279
Views
5
CrossRef citations to date
0
Altmetric
Review

Pharmacologic management of non-neurogenic functional obstruction in women

, , , &
Pages 657-667 | Received 21 Feb 2016, Accepted 11 Apr 2016, Published online: 28 Apr 2016

References

  • Haylen BT, De Ridder D, Freeman RM, et al. An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn. 2010;29:4–20.
  • Osman NI, Chapple CR, Abrams P, et al. Detrusor underactivity and the underactive bladder: a new clinical entity? A review of current terminology, definitions, epidemiology, aetiology, and diagnosis. Eur Urol. 2014;65:389–398.
  • Yoshimura N, Chancellor MB. Differential diagnosis and treatment of impaired bladder emptying. Rev Urol. 2004;6:S24–S31.
  • King AB, Goldman HB. Bladder outlet obstruction in women: functional causes. Curr Urol Rep. 2014;15:436.
  • Yoshimura N, Chancellor MB. Physiology and pharmacology of the bladder and urethra. In: Wein AJ, Kavoussi LR, Novick AC, et al., editors. Campbell-walsh urology. Philadelphia (PA): Saunders; 2012. p. 1786–1833.
  • Gacci M, Andersson K-E, Chapple C, et al. Latest evidence on the use of phosphodiesterase type 5 inhibitors for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. Eur Urol. 2016. doi:10.1016/j.eururo.2015.12.048.
  • Gupta P, Ehlert MJ, Sirls LT, et al. Percutaneous tibial nerve stimulation and sacral neuromodulation: an update. Curr Urol Rep. 2015;16:4.
  • Bosch JLHR. An update on sacral neuromodulation: where do we stand with this in the management of lower urinary tract dysfunction in 2010? BJU Int. 2010;106:1432–1442.
  • Artibani W, Cerruto MA. Dysfunctional voiding. Curr Opin Urol. 2014;24:330–335.
  • Groutz A, Blaivas JG, Pies C, et al. Learned voiding dysfunction (non-neurogenic, neurogenic bladder) among adults. Neurourol Urodyn. 2001;20:259–268.
  • Osman NI, Chapple CR. Fowler’s syndrome–a cause of unexplained urinary retention in young women? Nat Rev Urol. 2014;11:87–98.
  • Minardi D, d’Anzeo G, Parri G, et al. The role of uroflowmetry biofeedback and biofeedback training of the pelvic floor muscles in the treatment of recurrent urinary tract infections in women with dysfunctional voiding: a randomized controlled prospective study. Urology. 2010;75:1299–1304.
  • Carlson KV, Rome S, Nitti VW. Dysfunctional voiding in women. J Urol. 2001;165:143–147; discussion 147–148.
  • Prescribing Information: Valium. [ updated 2008]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/013263s083lbl.pdf
  • Riss J, Cloyd J, Gates J, et al. Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008;118:69–86.
  • Blok BF, Holstege G. The central control of micturition and continence: implications for urology. BJU Int. 1999;83(Suppl 2):1–6.
  • Ong J, Kerr DI. GABA-receptors in peripheral tissues. Life Sci. 1990;46:1489–1501.
  • László Á, Nádasy GL, Monos E, et al. The GABAergic system in human female genital organs [Internet]. In: Erdö SL, editor. GABA Outside the CNS. Berlin: Springer; 1992. p. 183–197.
  • Davidoff RA. Antispasticity drugs: mechanisms of action. Ann Neurol. 1985;17:107–116.
  • Mathew A, Mathew MC, Thomas M, et al. The efficacy of diazepam in enhancing motor function in children with spastic cerebral palsy. J Trop Pediatr. 2005;51:109–113.
  • Heymen S, Scarlett Y, Jones K, et al. Randomized, controlled trial shows biofeedback to be superior to alternative treatments for patients with pelvic floor dyssynergia-type constipation. Dis Colon Rectum. 2007;50:428–441.
  • Crisp CC, Vaccaro CM, Estanol MV, et al. Intra-vaginal diazepam for high-tone pelvic floor dysfunction: a randomized placebo-controlled trial. Int Urogynecol J. 2013;24:1915–1923.
