Factors affecting the preparation of nanocrystals: characterization, surface modifications and toxicity aspects

References

• Imono M, Uchiyama H, Yoshida S, et al. The elucidation of key factors for oral absorption enhancement of nanocrystal formulations: in vitro–in vivo correlation of nanocrystals. Eur J Pharm Biopharm. 2020;146:84–92. DOI:10.1016/j.ejpb.2019.12.002
   PubMed Web of Science ®Google Scholar
• Joseph E, Singhvi G. Nanomaterials for drug delivery and therapy: multifunctional nanocrystals for cancer therapy: a potential nanocarrier. Cambridge (MA): Elsevier; 2019.
   Google Scholar
• Gao L, Zhang D, Chen M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res. 2008;10:845–862.
   Web of Science ®Google Scholar
• Zhao J, Liu Y, Wang L, et al. Functional and modified nanocrystals technology for target drug delivery. J Nanosci Nanotechnol. 2018;18:5207–5221.
   PubMed Web of Science ®Google Scholar
• Möschwitzer JP. Drug nanocrystals in the commercial pharmaceutical development process. Int J Pharm. 2013;453:142–156.
   PubMed Web of Science ®Google Scholar
• Patel V, Sharma OP, Mehta T. Nanocrystal: a novel approach to overcome skin barriers for improved topical drug delivery. Expert Opin Drug Deliv. 2018;15:351–368.
   PubMed Web of Science ®Google Scholar
• Zhang J, Huang Y, Liu D, et al. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. Eur J Pharm Sci. 2013;48:740–747.
   PubMed Web of Science ®Google Scholar
• Pelikh O, Stahr PL, Huang J, et al. Nanocrystals for improved dermal drug delivery. Eur J Pharm Biopharm. 2018;128:170–178.
   PubMed Web of Science ®Google Scholar
• Jahangir MA, Imam SS, Muheem A, et al. Nanocrystals: characterization overview, applications in drug delivery, and their toxicity concerns. J Pharm Innov. 2020;17:1–12.
   Web of Science ®Google Scholar
• Gao L, Liu G, Ma J. Drug nanocrystals: in vivo performances. J Control Release. 2012;160:418–430.
   PubMed Web of Science ®Google Scholar
• Pardhi VP, Verma T, Flora SJS, et al. Nanocrystals: an overview of fabrication, characterization and therapeutic applications in drug delivery. Curr Pharm Des. 2018;24:5129–5146.
   PubMed Web of Science ®Google Scholar
• Junyaprasert VB, Morakul B. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian J Pharm Sci. 2015;10:13–23.
   Web of Science ®Google Scholar
• Malamatari M, Taylor KM, Malamataris S, et al. Pharmaceutical nanocrystals: production by wet milling and applications. Drug Discov Today. 2018;23:534–547.
   PubMed Web of Science ®Google Scholar
• Jarvis M, Krishnan V, Mitragotri S. Nanocrystals: a perspective on translational research and clinical studies. Bioeng Transl Med. 2019;4:5–16.
   PubMed Web of Science ®Google Scholar
• Sharma S, Verma A, Pandey G, et al. Investigating the role of Pluronic-g-Cationic polyelectrolyte as functional stabilizer for nanocrystals: impact on Paclitaxel oral bioavailability and tumor growth. Acta Biomater. 2015;26:169–183.
   PubMed Web of Science ®Google Scholar
• Zuo B, Sun Y, Li H, et al. Preparation and in vitro/in vivo evaluation of fenofibrate nanocrystals. Int J Pharm. 2013;455:267–275.
   PubMed Web of Science ®Google Scholar
• Liu T, Yu X, Yin H, et al. Advanced modification of drug nanocrystals by using novel fabrication and downstream approaches for tailor-made drug delivery. Drug Deliv. 2019;26:1092–1103.
   PubMed Web of Science ®Google Scholar
• Tuomela A, Hirvonen J, Peltonen L. Stabilizing agents for drug nanocrystals: effect on bioavailability. Pharmaceutics. 2016;8:16.
   PubMed Web of Science ®Google Scholar
• Fuhrmann K, Gauthier MA, Leroux JC. Targeting of injectable drug nanocrystals. Mol Pharm. 2014;11:1762–1771.
   PubMed Web of Science ®Google Scholar
• Junghanns JUAH, Müller RH. Nanocrystal technology, drug delivery and clinical applications. Int J Nanomed. 2008;3(3):295–310.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Fu Y, Zhang A, et al. Rod-shaped nintedanib nanocrystals improved oral bioavailability through multiple intestinal absorption pathways. Eur J Pharm Sci. 2022;168:106047.
   PubMed Web of Science ®Google Scholar
• Bakhaidar RB, Naveen NR, Basim P, et al. Response Surface Methodology (RSM) powered formulation development, optimization and evaluation of thiolated based mucoadhesive nanocrystals for local delivery of simvastatin. Polymers. 2022;14(23):5184. DOI:10.3390/polym14235184
   PubMed Web of Science ®Google Scholar
• Tashan E, Karakucuk A, Celebi N. Optimization and in vitro evaluation of ziprasidone nanosuspensions produced by a top-down approach. J Drug Deliv Sci Technol. 2019;52:37–45.
   Web of Science ®Google Scholar
• Parmar PK, Bansal AK. Novel nanocrystal-based formulations of apremilast for improved topical delivery. Drug Deliv Transl Res. 2021;11:966–983.
   PubMed Web of Science ®Google Scholar
• Pelikh O, Eckert RW, Pinnapireddy SR, et al. Hair follicle targeting with curcumin nanocrystals: influence of the formulation properties on the penetration efficacy. J Control Release. 2021;329:598–613.
   PubMed Web of Science ®Google Scholar
• Deguchi S, Ogata F, Watanabe M, et al. Nanocrystalline suspensions of irbesartan enhance oral bioavailability by improving drug solubility and leading endocytosis uptake into the intestine. Pharmaceutics. 2021;13(9):1404. DOI:10.3390/pharmaceutics13091404
   PubMed Web of Science ®Google Scholar
• Peltonen L, Hirvonen J. Drug nanocrystals – Versatile option for formulation of poorly soluble materials. Int J Pharm. 2018;537(1):73–83.
   PubMedGoogle Scholar
• Zhang G, Guan H, Li J, et al. Roles of effective stabilizers in improving oral bioavailability of naringenin nanocrystals: maintenance of supersaturation generated upon dissolution by inhibition of drug dimerization. Asian J Pharm Sci. 2022;17(5):741–750. DOI:10.1016/j.ajps.2022.09.001
   PubMed Web of Science ®Google Scholar
• Merisko-Liversidge E. Particles: nanocrystals: resolving pharmaceutical formulation issues associated with poorly water-soluble compounds. Orlando: Marcel Dekker; 2002.
