Drug metabolism and disposition diversity of Ranunculales phytometabolites: a systems perspective

References

• Hao DC, Ge GB, Xiao PG, et al. Drug metabolism and pharmacokinetic diversity of ranunculaceae medicinal compounds. Curr Drug Metab. 2015;16(4):294–321.
   PubMed Web of Science ®Google Scholar
• Hao DC, Xiao PG, Ma HY, et al. Mining chemodiversity from biodiversity: pharmacophylogeny of medicinal plants of Ranunculaceae. Chin J Nat Med. 2015;13(7):507–520.
   PubMed Web of Science ®Google Scholar
• Datta S, Mahdi F, Ali Z, et al. Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. J Nat Prod. 2014;77(1):111–117.
   PubMed Web of Science ®Google Scholar
• Hao DC, Gu XJ, Xiao PG. Medicinal plants: chemistry, biology and omics. 1st ed. Oxford: Elsevier-Woodhead; 2015. ISBN 9780081000854.
   Google Scholar
• Hao DC, Gu X, Xiao PG. Chemistry, biology, and phylogenetic analysis of Thalictrum pharmaceutical resources. Lishizhen Med Mat Med Res. 2015;26(7):1731–1733.
   Google Scholar
• Hagel JM, Morris JS, Lee EJ, et al. Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. BMC Plant Biol. 2015;15:227.
   PubMed Web of Science ®Google Scholar
• Hao DC, Gu XJ, Xiao PG. Recent advances in the chemical and biological studies of Aconitum pharmaceutical resources. J Chin Pharm Sci. 2013;22(3):209–221.
   Google Scholar
• Hao DC, Xiao PG. Genomics and evolution in traditional medicinal plants: road to a healthier life. Evol Bioinform. 2015;11:197–212.
   PubMed Web of Science ®Google Scholar
• Hao DC, Xiao PG, Liu M, et al. [Pharmaphylogeny vs. pharmacophylogenomics: molecular phylogeny, evolution and drug discovery]. Yao Xue Xue Bao. 2014;49(10):1387–1394.
   PubMedGoogle Scholar
• Hao DC, Xiao PG, Liu LW, et al. Essentials of pharmacophylogeny: knowledge pedigree, epistemology and paradigm shift. China J Chin Mat Med. 2015;40(17):3335–3342.
   Google Scholar
• Sun E, Xu FJ, Zhang ZH, et al. [Discussion about research progress and ideas on processing mechanism of traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi. 2014;39(3):363–369.
   PubMedGoogle Scholar
• Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Beijing: China Medical Science Press; 2015.
   Google Scholar
• Li CR, Li Q, Mei Q, et al. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii. Life Sci. 2015;126:57–68.
   PubMed Web of Science ®Google Scholar
• Tan X, Jia XB, Chen Y, et al. Thought and probe on basic research for Chinese materia medica based on intestinal absorption barrier. Chin Trad Herb Drug. 2009;40(10):1520–1524.
   Google Scholar
• Sun E, Wei YJ, Zhang ZH, et al. [Processing mechanism of Epimedium fried with suet oil based on absorption and metabolism of flavonoids]. Zhongguo Zhong Yao Za Zhi. 2014;39(3):383–390.
   PubMedGoogle Scholar
• Qian Q, Sun E, Fan H, et al. Effect of suet oil on in vivo pharmacokinetic characteristics of icariside I in extract from processed Epimedii Herba in rats. Chin Trad Herb Drug. 2012;43(10):1981–1985.
   Google Scholar
• Sun E, Zhang ZH, Cui L, et al. [Discussion on research ideas of synergistic mechanism of Epimedium fried with suet oil based on self-assembled micelles formation in vivo]. Zhongguo Zhong Yao Za Zhi. 2014;39(3):378–382.
   PubMedGoogle Scholar
• Jiang J, Li J, Zhang Z, et al. Mechanism of enhanced antiosteoporosis effect of circinal-icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate. Int J Nanomedicine. 2015;10:2377–2389.