  • Prescribing Information: Diastat. [updated 2014 Dec]. Available from: http://www.diastat.com/Portals/_default/Skins/diastat/Diastat-Administration-Instructions.pdf
  • Katz DF, Yuan A, Gao Y. Vaginal drug distribution modeling. Adv Drug Deliv Rev. 2015;92:2–13.
  • Capra P, Perugini P, Bleve M, et al. Innovative approach for interstitial cystitis: vaginal pessaries loaded diazepam—A preliminary study, innovative approach for interstitial cystitis: vaginal pessaries loaded diazepam—a preliminary study. J Pharm J Pharm. 2013;2013:e386546.
  • Rogalski MJ, Kellogg-Spadt S, Hoffmann AR, et al. Retrospective chart review of vaginal diazepam suppository use in high-tone pelvic floor dysfunction. Int Urogynecol J. 2010;21:895–899.
  • Prescribing Information: Lioresal. [updated 2013 Jan]. Available from: http://www.novartis.com.au/PI_PDF/lrst.pdf
  • Hill DR, Bowery NG. 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain. Nature. 1981;290:149–152.
  • Clearfield JS, Nelson MES, McGuire J, et al. Intrathecal baclofen dosing regimens: a retrospective chart review. Neuromodulation J Int Neuromodulation Soc. 2015. doi:10.1111/ner.12361.
  • Borrini L, Bensmail D, Thiebaut J-B, et al. Occurrence of adverse events in long-term intrathecal baclofen infusion: a 1-year follow-up study of 158 adults. Arch Phys Med Rehabil. 2014;95:1032–1038.
  • Xu D, Qu C, Meng H, et al. Dysfunctional voiding confirmed by transdermal perineal electromyography, and its effective treatment with baclofen in women with lower urinary tract symptoms: a randomized double-blind placebo-controlled crossover trial. BJU Int. 2007;100:588–592.
  • Stetkarova I, Brabec K, Vasko P, et al. Intrathecal baclofen in spinal spasticity: frequency and severity of withdrawal syndrome. Pain Physician. 2015;18:E633–E641.
  • Dykstra DD, Sidi AA, Scott AB, et al. Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients. J Urol. 1988;139:919–922.
  • Prescribing information: Botox. [revised 2016 Jan]. Available from: http://www.allergan.com/assets/pdf/botox_pi.pdf
  • Apostolidis A, Dasgupta P, Denys P, et al. Recommendations on the use of botulinum toxin in the treatment of lower urinary tract disorders and pelvic floor dysfunctions: a european consensus report. Eur Urol. 2009;55:100–120.
  • Kiris E, Burnett JC, Kane CD, et al. Recent advances in botulinum neurotoxin inhibitor development. Curr Top Med Chem. 2014;14:2044–2061.
  • Barr JR, Moura H, Boyer AE, et al. Botulinum neurotoxin detection and differentiation by mass spectrometry. Emerg Infect Dis. 2005;11:1578–1583.
  • Phelan MW, Franks M, Somogyi GT, et al. Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction. J Urol. 2001;165:1107–1110.
  • Fowler CJ, Betts CD, Christmas TJ, et al. Botulinum toxin in the treatment of chronic urinary retention in women. Br J Urol. 1992;70:387–389.
  • Kuo H-C. Botulinum A toxin urethral injection for the treatment of lower urinary tract dysfunction. J Urol. 2003;170:1908–1912.
  • Kuo H-C. Effectiveness of urethral injection of botulinum A toxin in the treatment of voiding dysfunction after radical hysterectomy. Urol Int. 2005;75:247–251.
  • Fowler CJ, Christmas TJ, Chapple CR, et al. Abnormal electromyographic activity of the urethral sphincter, voiding dysfunction, and polycystic ovaries: a new syndrome? BMJ. 1988;297:1436–1438.
  • Smith CP, Nishiguchi J, O’Leary M, et al. Single-institution experience in 110 patients with botulinum toxin A injection into bladder or urethra. Urology. 2005;65:37–41.
