588
Views
0
CrossRef citations to date
0
Altmetric
Research Article

PHF19 before and post induction treatment possess favorable potency of reflecting treatment response to protease inhibitors, event-free survival, and overall survival in multiple myeloma patients

, , , , &
Article: 2331389 | Received 20 Dec 2023, Accepted 12 Mar 2024, Published online: 21 Mar 2024

References

  • Cowan AJ, Green DJ, Kwok M, et al. Diagnosis and management of multiple myeloma. JAMA. 2022;327(5):464–477. doi:10.1001/jama.2022.0003
  • Huang J, Chan SC, Lok V, et al. The epidemiological landscape of multiple myeloma: a global cancer registry estimate of disease burden, risk factors, and temporal trends. Lancet Haematol. 2022;9(9):e670–e677. doi:10.1016/S2352-3026(22)00165-X
  • Rajkumar SV. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. 2022;97(8):1086–1107. doi:10.1002/ajh.26590
  • Goel U, Usmani S, Kumar S. Current approaches to management of newly diagnosed multiple myeloma. Am J Hematol. 2022;97(Suppl 1):S3–S25. doi:10.1002/ajh.26512
  • Dimopoulos MA, Moreau P, Terpos E, et al. Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(dagger). Ann Oncol. 2021;32(3):309–322. doi:10.1016/j.annonc.2020.11.014
  • Das S, Juliana N, Yazit NAA, et al. Multiple myeloma: challenges encountered and future options for better treatment. Int J Mol Sci. 2022;23(3):1649. doi:10.3390/ijms23031649
  • Liu W, Liu J, Song Y, et al. Mortality of lymphoma and myeloma in China, 2004-2017: an observational study. J Hematol Oncol. 2019;12(1):22. doi:10.1186/s13045-019-0706-9
  • Gupta N, Sharma A, Sharma A. Emerging biomarkers in multiple myeloma: a review. Clin Chim Acta. 2020;503:45–53. doi:10.1016/j.cca.2019.12.026
  • Vizan P, Gutierrez A, Espejo I, et al. The polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation. Sci Adv. 2020;6(32):eabb2745. doi:10.1126/sciadv.abb2745
  • Ghamlouch H, Boyle EM, Blaney P, et al. Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer. J Exp Clin Cancer Res. 2021;40(1):380. doi:10.1186/s13046-021-02185-1
  • Mason MJ, Schinke C, Eng CLP, et al. Multiple myeloma DREAM challenge reveals epigenetic regulator PHF19 as marker of aggressive disease. Leukemia. 2020;34(7):1866–1874. doi:10.1038/s41375-020-0742-z
  • Ren Z, Ahn JH, Liu H, et al. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood. 2019;134(14):1176–1189. doi:10.1182/blood.2019000578
  • Schinke CD, Bird JT, Qu P, et al. PHF19 inhibition as a therapeutic target in multiple myeloma. Curr Res Transl Med. 2021;69(3):103290. doi:10.1016/j.retram.2021.103290
  • Li Y, Gong J, Zhang L. PHD finger protein 19 expression in multiple myeloma: association with clinical features, induction therapy outcome, disease progression, and survival. J Clin Lab Anal. 2021;35(9):e23910. doi:10.1002/jcla.23910
  • Dimopoulos MA, Terpos E. Multiple myeloma. Ann Oncol. 2010;21( Suppl 7):vii143–vii150. doi:10.1093/annonc/mdq370
  • Ludwig H, Miguel JS, Dimopoulos MA, et al. International Myeloma Working Group recommendations for global myeloma care. Leukemia. 2014;28(5):981–992. doi:10.1038/leu.2013.293
  • Greipp PR, Miguel S, Durie J, et al. International staging system for multiple myeloma. J Clin Oncol. 2005;23(15):3412–3420. doi:10.1200/JCO.2005.04.242
  • Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised international staging system for multiple myeloma: a report from international myeloma working group. J Clin Oncol. 2015;33(26):2863–2869. doi:10.1200/JCO.2015.61.2267
  • Maeda M, Takeshima H, Iida N, et al. Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3. Gut. 2020;69(2):243–251. doi:10.1136/gutjnl-2018-317645
  • Choudhury SR, Ashby C, Tytarenko R, et al. The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma. J Hematol Oncol. 2020;13(1):108. doi:10.1186/s13045-020-00933-y