   PubMed Web of Science ®Google Scholar
• Sun E, Xu FJ, Zhang ZH, et al. Construction of research system for processing mechanism of traditional Chinese medicine based on chemical composition transformation combined with intestinal absorption barrier. Zhongguo Zhong Yao Za Zhi. 2014;39(3):370–377.
   PubMedGoogle Scholar
• Jiang YN, Mo HY. [Preparation of self-emulsifying soft capsule and its pharmacokinetic in rats for epimedium flavonoids]. Zhong Yao Cai. 2010;33(5):767–771.
   PubMedGoogle Scholar
• Jin X, Zhang ZH, Sun E, et al. Preparation of icariside II-phospholipid complex and its absorption across Caco-2 cell monolayers. Pharmazie. 2012;67(4):293–298.
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhao YH, Jia XB, et al. Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm Res. 2008;25(9):2190–2199.
   PubMed Web of Science ®Google Scholar
• Zhou J, Ma YH, Zhou Z, et al. Intestinal absorption and metabolism of Epimedium flavonoids in osteoporosis rats. Drug Metab Dispos. 2015;43(10):1590–1600.
   PubMed Web of Science ®Google Scholar
• Sun YH, He X, Yang XL, et al. Absorption characteristics of the total alkaloids from Mahonia bealei in an in situ single-pass intestinal perfusion assay. Chin J Nat Med. 2014;12(7):554–560.
   PubMed Web of Science ®Google Scholar
• Liu YZ, Yang XB, Yang XW, et al. [Biotransformation by human intestinal flora and absorption-transportation characteristic in a model of Caco-2 cell monolayer of d-corydaline and tetrahydropalmatine]. Zhongguo Zhong Yao Za Zhi. 2013;38(1):112–118.
   PubMedGoogle Scholar
• Wu P, Huang S, Ye Y, et al. Difference absorption of l-tetrahydropalmatine and dl-tetrahydropalmatine in intestine of rats. Acta Pharm Sin. 2007;42(5):534–537.
   Google Scholar
• Hong Z, Zhao L, Wang X, et al. High-performance liquid chromatography-time-of-flight mass spectrometry with adjustment of fragmentor voltages for rapid identification of alkaloids in rat plasma after oral administration of rhizoma Corydalis extracts. J Sep Sci. 2012;35(13):1690–1696.
   PubMed Web of Science ®Google Scholar
• Cheng XY, Shi Y, Sun H, et al. [Identification and analysis of absorbed components in rat plasma after oral administration of active fraction of Corydalis yanhusuo by LC-MS/MS]. Yao Xue Xue Bao. 2009;44(2):167–174.
   PubMedGoogle Scholar
• Li XY, Xie H, Lu TL, et al. [Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids]. Zhongguo Zhong Yao Za Zhi. 2015;40(9):1812–1816.
   PubMedGoogle Scholar
• Ma L, Yang XW. [Absorption of papaverine, laudanosine and cepharanthine across human intestine by using human Caco-2 cells monolayers model]. Yao Xue Xue Bao. 2008;43(2):202–207.
   PubMedGoogle Scholar
• Zhang YF, Yu Y, Zhou LL. [The pharmacokinetics study on Sinomenine transdermal patch on anaesthetized Beagle dogs]. Zhong Yao Cai. 2010;33(6):944–947.
   PubMedGoogle Scholar
• Li X, Li X, Zhou Y, et al. Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride. J Pharm Sci. 2010;99(4):1790–1799.
   PubMed Web of Science ®Google Scholar
• Miao XY. (Ming Dynasty). Annotation of Shen Nong Ben Cao Jing. Beijing: China Medical Science Press; 2011.
   Google Scholar
• Wang QH, Yang XL, Xiao W, et al. Microcrystalline preparation of akebia saponin D for its bioavailability enhancement in rats. Am J Chin Med. 2015;43(3):513–528.
