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Review

Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 721-738 | Received 08 Jan 2023, Accepted 08 Mar 2023, Published online: 13 Mar 2023

References

  • Zhang L, Du W, Li X, et al. Dissolving microneedles based on polysaccharide for dermatological diseases therapy. J Drug Deliv Sci Technol. 2022;78:103913. . 10.1016/j.jddst.2022.103913
  • Jain S, Barambhe M, Jain J, et al. Prevalence of skin diseases in rural central India: a community-based, cross-sectional, observational study. J Mahatma Gandhi Inst Med Sci. 2016;21(2):111.
  • Kavita A, Thakur JS, Narang T, et al. The burden of skin diseases in India: global burden of disease study 2017. Indian J Dermatol Venereol Leprol. 2021;0:1–5.
  • Karimkhani C, Dellavalle RP, Coffeng LE, et al. Global skin disease morbidity and mortality: an update from the global burden of disease study 2013. JAMA Dermatol. 2017;153(5):406–412.
  • Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134(6):1527–1534.
  • Dalgard FJ, Gieler U, Tomas-Aragones L, et al. The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European Countries. J Invest Dermatol. 2015;135(4):984–991.
  • Singh MK, Godden DR. 51 - Skin Cancer of the Head and Neck. Maxillofacial Surgery, Third Edit, Elsevier Inc. 2017, 714–727. DOI:10.1016/b978-0-7020-6056-4.00052-6.
  • Sabri AH, Ogilvie J, Abdulhamid K, et al. Expanding the applications of microneedles in dermatology. Eur J Pharm Biopharm. 2019;140:121–140.
  • Yang D, Chen M, Sun Y, et al. Microneedle-mediated transdermal drug delivery for treating diverse skin diseases. Acta Biomater. 2021;121:119–133.
  • Chen J, Ren H, Zhou P, et al. Microneedle-mediated drug delivery for cutaneous diseases. Front Bioeng Biotechnol. 2022;10:1–16.
  • Rapalli VK, Mahmood A, Waghule T, et al. Revisiting techniques to evaluate drug permeation through skin, expert opin. Drug Deliv. 2021;1812:1829–184210.1080/17425247.2021.2010702
  • Waghule T, Gorantla S, Rapalli VK, et al. Emerging trends in topical delivery of curcumin through lipid nanocarriers: effectiveness in skin disorders. AAPS Pharm Sci Tech. 2020;21. DOI:10.1208/s12249-020-01831-9
  • Gorantla S, Batra U, Samshritha RN, et al. Emerging trends in microneedle-based drug delivery strategies for the treatment of rheumatoid arthritis, expert opin. Drug Deliv. 2022;19(4):395–407.
  • Zhang W, Zhang W, Li C, et al. Recent advances of microneedles and their application in disease treatment. Int J Mol Sci. 2022;23(5):2401.
  • Quinn HL, Larrañeta E, Donnelly RF. Dissolving microneedles: safety considerations and future perspectives. Ther Deliv. 2016;7(5):283–285.
  • Priya S, Singhvi G. Microneedles-based drug delivery strategies: a breakthrough approach for the management of pain. Biomed Pharmacother. 2022;155:113717.
  • Kang NW, Kim S, Lee JY, et al. Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies. Expert Opin Drug Deliv. 2021;18(7):929–947.
  • Waghule T, Singhvi G, Dubey SK, et al. Microneedles: a smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother. 2019;109:1249–1258.
  • Zhao Z, Chen Y, Shi Y. Microneedles: a potential strategy in transdermal delivery and application in the management of psoriasis. RSC Adv. 2020;10(24):14040–14049.
  • Avcil M, Çelik A. Microneedles in drug delivery: progress and challenges. Micromach. 2021;12:1–15.
  • Dabholkar N, Gorantla S, Waghule T, et al. Biodegradable microneedles fabricated with carbohydrates and proteins: revolutionary approach for transdermal drug delivery. Int j biol macromol. 2021;170:602–621. DOI: 10.1016/j.ijbiomac.2020.12.177
  • Gorantla S, Singhvi G, Rapalli VK, et al. Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status, Ther. Deliv. 2020;11(4):269–284.