   Google Scholar
• Srivalli KMR, Mishra B. Drug nanocrystals: a way toward scale-up. Saudi Pharm J. 2016;24:386–404.
   PubMed Web of Science ®Google Scholar
• Romero GB, Keck CM, Müller RH. Simple low-cost miniaturization approach for pharmaceutical nanocrystals production. Int J Pharm. 2016;501:236–244.
   PubMedGoogle Scholar
• Tomić I, Juretić M, Jug M, et al. Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study. Int J Pharm. 2019;563:249–258.
   PubMed Web of Science ®Google Scholar
• Borchard G. Non-biological complex drugs: drug nanocrystals. Switzerland: Springer; 2015.
   Google Scholar
• Mohammad IS, Hu H, Yin L, et al. Drug nanocrystals: fabrication methods and promising therapeutic applications. Int J Pharm. 2019;562:187–202.
   PubMedGoogle Scholar
• Srivalli KMR, Mishra B. Drug nanocrystals: four basic prerequisites for formulation development and scale-up. Curr Drug Targets. 2015;16:136–147.
   PubMed Web of Science ®Google Scholar
• Bansal S, Bansal M, Kumria R. Nanocrystals: current strategies and trends. Int J Res Pharm BioMed Sci. 2012;4:10.
   Google Scholar
• Merisko-Liversidge EM, Liversidge GG. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicol Pathol. 2008;36:43–48.
   PubMed Web of Science ®Google Scholar
• Zingale E, Bonaccorso A, Carbone C, et al. Drug nanocrystals: focus on brain delivery from therapeutic to diagnostic applications. Pharmaceutics. 2022;14(4):691. DOI:10.3390/pharmaceutics14040691
   PubMed Web of Science ®Google Scholar
• Lu L, Xu Q, Wang J, et al. Drug nanocrystals for active tumor-targeted drug delivery. Pharmaceutics. 2022;14(4):797. DOI:10.3390/pharmaceutics14040797
   PubMed Web of Science ®Google Scholar
• Bilgili E, Guner G. Mechanistic modeling of wet stirred media milling for production of drug nanosuspensions. AAPS Pharm Sci Tech. 2020;22(1):2.
   PubMed Web of Science ®Google Scholar
• Parker N, Rahman M, Bilgili E. Impact of media material and process parameters on breakage kinetics–energy consumption during wet media milling of drugs. Eur J Pharm Biopharm. 2020;153:52–67.
   PubMed Web of Science ®Google Scholar
• Guner G, Kannan M, Berrios M, et al. Use of bead mixtures as a novel process optimization approach to nanomilling of drug suspensions. Pharm Res. 2021;38(7):1279–1296.
   PubMed Web of Science ®Google Scholar
• Li M, Alvarez P, Bilgili E. A microhydrodynamic rationale for selection of bead size in preparation of drug nanosuspensions via wet stirred media milling. Int J Pharm. 2017;524(1):178–192.
   PubMedGoogle Scholar
• Knieke C, Romeis S, Peukert W. Influence of process parameters on breakage kinetics and grinding limit at the nanoscale. AIChE J. 2011;57(7):1751–1758.
   Web of Science ®Google Scholar
• Li M, Yaragudi N, Afolabi A, et al. Sub-100nm drug particle suspensions prepared via wet milling with low bead contamination through novel process intensification. Chem Eng Sci. 2015;130:207–220.
   Web of Science ®Google Scholar
• Medarević D, Djuriš J, Ibrić S, et al. Optimization of formulation and process parameters for the production of carvedilol nanosuspension by wet media milling. Int J Pharm. 2018;540(1):150–161. DOI:10.1016/j.ijpharm.2018.02.011
   PubMedGoogle Scholar
• Juhnke M, Märtin D, John E. Generation of wear during the production of drug nanosuspensions by wet media milling. Eur J Pharm Biopharm. 2012;81(1):214–222.
   PubMed Web of Science ®Google Scholar
• Breitung-Faes S, Kwade A. Use of an enhanced stress model for the optimization of wet stirred media milling processes. Chem Eng Technol. 2014;37(5):819–826.
   Web of Science ®Google Scholar
• Flach F, Konnerth C, Peppersack C, et al. Impact of formulation and operating parameters on particle size and grinding media wear in wet media milling of organic compounds – a case study for pyrene. Adv Powder Technol. 2016;27(6):2507–2519. DOI:10.1016/j.apt.2016.09.026
   Web of Science ®Google Scholar
• Guner G, Seetharaman N, Elashri S, et al. Analysis of heat generation during the production of drug nanosuspensions in a wet stirred media mill. Int J Pharm. 2022;624:122020.
   PubMedGoogle Scholar
• Knieke C, Sommer M, Peukert W. Identifying the apparent and true grinding limit. Powder Technol. 2009;195(1):25–30.
   Web of Science ®Google Scholar
• Romero GB, Keck CM, Müller RH, et al. Development of cationic nanocrystals for ocular delivery. Eur J Pharm Biopharm. 2016;107:215–222.
   PubMed Web of Science ®Google Scholar
• Zong R, Ruan H, Zhu W, et al. Curcumin nanocrystals with tunable surface zeta potential: preparation, characterization and antibacterial study. J Drug Deliv Sci Technol. 2022;76:103771.
   Web of Science ®Google Scholar
• Medarević D, Ibrić S, Vardaka E, et al. Insight into the formation of glimepiride nanocrystals by wet media milling. Pharmaceutics. 2020;12(1):53. DOI:10.3390/pharmaceutics12010053
   PubMed Web of Science ®Google Scholar
• Ferrar JA, Sellers BD, Chan C, et al. Towards an improved understanding of drug excipient interactions to enable rapid optimization of nanosuspension formulations. Int J Pharm. 2020;578:119094.
   PubMed Web of Science ®Google Scholar
• Bilgili E, Li M, Afolabi A. Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions? Pharm Dev Technol. 2016;21(4):499–510. DOI:10.3109/10837450.2015.1022788
   PubMed Web of Science ®Google Scholar
• Kim EA, Park JS, Kim MS, et al. High-payload nanosuspension of centella asiatica extract for improved skin delivery with no irritation. Int J Nanomed. 2021;16:7417.
   PubMed Web of Science ®Google Scholar
• Tian Z, Zhao Y, Mai Y, et al. Nanocrystals with different stabilizers overcome the mucus and epithelial barriers for oral delivery of multicomponent Bufadienolides. Int J Pharm. 2022;616:121522.
