2,151
Views
0
CrossRef citations to date
0
Altmetric
Case Report

Case report: Venetoclax plus Azacitidine in treatment of acute undifferentiated leukemia

, , , , & ORCID Icon
Article: 2293494 | Received 11 May 2023, Accepted 02 Dec 2023, Published online: 14 Dec 2023

References

  • van den Ancker W, Terwijn M, Westers TM, et al. Acute leukemias of ambiguous lineage: diagnostic consequences of the WHO2008 classification. Leukemia. 2010;24(7):1392–1396. doi:10.1038/leu.2010.119
  • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–2405. doi:10.1182/blood-2016-03-643544
  • Qasrawi A, Gomes V, Chacko CA, et al. Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database. Leukemia Res. 2020;89:106301. doi:10.1016/j.leukres.2020.106301
  • Huang J, Zhou J, Xiao M, et al. The association of complex genetic background with the prognosis of acute leukemia with ambiguous lineage. Sci Rep. 2021;11(1):24290. doi:10.1038/s41598-021-03709-7
  • Hollenbach PW, Nguyen AN, Brady H, et al. Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro. PLoS One. 2010;5(2):e9332. doi:10.1371/journal.pone.0009332
  • Stresemann C, Lyko F. Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int J Cancer. 2008;123(1):8–13. doi:10.1002/ijc.23607
  • DiNardo CD, Jonas BA, Pullarkat V, et al. Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med. 2020;383(7):617–629. doi:10.1056/NEJMoa2012971
  • Wei AH, Strickland SA, Hou J, et al. Venetoclax combined with low-dose cytarabine for previously untreated patients with acute myeloid leukemia: results from a phase Ib/II study. J Clin Oncol. 2019;37(15):1277–1284. doi:10.1200/JCO.18.01600
  • Konopleva M, Pollyea DA, Potluri J, et al. Efficacy and biological correlates of response in a phase II study of venetoclax monotherapy in patients with acute myelogenous leukemia. Cancer Discov. 2016;6(10):1106–1117. doi:10.1158/2159-8290.cd-16-0313
  • Heesch S, Neumann M, Schwartz S, et al. Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization. Ann Hematol. 2013;92(6):747–758. doi:10.1007/s00277-013-1694-4
  • Duong VH, Begna KH, Kashanian S, et al. Favorable outcomes of acute leukemias of ambiguous lineage treated with hyperCVAD: a multi-center retrospective study. Ann Hematol. 2020;99(9):2119–2124. doi:10.1007/s00277-020-04179-z
  • Weinberg OK, Hasserjian RP, Baraban E, et al. Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group. Modern Pathol. 2019;32(9):1373–1385. doi:10.1038/s41379-019-0263-3
  • Gerr H, Zimmermann M, Schrappe M, et al. Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations. Br J Haematol. 2010;149(1):84–92. doi:10.1111/j.1365-2141.2009.08058.x
  • Hrusak O, de Haas V, Stancikova J, et al. International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia. Blood. 2018;132(3):264–276. doi:10.1182/blood-2017-12-821363
  • Rubnitz JE, Onciu M, Pounds S, et al. Acute mixed lineage leukemia in children: the experience of St Jude Children’s Research Hospital. Blood. 2009;113(21):5083–5089. doi:10.1182/blood-2008-10-187351
  • Liu QF, Fan ZP, Wu MQ, et al. Allo-HSCT for acute leukemia of ambiguous lineage in adults: the comparison between standard conditioning and intensified conditioning regimens. Ann Hematol. 2013;92(5):679–687. doi:10.1007/s00277-012-1662-4
  • Patel SH, Vasu S, Guo L, et al. Molecular complete remission following ivosidenib in a patient with an acute undifferentiated leukemia. J Natl Comprehen Cancer Network. 2020;18(1):6–10. doi:10.6004/jnccn.2019.7368
  •  Polishchuk V, Khazal S, Berulava G, et al. 55-Azacitidine monotherapy followed by related haploidentical hematopoietic stem cell transplantation achieves durable remission in a pediatric patient with acute undifferentiated leukemia refractory to high-dose chemotherapy. Pediatr Blood Cancer. 2016;63(6):1111–1112. doi:10.1002/pbc.25948.
  • Liu K, Li Y, Qiu S, et al. Efficacy of combination of venetoclax with azacitidine or chemotherapy in refractory/relapse acute leukemias of ambiguous lineage, not otherwise specified. Exp Hematol Oncol. 2021;10(1):46. doi:10.1186/s40164-021-00239-w
  • Kurosawa S, Toya T, Kishida Y, et al. Outcome of patients with acute undifferentiated leukemia after allogeneic hematopoietic stem cell transplantation. Leuk Lymphoma. 2018;59(12):3006–3009. doi:10.1080/10428194.2018.1441410
  • Chen X, Glytsou C, Zhou H, et al. Targeting mitochondrial structure sensitizes acute myeloid leukemia to venetoclax treatment. Cancer Discov. 2019;9(7):890–909. doi:10.1158/2159-8290.CD-19-0117
  • Pollyea Stevens DA, Jones BM, Winters CL, et al. Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia. Nat Med. 2018;24(12):1859–1866. doi:10.1038/s41591-018-0233-1
  • Lee JB, Khan DH, Hurren R, et al. Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production. Blood. 2021;138(3):234–245. doi:10.1182/blood.2020009081
  • DiNardo CD, Pratz KW, Letai A, et al. Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study. Lancet Oncol. 2018;19(2):216–228. doi:10.1016/S1470-2045(18)30010-X
  • Kadia TM, Kantarjian H, Kornblau S, et al. Clinical and proteomic characterization of acute myeloid leukemia with mutated RAS. Cancer. 2012;118(22):5550–5559. doi:10.1002/cncr.27596
  • Desikan SP, Ravandi F, Pemmaraju N, et al. A phase II study of azacitidine, venetoclax, and trametinib in relapsed or refractory acute myeloid leukemia harboring RAS pathway-activating mutations. Acta Haematol. 2022;145(5):529–536. doi:10.1159/000525566
  • Park J, Park H, Byun JM, et al. Pan-RAF inhibitor LY3009120 is highly synergistic with low-dose cytarabine, but not azacitidine, in acute myeloid leukemia with RAS mutations. Oncol Lett. 2021;22(5):745. doi:10.3892/ol.2021.13006
  • Liu X, Ye Q, Zhao XP, et al. RAS mutations in acute myeloid leukaemia patients: A review and meta-analysis. Clin Chim Acta. 2019;489:254–260. doi:10.1016/j.cca.2018.08.040
  • Manola KN. Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview. Br J Haematol. 2013;163(1):24–39. doi:10.1111/bjh.12484
  • Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209–2221. doi:10.1056/NEJMoa1516192