Kraepelin's dichotomy is true: contrasting brain dysfunction at the extremes of human growth and maturation. Excitability, the fundamental property of nervous tissue, is affected

References

• Antonova E, Sharma T, Morris R, Kumara V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr Res 2004; 70: 117–145
   PubMed Web of Science ®Google Scholar
• Arajærvi R, Haukka J, Varilo T, et al. Clinical phenotype of schizophrenia in a Finnish isolate. Schizophr Res 2004; 67: 195–205
   PubMedGoogle Scholar
• Barnes T, Musatsa RES, Hutton SB, et al. Comorbid substance use and age at onset of schizophrenia. Br J Psychiatry 2004; 188: 237–242
   Google Scholar
• Bleuler, E. 1911. Dementia Praecox or the Group of Schizophrenias. Translated by Zinkin J. New York: International University Press, 1950.
   Google Scholar
• Bonhoeffer K. Die Psychosen im Gefolge von akuten Infektionen, Allgemeinerkrankungen und inneren Erkrankungen. Handbuch der Psychiatrie, Spez Teil, 3 Abt, G. Aschaffenburg. Deuticke, Leipzig, Wien 1912; 51–118
   Google Scholar
• Bourgeois J-P, Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey: from fetal to adult stage. J Neurosci 1993; 13: 2801–2810
   PubMed Web of Science ®Google Scholar
• Brockington IF, Kendell RE, Leff JP. Definitions of schizophrenia: concordance and prediction of outcome. Psychol Med 1978; 8: 387–398
   PubMed Web of Science ®Google Scholar
• Böök JA. A genetic and neuropsychiatric investigationof a North-Swedish population. Acta Genet Stat Med 1953; 4: 1–100
   PubMedGoogle Scholar
• Böök JA, Wetterberg L, Modrzewska K. Schizophrenia in a North Swedish geographical isolate, 1900–1977. Epidemiology, genetics, biochemistry. Clin Genet 1987; 14: 373–394
   Google Scholar
• Cannon M, Jones P, Huttunen MO. School performance in Finnish Children, later Development, Schizophrenia. Arch Gen Psychiatry 1999; 56: 457–463
   PubMed Web of Science ®Google Scholar
• Christensen O, Christensen E. Fat consumption and schizophrenia. Acta Psychiatr Scand 1988; 78: 587–591
   PubMed Web of Science ®Google Scholar
• Crow TJ. Should schizophrenia as a disease entity concept survive into the third millennium?. WPA Series in Psychiatry, M. Maj, N. Sartorius. Schizophrenia. WPA. 1999; 2: 40–42
   Google Scholar
• Dean C, Surtees PG, Sashidharan SP. Comparison of research diagnostic systems in an Edinburgh community sample. Br J Psychiatry 1983; 142: 247–256
   PubMed Web of Science ®Google Scholar
• Dewey KG, Peerson JM, Brown KH, et al. Growth of breast-fed infants deviates from current reference data: a pooled analysis of US, Canadian and European data sets. Pediatrics 1995; 96: 495–502
   PubMed Web of Science ®Google Scholar
• Dohan FC. Cereals and schizophrenia. Data and hypothesis. Acta Psychiatr Scand 1966; 42: 125–152
   PubMed Web of Science ®Google Scholar
• Ettinger AB, Reed ML, Goldberg JF, Hirschfeld RMA. Prevalence of bipolar symptoms in epilepsy vs. other chronic health disorders. Neurology 2005; 65: 585–640
   Google Scholar
• Evensen H. Dementia praecox. Munksgard, Copenhagen, Denmark 1903
   Google Scholar
• Gomez-Pinilla F, Vaynman S. A “deficient environment” in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus. Exp Neurol 2005; 192: 235–243
   PubMed Web of Science ®Google Scholar
• Hagnell O, Lanke J, Rorsman B, Ojesjo L. Are we entering an age of melancholy. Psychol Med 1982; 12: 279–289
   PubMed Web of Science ®Google Scholar