  • Yalcintas EP, Ackerman DS, Korkmaz E, et al. Analysis of in vitro cytotoxicity of carbohydrate-based materials used for dissolvable microneedle arrays. Pharm Res. 2020;37(3). DOI:10.1007/s11095-019-2748-7
  • Nayak S, Kundu SC. Sericin-carboxymethyl cellulose porous matrices as cellular wound dressing material. J Biomed Mater Res - Part A. 2014;102(6):1928–1940.
  • Ita K. Dissolving microneedles for transdermal drug delivery: advances and challenges. Biomed Pharmacother. 2017;93:1116–1127.
  • Makvandi P, Kirkby M, Hutton ARJ, et al. Engineering Microneedle Patches for Improved Penetration: analysis, Skin Models and Factors Affecting Needle Insertion. Springer Singapore; 2021.
  • Roxhed N, Gasser TC, Griss P, et al. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J Microelectromechanical Syst. 2007;16(6):1429–1440.
  • Chen W, Wang C, Yan L, et al. Improved polyvinylpyrrolidone microneedle arrays with non-stoichiometric cyclodextrin. J Mater Chem B. 2014;2:1699–1705.
  • Abdelghany S, Tekko IA, Vora L, et al. Nanosuspension-based dissolving microneedle arrays for intradermal delivery of curcumin. Pharmaceutics. 2019;11(7):308.
  • Zhao Y, Tian Y, Ye W, et al. A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery. Biomater Sci. 2022;11(1):140–152.
  • Zhi D, Yang T, Zhang T, et al. Microneedles for gene and drug delivery in skin cancer therapy. J Control Release. 2021;335:158–177.
  • Desai VM, Priya S, Gorantla S, et al. Revolutionizing Therapeutic Delivery with Microneedle Technology for Tumor Treatment. Pharmaceutics. 2023;15(1):14.
  • Hamdan IMN, Tekko IA, Matchett KB, et al. Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays. J Pharm Sci. 2018;107(9):2439–2450.
  • Jamaledin R, Yiu CKY, Zare EN, et al. Advances in Antimicrobial Microneedle Patches for Combating Infections. Adv Mater. 2020;3233:1–29. DOI: 10.1002/adma.202002129.
  • Arshad MS, Zahra AT, Zafar S, et al. Antibiofilm Effects of Macrolide Loaded Microneedle Patches: prospects in Healing Infected Wounds. Pharm Res. 2021;38(1):165–177.
  • The Catholic University of Korea, Microneedle Patch for Psoriatic Plaques, (2016).
  • Leppert W, Malec-Milewska M, Zajaczkowska R, et al. Transdermal and Topical Drug Administration in the Treatment of Pain, Mol. A J Synth Chem Nat Prod Chem. 2018;23(3):681.
  • Silpa SR, V C. Review on Skin Cancer. Int Res J Pharm. 2013;4(8):83–88.
  • Sabri AH, Cater Z, Gurnani P, et al. Intradermal delivery of imiquimod using polymeric microneedles for basal cell carcinoma. Int J Pharm. 2020;589:119808.
  • Champeau M, Jary D, Vignion-Dewalle AS, et al. Introduction of a model of skin lesions on rats and testing of dissolving microneedles containing 5-aminolevulinic acid. Int J Pharm. 2021;594:120115.
  • Wei S, Quan G, Lu C, et al. Dissolving microneedles integrated with pH-responsive micelles containing AIEgen with ultra-photostability for enhancing melanoma photothermal therapy. Biomater Sci. 2020;8(20):5739–5750.
  • Wang C, Ye Y, Hochu GM, et al. Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody. Nano Lett. 2016;16(4):2334–2340.
  • Xu J, Danehy R, Cai H, et al. Microneedle Patch-Mediated Treatment of Bacterial Biofilms. ACS Appl Mater Interfaces. 2019;11(16):14640–14646.