   PubMedGoogle Scholar
• Bitterlich A, Laabs C, Krautstrunk I, et al. Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling. Eur J Pharm Biopharm. 2015;92:171–179.
   PubMed Web of Science ®Google Scholar
• Branham ML, Moyo T, Govender T. Preparation and solid-state characterization of ball milled saquinavir mesylate for solubility enhancement. Eur J Pharm Biopharm. 2012;80(1):194–202.
   PubMed Web of Science ®Google Scholar
• Konnerth C, Braig V, Ito A, et al. Formation of mefenamic acid nanocrystals with improved dissolution characteristics. Chemie Ingenieur Technik. 2017;89(8):1060–1071. DOI:10.1002/cite.201600190
   Web of Science ®Google Scholar
• Lu Y, Chen Y, Gemeinhart RA, et al. Developing nanocrystals for cancer treatment. Nanomedicine. 2015;10:2537–2552.
   PubMed Web of Science ®Google Scholar
• Zhang D, Tan T, Gao L, et al. Preparation of azithromycin nanosuspensions by high pressure homogenization and its physicochemical characteristics studies. Drug Dev Ind Pharm. 2007;33:569–575.
   PubMed Web of Science ®Google Scholar
• Keck CM, Müller RH. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm. 2006;62:3–16.
   PubMed Web of Science ®Google Scholar
• Kakran M, Shegokar R, Sahoo NG, et al. Fabrication of quercetin nanocrystals: comparison of different methods. Eur J Pharm Biopharm. 2012;80:113–121.
   PubMed Web of Science ®Google Scholar
• Oktay AN, Ilbasmis-Tamer S, Celebi N. The effect of critical process parameters of the high pressure homogenization technique on the critical quality attributes of flurbiprofen nanosuspensions. Pharm Dev Technol. 2019;24:1278–1286.
   PubMed Web of Science ®Google Scholar
• Sahoo NG, Kakran M, Shaal LA, et al. Preparation and characterization of quercetin nanocrystals. J Pharm Sci. 2011;100:2379–2390.
   PubMed Web of Science ®Google Scholar
• Martena V, Shegokar R, Di Martino P, et al. Effect of four different size reduction methods on the particle size, solubility enhancement and physical stability of nicergoline nanocrystals. Drug Dev Ind Pharm. 2014;40(9):1199–1205. DOI:10.3109/03639045.2013.810635
   PubMed Web of Science ®Google Scholar
• Krause KP, Kayser O, Mäder K, et al. Heavy metal contamination of nanosuspensions produced by high-pressure homogenisation. Int J Pharm. 2000;196(2):169–172. DOI:10.1016/S0378-5173(99)00414-7
   PubMed Web of Science ®Google Scholar
• Chen ML, John M, Lee SL, et al. Development considerations for nanocrystal drug products. Aaps J. 2017 May 1;19(3):642–651. DOI:10.1208/s12248-017-0064-x
   PubMed Web of Science ®Google Scholar
• Liu T, Yu X, Yin H. Impact of nanoparticle size and solid state on dissolution rate by investigating modified drug powders. Powder Technol. 2020;376:167–175.
   Web of Science ®Google Scholar
• Liu Q, Guan J, Sun Z, et al. Influence of stabilizer type and concentration on the lung deposition and retention of resveratrol nanosuspension-in-microparticles. Int J Pharm. 2019;569:118562.
   PubMed Web of Science ®Google Scholar
• Morakul B, Suksiriworapong J, Leanpolchareanchai J, et al. Precipitation-lyophilization-homogenization (PLH) for preparation of clarithromycin nanocrystals: influencing factors on physicochemical properties and stability. Int J Pharm. 2013;457(1):187–196. DOI:10.1016/j.ijpharm.2013.09.022
   PubMedGoogle Scholar
• Friedrich I, Reichl S, Müller-Goymann CC. Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS). Int J Pharm. 2005;305(1):167–175.
   PubMedGoogle Scholar
• Håkansson A. Flow pulsation plays an important role for high-pressure homogenization in laboratory-scale. Chem Eng Res Des. 2018;138:472–481.
   Web of Science ®Google Scholar
• Kakran M, Sahoo NG, Li L, et al. Fabrication of quercetin nanoparticles by anti-solvent precipitation method for enhanced dissolution. Powder Technol. 2012;223:59–64.
   Web of Science ®Google Scholar
• Fontana F, Figueiredo P, Zhang P, et al. Production of pure drug nanocrystals and nano co-crystals by confinement methods. Adv Drug Deliv Rev. 2018;131:3–21.
   PubMed Web of Science ®Google Scholar
• Bhakay A, Rahman M, Dave RN, et al. Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: formulation–processing aspects and challenges. Pharmaceutics. 2018;10(3):86. DOI:10.3390/pharmaceutics10030086
   PubMed Web of Science ®Google Scholar
• Lee H, Bang JB, Na YG, et al. Development and evaluation of tannic acid-coated nanosuspension for enhancing oral bioavailability of curcumin. Pharmaceutics. 2021;13:1460.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu W, Xiong S, et al. Highly stabilized nanocrystals delivering Ginkgolide B in protecting against the Parkinson’s disease. Int J Pharm. 2020;577:119053.
   PubMed Web of Science ®Google Scholar
• Matos RL, Lu T, Prosapio V, et al. Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process. J CO2 Util. 2019;30:48–62.
   Web of Science ®Google Scholar
• Haghighizadeh A, Mahdavi H, Rajabi O. Continuous and size-controlled preparation of ibuprofen nanosuspension by antisolvent crystallization method using hollow fiber membrane. J Pharm Innov. 2022;18(1):1–10.
   Web of Science ®Google Scholar
• Zhao J, Du J, Wang J, et al. Folic acid and poly(ethylene glycol) decorated paclitaxel nanocrystals exhibit enhanced stability and breast cancer-targeting capability. ACS Appl Mater Interfaces. 2021;13(12):14577–14586. DOI:10.1021/acsami.1c00184
   PubMed Web of Science ®Google Scholar
• Taymouri S, Ahmadi Z, Mirian M, et al. Simvastatin nanosuspensions prepared using a combination of Ph-sensitive and timed-release approaches for potential treatment of colorectal cancer. Pharm Dev Technol. 2021;26(3):335–348. DOI:10.1080/10837450.2021.1872086
   PubMed Web of Science ®Google Scholar
• Padrela L, Rodrigues MA, Duarte A, et al. Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – a comprehensive review. Adv Drug Deliv Rev. 2018;131:22–78.
