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Review

Pharmacotherapy during pediatric extracorporeal membrane oxygenation: a review

, &
Pages 1133-1142 | Received 24 Mar 2016, Accepted 09 Jun 2016, Published online: 01 Jul 2016

References

  • Zuppa AF, Barrett JS. Pharmacokinetics and pharmacodynamics in the critically ill child. Pediatr Clin North Am. 2008;55(3):735–755.
  • Varghese JM, Roberts JA, Lipman JL. Pharmacokinetics and pharmacodynamics in critically ill patients. Curr Opin Anaesthesiol. 2010;23(4):472–478.
  • Roberts JA, Abdul-Aziz MH, Lipman J, et al. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Inf Dis. 2014;14(6):498–509.
  • Jaquiss RD, Bronciki RA. An overview of mechanical circulatory support in children. Pediatr Crit Care Med. 2013;14(5 Suppl 1):S3–6.
  • Maslach-Hubbard A, Bratton SL. Extracorporeal membrane oxygenation for pediatric respiratory failure: history, development, and current status. World J Crit Care Med. 20132;4:29–39.
  • Hayes D Jr, Tobias JD, Kukreja J, et al. Extracorporeal life support for acute respiratory distress syndromes. Ann Thorac Med. 2013;8(3):133–141.
  • Bartlett RH, Gattinoni L. Current status of extracorporeal life support (ECMO) for cardiopulmonary failure. Minerva Anestesiol. 2010;76(7):534–540.
  • Dagan O, Klein J, Gruenwald C, et al. Preliminary studies of the effects of extracorporeal membrane oxygenator on the disposition of common pediatric drugs. Ther Drug Monit. 1993;15(4):263–3.
  • Koren G, Crean P, Klein J, et al. Sequestration of fentanyl by the cardiopulmonary bypass (CPBP). Eur J Clin Pharmacol. 1984;27:51–56.
  • van Saet A, De Wildt SN, Knibbe CA, et al. The effect of adult and pediatric cardiopulmonary bypass on pharmacokinetic and pharmacodynamic parameters. Curr Clin Pharamcol. 2013;8(4):297–318.
  • Wildschut ED, van Saet A, Pokorna P, et al. The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children. Pediatr Clin N Am. 2012;59:1183–1204.
  • Buck ML. Pharmacokinetic changes during extracorporeal membrane oxygenation: implications for drug therapy of neonates. Clin Pharmacokinet. 2003;42(5):403–417.
  • Shekar K, Fraser JF, Smith MT, et al. Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. J Crit Care. 2012;27:741.e9–18.
  • Wildschut ED, Ahsman MJ, Houmes RJ, et al. Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO). Curr Drug Metab. 2012;13(6):767–777.
  • Rosen DA, Rosen KR, Silvasi DL. In vitro variability in fentanyl absorption by different membrane oxygenators. J Cardiothorac Anesth. 1990;4(3):332–335.
  • Mulla H, Lawson G, Von Anrep C, et al. In vitro evaluation of sedative drug losses during extracorporeal membrane oxygenation. Perfusion. 2000;15:21–26.
  • Bhatt-Meht V, Annich G. Sedative clearance during extracorporeal membrane oxygenation. Perfusion. 2005;20:309–315.
  • Mehta NM, Halwick DR, Dodson BL, et al. Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med. 2007;33(6):1018–1024.
  • Wildschut ED, Ahsman MJ, Allegaert K, et al. Determinants of drug absorption in different ECMO circuits. Intensive Care Med. 2010;36:2109–2116.
  • Preston TJ, Hodge AB, Riley JB, et al. In vitro drug adsorption and plasma free hemoglobin levels associated with hollow fiber oxygenators in the extracorporeal life support (ECLS) circuit. J Extra Corpor Technol. 2007;39:234–237.
  • Preston TJ, Ratliff TM, Gomez D, et al. Modified surface coatings and their effect on drug absorption within the extracorporeal life support circuit. J Extra Corpor Technol. 2010;42(3):199–202.
  • Shekar K, Roberts JA, Mcdonald CI, et al. Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Crit Care. 2012;16(5):R194.
  • Wagner D, Pasko D, Phillips K, et al. In vitro clearance of dexmedetomidine in extracorporeal membrane oxygenation. Perfusion. 2013;28(1):40–46.
  • Lemaitre F, Hasni N, Leprince P, et al. Propofol, midazolam, vancomycin, and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood. Crit Care. 2015;19:40.
