Can the role of genetic factors in schizophrenia be enlightened by studies of candidate gene mutant mice behaviour?

References

• Adler LE, Olincy A, Waldo M, Harris JG, Griffith J, Stevens K, et al. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull 1998; 24: 189–202
   PubMed Web of Science ®Google Scholar
• Akbarian S, Huang HS. Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders. Brain Res Rev 2006; 52: 293–304
   PubMed Web of Science ®Google Scholar
• Almond SL, Fradley RL, Armstrong EJ, Heavens RB, Rutter AR, Newman RJ, et al. Behavioral and biochemical characterization of a mutant mouse strain lacking d-amino acid oxidase activity and its implications for schizophrenia. Mol Cell Neurosci 2006; 32: 324–334
   PubMedGoogle Scholar
• Amin E, Pearce JM, Brown MW, Aggleton JP. Novel temporal configurations of stimuli produce discrete changes in immediate-early gene expression in the rat hippocampus. Eur J Neurosci 2006; 24: 2611–2621
   PubMedGoogle Scholar
• Andreasen NC. Linking mind and brain in the study of mental illnesses: a project for a scientific psychopathology. Science 1997; 275: 1586–1593
   PubMed Web of Science ®Google Scholar
• Andreasen NC. A unitary model of schizophrenia: Bleuler's “fragmented phrene” as schizencephaly. Arch Gen Psychiatry 1999; 56: 781–787
   PubMed Web of Science ®Google Scholar
• Asada H, Kawamura Y, Maruyama K, Kume H, Ding RG, Kanbara N, et al. Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci USA 1997; 94: 6496–6499
   PubMed Web of Science ®Google Scholar
• Astur RS, Tropp J, Sava S, Constable RT, Markus EJ. Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation. Behav Brain Res 2004; 151: 103–115
   PubMed Web of Science ®Google Scholar
• Astur RS, St Germain SA, Baker EK, Calhoun V, Pearlson GD, Constable RT. fMRI hippocampal activity during a virtual radial arm maze. Appl Psychophysiol Biofeedback 2005; 30: 307–317
   PubMedGoogle Scholar
• Baddelay, AD. 1974. Working memory. New York: Academic Press. 47–90.
   Google Scholar
• Baddelay, AD. 1986. Working memory. Oxford: Clarendon Press.
   Google Scholar
• Baddeley AD. Working memory and executive control. Phil Trans R Soc London B Biol Sci 1996; 351: 1397–1404
   PubMed Web of Science ®Google Scholar
• Baruch I, Hemsley DR, Gray JA. Differential performance of acute and chronic schizophrenics in a latent inhibition task. J Nerv Ment Dis 1988; 176: 598–606
   PubMed Web of Science ®Google Scholar
• Bellack AS, Morrison RL, Wixted JT, Mueser KT. An analysis of social competence in schizophrenia. Br J Psychiatry 1990; 156: 809–818
   PubMed Web of Science ®Google Scholar
• Berman KF, Zec RF, Weinberger DR. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort. Arch Gen Psychiatry 1986; 43: 126–135
   PubMed Web of Science ®Google Scholar
• Bleuler, E. 1950. Dementia praecox, or the group of schizophrenias. New York: International Universities Press.