• Hegarty JD, Baldessarini RJ, Tohen M, Waternaux C, Oepen G. One hundred years of schizophrenia. A meta analysis of the outcome literature. Am J Psychiatry 1994; 151: 1409–1416
   PubMed Web of Science ®Google Scholar
• Herlofsen H, Ødegård Ø. A study of psychotic patients of consanguineous parentage. Acta Genet Scand Med 1955; 7: 391–402
   Google Scholar
• Howland RH. Bipolar disorder associated with primary generalised epilepsy. Br J Psychiatry 1993; 162: 699–700
   PubMedGoogle Scholar
• Hulshoffer HE, Hoek HW, Susser E, et al. Prenantal exposure to famine and brain morphology in schizophrenia. Am J Psychiatry 2000; 157: 1170–1172
   PubMedGoogle Scholar
• Isohanni M, Makikyro T, Moring J, Rasanen P, Hakko H, Partanen U, Koiranen M, Jones P. A comparison of clinical and research DSM-III-R diagnoses of schizophrenia in a Finnish national birth cohort: clinical and research diagnoses of schizophrenia. Soc Psychiatry Psychiatr Epidemiol 2000; 32: 303–308
   Google Scholar
• Jablensky A, Hugler H, Von Cranach M, Kalinov K. Kraepelin revisited. A reassessment and statistical analysis of dementa praecox and manic-depressive insanity in 1908. Psychol Med 1993; 23: 843–858
   PubMed Web of Science ®Google Scholar
• Jansen JKS. The development of neuromuscular junctions as a model of the generation of neuronal circuitry. Neurobiology of early infant behaviour, C von Euler, H Forssberg, H Lagercrantz. MacMillan Press Ltd, London 1989
   Google Scholar
• Joukamaa M, Heliovaara M, Knekt P, et al. Schizophrenia, neuroleptic medication and mortality. Br J Psychiatry 2006; 188: 122–127
   PubMed Web of Science ®Google Scholar
• Kallman F. The genetics of schizophrenia. Augustin, New York 1938
   Google Scholar
• Kendell RE. The choice of diagnostic criteria for biological research. Arch Gen Psychiatry 1982; 39: 1334–1339
   PubMed Web of Science ®Google Scholar
• Kendler K. A gene for “…”: The nature of gene action in psychiatric disorders. Am J Psychiatry 2005; 162: 1243–1252
   PubMed Web of Science ®Google Scholar
• Kennedy JL, Giuffra LA, Moises HW, Cavalli-Sforza LL, Pakstis AJ, Kidd JR, Castiglione CM, Sjogren B, Wetterberg L, Kidd KK, et al. Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 1988; 336: 167–170
   PubMed Web of Science ®Google Scholar
• Kessing LV. Cognitive impairment in the euthymic phase of affective disorder. Psychol Med 1998; 28: 1027–1038
   PubMed Web of Science ®Google Scholar
• Kilzieh N, Akiskal HS. Rapid-cycling bipolar disorder. An overview of research and clinical experience. Psychiatr Clin North Am 1988; 225: 585–607
   Google Scholar
• Klosterkötter J, Breuer H, Gross G, Huber G, Gnad M, Steinmeyer EM. New approaches to early recognition of idiopathic psychoses. Schizophrenia and Affective Psychoses. Nosology in Contemporary Psychology, F Ferrero, AE Haynal, N Sartorius. John Libbey CIC, Rome Paris London New York 1992; 97–102
   Google Scholar
• Klosterkötter, J. 1994. Warning signs and symptoms. The Bonn transition sequences study. In:. LF Saugstad. On the road prevention. Amsterdam New York Oxford: Elsevier. pp 30–42.
   Google Scholar
• Kraepelin E. Vergleichende Psychiatrie. Zentralbl Nervenheilkde Psychiatrie 1904; 27: 433–437
   Google Scholar
• Kraepelin, E. 1919. Dementia praecox and paraphrenia. Edinburgh: Livingstone. Published by Licence of the Board of Trade under the “Trading with the Enemy Amendment Act 1916”.