  • Harthan AA, Buckley KW, Heger ML, et al. Medication adsorption into contemporary membrane oxygenator units. J Pediatr Pharmacol Ther. 2014;19(4):288–295.
  • Gillogly A, Kilbourn C, Waldvogel J, et al. In vitro clearance of intravenous acetaminophen in extracorporeal membrane oxygenation. Perfusion. 2013;28(2):141–145.
  • Shekar K, Roberts JA, Mcdonald CI, et al. Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study. Crit Care. 2015;19:164.
  • Shekar K, Roberts JA, Barnett AG, et al. Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models. Crit Care. 2015;19:437.
  • Watt KM, Benjamin DK Jr, Cheifetz IM, et al. Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. Pediatr Infect Dis J. 2012;31(10):1042–1047.
  • Peek GJ, Firmin RK. The inflammatory and coagulative response to prolonged extracorporeal membrane oxygenation. Asaio J. 1999;45(4):250–263.
  • Vet NJ, De Hoog M, Tibboel, et al. The effect of inflammation on drug metabolism: a focus on pediatrics. Drug Discov Today. 2011;16(9–10):250–263.
  • Kearns GL, Abdel-Rahman SM, Alander SW, et al. Developmental pharmacology – drug disposition, action, and therapy in infants and children. N Engl J Med. 2003;349(12):1157–1167.
  • Bartlett RH. Extracorporeal life support for cardiopulmonary failure. Cur Probl Surg. 1990;27(10):621–705.
  • Carcillo JA, Doughty L, Kofos D, et al. Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Med. 2003;29(6):980–984.
  • Alkan-Bozkaya T, Akçevin A, Türkoğlu H, et al. Impact of pulsatile perfusion on clinical outcomes of neonates and infants with complex pathologies undergoing cardiopulmonary bypass procedures. Artif Organs. 2013;37(1):82–86.
  • Talor JJ, Undar A. Pediatric cardiopulmonary bypass: does perfusion mode matter? World J Pediatr Congenit Heart Surg. 2011;2(2):296–300.
  • O’Neil MP, Fleming JC, Badhwar A, et al. Pulsatile versus nonpulsatile flow during cardiopulmonary bypass: microcirculatory and systemic effects. Ann Thorac Surg. 2012;94(6):2046–2053.
  • Roy BJ, Cornish JD, Clark RH. Venovenous extracorporeal membrane oxygenation affects renal function. Pediatrics. 1995;95(4):573–578.
  • Bhatt-Mehta V, Johnson CE, Schumacher RE. Gentamicin pharmacokinetics in term neonates receiving extracorporeal membrane oxygenation. Pharmacotherapy. 1992;12(1):28–32.
  • Shekar K, Roberts JA, Ghassabian S, et al. Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern? J Antimicrob Chemother. 2013;68(3):726–727.
  • Vet NJ, Ista E, De Wildt SN, et al. Optimal sedation in pediatric intensive care patients: a systematic review. Intensive Care Med. 2013;39:1524–1534.
  • Curley MAQ, Wypij D, Watson S, et al. Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized control trial. Jama. 2015;313(4):379–389.
  • Verlaat CWM, Heesen GP, Vet NJ, et al. Randomized controlled trial of daily interruption of sedatives in critically ill children. Pediatr Anaesth. 2013;24(2):151–156.
  • DeBerry BB, Lynch JE, Chernin JM, et al. A survey for pain and sedation medications in pediatric patients during extracorporeal membrane oxygenation. Perfusion. 2005;20(3):139–143.
  • Fonsmark L, Rasmussen YH, Carl P. Occurrence of withdrawal in critically ill sedated children. Crit Care Med. 1999;27(1):196–199.
  • Ducharme C, Carnevale FA, Clermont MS, et al. A prospective study of adverse reactions to the weaning of opioids and benzodiazepines among critically ill children. Intensive Crit Care Nurs. 2005;21(3):179–186.
  • Ista E, van Dijk M, Gamel C, et al. Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: a first evaluation. Crit Care Med. 2008;36(8):2427–2432.
  • Loepke AW. Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine? Pediatr Crit Care Med. 2010;11(2):217–226.
  • Arnold JH, Truog RD, Scavone JM, et al. Changes in pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr. 1991;119(4):639–643.
  • Leuschen MP, Willett LD, Hoie E, et al. Plasma fentanyl levels in infants undergoing extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg. 1993;105(5):885–891.
