References
- Giacomini KM, Huang S-M, Tweedie DJ, et al. Membrane transporters in drug development. Nat Rev Drug Discov. 2010;9(3):215–236.
- Cesar-Razquin A, Snijder B, Frappier-Brinton T, et al. A call for systematic research on solute carriers. Cell. 2015;162(3):478–487.
- Wolking S, Schaeffeler E, Lerche H, et al. Impact of genetic polymorphisms of abcb1 (mdr1, p-glycoprotein) on drug disposition and potential clinical implications: update of the literature. Clin Pharmacokinet. 2015;54(7):709–735.
- Neul C, Schaeffeler E, Sparreboom A, et al. Impact of membrane drug transporters on resistance to small-molecule tyrosine kinase inhibitors. Trends Pharmacol Sci. 2016;37(11):904–932.
- Nies AT, Koepsell H, Winter S, et al. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology. 2009;50(4):1227–1240.
- Dujic T, Zhou K, Yee SW, et al. Variants in pharmacokinetic transporters and glycaemic response to metformin: a metgen meta-analysis. Clin Pharmacol Ther. 2016 [2016]. [Epub ahead of print]
- Kozyra M, Ingelman-Sundberg M, Lauschke VM. Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response. Genet Med. 2016;19(1):20–29.
- Schaeffeler E, Hellerbrand C, Nies AT, et al. DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med. 2011;3(12):82.
- Dujic T, Zhou K, Donnelly LA, et al. Association of organic cation transporter 1 with intolerance to metformin in type 2 diabetes: a GoDARTS study. Diabetes. 2015;64(5):1786–1793.
- Chen L, Yee SW, Giacomini KM. OCT1 in hepatic steatosis and thiamine disposition. Cell Cycle. 2015;14(3):283–284.
- Ohishi Y, Nakamuta M, Ishikawa N, et al. Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients. J Gastroenterol. 2014;49(2):332–342.
- Fisel P, Schaeffeler E, Schwab M. DNA methylation of ADME genes. Clin Pharmacol Ther. 2016;99(5):512–527.
- Giacomini KM, Yee SW, Mushiroda T, et al. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Nat Rev Drug Discov. 2017;16(1):1.
- Mann A, Han H, Eyal S. Imaging transporters: transforming diagnostic and therapeutic development. Clin Pharmacol Ther. 2016;100(5):479–488.
- Yee SW, Giacomini MM, Hsueh C-H, et al. Metabolomic and genome-wide association studies reveal potential endogenous biomarkers for OATP1B1. Clin Pharmacol Ther. 2016;100(5):524–536.