   Google Scholar
• Blough DS. Delayed matching in the pigeon. J Exp Anal Behav 1959; 2: 151–160
   PubMedGoogle Scholar
• Bohbot VD, Jech R, Ruzicka E, Nadel E, Kalina M, Stepankova K, et al. Rat spatial memory tasks adapted for humans: characterization in subjects with intact brain and subjects with selective medial temporal lobe thermal lesions. Physiol Res 2002; 51: s49–s65
   PubMedGoogle Scholar
• Boks MP, Rietkerk T, van de Beek MH, Sommer IE, de Koning TJ, Kahn RS. Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia. Eur Neuropsychopharmacol 2007; 17: 567–572
   PubMedGoogle Scholar
• Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normal and schizophrenics. Psychophysiology 1978; 15: 339–343
   PubMed Web of Science ®Google Scholar
• Braff DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Bull 1993; 19: 233–259
   PubMed Web of Science ®Google Scholar
• Braff DL, Geyer MA. Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry 1990; 47: 181–188
   PubMed Web of Science ®Google Scholar
• Braff DL, Light GA. Preattentional and attentional cognitive deficits as targets for treating schizophrenia. Psychopharmacology (Berlin) 2004; 174: 75–85
   PubMed Web of Science ®Google Scholar
• Braff DL, Geyer MA, Swerdlow NR. Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berlin) 2001; 156: 234–258
   PubMed Web of Science ®Google Scholar
• Braff DL, Freedman R, Schork NJ, Gottesman II. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 2007; 33: 21–32
   PubMed Web of Science ®Google Scholar
• Bramon E, Rabe-Hesketh S, Sham P, Murray RM, Frangou S. Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr Res 2004; 70: 315–329
   PubMed Web of Science ®Google Scholar
• Brebion G, Smith MJ, Gorman JM, Amador X. Reality monitoring failure in schizophrenia: the role of selective attention. Schizophr Res 1996; 22: 173–180
   PubMedGoogle Scholar
• Brown VJ, Bowman EM. Rodent models of prefrontal cortical function. Trends Neurosci 2002; 25: 340–343
   PubMedGoogle Scholar
• Brunskill EW, Ehrman LA, Williams MT, Klanke J, Hammer D, Schaefer TL, et al. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur J Neurosci 2005; 22: 1265–1276
   PubMed Web of Science ®Google Scholar
• Cardno AG, Gottesman II. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 2000; 97: 12–17
   PubMed Web of Science ®Google Scholar
• Carli M, Robbins TW, Evenden JL, Everitt BJ. Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res 1983; 9: 361–380
   PubMedGoogle Scholar
• Castner SA, Goldman-Rakic PS, Williams GV. Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia. Psychopharmacology (Berlin) 2004; 174: 111–125
   PubMed Web of Science ®Google Scholar
• Chen YJ, Johnson MA, Lieberman MD, Goodchild RE, Schobel S, Lewandowski N, et al. Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviours, and corticostriatal circuit components. J Neurosci 2008; 28: 6872–6883
   PubMed Web of Science ®Google Scholar
• Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKB is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001; 276: 38349–38352
   PubMed Web of Science ®Google Scholar
• Chudasama Y, Robbins TW. Psychopharmacological approaches to modulating attention in the five-choice serial reaction time task: implications for schizophrenia. Psychopharmacology (Berlin) 2004; 174: 86–98
   PubMedGoogle Scholar
• Chudasama Y, Robbins TW. Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans. Biol Psychol 2006; 73: 19–38
   PubMed Web of Science ®Google Scholar
• Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, Ogawa F, et al. Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 2007; 54: 387–402
   PubMed Web of Science ®Google Scholar
• Coleman MJ, Cook S, Matthysse S, Barnard J, Lo Y, Levy DL, et al. Spatial and object wo6rking memory impairments in schizophrenia patients: a Bayesian item-response theory analysis. J Abnorm Psychol 2002; 111: 425–435
   PubMedGoogle Scholar
• Cook RG, Brown MF, Riley DA. Flexible memory processing by rats: use of prospective and retrospective information in the radial maze. J Exp Psychol Anim Behav Process 1985; 11: 453–469
   PubMed Web of Science ®Google Scholar
• Cornblatt B, Obuchowski M, Schnur DB, O'Brien JD. Attention and clinical symptoms in schizophrenia. Psychiatr Q 1997; 68: 343–359
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 1994; 20: 31–46
   PubMed Web of Science ®Google Scholar
• Crider A. Perseveration in schizophrenia. Schizophr Bull 1997; 23: 63–74
   PubMed Web of Science ®Google Scholar
• Dalley JW, Cardinal RN, Robbins TW. Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 2004; 28: 771–784
   PubMed Web of Science ®Google Scholar
• de Bruin JP, Sanchez-Santed F, Heinsbroek RP, Donker A, Postmes P. A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation. Brain Res 1994; 652: 323–333
   PubMedGoogle Scholar
• Dias R, Robbins TW, Roberts AC. Primate analogue of the Wisconsin Card Sorting Test: effects of excitotoxic lesions of the prefrontal cortex in the marmoset. Behav Neurosci 1996; 110: 872–886
   PubMed Web of Science ®Google Scholar
• Drewe EA. The effect of type and area of brain lesion on Wisconsin card sorting test performance. Cortex 1974; 10: 159–170
   PubMedGoogle Scholar
• Ellenbroek, BA. 1991. The ethological analysis of monkeys in a social setting as an animal model for schizophrenia. Basel: Birkhauser. 265–284.