  • Dagan O, Klein J, Bohn D, et al. Effects of extracorporeal membrane oxygenation on morphine pharmacokinetics in infants. Crit Care Med. 1994;22(7):1099–1101.
  • Shekar K, Roberts JA, Mullany DV, et al. Increased sedation requirements in patients receiving extracorporeal membrane oxygenation for respiratory and cardiorespiratory failure. Anaesth Intensive Care. 2012;40:648–655.
  • Hodgson CL, Fan E. A step up for extracorporeal membrane oxygenation: active rehabilitation. Respir Care. 2013;58(8):1388–1389.
  • Arnold JH, Truog RD, Orav EJ, et al. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990;73:1136–1140.
  • Geiduschek JM, Lynn AM, Bratton SL, et al. Morphine pharmacokinetics during continuous infusion of morphine sulfate for infants receiving extracorporeal membrane oxygenation. Crit Care Med. 1997;25(2):360–364.
  • Peters JW, Anderson BJ, Simons SH, et al. Morphine pharmacokinetics during venoarterial extracorporeal membrane oxygenation in neonates. Intensive Care Med. 2005;31(2):257–263.
  • Peters JW, Anderson BJ, Simons SH, et al. Morphine metabolite pharmacokinetics during venoarterial extracorporeal membrane oxygenation in neonates. Clin Pharmacokinet. 2006;45(7):705–714.
  • Franck LS, Vilardi J, Durand D, et al. Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation. Am J Crit Care. 1998;7(5):364–369.
  • Ahsman MJ, Hanekamp M, Wildschut ED, et al. Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates. Clin Pharmacokinet. 2010;49(6):407–419.
  • Mulla H, McCormack P, Lawson G, et al. Pharmacokinetics of midazolam in neonates undergoing extracorporeal membrane oxygenation. Anesthesiology. 2003 Aug;99(2):275–282.
  • Hammaren E, Rosenberg PH, Hynynen M. Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro. Br J Anaesth. 1999;82(1):38–40.
  • Diedrich DA, Brown DR. Propofol infusion syndrome in the ICU. J Intensive Care Med. 2011;26(2):59–72.
  • Wiesenack C, Wiesner G, Keyl C, et al. In vivo uptake and elimination of isoflurane by different membrane oxygenators during cardiopulmonary bypass. Anesthesiology. 2002 Jul;97(1):133–138.
  • Kaczala GW, Paulus SC, Al-Dajani N, et al. Bloodstream infections in pediatric ECLS: usefulness of daily blood culture monitoring and predictive value of biological markers. The British Columbia experience. Pediatr Surg In. 2009;25(2):169–173.
  • Bizzarro MJ, Conrad SA, Kaufman DA, et al. Extracorporeal life support organization task force on infections, extracorporeal membrane oxygenation. Infections acquired during extracorporeal membrane oxygenation in neonates, children, and adults. Pediatr Crit Care Med. 2011;12(3):277–281.
  • Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998;26(1):1–10.
  • Hoie EB, Swigart SA, Leuschen MP, et al. Vancomycin pharmacokinetics in infants undergoing extracorporeal membrane oxygenation. Clin Pharm. 1990;9(9):711–715.
  • Amaker RD, DiPiro JT, Bhatia J. Pharmacokinetics of vancomycin in critically ill infants undergoing extracorporeal membrane oxygenation. Antimicrob Agents Chemother. 1996;40(5):1139–1142.
  • Buck ML. Vancomycin pharmacokinetics in neonates receiving extracorporeal membrane oxygenation. Pharmacotherapy. 1998;18(5):1082–1086.
  • Mulla H, Pooboni S. Population pharmacokinetics of vancomycin in patients receiving extracorporeal membrane oxygenation. Br J Clin Pharmacol. 2005;60(3):265–275.
  • Southgate WM, DiPiro JT, Robertson AF. Pharmacokinetics of gentamicin in neonates on extracorporeal membrane oxygenation. Antimicrob Agents Chemother. 1989;33(6):817–819.
  • Cohen P, Collart L, Prober CG, et al. Gentamicin pharmacokinetics in neonates undergoing extracorporeal membrane oxygenation. Pediatr Infect Dis J. 1990;9(8):562–566.
  • Munzenberger PJ, Massoud N. Pharmacokinetics of gentamicin in neonatal patients supported with extracorporeal membrane oxygenation. ASAIO Trans. 1991;37(1):16–18.