  • Permana AD, Mir M, Utomo E, et al. Bacterially sensitive nanoparticle-based dissolving microneedles of doxycycline for enhanced treatment of bacterial biofilm skin infection: a proof of concept study. Int J Pharm X. 2020;2:100047.
  • Zhu W, Mei J, Zhang X, et al. Photothermal Nanozyme‐based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron‐actuated Janus Ion Therapy. Adv Mater. 2022;34(51):2207961.
  • Dillon C, Hughes H, O’reilly NJ, et al. Formulation and characterisation of dissolving microneedles for the transdermal delivery of therapeutic peptides. Int J Pharm. 2017;526(1–2):125–136.
  • Fisher MC, Hawkins NJ, Sanglard D, et al. Worldwide emergence of resistance to antifungal drugs challenges human health and food security. Science. 2018;80). 742(6390):739–742.
  • Wang F, Zhang X, Chen G, et al. Living Bacterial Microneedles for Fungal Infection Treatment. Research. 2020;1–9. DOI:10.34133/2020/2760594
  • Zan P, Than A, Duong PK, et al. Antimicrobial Microneedle Patch for Treating Deep Cutaneous Fungal Infection. Adv Ther. 2019;2(10):1–7.
  • Permana AD, Paredes AJ, Volpe-Zanutto F, et al. Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis. Eur J Pharm Biopharm. 2020;154:50–61.
  • Peng K, Vora LK, Tekko IA, et al. Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: potential for enhanced treatment of cutaneous fungal infections. J Control Release. 2021;339:361–380.
  • Tomar Y, Gorantla S, Singhvi G. Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches, Drug Discov. Today. 2022;28(2):103465.
  • Rapalli VK, Waghule T, Gorantla S, et al. Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems. Drug Discov Today. 2020;25(12):2212–2226.
  • Parisi R, Symmons DPM, Griffiths CEM, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133(2):377–385.
  • Rapalli VK, Singhvi G, Dubey SK, et al. Emerging landscape in psoriasis management: from topical application to targeting biomolecules. Biomed Pharmacother. 2018;106:707–713.
  • Sartawi Z, Blackshields C, Faisal W. Dissolving microneedles: applications and growing therapeutic potential. J Control Release. 2022;348:186–205.
  • Yu K, Yu X, Cao S, et al. Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis. Acta Pharm Sin B. 2021;11(2):505–519.
  • Zhao Z, Wang H, Yao L, et al. Efficient local delivery of FK506 using blocking patches in psoriasis. J Colloid Interface Sci. 2023;630:676–687.
  • Tekko IA, Permana AD, Vora L, et al. Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: potential for enhanced treatment of psoriasis. Eur J Pharm Sci. 2020;152:105469.
  • Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov. 2022;211:21–40. DOI: 10.1038/s41573-021-00266-6.
  • Kim J, Eui Kim B, Leung DYM, et al. Pathophysiology of atopic dermatitis: clinical implications. Allergy Asthma Proc. 2019;40(2):84–92.
  • Jang M, Kang BM, Yang H, et al. High-Dose Steroid Dissolving Microneedle for Relieving Atopic Dermatitis. Adv Healthc Mater. 2021;10(7):2001691.
  • Chen MC, Chen CS, Wu YW, et al. Poly-γ-Glutamate microneedles as transdermal immunomodulators for ameliorating atopic dermatitis-like skin lesions in Nc/Nga mice. Acta Biomater. 2020;114:183–192.
  • Huang Y, Yu H, Wang L, et al. Research progress on cosmetic microneedle systems: preparation, property and application, Eur. Polym J. 2022;163:110942.
  • Xing M, Zhang S, Ma Y, et al. Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy. J Drug Deliv Sci Technol. 2022;75:103667.
  • Xing M, Yang G, Zhang S, et al. Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine. Eur J Pharm Sci. 2021;165:105935.