   Google Scholar
• Ellenbroek BA. Pre-attentive processing and schizophrenia: animal studies. Psychopharmacology (Berlin) 2004; 174: 65–74
   PubMedGoogle Scholar
• Elliott R, McKenna PJ, Robbins TW, Sahakian BJ. Neuropsychological evidence for frontostriatal dysfunction in schizophrenia. Psychol Med 1995; 25: 619–630
   PubMed Web of Science ®Google Scholar
• Ellison G. Monoamine neurotoxins: selective and delayed effects on behaviour in colonies of laboratory rats. Brain Res 1976; 103: 81–92
   PubMedGoogle Scholar
• Elvevag B, Goldberg TE. Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 2000; 14: 1–21
   PubMed Web of Science ®Google Scholar
• Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 2004; 36: 131–137
   PubMed Web of Science ®Google Scholar
• Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, et al. Behavioural and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci USA 2004; 101: 13648–13653
   PubMedGoogle Scholar
• Erickson SL, O'Shea KS, Ghaboosi N, Loverro L, Frantz G, Bauer M, et al. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 1997; 124: 4999–5011
   PubMed Web of Science ®Google Scholar
• Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier DA. Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav 2006; 5: 433–440
   PubMed Web of Science ®Google Scholar
• Freedman R. Schizophrenia. New Engl J Med 2003; 349: 1738–1749
   PubMed Web of Science ®Google Scholar
• Freedman R, Waldo M, Bickford-Wimer P, Nagamoto H. Elementary neuronal dysfunctions in schizophrenia. Schizophr Res 1991; 4: 233–243
   PubMed Web of Science ®Google Scholar
• Freedman R, Adler LE, Bickford P, Byerley W, Coon H, Cullum CM, et al. Schizophrenia and nicotinic receptors. Harv Rev Psychiatry 1994; 2: 179–92
   PubMed Web of Science ®Google Scholar
• Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, et al. The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep 2003; 5: 155–161
   PubMedGoogle Scholar
• Garner JP, Thogerson CM, Wurbel H, Murray JD, Mench JA. Animal neuropsychology: validation of the Intra-Dimensional Extra-Dimensional set shifting task for mice. Behav Brain Res 2006; 173: 53–61
   PubMed Web of Science ®Google Scholar
• Genovese RF, Oubre JL, Jakubowski EM, Fleming PJ, Saxena A, Rockwood GA, et al. Evaluation of cognitive and biochemical effects of low-level exposure to sarin in rhesus and African green monkeys. Toxicology 2007; 231: 11–20
   PubMedGoogle Scholar
• Gerlai R, Pisacane P, Erickson S. Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav Brain Res 2000; 109: 219–227
   PubMedGoogle Scholar
• Geyer MA. Are cross-species measures of sensorimotor gating useful for the discovery of procognitive cotreatments for schizophrenia?. Dialogues Clin Neurosci 2006; 8: 9–16
   PubMedGoogle Scholar
• Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci USA 1998; 95: 9991–9996
   PubMed Web of Science ®Google Scholar
• Gogos JA, Santha M, Takacs Z, Beck KD, Luine V, Lucas LR, et al. The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. Nat Genet 1999; 21: 434–439
   PubMed Web of Science ®Google Scholar
• Goldman-Rakic PS. Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates. Prog Brain Res 1990; 85: 325–335
   PubMed Web of Science ®Google Scholar
• Goldman-Rakic, PS. 1991. Prefrontal cortical dysfunction in working memory: the relevance of working memory. New York: Raven. 1–23.
   Google Scholar
• Goldman-Rakic PS. Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci 1994; 6: 348–357
   PubMed Web of Science ®Google Scholar
• Golub MS, Germann SL, Lloyd KC. Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res 2004; 153: 159–170
   PubMedGoogle Scholar
• Gottesman, II, Shields, J. 1972. Schizophrenia and genetics: A twin study vantage point. New York: Academic Press Inc.
