Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 13, 2017 - Issue 1
Submit an article Journal homepage
1,586
Views
9
CrossRef citations to date
0
Altmetric
Editorial

Utility of the adverse outcome pathway concept in drug development

Thomas HartungCenter for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;Center for Alternatives to Animal Testing (CAAT), Pharmacology and Toxicology, University of Konstanz, Konstanz, GermanyCorrespondence[email protected]
View further author information
Pages 1-3 | Received 11 Jul 2016, Accepted 05 Oct 2016, Published online: 21 Oct 2016

References

  • USA National Research Council/National Academy of Sciences in 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. Available from: http://www.nap.edu/catalog/11970/toxicity-testing-in-the-21st-century-avision-and-a.
  • Hartung T, McBride M. Food for thought … on mapping the human toxome. ALTEX. 2011;28(2):83–93.
  • Kleensang A, Maertens A, Rosenberg M, et al. T4 workshop report: pathways of toxicity. ALTEX. 2014 Jan 1;31(1):53–61.
  • Bouhifd M, Andersen ME, Baghdikian C, et al. The Human Toxome project. ALTEX. 2015;32(2):112–124.
  • Tollefsen KE, Scholz S, Cronin MT, et al. Applying adverse outcome pathways (AOPs) to support integrated approaches to testing and assessment (IATA). Regulat Toxicol Pharmacol. 2014;70:629–640.
  • Hartung T, Luechtefeld T, Maertens A, et al. Integrated testing strategies for safety assessments. ALTEX. 2013;30(1):3–18.
  • Hartung T, van Vliet E, Jaworska J, et al. Food for thought – systems toxicology. ALTEX. 2012;29(2):119–128.
  • Hartung T. Food for thought … on animal tests. ALTEX. 2008;25(1):3–16.
  • Hartung T. Food for thought … on cell culture. ALTEX. 2007;24(3):143–152.
  • Bouhifd M, Hartung T, Hogberg HT, et al. Review: toxicometabolomics. J Appl Toxicol. 2013;33(12):1365–1383.
  • Ramirez T, Daneshian M, Kamp H, et al. Metabolomics in toxicology and preclinical research. ALTEX. 2013;30(2):209–225.
  • Bouhifd M. Quality assurance of metabolomics. ALTEX. 2015;32(4):319–326.
  • Maertens A, Luechtefeld T, Kleensang A, et al. MPTP’s pathway of toxicity indicates central role of transcription factor SP1. Arch Toxicol. Springer Berlin Heidelberg. 2015;89(5):743–775.
  • Maertens A, Bouhifd M, Zhao L, et al. Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis. Arch Toxicol. 2016 Apr 2. published online. DOI: 10.1007/s00204-016-1695-x
  • Rovida C, Asakura C, Daneshian M, et al. Toxicity testing in the 21st century beyond environmental chemicals. ALTEX. 2015;32(1):25–40.
  • Hartung T, Hoffmann S, Stephens M. Mechanistic validation. ALTEX. 2013;30(2):119–130.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.