   Google Scholar
• Kraepelin E. Die Erscheinungsformen des Irreseins. Zschr Ges Neurol Psychiatrie 1920; 62: 1–29
   Google Scholar
• Kraepelin, E. 1983. Lebenserinnerungen. Herausgegeben von H. Hippius, G. Pieters, D. Ploog. Berlin: Springer.
   Google Scholar
• Kretschmer E. Körperbau und Character. Springer Verlag, Heidelberg 1921; 321
   Google Scholar
• Larsson, Alström. 1967. Suspected schizophrenic insufficiency in young people. Acta Psychiatr Scand Suppl 198, 13.
   Google Scholar
• Leaf A, Kang JX, Xiao YF, et al. Functional and electrophysiologic effects of polyunsaturated fatty acids on excitable tissues: heart and brain. Prostaglandin Leukotriene Essential Fatty Acids 1999; 60: 307–312
   PubMed Web of Science ®Google Scholar
• Lehtinen V, Aaltonen J, Koffert T, et al. Two-year outcome in first episode psychosis treated according to an integrated model. Is immediate neuroleptisation always needed?. Eur Psychiatry 2000; 15: 312–320
   PubMed Web of Science ®Google Scholar
• Liu JTY, Ziegler DK. Psychiatric symptoms with initiation of carbidopa-levodopa treatment. Neurology 1976; 26: 699–700
   PubMedGoogle Scholar
• Mauz F. Die Prognostic der Endogenen Psychoses. Georg Thieme, Stuttgart 1930
   Google Scholar
• McEvoy JP, Meyer JM, Goff DC, et al. Prevalence of the metabolic syndrome in patients with schizophrenia. Baseline results from the clinical antipsychotic trial of intervention effectiveness (CATIE). Schizophr Res 2005; 80: 19–32
   PubMed Web of Science ®Google Scholar
• McGlashan TH. Rationale and parameters for medication-free research in psychosis. Schizophr Bull 2006; 32: 300–302
   PubMed Web of Science ®Google Scholar
• Meltzer HY, McBride E, Poppel RW. Rod (nemaline) bodies in the skeletal muscle of an acute schizophrenic. Neurology 1973; 23: 769–780
   PubMedGoogle Scholar
• Murray GK, Jones PS, Moltnen K, et al. Infant motor development and adult cognitive functions in schizophrenia. Schizophr Res 2006; 81: 65–74
   PubMed Web of Science ®Google Scholar
• Pavlov I. Conditioned reflexes. Oxford University Press, London 1927
   Google Scholar
• Pichot P. A century of psychiatry. Roger Dacosta, Paris 1983; 125
   Google Scholar
• Propping P. Genetic disorders presenting as “schizophrenia”. Karl Bonhoeffer's early view of the psychoses in the light of medical genetics. Hum Genet 1983; 65: 1–10
   PubMedGoogle Scholar
• Renaudin, P. 1856. Recherches statistiques relative à l'aliénation mentale. Ann Méd Psychol. 339–360.