   PubMed Web of Science ®Google Scholar
• Dutta A, Verma S, Sankhwar S, et al. Bioavailability, antioxidant and non toxic properties of a radioprotective formulation prepared from isolated compounds of Podophyllum hexandrum: a study in mouse model. Cell Mol Biol. 2012;58 Suppl:OL1646–OL1653.
   Google Scholar
• Liu ZQ, Chan K, Zhou H, et al. The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro. Life Sci. 2005;77(25):3197–3209.
   PubMed Web of Science ®Google Scholar
• Long LH, Wu PF, Chen XL, et al. HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats. Acta Pharmacol Sin. 2010;31(11):1508–1514.
   PubMed Web of Science ®Google Scholar
• Li SZ. (Ming Dynasty). Ben Cao Gang Mu. Beijing: Traditional Chinese Medicine Classics Press; 2015.
   Google Scholar
• Yan H, Yan M, Li HD, et al. Pharmacokinetics and penetration into synovial fluid of systemical and electroporation administered sinomenine to rabbits. Biomed Chromatogr. 2015;29(6):883–889.
   PubMed Web of Science ®Google Scholar
• Zhang ZD, Zhou CM, Jin GZ, et al. Pharmacokinetics and autoradiography of 3H or 14Cstepholidine. Acta Pharm Sin. 1990;11(4):289–292.
   Web of Science ®Google Scholar
• Natesan S, Reckless GE, Barlow KBL, et al. The antipsychotic potential of l-stepholidine–a naturally occurring dopamine receptor D1 agonist and D2 antagonist. Psychopharmacology. 2008;199(2):275–289.
   PubMed Web of Science ®Google Scholar
• Shen Q, Wang L, Zhou H, et al. Stereoselective binding of chiral drugs to plasma proteins. Acta Pharmacol Sin. 2013;34(8):998–1006.
   PubMed Web of Science ®Google Scholar
• Sun DL, Huang SD, Wu PS, et al. Stereoselective protein binding of tetrahydropalmatine enantiomers in human plasma, HSA, and AGP, but not in rat plasma. Chirality. 2010;22(6):618–623.
   PubMed Web of Science ®Google Scholar
• Hong Z, Fan G, Le J, et al. Brain pharmacokinetics and tissue distribution of tetrahydropalmatine enantiomers in rats after oral administration of the racemate. Biopharm Drug Dispos. 2006;27(3):111–117.
   PubMed Web of Science ®Google Scholar
• Wang C, Wang S, Fan G, et al. Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem. 2010;396(5):1731–1740.
   PubMed Web of Science ®Google Scholar
• Könczöl A, Müller J, Földes E, et al. Applicability of a blood-brain barrier specific artificial membrane permeability assay at the early stage of natural product-based CNS drug discovery. J Nat Prod. 2013;76(4):655–663.
   PubMed Web of Science ®Google Scholar
• Sedo A, Vlasicová K, Barták P, et al. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV. Phytother Res. 2002;16(1):84–87.
   PubMed Web of Science ®Google Scholar
• Concheiro M, Newmeyer MN, da Costa JL, et al. Morphine and codeine in oral fluid after controlled poppy seed administration. Drug Test Anal. 2015;7(7):586–591.
   PubMed Web of Science ®Google Scholar
• Gao Y, Hu S, Zhang M, et al. Simultaneous determination of four alkaloids in mice plasma and brain by LC-MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts. J Pharm Biomed Anal. 2014;92:6–12.
   PubMed Web of Science ®Google Scholar
• Swanson HI. Drug metabolism by the host and gut microbiota: a partnership or rivalry? Drug Metab Dispos. 2015;43(10):1499–1504.
   PubMed Web of Science ®Google Scholar
• Gong CY, Xiao W, Wang ZZ, et al. [Stability of akebia saponin D in gastrointestinal contents of rats]. Zhongguo Zhong Yao Za Zhi. 2014;39(12):2311–2313.