   Google Scholar
• Gould TD, Gottesman II. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 2006; 5: 113–119
   PubMed Web of Science ®Google Scholar
• Graham F. The more or less startling effects of weak prepulses. Psychophysiology 1975; 12: 238–248
   PubMed Web of Science ®Google Scholar
• Gray NS, Pickering AD, Hemsley DR, Dawling S, Gray JA. Abolition of latent inhibition by a single 5 mg dose of d-amphetamine in man. Psychopharmacology (Berlin) 1992; 107: 425–430
   PubMed Web of Science ®Google Scholar
• Gray NS, Pilowsky LS, Gray JA, Kerwin RW. Latent inhibition in drug naive schizophrenics: relationship to duration of illness and dopamine D2 binding using SPET. Schizophr Res 1995; 17: 95–107
   PubMed Web of Science ®Google Scholar
• Grillet N, Pattyn A, Contet C, Kieffer BL, Goridis C, Brunet JF. Generation and characterization of Rgs4 mutant mice. Mol Cell Biol 2005; 25: 4221–4228
   PubMedGoogle Scholar
• Gruzelier J, Seymour K, Wilson L, Jolley A, Hirsch S. Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Arch Gen Psychiatry 1988; 45: 623–629
   PubMed Web of Science ®Google Scholar
• Guterman Y, Josiassen RC, Bashore TE, Johnson M, Lubow RE. Latent inhibition effects reflected in event-related brain potentials in healthy controls and schizophrenics. Schizophr Res 1996; 20: 315–326
   PubMed Web of Science ®Google Scholar
• Haasio K, Huotari M, Nissinen E, Mannisto PT. Tissue histopathology, clinical chemistry and behaviour of adult Comt-gene-disrupted mice. J Appl Toxicol 2003; 23: 213–219
   PubMedGoogle Scholar
• Hahn CG, Wang HY, Cho DS, Talbot K, Gur RE, Berrettini WH, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med 2006; 12: 824–828
   PubMed Web of Science ®Google Scholar
• Hajos M. Targeting information-processing deficit in schizophrenia: a novel approach to psychotherapeutic drug discovery. Trends Pharmacol Sci 2006; 27: 391–398
   PubMed Web of Science ®Google Scholar
• Han DH, Kee BS, Min KJ, Lee YS, Na C, Park DB, et al. Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients. Neuroreport 2006; 17: 95–99
   PubMedGoogle Scholar
• Han DH, Park DB, Na C, Kee BS, Lee YS. Association of aggressive behavior in Korean male schizophrenic patients with polymorphisms in the serotonin transporter promoter and catecholamine-O-methyltransferase genes. Psychiatry Res 2004; 129: 29–37
   PubMedGoogle Scholar
• Hanlon FM, Weisend MP, Hamilton DA, Jones AP, Thoma RJ, Huang M, et al. Impairment on the hippocampal-dependent virtual Morris water task in schizophrenia. Schizophr Res 2006; 87: 67–80
   PubMed Web of Science ®Google Scholar
• Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10: 40–68
   PubMed Web of Science ®Google Scholar
• Hartman M, Steketee MC, Silva S, Lanning K, McCann H. Working memory and schizophrenia: evidence for slowed encoding. Schizophr Res 2003; 59: 99–113
   PubMed Web of Science ®Google Scholar
• Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, et al. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Commun 2008; 373: 298–302
   PubMed Web of Science ®Google Scholar
• Hayase T, Yamamoto Y, Yamamoto K. Behavioral effects of ketamine and toxic interactions with psychostimulants. BMC Neurosci 2006; 7: 25–35
   PubMedGoogle Scholar
• Herman LM. Interference and auditory short-term memory in the bottlenosed dolphin. Anim Learn Behav 1975; 3: 43–48
   Google Scholar
• Herremans AH, Hijzen TH. The delayed-conditional-discrimination task improves measurement of working memory in rats. Neurosci Biobehav Rev 1997; 21: 371–379
   PubMedGoogle Scholar
• Heusner CL, Beutler LR, Houser CR, Palmiter RD. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specific motor deficits. Genesis 2008; 46: 357–367
   PubMedGoogle Scholar
• Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci USA 2007; 104: 14501–14506
   PubMed Web of Science ®Google Scholar
• Hoyle E, Genn RF, Fernandes C, Stolerman IP. Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology (Berlin) 2006; 189: 211–223
   PubMedGoogle Scholar
• Huotari M, Santha M, Lucas LR, Karayiorgou M, Gogos JA, Mannisto PT. Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. J Pharmacol Exp Ther 2002; 303: 1309–1316
   PubMedGoogle Scholar
• Jones GH, Marsden CA, Robbins TW. Behavioural rigidity and rule-learning deficits following isolation-rearing in the rat: neurochemical correlates. Behav Brain Res 1991; 43: 35–50
   PubMed Web of Science ®Google Scholar
• Karl T, Duffy L, Scimone A, Harvey RP, Schofield PR. Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia. Genes Brain Behav 2007; 6: 677–687
   PubMedGoogle Scholar
• Kas MJ, Fernandes C, Schalkwyk LC, Collier DA. Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Mol Psychiatry 2006; 12: 324–330
   PubMedGoogle Scholar
• Kendler KS. Reflections on the relationship between psychiatric genetics and psychiatric nosology. Am J Psychiatry 2006; 163: 1138–1146
   PubMed Web of Science ®Google Scholar
• Koike H, Arguello PA, Kvajo M, Karayiorgou M, Gogos JA. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci USA 2006; 103: 3693–3697
   PubMed Web of Science ®Google Scholar
• Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, et al. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol Psychiatry 2004; 56: 169–176
   PubMed Web of Science ®Google Scholar
• Kosmidis MH, Breier A, Fantie BD. Avoidance learning in schizophrenia: a dissociation between the effects of aversive and non-aversive stimuli. Schizophr Res 1999; 38: 51–59
   PubMedGoogle Scholar
• Kraepelin, E. 1971. Dementia praecox. New York: Churchill Livingstone.
