Psychiatry 2006; 188: 46–50
  • Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M, Gelenberg AJ. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr Scand 2006; 113: 31–35
  • Hibbeln JR. Fish consumption and major depression. Lancet 1998; 351: 1213
  • Hibbeln JR, Salem N, Jr. Dietary polyunsaturated fatty acids and depression: When cholesterol does not satisfy. Am J Clin Nutr 1995; 62: 1–9
  • Hibbeln JR, Linnoila M, Umhau JC, Rawlings R, George DT, Salem N. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biol Psychiatry 1998a; 44: 235–242
  • Hibbeln JR, Umhau JC, Linniola M, George DT, Ragan PW, Shoaf SE, Vaughan MR, Rawlings R, Salem N. A Replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. Biol Psychiatry 1998b; 44: 243–249
  • Hirashima F, Parow AM, Stoll AL, Demopulos CM, Damico KE, Rohan ML, et al. Omega-3 fatty acid treatment and T2 whole brain relaxation times in bipolar disorder. Am J Psychiatry 2004; 161: 1922–1924
  • Horrobin DF. Phospholipid metabolism and depression. Hum Psychopharmacol Clin Exp 2001; 16: 45–52
  • Horrobin DF, Bennett CN. Depression and bipolar disorder: relationships to impaired fatty acid and phospholipids metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis. Possible candidate genes. Prostaglandins Leukot Essent Fatty Acids 1999; 60: 217–234
  • Hu HB, Willett WC. Optimal diets for prevention of coronary heart disease. J Am Med Assoc 2002; 288: 2569–2578
  • Keck, PE, Mintz, J, McElroy, SL, Freeman, MP, Suppes, T, Frye, MA, Altshuler, LL, Kupka, R, Nolen, WA, Leverich, GS, Denicoff, KD, Grunze, H, Duan, N, Post, RM. 2006. Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry [Epub ahead of print].
  • Kinrys G. Hypomania associated with Omega-3 fatty acids [letter]. Arch Gen Psychiatry 2000; 57: 715–716
  • Kris-Etherton PM, Harris WS, Appel LJ, Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 2003; 23: e20–30
  • Lee KW, Lip GY. The role of Omega-3 fatty acids in the secondary prevention of cardiovascular disease. Q J Med 2003; 96: 465–480
  • Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. Am J Obstet Gynecol 2003; 188: 1348–1353
  • Marangell LB, Martinez JM, Zboyan HA, Kertz B, Seung Kim HF, Puryear LJ. A Double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. Am J Psychiatry 2003; 160: 996–998
  • Marangell LB, Martinez JM, Zboyan HA, Chong H, Puryear LJ. Omega-3 fatty acids for the prevention of postpartum depression: Negatvie data from a preliminary, open-label pilot study. Depression Anxiety 2004; 19: 20–23
  • Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002; 159: 477–479
  • Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled double-blind pilot study. Am J Psychiatry 2006; 163: 1098–1100
  • Osher Y, Bersudski Y, Belmaker RH. Omega-EPA in bipolar depression: Report of a small open-label study. J Clin Psychiatry 2005; 66: 726–729
  • Parker G, Gibson NA, Brotchie H, Heruc G, Rees AM, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. Am J Psychiatry 2006; 163: 969–978
  • Peet M, Horrobin DF. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry 2002; 59: 913–919
  • Peet M, Murphy B, Shay J, Horrobin D. Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients. Biol Psychiatry 1998; 43: 315–319
  • Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes TM, Keck PE, Jr, McElroy SL, Kupka R, Nolen WA, Grunze H, Walden J. An overview of recent findings of the Stanley Foundation of Bipolar Network (Part 1). Bipolar Disord 2003; 5: 310–319
  • Shaldubina A, Nemets B, Bersudsky Y. Lack of effect of EPA in Porsolt forced swimming test model of depression. Acta Neuropsychiatr 2002; 14: 203–206
  • Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RA. Randomized double-blind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids 2005; 72: 211–218
  • Stoll AL, Severus E, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB. Omega 3 fatty acids in bipolar disorder: A Preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999; 56: 407–412
  • Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder: A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003; 13: 267–271
  • Su, KP, Shen, WW. 2000. Are omega 3 fatty acids beneficial in depression but not mania?, [letter]. Arch Gen Psychiatry, 716.
  • Tanskanen A, Hibbeln JR, Hintikka J, Haatainen K, Honkalampi K, Viinamaki H. Fish consumption, depression, and suicidality in a general population. Arch Gen Psychiatry 2001; 58: 512–513
  • von Schacky C. The role of omega-3 fatty acids in cardiovascular disease. Curr Artheroscler Rep 2003; 5: 139–145
  • Williams AL, Katz D, Ali A, Girard C, Goodman J, Bell I. Do essential fatty acids have a role in the treatment of depression?. J Affect Disord 2006; 93: 117–123
  • Zanarini MC, Frankenburg FR. Omega-3 fatty acid treatment of women with borderline personality disorder: A double-blind, placebo-controlled pilot study. Am J Psychiatry 2003; 160: 167–169

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.