   PubMedGoogle Scholar
• Chen Y, Wang J, Jia X, et al. Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Molecules. 2011;16(2):1336–1348.
   PubMed Web of Science ®Google Scholar
• Zhou J, Chen Y, Wang Y, et al. A comparative study on the metabolism of Epimedium koreanum Nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora. Molecules. 2013;19(1):177–203.
   PubMed Web of Science ®Google Scholar
• Wei Y, Li P, Fan H, et al. Metabolite profiling of four major flavonoids of Herba Epimedii in zebrafish. Molecules. 2012;17(1):420–432.
   PubMed Web of Science ®Google Scholar
• Wei YJ, Xue XL, Liu W, et al. [Metabolism study of asperosaponin VI by using zebrafish]. Yao Xue Xue Bao. 2013;48(2):281–285.
   PubMedGoogle Scholar
• Li L, Ye M, Bi K, et al. Liquid chromatography-tandem mass spectrometry for the identification of L-tetrahydropalmatine metabolites in Penicillium janthinellum and rats. Biomed Chromatogr. 2006;20(1):95–100.
   PubMed Web of Science ®Google Scholar
• Wong SP, Shen P, Lee L, et al. Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract. J Pharm Biomed Anal. 2009;50(2):216–223.
   PubMed Web of Science ®Google Scholar
• Shen P, Wong SP, Yong EL. Sensitive and rapid method to quantify icaritin and desmethylicaritin in human serum using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;857(1):47–52.
   PubMed Web of Science ®Google Scholar
• Liang DL, Zheng SL. Effects of icaritin on cytochrome P450 enzymes in rats. Pharmazie. 2014;69(4):301–305.
   PubMed Web of Science ®Google Scholar
• Xu SF, Jin T, Lu YF, et al. Effect of icariin on UDP-glucuronosyltransferases in mouse liver. Planta Med. 2014;80(5):387–392.
   PubMed Web of Science ®Google Scholar
• Madgula VL, Ali Z, Smillie T, et al. Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay. Planta Med. 2009;75(4):329–332.
   PubMed Web of Science ®Google Scholar
• Yao YM, Cao W, Cao YJ, et al. Effect of sinomenine on human cytochrome P450 activity. Clin Chim Acta. 2007;379(1–2):113–118.
   PubMed Web of Science ®Google Scholar
• Shan YQ, Zhu YP, Pang J, et al. Tetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein function. Biol Pharm Bull. 2013;36(10):1562–1569.
   PubMed Web of Science ®Google Scholar
• Patil D, Gautam M, Gairola S, et al. Effect of botanical immunomodulators on human CYP3A4 inhibition: implications for concurrent use as adjuvants in cancer therapy. Integr Cancer Ther. 2014;13(2):167–175.
   PubMed Web of Science ®Google Scholar
• Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol. 2004;485(1–3):69–79.
   PubMed Web of Science ®Google Scholar
• Sun SY, Wang YQ, Li LP, et al. Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes. Chirality. 2013;25(1):43–47.
   PubMed Web of Science ®Google Scholar
• Lei Y, Tan J, Wink M, et al. An isoquinoline alkaloid from the Chinese herbal plant Corydalis yanhusuo W.T. Wang inhibits P-glycoprotein and multidrug resistance-associate protein 1. Food Chem. 2013;136(3–4):1117–1121.
   PubMed Web of Science ®Google Scholar
• Ji HY, Liu KH, Lee H, et al. Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Molecules. 2011;16(8):6591–6602.
   PubMed Web of Science ®Google Scholar
• Ji HY, Liu KH, Jeong JH, et al. Effect of a new prokinetic agent DA-9701 formulated with Corydalis tuber and Pharbitidis Semen on cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes. Evid Based Complement Alternat Med. 2012;2012:650718.
   PubMed Web of Science ®Google Scholar
• Cao YF, He RR, Cao J, et al. Drug-drug interactions potential of icariin and its intestinal metabolites via inhibition of intestinal UDP-glucuronosyltransferases. Evid Based Complement Alternat Med. 2012;2012:395912.