   Google Scholar
• Kramer R, Bucay N, Kane DJ, Martin LE, Tarpley JE, Theill LE. Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci USA 1996; 93: 4833–4838
   PubMedGoogle Scholar
• Kumari V, Soni W, Mathew VM, Sharma T. Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness, symptoms, and medication. Arch Gen Psychiatry 2000; 57: 609–614
   PubMedGoogle Scholar
• Kvajo M, McKellar H, Arguello PA, Drew LJ, Moore H, MacDermott AB, et al. A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci USA 2008; 105: 7076–7081
   PubMedGoogle Scholar
• Lai WS, Xu B, Westphal KG, Paterlini M, Olivier B, Pavlidis P, et al. Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proc Natl Acad Sci USA 2006; 103: 16906–16911
   PubMed Web of Science ®Google Scholar
• Lanser MG, Ellenbroek BA, Zitman FG, Heeren DJ, Cools AR. The role of medial prefrontal cortical dopamine in spontaneous flexibility in the rat. Behav Pharmacol 2001; 12: 163–171
   PubMedGoogle Scholar
• Lapiz MD, Morilak DA. Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability. Neuroscience 2006; 137: 1039–1049
   PubMed Web of Science ®Google Scholar
• Law AJ, Kleinman JE, Weinberger DR, Weickert CS. Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet 2007; 16: 129–141
   PubMed Web of Science ®Google Scholar
• Le PG, Grottick AJ, Higgins GA, Martin JR, Jenck F, Moreau JL. Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia. Behav Pharmacol 2000; 11: 257–268
   PubMedGoogle Scholar
• Lhuillier L, Mombereau C, Cryan JF, Kaupmann K. GABA(B) Receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. Neuropsychopharmacology 2006; 32: 388–398
   PubMedGoogle Scholar
• Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, Ehninger D, et al. Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci USA 2007; 104: 18280–18285
   PubMed Web of Science ®Google Scholar
• Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O'Brien EP, et al. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet 2003; 35: 84–9
   PubMed Web of Science ®Google Scholar
• Linden AM, Shannon H, Baez M, Yu JL, Koester A, Schoepp DD. Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berlin) 2005; 179: 284–91
   PubMedGoogle Scholar
• Liston C, Miller MM, Goldwater DS, Radley JJ, Rocher AB, Hof PR, et al. Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J Neurosci 2006; 26: 7870–7874
   PubMed Web of Science ®Google Scholar
• Lubow, RE. 1989. Latent inhibition and conditioned attention. Cambridge: Cambridge University Press.
   Google Scholar
• Lubow RE. Latent inhibition as a measure of learned inattention: some problems and solutions. Behav Brain Res 1997; 88: 75–83
   PubMed Web of Science ®Google Scholar
• Lubow RE. Construct validity of the animal latent inhibition model of selective attention deficits in schizophrenia. Schizophr Bull 2005; 31: 139–153
   PubMed Web of Science ®Google Scholar
• Lubow RE, Gewirtz JC. Latent inhibition in humans: data, theory, and implications for schizophrenia. Psychol Bull 1995; 117: 87–103
   PubMed Web of Science ®Google Scholar
• Mackintosh, NJ. 1983. Conditioning and Associative Learning. Oxford: Oxford University Press.