   PubMed Web of Science ®Google Scholar
• Wu KE, Li J, Wang W, et al. Formation and characterization of solid dispersions of piroxicam and polyvinylpyrrolidone using spray drying and precipitation with compressed antisolvent. J Pharm Sci. 2009;98:2422–2431.
   PubMed Web of Science ®Google Scholar
• Lee CW, Kim SJ, Youn YS, et al. Preparation of bitter taste masked cetirizine dihydrochloride/β-cyclodextrin inclusion complex by supercritical antisolvent (SAS) process. J Supercrit Fluids. 2010;55:348–357.
   Web of Science ®Google Scholar
• Yekefallah M, Raofie F. Preparation of stable nanosuspensions from Asplenium scolopendrium leaves via rapid expansion of supercritical solution into aqueous solutions (RESSAS). J Drug Deliv Sci Technol. 2021;64:102566.
   Web of Science ®Google Scholar
• Sodeifian G, Sajadian SA, Derakhsheshpour R. CO2 utilization as a supercritical solvent and supercritical antisolvent in production of sertraline hydrochloride nanoparticles. J CO2 Util. 2022;55:101799.
   Web of Science ®Google Scholar
• Amani M, Saadati Ardestani N, Majd NY. Utilization of supercritical CO2 gas antisolvent (GAS) for production of Capecitabine nanoparticles as anti-cancer drug: analysis and optimization of the process conditions. J CO2 Util. 2021;46:101465.
   Web of Science ®Google Scholar
• Arzi RS, Sosnik A. Electrohydrodynamic atomization and spray-drying for the production of pure drug nanocrystals and co-crystals. Adv Drug Deliv Rev. 2018;131:79–100.
   PubMed Web of Science ®Google Scholar
• Poozesh S, Bilgili E. Scale-up of pharmaceutical spray drying using scale-up rules: a review. Int J Pharm. 2019;562:271–292.
   PubMedGoogle Scholar
• Li X, Anton N, Arpagaus C, et al. Nanoparticles by spray drying using innovative new technology: the büchi nano spray dryer B-90. J Control Release. 2010;147:304–310.
   PubMed Web of Science ®Google Scholar
• Paredes AJ, Llabot JM, Sanchez Bruni S, et al. Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying. Drug Dev Ind Pharm. 2016;42:1564–1570.
   PubMed Web of Science ®Google Scholar
• Hecq J, Deleers M, Fanara D, et al. Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine. Int J Pharm. 2005;299(1):167–177. DOI:10.1016/j.ijpharm.2005.05.014
   PubMedGoogle Scholar
• Hou Y, Shao J, Fu Q, et al. Spray-dried nanocrystals for a highly hydrophobic drug: increased drug loading, enhanced redispersity, and improved oral bioavailability. Int J Pharm. 2017;516(1):372–379. DOI:10.1016/j.ijpharm.2016.11.043
   PubMedGoogle Scholar
• Ambrus R, Radacsi N, Szunyogh T, et al. Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization. J Pharm Biomed Anal. 2013;76:1–7.
   PubMed Web of Science ®Google Scholar
• Nyström M, Roine J, Murtomaa M, et al. Solid state transformations in consequence of electrospraying – a novel polymorphic form of piroxicam. Eur J Pharm Biopharm. 2015;89:182–189.
   PubMed Web of Science ®Google Scholar
• Zheng F, Wang D, Fang H, et al. Controlled crystallization of sodium chloride nanocrystals in microdroplets produced by electrospray from an ultra-dilute solution. Eur J Inorg Chem. 2016;2016(12):1860–1865. DOI:10.1002/ejic.201501453
   Google Scholar
• Nguyen DN, Clasen C, Van den Mooter G. Pharmaceutical applications of electrospraying. J Pharm Sci. 2016;105(9):2601–2620.
   PubMed Web of Science ®Google Scholar
• Liu D, Zhang H, Fontana F, et al. Current developments and applications of microfluidic technology toward clinical translation of nanomedicines. Adv Drug Deliv Rev. 2018;128:54–83.
   PubMed Web of Science ®Google Scholar
• Hakke V, Sonawane S, Anandan S, et al. Process intensification approach using microreactors for synthesizing nanomaterials—a critical review. Nanomaterials. 2021;11(1):98. DOI:10.3390/nano11010098
   Web of Science ®Google Scholar
• Patil A, Patil P, Pardeshi S, et al. Combined microfluidics and drying processes for the continuous production of micro-/nanoparticles for drug delivery: a review. Dry Technol. 2023;1–36. DOI:10.1080/07373937.2023.2167827
   Web of Science ®Google Scholar
• Bojang AA, Design WH. Fundamental principles of fabrication and applications of microreactors. Processes. 2020;8(8):891.
   Web of Science ®Google Scholar
• Hamdallah SI, Zoqlam R, Erfle P, et al. Microfluidics for pharmaceutical nanoparticle fabrication: the truth and the myth. Int J Pharm. 2020;584:119408.
   PubMed Web of Science ®Google Scholar
• Kim S, Wang H, Yan L, et al. Continuous preparation of itraconazole nanoparticles using droplet-based microreactor. Chem Eng. 2020;393:124721.
   Web of Science ®Google Scholar
• Ali HSM, York P, Blagden N. Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. Int J Pharm. 2009;375(1):107–113.
   PubMedGoogle Scholar
• Zhang X, Chen H, Qian F, et al. Preparation of itraconazole nanoparticles by anti-solvent precipitation method using a cascaded microfluidic device and an ultrasonic spray drier. Chem Eng J. 2018;334:2264–2272.
   Web of Science ®Google Scholar
• Rahimi M, Valeh-E-Sheyda P, Rashidi H. Statistical optimization of curcumin nanosuspension through liquid anti-solvent precipitation (LASP) process in a microfluidic platform: box-Behnken design approach. Korean J Chem Eng. 2017;34(11):3017–3027.
   Web of Science ®Google Scholar
• Arzi RS, Kay A, Raychman Y, et al. Excipient-free pure drug nanoparticles fabricated by microfluidic hydrodynamic focusing. Pharmaceutics. 2021;13(4):529. DOI:10.3390/pharmaceutics13040529
   PubMed Web of Science ®Google Scholar
• Odetade DF, Vladisavljevic GT. Microfluidic fabrication of hydrocortisone nanocrystals coated with polymeric stabilisers. Micromach. 2016;7(12):236.
   PubMed Web of Science ®Google Scholar
• Xia D, Quan P, Piao H, et al. Preparation of stable nitrendipine nanosuspensions using the precipitation–ultrasonication method for enhancement of dissolution and oral bioavailability. Eur J Pharm Sci. 2010;40:325–334.