  • Crowner BE, Torres-Russotto D, Carter AR, et al. Systemic weakness after therapeutic injections of botulinum toxin A: a case series and review of the literature. Clin Neuropharmacol. 2010;33:243–247.
  • Wyndaele JJ, Van Dromme SA. Muscular weakness as side effect of botulinum toxin injection for neurogenic detrusor overactivity. Spinal Cord. 2002;40:599–600.
  • Smith CP, Chancellor MB. Emerging role of botulinum toxin in the management of voiding dysfunction. J Urol. 2004;171:2128–2137.
  • Benecke R. Clinical relevance of botulinum toxin immunogenicity. BioDrugs Clin Immunother Biopharm Gene Ther. 2012;26:e1–e9.
  • Schulte-Baukloh H, Weiss C, Stolze T, et al. Botulinum-A toxin detrusor and sphincter injection in treatment of overactive bladder syndrome: objective outcome and patient satisfaction. Eur Urol. 2005;48:984–990; discussion 990.
  • Kuo H-C. Effect of botulinum a toxin in the treatment of voiding dysfunction due to detrusor underactivity. Urology. 2003;61:550–554.
  • Langford CF, Udvari Nagy S, Ghoniem GM. Levator ani trigger point injections: an underutilized treatment for chronic pelvic pain. Neurourol Urodyn. 2007;26:59–62.
  • Kuo TLC, Ng LG, Chapple CR. Pelvic floor spasm as a cause of voiding dysfunction. Curr Opin Urol. 2015;25:311–316.
  • Diokno AC, Hollander JB, Bennett CJ. Bladder neck obstruction in women: a real entity. J Urol. 1984;132:294–298.
  • Yalla SV, Resnick NM. Initiation of voiding in humans: the nature and temporal relationship of urethral sphincter responses. J Urol. 1997;157:590–595.
  • Crowe R, Noble J, Robson T, et al. An increase of neuropeptide Y but not nitric oxide synthase-immunoreactive nerves in the bladder neck from male patients with bladder neck dyssynergia. J Urol. 1995;154:1231–1236.
  • Kuo H-C. Videourodynamic characteristics and lower urinary tract symptoms of female bladder outlet obstruction. Urology. 2005;66:1005–1009.
  • Brucker BM, Fong E, Shah S, et al. Urodynamic differences between dysfunctional voiding and primary bladder neck obstruction in women. Urology. 2012;80:55–60.
  • Kumar A, Mandhani A, Gogoi S, et al. Management of functional bladder neck obstruction in women: use of alpha-blockers and pediatric resectoscope for bladder neck incision. J Urol. 1999;162:2061–2065.
  • Blaivas JG, Flisser AJ, Tash JA. Treatment of primary bladder neck obstruction in women with transurethral resection of the bladder neck. J Urol. 2004;171:1172–1175.
  • Zhang P, Wu Z-J, Xu L, et al. Bladder neck incision for female bladder neck obstruction: long-term outcomes. Urology. 2014;83:762–766.
  • Markić D, Maričić A, Oguić R, et al. Transurethral bladder neck incision in women with primary bladder neck obstruction. Wien Klin Wochenschr. 2014;126:217–222.
  • Peng C-H, Kuo H-C. Transurethral incision of bladder neck in treatment of bladder neck obstruction in women. Urology. 2005;65:275–278.
  • Jin X, Qu H, Liu H, et al. Modified transurethral incision for primary bladder neck obstruction in women: a method to improve voiding function without urinary incontinence. Urology. 2012;79:310–313.
  • Nasu K, Moriyama N, Fukasawa R, et al. Quantification and distribution of alpha1-adrenoceptor subtype mRNAs in human proximal urethra. Br J Pharmacol. 1998;123:1289–1293.
  • Taki N, Taniguchi T, Okada K, et al. Evidence for predominant mediation of alpha1-adrenoceptor in the tonus of entire urethra of women. J Urol. 1999;162:1829–1832.
  • Van Asseldonk B, Barkin J, Elterman DS. Medical therapy for benign prostatic hyperplasia: a review. Can J Urol. 2015;22(Suppl 1):7–17.