  • Dodge WF, Jelliffe RW, Zwischenberger JB, et al. Population pharmacokinetic models: effect of explicit versus assumed constant serum concentration assay error patterns upon parameter values of gentamicin in infants on and off extracorporeal membrane oxygenation. Ther Drug Monit. 1994;16(6):552–559.
  • Ahsman MJ, Wildschut ED, Tibboel D, et al. Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation. Antimicrob Agents Chemother. 2010;54(5):1734–1741.
  • Lindsay CA, Bawdon R, Quigley R. Clearance of ticarcillin-clavulonic acid by continuous venovenous hemofiltration in three critically ill children, two with and one without concomitant extracorporeal membrane oxygenation. Pharmacotherapy. 1996;16(3):458–462.
  • Wildschut ED, De Hoog M, Ahsman MJ, et al. Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support. PLoS One. 2010;5(6):e10938.
  • Eyler RF, Klein KC, Mueller BA. The pharmacokinetics of oseltamivir and oseltamivir carboxylate in a critically ill pediatric patient receiving extracorporeal membrane oxygenation and continuous venovenous hemodialysis. J Pediatr Pharmacol Ther. 2012;17(2):173–176.
  • Aebi C, Headrick CL, McCracken GH, et al. Intravenous ribavirin therapy in a neonate with disseminated adenovirus infection undergoing extracorporeal membrane oxygenation: pharmacokinetics and clearance by hemofiltration. J Pediatr. 1997;130(4):612–615.
  • Brüggemann RJ, Antonius T, Heijst AV, et al. Therapeutic drug monitoring of voriconazole in a child with invasive aspergillosis requiring extracorporeal membrane oxygenation. Ther Drug Monit. 2008;30(6):643–646.
  • Spriet I, Annaert P, Meersseman P, et al. Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation. J Antimicrob Chemother. 2009;63(4):767–770.
  • Ruiz S, Papy E, Da Silva D, et al. Potential voriconazole and caspofungin sequestration during extracorporeal membrane oxygenation. Intensive Care Med. 2009;35(1):183–184.
  • Koch B, Wildschut ED, De Goede AL, et al. Insufficient serum caspofungin levels in a paediatric patient on ECMO. Med Mycol Case Rep. 2012;2:23–24.
  • van der Vorst MM, Wildschut E, Houmes RJ, et al. Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation. Crit Care. 2006;10(6):R168.
  • van der Vorst MM, den Hartigh J Wildschut E, et al. An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation. Crit Care. 2007;11(5):R111.
  • Wells TG, Fasules JW, Taylor BJ, et al. Pharmacokinetics and pharmacodynamics of bumetanide in neonates treated with extracorporeal membrane oxygenation. J Pediatr. 1992;121(6):974–980.
  • McBride BF, White CM, Campbell M, et al. Nicardipine to control neonatal hypertension during extracorporeal membrane oxygen support. Ann Pharmacother. 2003;37:667–670.
  • Tobias JD, Pietsch JB, Lynch A. Nicardipine to control mean arterial pressure during extracorporeal membrane oxygenation. Pediatr Anaesth. 1996;6:57–60.
  • Smith T, Rosen DA, Russo P, et al. Nesiritide during extracorporeal membrane oxygenation. Pediatr Anaesth. 2005;15:152–157.
  • Kendrick JG, Macready JJ, Kissoon N. Amiodarone treatment of junctional ectopic tachycardia in a neonate receiving extracorporeal membrane oxygenation. Ann Pharmacother. 2006;40:1872–1875.
  • Robinson B, Eshaghpour E, Ewing S, et al. Hypertrophic obstructive cardiomyopathy in an infant of a diabetic mother: support by extracorporeal membrane oxygenation and treatment with beta-adrenergic blockade and increased intravenous fluid administration. Asaio J. 1998;44:845–847.
  • Ahsman MJ, Witjes BC, Wildschut ED, et al. Sildenafil exposure in neonates with pulmonary hypertension after administration via a nasogastric tube. Arch Dis Child Fetal Neonatal Ed. 2010;95(2):F109–14.
  • Wells TG, Heulitt MJ, Taylor BJ, et al. Pharmacokinetics and pharmacodynamics of ranitidine in neonates treated with extracorporeal membrane oxygenation. J Clin Pharmacol. 1998;38(5):402–407.