   PubMed Web of Science ®Google Scholar
• Choi JS. Design of cilostazol nanocrystals for improved solubility. J Pharm Innov. 2020;15:416–423.
   Web of Science ®Google Scholar
• Elmowafy M, Shalaby K, Al-Sanea MM, et al. Influence of stabilizer on the development of luteolin nanosuspension for cutaneous delivery: an in vitro and in vivo evaluation. Pharmaceutics. 2021;13:1812.
   PubMed Web of Science ®Google Scholar
• Wang N, Qi F, He X, et al. Preparation and pharmacokinetic characterization of an anti-virulence compound nanosuspensions. Pharmaceutics. 2021;13:1586.
   PubMed Web of Science ®Google Scholar
• Rangaraj N, Pailla SR, Chowta P, et al. Fabrication of ibrutinib nanosuspension by quality by design approach: intended for enhanced oral bioavailability and diminished fast fed variability. AAPS Pharm Sci Tech. 2019;20(8):326. DOI:10.1208/s12249-019-1524-7
   PubMed Web of Science ®Google Scholar
• Choi JS, Park JS. Effects of paclitaxel nanocrystals surface charge on cell internalization. Eur J Pharm Sci. 2016;93:90–96.
   PubMed Web of Science ®Google Scholar
• Mei D, Gong L, Zou Y, et al. Platelet membrane-cloaked paclitaxel-nanocrystals augment postoperative chemotherapeutical efficacy. J Control Release. 2020;324:341–353.
   PubMed Web of Science ®Google Scholar
• Magar KT, Boafo GF, Zoulikha M, et al. Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro. Chin Chem Lett. 2023;34(1):107453. DOI:10.1016/j.cclet.2022.04.051
   Web of Science ®Google Scholar
• Huang F, Jiang X, Sallam MA, et al. A nanocrystal platform based on metal-phenolic network wrapping for drug solubilization. AAPS Pharm Sci Tech. 2022;23(3):76. DOI:10.1208/s12249-022-02220-0
   PubMed Web of Science ®Google Scholar
• Li Y, Teng C, Azevedo HS, et al. Cocrystallization-like strategy for the codelivery of hydrophobic and hydrophilic drugs in a single carrier material formulation. Chin Chem Lett. 2021;32(10):3071–3075. DOI:10.1016/j.cclet.2021.03.085
   Web of Science ®Google Scholar
• Teng C, Li B, Lin C, et al. Targeted delivery of baicalein-p53 complex to smooth muscle cells reverses pulmonary hypertension. J Control Release. 2022;341:591–604.
   PubMed Web of Science ®Google Scholar
• Teng C, Lin C, Huang F, et al. Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease. Acta Pharm Sin B. 2020;10(8):1521–1533. DOI:10.1016/j.apsb.2020.06.005
   PubMed Web of Science ®Google Scholar
• Jadhav PA, Yadav AV. Design, development and characterization of ketorolac tromethamine polymeric nanosuspension. Ther Deliv. 2019;10(9):585–597.
   PubMed Web of Science ®Google Scholar
• Salazar J, Heinzerling O, Müller RH, et al. Process optimization of a novel production method for nanosuspensions using design of experiments (DoE). Int J Pharm. 2011;420:395–403.
   PubMed Web of Science ®Google Scholar
• Salazar J, Müller RH, Möschwitzer JP. Performance comparison of two novel combinative particle-size-reduction technologies. J Pharm Sci. 2013;102:1636–1649.
   PubMed Web of Science ®Google Scholar
• Bukovec P, Meden A, Smrkolj M, et al. Influence of crystal habit on the dissolution of simvastatin single crystals. Acta Chim Slov. 2015;62:958–966.
   PubMed Web of Science ®Google Scholar
• Guo M, Wei M, Li W, et al. Impacts of particle shapes on the oral delivery of drug nanocrystals: mucus permeation, transepithelial transport and bioavailability. J Control Release. 2019;307:64–75.
   PubMed Web of Science ®Google Scholar
• Jain D, Thakur PS, Thakore SD, et al. Impact of differential particle size of fenofibrate nanosuspensions on biopharmaceutical performance using physiologically based absorption modeling in rats. J Drug Deliv Sci Technol. 2020;60:102040.
   Web of Science ®Google Scholar
• Al-Zubaydi F, Gao D, Kakkar D, et al. Breast intraductal nanoformulations for treating ductal carcinoma in situ II: dose de-escalation using a slow releasing/slow bioconverting prodrug strategy. Drug Deliv Transl Res. 2022;12:240–256.
   PubMed Web of Science ®Google Scholar
• Al Zahraa G, Eissa NG, El Nahas HM, et al. Fast disintegrating tablet of doxazosin mesylate nanosuspension: preparation and characterization. J Drug Deliv Sci Technol. 2021;61:102210.
   Web of Science ®Google Scholar
• Patel HP, Chaudhari PS, Gandhi PA, et al. Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: optimization and in vivo pharmacokinetic studies. Int J Pharm. 2021;600:120474.
   PubMed Web of Science ®Google Scholar
• Wadhawan J, Parmar PK, Bansal AK. Nanocrystals for improved topical delivery of medium soluble drug: a case study of acyclovir. J Drug Deliv Sci Technol. 2021;65:102662.
   Web of Science ®Google Scholar
• Fu Q, Jin X, Zhang Z, et al. Preparation and in vitro antitumor effects on MDA-MB-231 cells of niclosamide nanocrystals stabilized by poloxamer188 and PBS. Int J Pharm. 2020;584:119432.
   PubMed Web of Science ®Google Scholar
• Huang G, Xie J, Shuai S, et al. Nose-to-brain delivery of drug nanocrystals by using Ca2+ responsive deacetylated gellan gum based in situ-nanogel. Int J Pharm. 2021;594:120182.
   PubMed Web of Science ®Google Scholar
• Coty JB, Martin C, Telo I, et al. Use of Spray Flash Evaporation (SFE) technology to improve dissolution of poorly soluble drugs: case study on furosemide nanocrystals. Int J Pharm. 2020;589:119827.
   PubMedGoogle Scholar
• Wang J, Lv FM, Wang DL, et al. Synergistic antitumor effects on drug-resistant breast cancer of paclitaxel/lapatinib composite nanocrystals. Molecules. 2020;25:604.
   PubMed Web of Science ®Google Scholar
• Zhao D, Hu C, Fu Q, et al. Combined chemotherapy for triple negative breast cancer treatment by paclitaxel and niclosamide nanocrystals loaded thermosensitive hydrogel. Eur J Pharm Sci. 2021;167:105992.