  • Prescribing information: Flomax. [revised 2016 Jan]. Available from: http://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Flomax%20Caps/Flomax.pdf
  • Guthrie RM, Siegel RL. A multicenter, community-based study of doxazosin in the treatment of concomitant hypertension and symptomatic benign prostatic hyperplasia: the Hypertension and BPH Intervention Trial (HABIT). Clin Ther. 1999;21:1732–1748.
  • Martell N, Luque M, HT-BPH Group. Doxazosin added to single-drug therapy in hypertensive patients with benign prostatic hypertrophy. J Clin Hypertens Greenwich Conn. 2001;3:218–223.
  • Prescribing information: Hytrin. [revised 2009 Jul]. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019057s022lbl.pdf
  • Lepor H, Knapp-Maloney G, Sunshine H. A dose titration study evaluating terazosin, a selective, once-a-day alpha 1-blocker for the treatment of symptomatic benign prostatic hyperplasia. J Urol. 1990;144:1393–1397; discussion 1397–1398.
  • Lepor H, Henry D, Laddu AR. The efficacy and safety of terazosin for the treatment of symptomatic BPH. Prostate. 1991;18:345–355.
  • Kessler TM, Studer UE, Burkhard FC. The effect of terazosin on functional bladder outlet obstruction in women: a pilot study. J Urol. 2006;176:1487–1492.
  • Low BY, Liong ML, Yuen KH, et al. Terazosin therapy for patients with female lower urinary tract symptoms: a randomized, double-blind, placebo controlled trial. J Urol. 2008;179:1461–1469.
  • Page No:8 Narayan P, Evans CP, Moon T. Long-term safety and efficacy of tamsulosin for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. J Urol. 2003;170:498–502.
  • Reitz A, Haferkamp A, Kyburz T, et al. The effect of tamsulosin on the resting tone and the contractile behaviour of the female urethra: a functional urodynamic study in healthy women. Eur Urol. 2004;46:235–240.
  • Pischedda A, Pirozzi Farina F, Madonia M, et al. Use of alpha1-blockers in female functional bladder neck obstruction. Urol Int. 2005;74:256–261.
  • Chang S-J, Chiang I-N, Yu H-J. The effectiveness of tamsulosin in treating women with voiding difficulty. Int J Urol Off J Jpn Urol Assoc. 2008;15:981–985.
  • Lee K-S, Han DH, Lee Y-S, et al. Efficacy and safety of tamsulosin for the treatment of non-neurogenic voiding dysfunction in females: a 8-week prospective study. J Korean Med Sci. 2010;25:117–122.
  • Kim S-O, Hwang EC, Oh KJ, et al. Efficacy and safety of combined therapy with tamsulosin and tolterodine in female patients with a maximal flow rate less than 12 ml/s. Int Urogynecol J. 2011;22:1287–1291.
  • Pummangura N, Kochakarn W. Efficacy of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) in women. Asian J Surg Asian Surg Assoc. 2007;30:131–137.
  • Costantini E, Lazzeri M, Bini V, et al. Open-label, longitudinal study of tamsulosin for functional bladder outlet obstruction in women. Urol Int. 2009;83:311–315.
  • Hajebrahimi S, Asrbadr YA, Azaripour A, et al. Effect of tamsulosin versus prazosin on clinical and urodynamic parameters in women with voiding difficulty: a randomized clinical trial. Int J Gen Med. 2011;4:35–39.
  • Kim S-O, Choi HS, Kwon D. The α1 adrenoceptor antagonist tamsulosin for the treatment of voiding symptoms improves nocturia and sleep quality in women. Urol J. 2014;11:1636–1641.
  • Swinn MJ, Kitchen ND, Goodwin RJ, et al. Sacral neuromodulation for women with Fowler’s syndrome. Eur Urol. 2000;38:439–443.
  • Goh M, Diokno AC. Sacral neuromodulation for nonobstructive urinary retention–is success predictable? J Urol. 2007;178:197–199; discussion 199.
  • DasGupta R, Fowler CJ. Urodynamic study of women in urinary retention treated with sacral neuromodulation. J Urol. 2004;171:1161–1164.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.