  • Saini A, Spinella PC. Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation. Clin Lab Med. 2014;34(3):655–673.
  • Annich G, Adachi I. Anticoagulation for pediatric mechanical circulatory support. Pediatr Crit Care Med. 2013;14(5 Suppl 1):S37–42.
  • Stocker CF, Horton SB. Anticoagulation strategies and difficulties in neonatal and pediatric extracorporeal membrane oxygenation (ECMO). Perfusion. 2016;31(2):95–102.
  • Green TP, Isham-Schopf B, Irmiter RJ, et al. Inactivation of heparin during extracorporeal circulation in infants. Clin Pharmacol Ther. 1990;48(2):148–154.
  • Elliott ES, Buck ML. Phenobarbital dosing and pharmacokinetics in a neonate receiving extracorporeal membrane oxygenation. Ann Pharmacother. 1999;33(4):419–422.
  • Mulla H, Nabi F, Nichani S, et al. Population pharmacokinetics of theophylline during paediatric extracorporeal membrane oxygenation. Br J Clin Pharmacol. 2003;55(1):23–31.
  • Martin GR, Chauvin L, Short BL. Effects of hydralazine on cardiac performance in infants receiving extracorporeal membrane oxygenation. J Pediatr. 1991;118:944–948.
  • Stone DM, Frattarelli DA, Karthikeyan S, et al. Altered prostaglandin E1 dosage during extracorporeal membrane oxygenation in a newborn with ductal-dependent congenital heart disease. Pediatr Cardiol. 2006;27(3):360–363.
  • Paden ML, Conrad SA, Rycus PT, et al. Extracorporeal life support organization registry report 2012. ASAIO Journal. 2013;59:202–210.
  • Anderson BJ, Merry AF. Data sharing for pharmacokinetic studies. Pediatr Anaesth. 2009;19(10):1005–1010.
  • Ince I, de Wildt SN, Tibboel D, et al. Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling. Drug Discov Today. 2009;14(5–6):316–320.
  • Shekar K, Roberts JA, Welch S, et al. ASAP ECMO: antibiotic, sedative, and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimize drug therapy during ECMO. BMC Anesthesiol. 2012;12:29.
  • Laughon MM, Benjamin DK Jr, Capparelli EV, et al. Innovative clinical trial design for pediatric therapeutics. Expert Rev Clin Pharmacol. 2011;4(5):643–652.
  • Musteata FM. Pharmacokinetic applications of microdevices and microsampling techniques. Bioanalysis. 2009;1(1):171–185.
  • Li W, Tse FL. Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules. Biomed Chromatogr. 2010;24(1):49–65.
  • Edelbroek PM, van der Heijden J, Stolk LM. Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls. Ther Drug Monit. 2009;31(3):327–336.
  • Nováková L, Vlcková H. A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation. Anal Chim Acta. 2009;656(1–2):8–35.
  • Millership JS. Microassay of drugs and modern measurements techniques. Paediatr Anaesth. 2011;21(3):197–205.
  • Anderson BJ. My child is unique; the pharmacokinetics are universal. Paediatr Anaesth. 2012;22(6):530–538.
  • Tod Jullien V, Pons G. Facilitation of drug evaluation in children by population methods and modeling. Clin Pharmacokinet. 2008;47(4):231–243.
  • Knibbe CA, Krekels EH, Danhof M. Advances in paediatric pharmacokinetics. Expert Opin Drug Metab Toxicol. 2011;7(1):1–8.
  • Sherwin CMT, Kiang TKL, Spigarelli MG, et al. Fundamentals of population pharmacokinetic modeling: validation methods. Clin Pharmacokinet. 2012;51(9):573–590.
  • Barrett JS, Della Casa Alberighi O, Läer S, et al. Physiologically based pharmacokinetic (PBPK) modeling in children. Clin Pharmacol Ther. 2012;92(1):40–49.
  • Holford N, Ma SC, Ploeger BA. Clinical trial simulation: a review. Clin Pharmacol Ther. 2010;88(2):166–182.
  • Bělohlávek J, Springer D, Mlček M, et al. Early vancomycin, amikacin and gentamicin concentrations in pulmonary artery and pulmonary tissue are not affected by VA ECMO (venoarterial extracorporeal membrane oxygenation) in a pig model of prolonged cardiac arrest. Pulm Pharmacol Ther. 2013 Dec;26(6):655–660.

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