   PubMedGoogle Scholar
• Chen P, Braithwaite RA, George C, et al. The poppy seed defense: a novel solution. Drug Test Anal. 2014;6(3):194–201.
   PubMed Web of Science ®Google Scholar
• Hao DC, Xiao B, Xiang Y, et al. Deleterious nonsynonymous single nucleotide polymorphisms in human solute carriers: the first comparison of three prediction methods. Eur J Drug Metab Pharmacokinet. 2013;38(1):53–62.
   PubMed Web of Science ®Google Scholar
• Yan J, He X, Feng S, et al. Up-regulation on cytochromes P450 in rat mediated by total alkaloid extract from Corydalis yanhusuo. BMC Complement Altern Med. 2014;14:306.
   PubMed Web of Science ®Google Scholar
• Vrba J, Vrublova E, Modriansky M, et al. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicol Lett. 2011;203(2):135–141.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Dong X, Le J, et al. A practical strategy for characterization of the metabolic profile of chiral drugs using combinatory liquid chromatography-mass spectrometric techniques: application to tetrahydropalmatine enantiomers and their metabolites in rat urine. J Pharm Biomed Anal. 2014;94:152–162.
   PubMed Web of Science ®Google Scholar
• Jin H, Dai J, Chen X, et al. Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice. J Pharmacol Exp Ther. 2010;332(3):738–746.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Hellum BH, Liang A, et al. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine. Phytother Res. 2012;26(2):277–283.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Hellum BH, Liang A, et al. Inhibitory mechanisms of human CYPs by three alkaloids isolated from traditional Chinese herbs. Phytother Res. 2015;29(6):825–834.
   PubMed Web of Science ®Google Scholar
• Mao X, Peng Y, Zheng J. In vitro and in vivo characterization of reactive intermediates of corynoline. Drug Metab Dispos. 2015;43(10):1491–1498.
   PubMed Web of Science ®Google Scholar
• Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;789(1):43–57.
   PubMed Web of Science ®Google Scholar
• Meyer GMJ, Meyer MR, Wink CSD, et al. Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse. Biochem Pharmacol. 2013;86(10):1497–1506.
   PubMed Web of Science ®Google Scholar
• Meyer GMJ, Meyer MR, Wissenbach DK, et al. Studies on the metabolism and toxicological detection of glaucine, an isoquinoline alkaloid from Glaucium flavum (Papaveraceae), in rat urine using GC-MS, LC-MS(n) and LC-high-resolution MS(n). J Mass Spectrom. 2013;48(1):24–41.
   PubMed Web of Science ®Google Scholar
• Zhao M, Li LP, Sun DL, et al. Stereoselective metabolism of tetrahydropalmatine enantiomers in rat liver microsomes. Chirality. 2012;24(5):368–373.
   PubMed Web of Science ®Google Scholar
• Yi SJ, Cho JY, Lim KS, et al. Effects of Angelicae tenuissima radix, Angelicae dahuricae radix andScutellariae radix extracts on cytochrome P450 activities in healthy volunteers. Basic Clin Pharmacol Toxicol. 2009;105:249–256.
   PubMed Web of Science ®Google Scholar
• Guo LQ, Taniguchi M, Chen QY, et al. Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions. Jpn J Pharmacol. 2001;85:399–408.
   PubMedGoogle Scholar
• Ge GB, Ning J, Hu L, et al. A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications. Chem Commun. 2013;49:9779–9781.
   PubMed Web of Science ®Google Scholar
• Wu JJ, Ge GB, He YQ, et al. Gomisin A is a novel isoform-specific probe for the selective sensing of human cytochrome p450 3A4 in liver microsomes and living cells. AAPS J. 2016;18(1):134–145.
   PubMed Web of Science ®Google Scholar
• Dai ZR, Ge GB, Feng L, et al. A highly selective ratiometric two-photon fluorescent probe for human cytochrome p450 1A. J Am Chem Soc. 2015;137(45):14488–14495.