   PubMed Web of Science ®Google Scholar
• Stefaniak AB, Hackley VA, Roebben G, et al. Nanoscale reference materials for environmental, health and safety measurements: needs, gaps and opportunities. Nanotoxicology. 2013;7:1325–1337.
   PubMed Web of Science ®Google Scholar
• Lapresta-Fernández A, Salinas-Castillo A, Anderson De La Llana S, et al. A general perspective of the characterization and quantification of nanoparticles: imaging, spectroscopic, and separation techniques. Crit Rev Solid State Mater Sci. 2014;39:423–458.
   Web of Science ®Google Scholar
• Vladár AE, Hodoroaba VD. Characterization of nanoparticles: characterization of nanoparticles by scanning electron microscopy. [place unknown]: Elsevier; 2020.
   Google Scholar
• Asano N, Lu J, Asahina S, et al. Direct observation techniques using scanning electron microscope for hydrothermally synthesized nanocrystals and nanoclusters. Nanomaterials. 2021;11:908.
   Web of Science ®Google Scholar
• Angeloni L, Reggente M, Passeri D, et al. Identification of nanoparticles and nanosystems in biological matrices with scanning probe microscopy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018;10:1521.
   Web of Science ®Google Scholar
• Maver U, Velnar T, Gaberšček M, et al. Recent progressive use of atomic force microscopy in biomedical applications. TRAC-Trends Anal Chem. 2016;80:96–111.
   Web of Science ®Google Scholar
• Korayem MH, Khaksar H. A survey on dynamic modeling of manipulation of nanoparticles based on atomic force microscope and investigation of involved factors. J Nanopart Res. 2020;22:1–19.
   PubMed Web of Science ®Google Scholar
• Shi X, Qing W, Marhaba T, et al. Atomic force microscopy-Scanning electrochemical microscopy (AFM-SECM) for nanoscale topographical and electrochemical characterization: principles, applications and perspectives. Electrochim Acta. 2020;332:135472.
   Web of Science ®Google Scholar
• Sitterberg J, Özcetin A, Ehrhardt C, et al. Utilising atomic force microscopy for the characterisation of nanoscale drug delivery systems. Eur J Pharm Biopharm. 2010;74:2–13.
   PubMed Web of Science ®Google Scholar
• Li K, Du S, Ginkel SV, et al. Atomic force microscopy study of the interaction of DNA and nanoparticles. Nanomaterial. 2014;811:93–109.
   Google Scholar
• Harrison AJ, Bilgili EA, Beaudoin SP, et al. Atomic force microscope infrared spectroscopy of griseofulvin nanocrystals. Anal Chem. 2013;85:11449–11455.
   PubMed Web of Science ®Google Scholar
• Hassellöv M, Readman JW, Ranville JF, et al. Nanoparticle analysis and characterization methodologies in environmental risk assessment of engineered nanoparticles. Ecotoxicology. 2008;17:344–361.
   PubMed Web of Science ®Google Scholar
• Lamprecht C, Hinterdorfer P, Ebner A. Applications of biosensing atomic force microscopy in monitoring drug and nanoparticle delivery. Expert Opin Drug Deliv. 2014;11:1237–1253.
   PubMed Web of Science ®Google Scholar
• Deng X, Xiong F, Li X, et al. Application of atomic force microscopy in cancer research. J Nanobiotechnology. 2018;16:1–15.
   PubMed Web of Science ®Google Scholar
• Wang ZL. Transmission electron microscopy of shape-controlled nanocrystals and their assemblies. J Phys Chem B. 2000;104:1153–1175.
   Web of Science ®Google Scholar
• Malatesta M. Transmission electron microscopy as a powerful tool to investigate the interaction of nanoparticles with subcellular structures. Int J Mol Sci. 2021;22:12789.
   PubMed Web of Science ®Google Scholar
• Mühlfeld C, Rothen-Rutishauser B, Vanhecke D, et al. Visualization and quantitative analysis of nanoparticles in the respiratory tract by transmission electron microscopy. Part Fibre Toxicol. 2007;4:1–17.
   PubMedGoogle Scholar
• Carvalho PM, Felício MR, Santos NC, et al. Application of light scattering techniques to nanoparticle characterization and development. Front Chem. 2018;6:237.
   PubMed Web of Science ®Google Scholar
• Brar SK, Verma M. Measurement of nanoparticles by light-scattering techniques. TRAC-Trends Anal Chem. 2011;30:4–17.
   Web of Science ®Google Scholar
• Xu R. Light scattering: a review of particle characterization applications. Particuology. 2015;18:11–21.
   Web of Science ®Google Scholar
• Li T, Senesi AJ, Lee B. Small angle X-ray scattering for nanoparticle research. Chem Rev. 2016;116:11128–11180.
   PubMed Web of Science ®Google Scholar
• Kammler HK, Beaucage G, Kohls DJ, et al. Monitoring simultaneously the growth of nanoparticles and aggregates by in situ ultra-small-angle x-ray scattering. J Appl Phys. 2005;97:054309.
   Web of Science ®Google Scholar
• Agbabiaka A, Wiltfong M, Park C. Small angle X-ray scattering technique for the particle size distribution of nonporous nanoparticles. J Nanoparticles. 2013;2013:640436.
   Google Scholar
• Li T, Hawley A, Rades T, et al. Exposure of liposomes containing nanocrystallised ciprofloxacin to digestive media induces solid-state transformation and altered in vitro drug release. J Control Release. 2020;323:350–360.
   PubMed Web of Science ®Google Scholar
• Lai SY, Knudsen KD, Sejersted BT, et al. Silicon nanoparticle ensembles for lithium-ion batteries elucidated by small-angle neutron scattering. ACS Appl Energy Mater. 2019;2:3220–3227.
   Web of Science ®Google Scholar
• Luo Z, Marson D, Ong QK, et al. Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering. Nat Commun. 2018;9:1–10.
   PubMed Web of Science ®Google Scholar
• Costabile G, Provenzano R, Azzalin A, et al. Pegylated mucus-penetrating nanocrystals for lung delivery of a new FtsZ inhibitor against Burkholderia cenocepacia infection. Nanomed Nanotechnol Biol Med. 2020;23:102113.
   PubMed Web of Science ®Google Scholar
• Lu Y, Li Y, Wu W. Injected nanocrystals for targeted drug delivery. Acta Pharm Sin B. 2016;6:106–113.
   PubMed Web of Science ®Google Scholar
• Liu J, Tu L, Cheng M, et al. Mechanisms for oral absorption enhancement of drugs by nanocrystals. J Drug Deliv Sci Technol. 2020;56:101607.