  • Lee WS, Lee HJ, Choi GS, et al. Guidelines for management of androgenetic alopecia based on BASP classification-the Asian consensus committee guideline. J Eur Acad Dermatol Venereol. 2013;27(8):1026–1034.
  • Zhou Y, Jia L, Zhou D, et al. Advances in microneedles research based on promoting hair regrowth. J Control Release. 2023;353:965–974.
  • Cárcamo-Martínez Á, Mallon B, Anjani QK, et al. Enhancing intradermal delivery of tofacitinib citrate: comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays. Int J Pharm. 2021;593:120152.
  • Response of Topical Capsaicin in Alopecia Areata - Full Text View - ClinicalTrials.Gov. [Cited Jan 1 2023]. 2023. Available from: https://clinicaltrials.gov/ct2/show/NCT00176969
  • Eum J, Kim Y, Um DJ, et al. Solvent-free polycaprolactone dissolving microneedles generated via the thermal melting method for the sustained release of capsaicin. Micromach. 2021;12(2):167.
  • Zhang Z, Liu Y, Chen Y, et al., Transdermal Delivery of 5-Aminolevulinic Acid by Nanoethosome Gels for Photodynamic Therapy of Hypertrophic Scars, (2018).
  • Wang L, Yang J, Ran B, et al. Small Molecular TGF-β1-Inhibitor-Loaded Electrospun Fibrous Scaffolds for Preventing Hypertrophic Scars. ACS Appl Mater Interfaces. 2017;9(38):32545–32553.
  • Chen Y, Duan Y, Li M, et al. Research progress on the application of microneedle transdermal drug delivery system in dermatology. Life Res. 2022;5(2):14.
  • Xie Y, Wang H, Mao J, et al. Enhanced in vitro efficacy for inhibiting hypertrophic scar by bleomycin-loaded dissolving hyaluronic acid microneedles †. J Mater Chem B. 2019;7(42):6604.
  • Lin S, Quan G, Hou A, et al. Strategy for hypertrophic scar therapy: improved delivery of triamcinolone acetonide using mechanically robust tip-concentrated dissolving microneedle array. J Control Release. 2019;306:69–82.
  • Demartis S, Anjani QK, Volpe-Zanutto F, et al. Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management. Int J Pharm. 2022;627:122217.
  • Zhao Y, Zhou Y, Yang D, et al. Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma. Acta Biomater. 2021;135:164–178.
  • Hao Y, Chen YW, He XL, et al. Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy. Bioact Mater. 2020;5(3):542–552.
  • Mir M, Permana AD, Ahmed N, et al. Enhancement in site-specific delivery of carvacrol for potential treatment of infected wounds using infection responsive nanoparticles loaded into dissolving microneedles: a proof of concept study. Eur J Pharm Biopharm. 2020;147:57–68.
  • Permana AD, Anjani QK, Sartini E, et al. Donnelly, Selective delivery of silver nanoparticles for improved treatment of biofilm skin infection using bacteria-responsive microparticles loaded into dissolving microneedles, Mater. Sci Eng C. 2021;120:111786.
  • Abdelghany S, Alshaer W, Al Thaher Y, et al. Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections. Beilstein J Nanotechnol. 2022;13:517–527.
  • Sun Y, Liu J, Wang H, et al. NIR Laser-Triggered Microneedle-Based Liquid Band-Aid for Wound Care. Adv Funct Mater. 2021;31(29):1–10.
  • Woodhouse I, Nejati S, Selvamani V, et al. Flexible Microneedle Array Patch for Chronic Wound Oxygenation and Biofilm Eradication. ACS Appl Bio Mater. 2021;4(7):5405–5415.
  • Chi J, Zhang X, Chen C, et al. Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing. Bioact Mater. 2020;5(2):253–259.
  • Park SY, Lee HU, Lee YC, et al. Wound healing potential of antibacterial microneedles loaded with green tea extracts, Mater. Sci Eng C. 2014;42:757–762.