   PubMed Web of Science ®Google Scholar
• Qian Q, Li SL, Sun E, et al. Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry. J Pharm Biomed Anal. 2012;66:392–398.
   PubMed Web of Science ®Google Scholar
• Cui L, Sun E, Zhang Z, et al. Metabolite profiles of epimedin B in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Agric Food Chem. 2013;61(15):3589–3599.
   PubMed Web of Science ®Google Scholar
• Wang C, Wu C, Zhang J, et al. Systematic considerations for a multicomponent pharmacokinetic study of Epimedii wushanensis herba: From method establishment to pharmacokinetic marker selection. Phytomedicine. 2015;22(4):487–497.
   PubMed Web of Science ®Google Scholar
• Silberberg M, Morand C, Mathevon T, et al. The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. Eur J Nutr. 2006;45(2):88–96.
   PubMed Web of Science ®Google Scholar
• Liu Z, Hu M. Natural polyphenol disposition via coupled metabolic pathways. Expert Opin Drug Metab Toxicol. 2007;3(3):389–406.
   PubMed Web of Science ®Google Scholar
• Montani C, Penza M, Jeremic M, et al. Genistein is an efficient estrogen in the whole-body throughout mouse development. Toxicol Sci. 2008;103(1):57–67.
   PubMed Web of Science ®Google Scholar
• Lv X, Ge GB, Feng L, et al. An optimized ratiometric fluorescent probe for sensing human UDP-glucuronosyltransferase 1A1 and its biological applications. Biosens Bioelectron. 2015;72:261–267.
   PubMed Web of Science ®Google Scholar
• Jiang L, Liang SC, Wang C, et al. Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4. Sci Rep. 2015;5:9627.
   PubMed Web of Science ®Google Scholar
• Sun L, Chen W, Qu L, et al. Icaritin reverses multidrug resistance of HepG2/ADR human hepatoma cells via downregulation of MDR1 and P‑glycoprotein expression. Mol Med Rep. 2013;8(6):1883–1887.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang QS, Cui YL, et al. Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins. Int J Nanomedicine. 2012;7:4239–4249.
   PubMed Web of Science ®Google Scholar
• Li Z, Cheung FSG, Zheng J, et al. Interaction of the bioactive flavonol, icariin, with the essential human solute carrier transporters. J Biochem Mol Toxicol. 2014;28(2):91–97.
   PubMed Web of Science ®Google Scholar
• Tsai TH, Wu JW. Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein in Sprague-Dawley rats. Life Sci. 2003;72(21):2413–2426.
   PubMed Web of Science ®Google Scholar
• Hsueh TY, Wu YT, Lin LC, et al. Herb-drug interaction of Epimedium sagittatum (Sieb. et Zucc.) maxim extract on the pharmacokinetics of sildenafil in rats. Molecules. 2013;18(6):7323–7335.
   PubMed Web of Science ®Google Scholar
• van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption. Expert Opin Drug Metab Toxicol. 2005;1(2):175–185.
   PubMedGoogle Scholar
• Lu Z, Chen W, Viljoen A, et al. Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds. Phytother Res. 2010;24(2):211–218.
   PubMed Web of Science ®Google Scholar
• Liu ZQ, Zhou H, Liu L, et al. Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats. J Ethnopharmacol. 2005;99(1):61–67.
   PubMed Web of Science ®Google Scholar
• Li Y, Duan Z, Tian Y, et al. A novel perspective and approach to intestinal octreotide absorption: sinomenine-mediated reversible tight junction opening and its molecular mechanism. Int J Mol Sci. 2013;14(6):12873–12892.
   PubMed Web of Science ®Google Scholar
• Zhang ZJ, Tan QR, Tong Y, et al. An epidemiological study of concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction. PLoS One. 2011;6(2):e17239.
   Google Scholar
• Liu J, Ye H, Lou Y. Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells. Pharmazie. 2005;60(2):120–125.