   Google Scholar
• Salvesen R, Bekkelund SI. Migraine as compared to other headaches, is worse during Midnight Sun summer than during Polar night. Headache 2000; 40: 824–829
   PubMedGoogle Scholar
• Saugstad LF. Inbreeding in Norway. Ann Hum Genet London 1977a; 40: 481–491
   PubMed Web of Science ®Google Scholar
• Saugstad LF. The relation between inbreeding, migration and population density in Norway. Ann Hum Genet London 1977b; 40: 331–341
   PubMedGoogle Scholar
• Saugstad LF. Age at puberty and mental illness. Towards a neurodevelopmental aetiology of Kraepelin's endogenous psychoses. Br J Psychiatry 1989a; 155: 536–544
   PubMedGoogle Scholar
• Saugstad LF. Social class, marriage, and fertility in schizophrenia. Schizophr Bull 1989b; 15: 9–43
   PubMed Web of Science ®Google Scholar
• Saugstad LF. Culture and mental illness in the Nordic countries. Suicide attempts in the Nordic countries, T Bjerke, T Stiles. Tapir, Trondheim 1991; 17–44
   Google Scholar
• Saugstad LF. Nosological implications of the maturational etiology of Kraepelin's endogeneous psychoses. Schizophrenia and affective psychoses. Nosology in contemporary psychiatry, FP Ferrero, AE Haynal, N Sartorius. John Libbey, Rome 1992; 73–87
   Google Scholar
• Saugstad LF. The maturational theory of brain development and cerebral excitability in the multifactorially inherited manic-depressive psychosis and schizophrenia. [Special issue: Developmental psychophysiology. Int J Psychophysiol 1994a; 18(3)189–203
   PubMedGoogle Scholar
• Saugstad, LF. 1994b. Deviation in cerebral excitability. Possible clinical implications. International Journal of Psychophysiology, Vol. 18(3)) December, Special issue: Developmental psychophysiology, 205–212.
   PubMedGoogle Scholar
• Saugstad, LF. 1994c. In Ødegård's footsteps and further: The maturational theory of brain development and Kraepelin's multifactorially inherited psychoses. In:. Psychiatry and Mental Health – the Legacy of Ørnulv Ødegård. Stockholm: Författares Bokmaskin. p 167–240.
   Google Scholar
• Saugstad, LF. 1997. Cerebral laterality and rate of maturation. In:, , The IVth Laterality Symposium, 5–7 July, Imperial College, London, Gruzelier J, Saugstad LF, organisers. Abstract in Int J Psychophysiol. 28:37–62
   Google Scholar
• Saugstad LF. Cerebral lateralisation and rate of maturation. Int J Psychophysiol 1998; 28(1)37–62
   PubMedGoogle Scholar
• Saugstad LF. On the relation between nature and nurture or the relevance of human growth and maturation in psychiatry. [Special issue: Nature and nurture in epilepsy and psychiatry – Implications for new treatment strategies]. Acta Neurol Scand Suppl 2000; 102(Suppl 175)17–19
   Google Scholar
• Saugstad LF. Changing panorama of mental illness, the role of environment – a key to prevention?. J Norw Epidemiol 2002; 12: 291–300
   Google Scholar
• Saugstad LF. From superior adaptation and function to brain dysfunction – the neglect of epigenetic factors. Nutrition Health 2004; 18: 3–27
   PubMedGoogle Scholar
• Saugstad LF. A ”new-old” way of thinking about brain disorder, cerebral excitability – the fundamental property of nervous tissue. Med Hypothesis 2005a; 64: 142–150
   PubMedGoogle Scholar
• Saugstad LF. Are neurodegenerative disorder and psychotic manifestations avoidable brain dysfunctions with adequate dietary omega-3?. Nutrition Health 2005b; 18: 203–215
   Google Scholar
• Saugstad, LF. 2006. From genetics to epigenetics. Nutrition Health. 19.