  • Frydman GH, Olaleye D, Annamalai D, et al. Manuka honey microneedles for enhanced wound healing and the prevention and/or treatment of Methicillin-resistant Staphylococcus aureus (MRSA) surgical site infection. Sci Rep. 2020;10(1):1–11.
  • Albarahmieh E, AbuAmmouneh L, Kaddoura Z, et al. Fabrication of Dissolvable Microneedle Patches Using an Innovative Laser-Cut Mould Design to Shortlist Potentially Transungual Delivery Systems: in Vitro Evaluation. AAPS Pharm Sci Tech. 2019;20:1–14.
  • Nasiri MI, Vora LK, Ershaid JA, et al. Nanoemulsion-based dissolving microneedle arrays for enhanced intradermal and transdermal delivery, Drug Deliv. Transl Res. 2022;12(4):881–896.
  • Du H, Liu P, Zhu J, et al. Hyaluronic Acid-Based Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of Psoriasis. ACS Applied Materials & Interfaces. 2019;11(46):43588–43598.
  • Huang C, Gou K, Yue X, et al. A novel hyaluronic acid-based dissolving microneedle patch loaded with ginsenoside Rg3 liposome for effectively alleviate psoriasis, Mater. Des. 2022;224:111363.
  • Men Z, Su T, Tang Z, et al. Tacrolimus nanocrystals microneedle patch for plaque psoriasis. Int J Pharm. 2022;627:627.
  • Peng S, Cheng L, Wu Q, et al. A Modified Hyaluronic Acid–Based Dissolving Microneedle Loaded with Daphnetin Improved the Treatment of Psoriasis. Front Bioeng Biotechnol. 2022;10. DOI:10.3389/fbioe.2022.900274
  • Jeong HR, Kim JY, Kim SN, et al. Local dermal delivery of cyclosporin A, a hydrophobic and high molecular weight drug, using dissolving microneedles. Eur J Pharm Biopharm. 2018;127:237–243.
  • Wu D, Shou X, Yu Y, et al. Biologics-Loaded Photothermally Dissolvable Hyaluronic Acid Microneedle Patch for Psoriasis Treatment. Adv Funct Mater. 2022;32(47):2205847.
  • Chiu YH, Wu YW, Hung JI, et al. Epigallocatechin gallate/l-ascorbic acid–loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis. Acta Biomater. 2021;130:223–233.
  • Wan T, Pan Q, Ping Y, et al. Microneedle-assisted genome editing: a transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders, 2021.
  • Kim MJ, Seong KY, Kim DS, et al. Minoxidil-loaded hyaluronic acid dissolving microneedles to alleviate hair loss in an alopecia animal model. Acta Biomater. 2022;143:189–202.
  • Ning X, Wiraja C, Chew WTS, et al. Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment. Acta Pharm Sin B. 2021;11(9):2937–2944.
  • Xing M, Wang X, Zhao L, et al. Novel dissolving microneedles preparation for synergistic melasma therapy: combined effects of tranexamic acid and licorice extract. Int J Pharm. 2021;600:120406.
  • Pamornpathomkul B, Ngawhirunpat T, Tekko IA, et al. Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery. Eur J Pharm Sci. 2018;121:200–209.
  • Panion, BF Biotech Inc. Evaluate the efficacy and safety of brightening micro-needle patch on facial solar lentigines. 2022. [Cited 30 December 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT04583852?term=dissolving+microneedle&draw=2&rank=1
  • Falo L. Microneedle array plus doxorubicin in cutaneous squamous cell cancer (cSCC). 2022. [Cited 30 December 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT05377905?term=microneedle&draw=2&rank=8
  • Shanghai dermatology hospital, soluble hyaluronic acid microneedle VS Non-ablative Fractional Laser on Infraorbital Wrinkles. 2022. [Cited 30 December 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT04989361?term=microneedle&draw=2&rank=9
  • SkinJect Inc. Placebo microneedles in healthy volunteers (part i) and efficacy/safety of doxorubicin microneedles in basal cell cancer subjects (part II), clinicaltrials.Gov. 2021. [Cited 30 December 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT04928222?term=microneedle&draw=2&rank=37
  • SkinJect Inc. Open-label dose escalation trial to evaluate dose limiting toxicity and maximum tolerated dose of microneedle arrays containing doxorubicin (D-MNA) in BCC, clinicaltrials.Gov. 2021. [Cited 30 December 2022]. Available from: https://clinicaltrials.gov/ct2/show/NCT03646188?term=microneedle&draw=2&rank=45
  • Tan CWX, Tan WD, Srivastava R, et al. Dissolving triamcinolone-embedded microneedles for the treatment of keloids: a single-blinded intra-individual controlled clinical trial, dermatol. Dermatol Ther (Heidelb). 2019;9(3):601–611.