   Google Scholar
• Mackintosh NJ, Holgate V. Serial reversal training and nonreversal shift learning. J Comp Physiol Psychol 1969; 67: 89–93
   PubMedGoogle Scholar
• McGhie A, Chapman J. Disorders of attention and perception in early schizophrenia. Br J Med Psychol 1961; 34: 103–116
   PubMed Web of Science ®Google Scholar
• McGue M, Gottesman II. A single dominant gene still cannot account for the transmission of schizophrenia. Arch Gen Psychiatry 1989; 46: 478–480
   PubMedGoogle Scholar
• Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P. Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 2001; 6: 293–301
   PubMed Web of Science ®Google Scholar
• Miyakawa T, Leiter LM, Gerber DJ, Gainetdinov RR, Sotnikova TD, Zeng H, et al. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci USA 2003; 100: 8987–8992
   PubMed Web of Science ®Google Scholar
• Mori T, Ito S, Narita M, Suzuki T, Sawaguchi T. Combined effects of psychostimulants and morphine on locomotor activity in mice. J Pharmacol Sci 2004; 96: 450–458
   PubMedGoogle Scholar
• Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S. Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proc Natl Acad Sci USA 2005; 102: 4170–4175
   PubMedGoogle Scholar
• Munafo MR, Bowes L, Clark TG, Flint J. Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies. Mol Psychiatry 2005; 10: 765–770
   PubMed Web of Science ®Google Scholar
• Myerson BJ. Exploratory and soci-sexual behaviour in the male laboratory rat: a methodological approach for the investigation of drug action. Acta Pharmacol Toxicol 1981; 48: 168–180
   PubMedGoogle Scholar
• Myin-Germeys I, van Os J. Stress-reactivity in psychosis: evidence for an affective pathway to psychosis. Clin Psychol Rev 2007; 27: 409–424
   PubMed Web of Science ®Google Scholar
• Nakahara K, Hayashi T, Konishi S, Miyashita Y. Functional MRI of macaque monkeys performing a cognitive set-shifting task. Science 2002; 295: 1532–1536
   PubMedGoogle Scholar
• Nam HJ, Kim N, Park T, Oh S, Jeon HO, Yoon SC, et al. Cognitive profiles of healthy siblings of schizophrenia patients: application of the cognitive domains of the MATRICS consensus battery. World J Biol Psychiatry Epub Sep 2008; 16: 1–9
   Google Scholar
• Nestor, PG. 1998. The mind adrift: attentional dysregulation in schizophrenia. Cambridge, MA: MIT Press. 527–546.
   Google Scholar
• Norflus F, Tifft CJ, McDonald MP, Goldstein G, Crawley JN, Hoffmann A, et al. Bone marrow transplantation prolongs life span and ameliorates neurologic manifestations in Sandhoff disease mice. J Clin Invest 1998; 101: 1881–1888
   PubMed Web of Science ®Google Scholar
• Norton N, Williams HJ, Owen MJ. An update on the genetics of schizophrenia. Curr Opin Psychiatry 2006; 19: 158–164
   PubMed Web of Science ®Google Scholar
• O'Donnell BF, Swearer JM, Smith LT, Nestor PG, Shenton ME, McCarley RW. Selective deficits in visual perception and recognition in schizophrenia. Am J Psychiatry 1996; 153: 687–692
   PubMed Web of Science ®Google Scholar
• O'Tuathaigh CM, Babovic D, O'meara G, Clifford JJ, Croke DT, Waddington JL. Susceptibility genes for schizophrenia: Characterisation of mutant mouse models at the level of phenotypic behaviour. Neurosci Biobehav Rev 2007a; 31: 60–78
   PubMedGoogle Scholar
• O'Tuathaigh CM, Babovic D, O'Sullivan GJ, Clifford JJ, Tighe O, Croke DT, et al. Phenotypic characterization of spatial cognition and social behavior in mice with'knockout' of the schizophrenia risk gene neuregulin 1. Neuroscience 2007b; 147: 18–27
   PubMed Web of Science ®Google Scholar
• Oranje B, Geyer MA, Bocker KB, Leon KJ, Verbaten MN. Prepulse inhibition and P50 suppression: commonalities and dissociations. Psychiatry Res 2006; 143: 147–158
   PubMed Web of Science ®Google Scholar
• Orr-Urtreger A, Göldner FM, Saeki M, Lorenzo I, Goldberg L, De Biasi M, et al. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci 1997; 17: 9165–71
   PubMedGoogle Scholar
• Owen MJ, Craddock N, O'Donovan MC. Schizophrenia: genes at last?. Trends Genet 2005; 21: 518–525
   PubMed Web of Science ®Google Scholar
• Papaleo F, Crawley JN, Song J, Lipska BK, Pickel J, Weinberger DR, et al. Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. J Neurosci 2008; 28: 8709–8723
   PubMed Web of Science ®Google Scholar
• Park S. Association of an oculomotor delayed response task and the Wisconsin Card Sort Test in schizophrenic patients. Int J Psychophysiol 1997; 27: 147–151
   PubMedGoogle Scholar
• Park S, Puschel J, Sauter BH, Rentsch M, Hell D. Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study. Biol Psychiatry 1999; 46: 392–400
   PubMed Web of Science ®Google Scholar
• Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, et al. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci 2005; 8: 1586–1594
   PubMed Web of Science ®Google Scholar
• Paylor R, Nguyen M, Crawley JN, Patrick J, Beaudet A, Orr-Urtreger A. Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn Mem 1998; 5(4–5)302–312
   PubMed Web of Science ®Google Scholar
• Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock P, et al. Comparison of treatment effects between animal experiments and clinical trials: systematic review. Br Med J 2007; 334(7586)197–202
   PubMed Web of Science ®Google Scholar
• Perlstein WM, Carter CS, Barch DM, Baird JW. The Stroop task and attention deficits in schizophrenia: a critical evaluation of card and single-trial Stroop methodologies. Neuropsychology 1998; 12: 414–425
   PubMed Web of Science ®Google Scholar
• Pickard BS, Malloy MP, Christoforou A, Thomson PA, Evans KL, Morris SW, et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol Psychiatry 2006; 11: 847–57
   PubMed Web of Science ®Google Scholar
• Pickard BS, Malloy MP, Porteous DJ, Blackwood DH, Muir WJ. Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. Am J Med Genet B Neuropsychiatr Genet 2005; 136B: 26–32
   PubMedGoogle Scholar
• Pletnikov MV, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov MV, Huang H, et al. Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 2008; 13: 173–186
   PubMedGoogle Scholar
• Powell CM, Miyakawa T. Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder?. Biol Psychiatry 2006; 59: 1198–1207
   PubMed Web of Science ®Google Scholar
• Rimer M, Barrett DW, Maldonado MA, Vock VM, Gonzalez-Lima F. Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibition. Neuroreport 2005; 16: 271–275
   PubMedGoogle Scholar
• Robbins, TW. 1993. Methods for assessing attention and stimulus control in the rat. New York: Oxford University Press. 13–47.
   Google Scholar
• Robbins TW. Homology in behavioural pharmacology: an approach to animal models of human cognition. Behav Pharmacol 1998; 9: 509–519
   PubMedGoogle Scholar
• Robbins TW. The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berlin) 2002; 163: 362–380
   PubMed Web of Science ®Google Scholar
• Rogers RD, Andrews TC, Grasby PM, Brooks DJ, Robbins TW. Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci 2000; 12: 142–162
   PubMed Web of Science ®Google Scholar
• Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron 2006; 52: 139–153
   PubMed Web of Science ®Google Scholar
• Rossi A, Daneluzzo E, Mattei P, Bustini M, Casacchia M, Stratta P. Wisconsin card sorting test and Stroop test performance in schizophrenia: a shared construct. Neurosci Lett 1997; 226: 87–90
   PubMed Web of Science ®Google Scholar
• Roy K, Murtie JC, El-Khodor BF, Edgar N, Sardi SP, Hooks BM, et al. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci USA 2007; 104: 8131–8136
   PubMed Web of Science ®Google Scholar
• Ruff RM, Evans RW, Light RH. Automatic detection vs controlled search: a paper-and-pencil approach. Percept Mot Skills 1986; 62: 407–416
   PubMed Web of Science ®Google Scholar
• Rushe TM, Woodruff PW, Murray RM, Morris RG. Episodic memory and learning in patients with chronic schizophrenia. Schizophr Res 1999; 35: 85–96
   PubMed Web of Science ®Google Scholar
• Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, et al. Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum Mol Genet 2008; 17: 3191–3203
   PubMedGoogle Scholar
• Sams-Dodd F. A test of the predictive validity of animal models of schizophrenia based on phencyclidine and d-amphetamine. Neuropsychopharmacology 1998; 18: 293–304
   PubMed Web of Science ®Google Scholar
• Sasaki M, Konno R, Nishio M, Niwa A, Yasumura Y, Enami J. A single-base-pair substitution abolishes d-amino-acid oxidase activity in the mouse. Biochim Biophys Acta 1992; 1139: 315–318
   PubMedGoogle Scholar
• Snitz BE, Macdonald AW III, Carter CS. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull 2006; 32: 179–194
   PubMed Web of Science ®Google Scholar
• Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71: 877–892
   PubMed Web of Science ®Google Scholar
• Strauss JS, Kokes RF, Klorman R, Sacksteder JL. Premorbid adjustment in schizophrenia: concepts, measures, and implications. Part I. The concept of premorbid adjustment. Schizophr Bull 1977; 3: 182–185
   PubMed Web of Science ®Google Scholar
• Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM. Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 1997; 69: 71–77
   PubMed Web of Science ®Google Scholar
• Swerdlow NR, Geyer MA, Braff DL. Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berlin) 2001; 156: 194–215
   PubMed Web of Science ®Google Scholar
• Tecott LH, Nestler EJ. Neurobehavioral assessment in the information age. Nat Neurosci 2004; 7: 462–466
   PubMed Web of Science ®Google Scholar
• Thaker GK, Carpenter WT, Jr. Advances in schizophrenia. Nat Med 2001; 7: 667–671
   PubMed Web of Science ®Google Scholar
• Thorpe CM, Jacova C, Wilkie DM. Some pitfalls in measuring memory in animals. Neurosci Biobehav Rev 2004; 28: 711–718
   PubMedGoogle Scholar
• Vaitl D, Lipp OV. Latent inhibition and autonomic responses: a psychophysiological approach. Behav Brain Res 1997; 88: 85–93
   PubMed Web of Science ®Google Scholar
• van, Os, Marcelis, M. 1998. The ecogenetics of schizophrenia: a review. Schizophr Res, 32:127–135.
