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Expert Opinion on Drug Metabolism & Toxicology Volume 13, 2017 - Issue 6
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Articles

Clinical dynamics of Dienogest for the treatment of endometriosis: from bench to bedside

Antonio Simone LaganàUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University of Messina, Messina, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-1543-2802View further author information
ORCID Icon,
Salvatore Giovanni VitaleUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University of Messina, Messina, ItalyView further author information
,
Roberta GraneseUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University of Messina, Messina, ItalyView further author information
,
Vittorio PalmaraUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University of Messina, Messina, ItalyView further author information
,
Helena Ban FrangežDepartment of Reproduction, University Medical Center Ljubljana, Ljubljana, SloveniaView further author information
,
Eda Vrtačnik-BokalDepartment of Reproduction, University Medical Center Ljubljana, Ljubljana, SloveniaView further author information
,
Benito ChiofaloUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University of Messina, Messina, ItalyView further author information
&
Onofrio TrioloUnit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University of Messina, Messina, ItalyView further author information
 show all
Pages 593-596 | Received 26 Sep 2016, Accepted 16 Feb 2017, Published online: 01 Mar 2017

References

  • Dunselman GA, Vermeulen N, Becker C, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29(3):400–412.
  • Laganà AS, Condemi I, Retto G, et al. Analysis of psychopathological comorbidity behind the common symptoms and signs of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2015;194:30–33.
  • Guo SW. Epigenetics of endometriosis. Mol Hum Reprod. 2009;15(10):587–607.
  • Li MQ, Wang Y, Chang KK, et al. CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions. Cell Death Dis. 2014;5:e1436.
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  • Andres Mde P, Lopes LA, Baracat EC, et al. Dienogest in the treatment of endometriosis: systematic review. Arch Gynecol Obstet. 2015;292(3):523–529.
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  • Katayama H, Katayama T, Uematsu K, et al. Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model. Hum Reprod. 2010;25(11):2851–2858.
  • Köhler G, Faustmann TA, Gerlinger C, et al. A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis. Int J Gynaecol Obstet. 2010;108(1):21–25.
  • Momoeda M, Taketani Y. Randomized double-blind, multicentre, parallel-group dose–response study of dienogest in patients with endometriosis. Jpn Pharmacol Ther. 2007;35:769–783.
  • Strowitzki T, Faustmann T, Gerlinger C, et al. Safety and tolerability of dienogest in endometriosis: pooled analysis from the European clinical study program. Int J Womens Health. 2015;7:393–401.
  • Petraglia F, Hornung D, Seitz C, et al. Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment. Arch Gynecol Obstet. 2012;285(1):167–173.
  • Park SY, Kim SH, Chae HD, et al. Efficacy and safety of dienogest in patients with endometriosis: a single-center observational study over 12 months. Clin Exp Reprod Med. 2016;43(4):215–220.
  • Saito F, Tashiro H, Yamaguchi M, et al. Development of a mouse model for testing therapeutic agents: the anticancer effect of dienogest on endometrial neoplasms. Gynecol Endocrinol. 2016;32(5):403–407.

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