  • Petruk S, Cai J, Sussman R, et al. Delayed accumulation of H3K27me3 on nascent DNA Is essential for recruitment of transcription factors at early stages of stem cell differentiation. Mol Cell. 2017;66(2):247–257 e245. doi:10.1016/j.molcel.2017.03.006
  • Boyle EM, Rosenthal A, Ghamlouch H, et al. Plasma cells expression from smouldering myeloma to myeloma reveals the importance of the PRC2 complex, cell cycle progression, and the divergent evolutionary pathways within the different molecular subgroups. Leukemia. 2022;36(2):591–595. doi:10.1038/s41375-021-01379-y
  • Yu T, Du C, Ma X, et al. Polycomb-like protein 3 induces proliferation and drug resistance in multiple myeloma and is regulated by miRNA-15a. Mol Cancer Res. 2020;18(7):1063–1073. doi:10.1158/1541-7786.MCR-19-0852
  • Garcia-Montolio M, Ballare C, Blanco E, et al. Polycomb factor PHF19 controls cell growth and differentiation toward erythroid pathway in chronic myeloid leukemia cells. Front Cell Dev Biol. 2021;9:655201. doi:10.3389/fcell.2021.655201
  • Keane NA, Glavey SV, Krawczyk J, et al. AKT as a therapeutic target in multiple myeloma. Expert Opin Ther Targets. 2014;18(8):897–915. doi:10.1517/14728222.2014.924507
  • Ghislin S, Deshayes F, Middendorp S, et al. PHF19 and Akt control the switch between proliferative and invasive states in melanoma. Cell Cycle. 2012;11(8):1634–1645. doi:10.4161/cc.20095
  • Xu B, Li J, Xu D, et al. PLK4 inhibitor plus bortezomib exhibits a synergistic effect on treating multiple myeloma via inactivating PI3K/AKT signaling. Ir J Med Sci. 2023;192(2):561–567. doi:10.1007/s11845-022-03007-9
  • Yang J, Qian J, Wezeman M, et al. Targeting β2-microglobulin for induction of tumor apoptosis in human hematological malignancies. Cancer Cell. 2006;10(4):295–307. doi:10.1016/j.ccr.2006.08.025
  • Kin K, Kasahara T, Itoh Y, et al. beta2-Microglobulin production by highly purified human T and B lymphocytes in cell culture stimulated with various mitogens. Immunology. 1979;36(1):47–54.
  • Schardijn GH, van Eps S, W L. β2-microglobulin: its significance in the evaluation of renal function. Kidney Int. 1987;32(5):635–641. doi:10.1038/ki.1987.255
  • Schmidt-Hieber M, Gutierrez ML, Perez-Andres M, et al. Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells. Haematologica. 2013;98(2):279–287. doi:10.3324/haematol.2011.060632
  • Lee EF, Harris TJ, Tran S, et al. BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival. Cell Death Dis. 2019;10(5):342. doi:10.1038/s41419-019-1568-3
  • Luanpitpong S, Janan M, Yosudjai J, et al. Bcl-2 family members Bcl-xL and Bax cooperatively contribute to bortezomib resistance in mantle cell lymphoma. Int J Mol Sci. 2022;23(22):14474. doi:10.3390/ijms232214474
  • Pinto V, Bergantim R, Caires HR, et al. Multiple myeloma: available therapies and causes of drug resistance. Cancers (Basel). 2020;12(2):407. doi:10.3390/cancers12020407
  • Callander NS, Baljevic M, Adekola K, et al. Nccn guidelines(R) insights: multiple myeloma, version 3.2022. J Natl Compr Canc Netw. 2022;20(1):8–19. doi:10.6004/jnccn.2022.0002
  • Zhang T, Wang S, Lin T, et al. Systematic review and meta-analysis of the efficacy and safety of novel monoclonal antibodies for treatment of relapsed/refractory multiple myeloma. Oncotarget. 2017;8(20):34001–34017. doi:10.18632/oncotarget.16987
  • Mateos MV, Dimopoulos MA, Cavo M, et al. Daratumumab plus bortezomib, melphalan, and prednisone for untreated myeloma. N Engl J Med. 2018;378(6):518–528. doi:10.1056/NEJMoa1714678
  • Facon T, Cook G, Usmani SZ, et al. Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA. Leukemia. 2022;36(4):1066–1077. doi:10.1038/s41375-021-01488-8
  • Facon T, Kumar SK, Plesner T, et al. Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma (MAIA): overall survival results from a randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(11):1582–1596. doi:10.1016/S1470-2045(21)00466-6