   PubMedGoogle Scholar
• Venables, PH. 1964. Input dysfunction in schizophrenia. New York: Academic Press. 1–47.
   Google Scholar
• Watson DJ, Sullivan JR, Frank JG, Stanton ME. Serial reversal learning of position discrimination in developing rats. Dev Psychobiol 2006; 48: 79–94
   PubMed Web of Science ®Google Scholar
• Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, et al. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 2004; 61: 544–55
   PubMed Web of Science ®Google Scholar
• Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 1986; 43: 114–124
   PubMed Web of Science ®Google Scholar
• Weiner I. The “two-headed” latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment. Psychopharmacology (Berlin) 2003; 169: 257–297
   PubMed Web of Science ®Google Scholar
• Weiss KM. A simple clinical assessment of attention in schizophrenia. Psychiatry Res 1996; 60: 147–154
   PubMedGoogle Scholar
• Willner P. The validity of animal models of depression. Psychopharmacology (Berlin) 1984; 83: 1–16
   PubMed Web of Science ®Google Scholar
• Willner P. Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog Neuropsychopharmacol Biol Psychiatry 1986; 10: 677–690
   PubMed Web of Science ®Google Scholar
• Wobrok T, Ecker UK, Scherk H, Schneider-Axmann T, Falkai P, Gruber O. Cognitive impairment of executive function as a core symptom of schizophrenia. World J Biol Psychiatry Epub Jan 2008; 29: 1–10
   Google Scholar
• Wolpowitz D, Mason TB, Dietrich P, Mendelsohn M, Talmage DA, Role LW. Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron 2000; 25: 79–91
   Google Scholar
• Wood SJ, Pantelis C, Proffitt T, Phillips LJ, Stuart GW, Buchanan JA, et al. Spatial working memory ability is a marker of risk-for-psychosis. Psychol Med 2003; 33: 1239–1247
   PubMed Web of Science ®Google Scholar
• Woolley ML, Ballard TM. Age-related impairments in operant DMTP performance in the PS2APP mouse, a transgenic mouse model of Alzheimer's disease. Behav Brain Res 2005; 161: 220–228
   PubMedGoogle Scholar
• Yamada K, Nakamura K, Minabe Y, Iwayama-Shigeno Y, Takao H, Toyota T, et al. Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. Biol Psychiatry 2004; 56: 683–690
   PubMed Web of Science ®Google Scholar
• Yogev H, Hadar U, Gutman Y, Sirota P. Perseveration and over-switching in schizophrenia. Schizophr Res 2003; 61: 315–321
   PubMed Web of Science ®Google Scholar
• Young JW, Minassian A, Paulus MP, Geyer MA, Perry W. A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioural Pattern Monitor. Neurosci Biobehav Rev 2007; 31: 882–896
   PubMedGoogle Scholar
• Zhang Q, Li W, Novak EK, Karim A, Mishra VS, Kingsmore SF, et al. The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking. Hum Mol Genet 2002; 11: 697–706
   PubMedGoogle Scholar
• Zola-Morgan S, Squire LR. Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia. Behav Neurosci 1985; 99: 22–34
   PubMed Web of Science ®Google Scholar
• Zubin J, Spring B. Vulnerability. A new view of schizophrenia. J Abnorm Psychol 1977; 86: 103–126
   PubMed Web of Science ®Google Scholar