   Google Scholar
• Saugstad LF, Ødegård Ø. Predominance of extreme geographical proximity of the spouses of heirs to independent farms in a mountain valley in Norway between 1600 and 1840. Ann Hum Genet London 1977; 40: 419–430
   PubMedGoogle Scholar
• Saugstad LF, Ødegård Ø. Mortality in psychiatric hospitals in Norway 1950–1974. Acta Psychiatr Scand 1979; 59: 431–447
   PubMedGoogle Scholar
• Saugstad LF, Ødegård Ø. Ingen internasjonal tilnaerming etter 10ar med den internasjonale diagnoseliste ICD-8. Nord Psykiatr Tidsskr 1980; 34: 455–464
   Google Scholar
• Saugstad LF, Ødegård Ø. Persistent discrepancy in international diagnostic practice since 1970. Acta Psychiatr Scand 1983; 68: 501–510
   PubMedGoogle Scholar
• Saugstad LF, Ødegård Ø. Recent Rise in supposedly stress-dependent causes of death in Psychiatric Hospitals in Norway, indicating increased “stress” in Hospital?. Acta Psychiatr Scand 1985; 71: 402–409
   PubMedGoogle Scholar
• Saugstad LF, Ødegård Ø. Inbreeding and schizophrenia. Clin Genet 1986; 39: 261–271
   Google Scholar
• Saugstad LF, Ødegård Ø. Inbreeding and the epidemiology of schizophrenia. Human genetics, F Vogel, K Sperling. Springer Verlag, Berlin, Heidelberg 1987; 466–473
   Google Scholar
• Scheller-Gilkey G, Lewine RRI, Cudl J, et al. Schizophrenia substance abuse and brain morphology. Schizophr Res 1989; 35: 113–120
   Google Scholar
• St Clair D, Xu M, Wang P, et al. Rates of schizophrenia following prenatal exposure to the Chinese Famine 1959–1961. J Am Med Assoc 2006; 294: 557–562
   Google Scholar
• Stenbäck A, Achte KA. Hospital first admissions and social class. Acta Psychiatr Scand 1967; 40: 113–124
   Google Scholar
• Strømgren, E. 1976. Lærebok i psykiatri.
   Google Scholar
• Strømgren E. Changes in the incidence of schizophrenia?. Br J Psychiatry 1987; 150: 1–7
   PubMed Web of Science ®Google Scholar
• Strømgren E. Changing clinical picture in schizophrenia?. Psychiatry and mental health – the legacy of Ørnulv Ødegård, LF Saugstad, HL Freeman, MK Palomäki. LFSF, Oslo 1994; 61–65
   Google Scholar
• Susser M, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, Gorman JM. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry 1996; 53: 25–31
   PubMed Web of Science ®Google Scholar
• Suvisaari J, Haukka J, Tanskanen A, Lönnsqvist J. Age at onset and outcome in schizophrenia are related to the degree of familial loading. Br J Psychiatry 1998; 173: 494–500
   PubMed Web of Science ®Google Scholar
• Witchel HJ, Hancox JC, Nutt DJ. Psychotropic drugs, cardiac arrhythmia, and sudden death. J Clin Psychopharmacol 2003; 23: 58–77
   PubMed Web of Science ®Google Scholar
• Wyatt RJ. Neuroleptics and the natural course of schizophrenia. Schizophr Bull 1997; 17: 325–351
   Google Scholar
• Zecevic N, Bourgeois FP, Rakics P. Changes in synaptic density in motor cortex in rhesus monkey during fetal and postnatal life. Dev Brain Res 1989; 50: 11–32
   PubMedGoogle Scholar
• Zhang Z-J, Yao Z-J, Liu W, et al. Effects of anti-psychotics on fat deposition and changes in leptin and insulin levels. Br J Psychiatry 2004; 184: 58–62
   PubMed Web of Science ®Google Scholar
• Ødegård Ø. Mortality in Norwegian mental hospitals from 1915–1935. Acta Psychiatr Scand 1937; 11: 323–356
   Google Scholar
• Ødegård Ø. The incidence of mental illness in Norway during World Warl II. Acta Psychol Neurol 1954; 4: 333–353
   Google Scholar
• Ødegård Ø. A clinical study of delayed admissions to a mental hospital. Mental Hygiene 1958; 42: 67–77
   PubMedGoogle Scholar
• Ødegård Ø. Hospitalized psychoses in Norway: Time trend 1926–65. Social Psychiatry 1971; 6: 53–58
   Google Scholar
• Ødegård Ø. The multifactorial theory of inheritance in predisposition to schizophrenia. Genetic factors in schizophrenia III, AR Kaplan. Charles Thomas, Springfield, IL 1972; 256–275
   Google Scholar