   Web of Science ®Google Scholar
• Peltonen L, Strachan C. Understanding critical quality attributes for nanocrystals from preparation to delivery. Molecules. 2015;20:22286–22300.
   PubMed Web of Science ®Google Scholar
• Yang H, Kim H, Jung S, et al. Pharmaceutical strategies for stabilizing drug nanocrystals. Curr Pharm Des. 2018;24:2362–2374.
   PubMed Web of Science ®Google Scholar
• Sapsford KE, Tyner KM, Dair BJ, et al. Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques. Anal Chem. 2011;83:4453–4488.
   PubMed Web of Science ®Google Scholar
• Hall JB, Dobrovolskaia MA, Patri AK, et al. Characterization of nanoparticles for therapeutics. Future Med. 2007;2:789–803.
   Google Scholar
• Newbury DE, Ritchie NW. Is scanning electron microscopy/energy dispersive X‐ray spectrometry (SEM/EDS) quantitative? Scanning. 2013;35:141–168.
   PubMed Web of Science ®Google Scholar
• Witika BA, Smith VJ, Walker RB. Quality by design optimization of cold sonochemical synthesis of zidovudine-lamivudine nanosuspensions. Pharmaceutics. 2020;12:367.
   PubMed Web of Science ®Google Scholar
• Dumont E, De Bleye C, Sacré PY, et al. From near-infrared and Raman to surface-enhanced Raman spectroscopy: progress, limitations and perspectives in bioanalysis. Bioanalysis. 2016;8:1077–1103.
   PubMed Web of Science ®Google Scholar
• Chogale MM, Ghodake VN, Patravale VB. Performance parameters and characterizations of nanocrystals: a brief review. Pharmaceutics. 2016;8:26.
   PubMed Web of Science ®Google Scholar
• de Waard H, De Beer T, Hinrichs WL, et al. Controlled crystallization of the lipophilic drug fenofibrate during freeze-drying: elucidation of the mechanism by in-line Raman spectroscopy. Aaps J. 2010;12:569–575.
   PubMed Web of Science ®Google Scholar
• Ingham B. X-ray scattering characterisation of nanoparticles. Crystallogr Rev. 2015;21:229–303.
   Web of Science ®Google Scholar
• Pinna N. Scattering methods and the properties of polymer materials: x-Ray diffraction from nanocrystals. Berlin: Springer; 2005.
   Google Scholar
• Sahibzada MUK, Sadiq A, Faidah HS, et al. Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity. Drug Des Devel Ther. 2018;12:303.
   PubMed Web of Science ®Google Scholar
• Bunjes H, Unruh T. Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering. Adv Drug Deliv Rev. 2007;59:379–402.
   PubMed Web of Science ®Google Scholar
• Gill P, Moghadam TT, Ranjbar B. Differential scanning calorimetry techniques: applications in biology and nanoscience. J Biomol Tech. 2010;21:167.
   PubMedGoogle Scholar
• Koshy O, Subramanian L, Thomas S. Thermal and rheological measurement techniques for nanomaterials characterization: differential scanning calorimetry in nanoscience and nanotechnology. Cambridge (MA): Elsevier; 2017.
   Google Scholar
• Li J, Yang M, Xu WR. Enhanced oral bioavailability of fluvastatin by using nanosuspensions containing cyclodextrin. Drug Des Devel Ther. 2018;12:3491.
   PubMed Web of Science ®Google Scholar
• Ullah N, Khan S, Ahmed S, et al. Dexibuprofen nanocrystals with improved therapeutic performance: fabrication, characterization, in silico modeling, and in vivo evaluation. Int J Nanomed. 2018;13:1677.
   PubMed Web of Science ®Google Scholar
• Liu P, Viitala T, Kartal-Hodzic A, et al. Interaction studies between indomethacin nanocrystals and PEO/PPO copolymer stabilizers. Pharm Res. 2015;32:628–639.
   PubMed Web of Science ®Google Scholar
• Cheng M, Yuan F, Liu J, et al. Fabrication of fine puerarin nanocrystals by box–behnken design to enhance intestinal absorption. AAPS Pharm Sci Tech. 2020;21:1–12.
   Web of Science ®Google Scholar
• Gao Y, Vogus D, Zhao Z, et al. Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long‐term treatment of inflammatory arthritis. Bioeng Transl Med. 2022;7:10245.
   Web of Science ®Google Scholar
• Lohan SB, Saeidpour S, Colombo M, et al. Nanocrystals for improved drug delivery of dexamethasone in skin investigated by EPR spectroscopy. Pharmaceutics. 2020;12:400.
   PubMed Web of Science ®Google Scholar
• Baba K, Hashida N, Tujikawa M, et al. The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes. Int J Pharm. 2021;592:120067.
   PubMedGoogle Scholar
• Sun Y, Chen D, Zhao Y, et al. Exploitation of nanocrystal suspension as an effective oral formulation for oxfendazole. Drug Deliv Transl Res. 2022;12:1219–1229.
   PubMed Web of Science ®Google Scholar
• Kong J, Wu K, Ji Y, et al. Enhanced bioavailability by orally administered sirolimus nanocrystals. ACS Appl Bio Mater. 2019;2:4612–4621.
   PubMedGoogle Scholar
• Chang D, Ma Y, Cao G, et al. Improved oral bioavailability for lutein by nanocrystal technology: formulation development, in vitro and in vivo evaluation. Artif Cells Nanomed Biotechnol. 2018;46:1018–1024.
   PubMed Web of Science ®Google Scholar
• Fan Y, Hao W, Cui Y, et al. Cancer cell membrane-coated nanosuspensions for enhanced chemotherapeutic treatment of glioma. Molecules. 2021;26:5103.
   PubMed Web of Science ®Google Scholar
• Nagai N, Seiriki R, Deguchi S, et al. Hydrogel formulations incorporating drug nanocrystals enhance the therapeutic effect of rebamipide in a hamster model for oral mucositis. Pharmaceutics. 2020;12:532.
   PubMed Web of Science ®Google Scholar
• Jain S, Patel K, Arora S, et al. Formulation, optimization, and in vitro–in vivo evaluation of olmesartan medoxomil nanocrystals. Drug Deliv Transl Res. 2017;7:292–303.
   PubMed Web of Science ®Google Scholar
• Liu Q, Mai Y, Gu X, et al. A wet-milling method for the preparation of cilnidipine nanosuspension with enhanced dissolution and oral bioavailability. J Drug Deliv Sci Technol. 2020;55:101371.
   Web of Science ®Google Scholar
• Mehta CH, Narayan R, Aithal G, et al. Molecular simulation driven experiment for formulation of fixed dose combination of Darunavir and Ritonavir as anti-HIV nanosuspension. J Mol Liq. 2019;293:111469.