  • Yan L, Chen X. Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery, United States; US9526884B2, 2016 Available from: https://patents.google.com/patent/US9526884B2/pt-PT
  • Tankovich N. Biodegardable microneedle device, United States; US10973757B2. 2021 https://patents.google.com/patent/US10973757B2/en?oq=US+10%2C973%2C757+B2
  • Yen Lim C. Method of fabricating microneedle patches, United States; US11504512B2, 2022 Available from: https://patents.google.com/patent/US11504512B2/en?oq=US+11%2C504%2C512+B2
  • Yen Chee L, Hong Liang T. Dissolving microneedle patches comprising corticosteroid, United States; US20200206488A1. 2020. Available from: https://patents.google.com/patent/US20200206488A1/en?oq=.:+US+2020%2F0206488+A1
  • Yen Lim C, Pyramidal microneedles with enhanced drug loading capacity and method for manufacturing, United States; US20220362533A1, 2022 Available from: https://patents.google.com/patent/US20220362533A1/en?oq=US+2022%2F0362533+A1.
  • Qinying MX, Zhenghan Y, Gensheng Z, et al. A kind of soluble microneedle patch and preparation method thereof loading drug China; CN109701152A. 2019. Available from: https://patents.google.com/patent/CN109701152A/en?oq=CN109701152A.
  • Kosuda MEKM, Cirelli K, Beliveau A, et al., Silk fibroin-based microneedles and uses thereof, United States: WIPO; WO2021/072313A1, 2021. Available from: https://patents.google.com/patent/WO2021072313A1/en?q=microneedle+tumors&oq=microneedle+for+tumors&page=1.
  • Guo Q, Wang C, Zhang Q, et al. Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine. Appl Mater Today. 2021;24:101110.
  • Yufang Z, Zhengfang T, Zhu Yu YRZ, et al. Transdermal drug delivery microneedle system with photothermal effect, and preparation method and application thereof. China, CN108578355B. 2021. Available from: https://patents.google.com/patent/CN108578355B/en?oq=CN108578355B.
  • Jun S, Siqi G, Xiaoqi X, et al. Self-dissolving microneedle for treating scar. China; CN111035628A. 2020. Available from: https://patents.google.com/patent/CN111035628A/en?q=dissolving+microneedle&oq=dissolving+microneedle.
  • Gorantla S, Dabholkar N, Sharma S, et al. Chitosan-based microneedles as a potential platform for drug delivery through the skin: trends and regulatory aspects. Int j biol macromol. 2021;184:438–453.
  • Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008;29(13):2113–2124. DOI:10.1016/j.biomaterials.2007.12.048.
  • Lau S, Fei J, Liu H, et al. Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery. J Control Release. 2017;265:113–119.
  • Thakur RRS, Tekko IA, Al-Shammari F, et al. Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery, Drug Deliv. Transl Res. 2016;6(6):800–815.
  • Jung JH, Jin SG. Microneedle for transdermal drug delivery: current trends and fabrication. J Pharm Investig. 2021;51(5):503–517.
  • González García LE, MacGregor MN, Visalakshan RM, et al. Self-sterilizing antibacterial silver-loaded microneedles. Chem Commun. 2019;55(2):171–174.

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