   PubMed Web of Science ®Google Scholar
• Liu KP, Wang L, Li Y, et al. Preparation, pharmacokinetics, and tissue distribution properties of icariin-loaded stealth solid lipid nanoparticles in mice. Chin Herb Med. 2012;4(2):170–174.
   Google Scholar
• Zhang M, Le J, Wen J, et al. Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography. J Sep Sci. 2011;34(22):3279–3286.
   PubMed Web of Science ®Google Scholar
• Hong Z, Wen J, Zhang Q, et al. Study on the stereoselective excretion of tetrahydropalmatine enantiomers in rats and identification of in vivo metabolites by liquid chromatography-tandem mass spectrometry. Chirality. 2010;22(3):355–360.
   PubMed Web of Science ®Google Scholar
• Smith ML, Nichols DC, Underwood P, et al. Morphine and codeine concentrations in human urine following controlled poppy seeds administration of known opiate content. Forensic Sci Int. 2014;241:87–90.
   PubMed Web of Science ®Google Scholar
• Tsai PL, Tsai TH. Hepatobiliary excretion of berberine. Drug Metab Dispos. 2004;32(4):405–412.
   PubMed Web of Science ®Google Scholar
• Schep LJ, Slaughter RJ, Beasley DM. Nicotinic plant poisoning. Clin Toxicol. 2009;47(8):771–781.
   PubMed Web of Science ®Google Scholar
• Desgrouas C, Taudon N, Bun SS, et al. Ethnobotany, phytochemistry and pharmacology of Stephania rotunda Lour. J Ethnopharmacol. 2014;154(3):537–563.
   PubMed Web of Science ®Google Scholar
• Yang XB, Yang XW, Liu JX. [Study on material base of corydalis rhizoma]. Zhongguo Zhong Yao Za Zhi. 2014;39(1):20–27.
   PubMedGoogle Scholar
• Hao DC, Xiao PG. Network pharmacology: a Rosetta Stone for traditional Chinese medicine. Drug Dev Res. 2014;75(5):299–312.
   PubMed Web of Science ®Google Scholar
• Zou LW, Li YG, Wang P, et al. Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2. Eur J Med Chem. 2016;112:280–288.
   PubMed Web of Science ®Google Scholar
• Zhai YK, Guo X, Pan YL, et al. A systematic review of the efficacy and pharmacological profile of Herba Epimedii in osteoporosis therapy. Pharmazie. 2013;68(9):713–722.
   PubMed Web of Science ®Google Scholar
• Yang L, Liu HT, Ma H, et al. Application of systems biology to absorption, distribution, metabolism and excretion in traditional Chinese medicine. World Sci Tech-Modern TCM Mat Med. 2007;9(1):98–104.
   Google Scholar
• Shi SJ, Chen H, Gu SF, et al. Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta Pharmacol Sin. 2003;24(10):1011–1015.
   PubMed Web of Science ®Google Scholar
• Wang X, Liu X, Cai H, et al. Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore Extracts. J Sep Sci. 2015;38(8):1286–1293.
   PubMed Web of Science ®Google Scholar
• Hong Z, Le J, Lin M, et al. Comparative studies on pharmacokinetic fates of tetrahydropalmatine enantiomers in different chemical environments in rats. Chirality. 2008;20(2):119–124.
   PubMed Web of Science ®Google Scholar
• Zhang X, Guan J, Zhu H, et al. Simultaneous determination of scutellarin and tetrahydropalmatine of Deng-yan granule in rat plasma by UFLC-MS/MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;971:126–132.
   PubMed Web of Science ®Google Scholar
• Hagel JM, Mandal R, Han B, et al. Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. BMC Plant Biol. 2015;15:220.
   PubMed Web of Science ®Google Scholar
• Lv X, Wang DD, Feng L, et al. A highly selective marker reaction for measuring the activity of human carboxylesterase 1 in complex biological samples. RSC Adv. 2016;6:4302–4309.
   Web of Science ®Google Scholar