   Web of Science ®Google Scholar
• Tekko IA, Permana AD, Vora L, et al. Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: potential for enhanced treatment of psoriasis. Eur J Pharm Sci. 2020;152:105469.
   PubMed Web of Science ®Google Scholar
• Youssef JR, Boraie NA, Ibrahim HF, et al. Glibenclamide nanocrystal-loaded bioactive polymeric scaffolds for skin regeneration: in vitro characterization and preclinical evaluation. Pharmaceutics. 2021;13:1469.
   PubMed Web of Science ®Google Scholar
• Lv Y, Wu W, Corpstein CD, et al. Biological and intracellular fates of drug nanocrystals through different delivery routes: recent development enabled by bioimaging and PK modeling. Adv Drug Deliv Rev. 2022;188:114466.
   PubMed Web of Science ®Google Scholar
• Mittapelly N, Thalla M, Pandey G, et al. Long acting ionically paired embonate based nanocrystals of donepezil for the treatment of Alzheimer’s disease: a proof of concept study. Pharm Res. 2017;34:2322–2335.
   PubMed Web of Science ®Google Scholar
• Kumar M, Jha A, Dr M, et al. Targeted drug nanocrystals for pulmonary delivery: a potential strategy for lung cancer therapy. Exp Opin Drug Deliv. 2020;17(10):1459–1472
   PubMed Web of Science ®Google Scholar
• Khatib I, Khanal D, Ruan J, et al. Ciprofloxacin nanocrystals liposomal powders for controlled drug release via inhalation. Int J Pharm. 2019;566:641–651.
   PubMed Web of Science ®Google Scholar
• Shi C, Ignjatović J, Liu T, et al. In vitro-in vivo-in silico approach in the development of inhaled drug products: nanocrystal-based formulations with budesonide as a model drug. Asian J Pharm Sci. 2021;16:350–362.
   PubMed Web of Science ®Google Scholar
• Permana AD, Utami RN, Layadi P, et al. Thermosensitive and mucoadhesive in situ ocular gel for effective local delivery and antifungal activity of itraconazole nanocrystal in the treatment of fungal keratitis. Int J Pharm. 2021;602:120623.
   PubMedGoogle Scholar
• McGuckin MB, Wang J, Ghanma R, et al. Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes. J Control Release. 2022;345:334–353.
   PubMed Web of Science ®Google Scholar
• Wu C, Li B, Zhang Y, et al. Intranasal delivery of paeoniflorin nanocrystals for brain targeting. Asian J Pharm Sci. 2020;15(3):326–335. DOI:10.1016/j.ajps.2019.11.002
   PubMed Web of Science ®Google Scholar
• Liang Y, Fu X, Du C, et al. Enzyme/Enzyme/Ph-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal. Artif Cells Nanomed Biotechnol. 2020;48:1114–1124.
   PubMed Web of Science ®Google Scholar
• Chai Z, Ran D, Lu L, et al. Ligand-modified cell membrane enables the targeted delivery of drug nanocrystals to glioma. ACS Nano. 2019;13:5591–5601.
   PubMed Web of Science ®Google Scholar
• Ci LQ, Huang ZG, Lv FM, et al. Enhanced delivery of imatinib into vaginal mucosa via a new positively charged nanocrystal-loaded in situ hydrogel formulation for treatment of cervical cancer. Pharmaceutics. 2019;11:15.
   PubMed Web of Science ®Google Scholar
• Park JE, Park J, Jun Y, et al. Expanding therapeutic utility of carfilzomib for breast cancer therapy by novel albumin-coated nanocrystal formulation. J Control Release. 2019;302:148–159.
   PubMed Web of Science ®Google Scholar
• Noh JK, Naeem M, Cao J, et al. Herceptin-functionalized pure paclitaxel nanocrystals for enhanced delivery to HER2-postive breast cancer cells. Int J Pharm. 2016;513:543–553.
   PubMed Web of Science ®Google Scholar
• Han X, Su R, Huang X, et al. Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance. Asian J Pharm Sci. 2019;14:569–580.
   PubMed Web of Science ®Google Scholar
• Xie J, Yan C, Yan Y, et al. Multi-modal Mn–Zn ferrite nanocrystals for magnetically-induced cancer targeted hyperthermia: a comparison of passive and active targeting effects. Nanoscale. 2016;8:16902–16915.
   PubMed Web of Science ®Google Scholar
• Shegokar R, Singh KK. Surface modified nevirapine nanosuspensions for viral reservoir targeting: in vitro and in vivo evaluation. Int J Pharm. 2011;421:341–352.
   PubMed Web of Science ®Google Scholar
• Sohn JS, Yoon DS, Sohn JY, et al. Development and evaluation of targeting ligands surface modified paclitaxel nanocrystals. Mater Sci Eng C. 2017;72:228–237.
   PubMed Web of Science ®Google Scholar
• Quan P, Shi K, Piao H, et al. A novel surface modified nitrendipine nanocrystals with enhancement of bioavailability and stability. Int J Pharm. 2012;430:366–371.
   PubMed Web of Science ®Google Scholar
• Peng J, Chen J, Xie F, et al. Herceptin-conjugated paclitaxel loaded PCL-PEG worm-like nanocrystal micelles for the combinatorial treatment of HER2-positive breast cancer. Biomaterials. 2019;222:119420.
   PubMed Web of Science ®Google Scholar
• Lv F, Wang J, Chen H, et al. Enhanced mucosal penetration and efficient inhibition efficacy against cervical cancer of PEGylated docetaxel nanocrystals by TAT modification. J Control Release. 2021;336:572–582.
   PubMed Web of Science ®Google Scholar
• Khan MA, Ansari MM, Arif ST, et al. Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability. Drug Deliv. 2021;28:2510–2524.
   PubMed Web of Science ®Google Scholar
• Agrawal S, Dwivedi M, Ahmad H, et al. CD44 targeting hyaluronic acid coated lapatinib nanocrystals foster the efficacy against triple-negative breast cancer. Nanomed Nanotechnol Biol Med. 2018;14:327–337.
   PubMed Web of Science ®Google Scholar
• Zhu S, Zhang S, Pang L, et al. Effects of armodafinil nanocrystal nasal hydrogel on recovery of cognitive function in sleep-deprived rats. Int J Pharm. 2021;597:120343.
   PubMedGoogle Scholar
• Li W, Li Z, Wei L, et al. Evaluation of paclitaxel nanocrystals in vitro and in vivo. Drug Res. 2018;68:205–212.
   Web of Science ®Google Scholar