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Review

Injectable combination therapies for the management of diabetes: an Indian perspective

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Pages 209-216 | Received 04 Nov 2019, Accepted 24 Feb 2020, Published online: 02 Mar 2020

References

  • Dutta D, Mukhopadhyay S. Intervening at prediabetes stage is critical to controlling the diabetes epidemic among Asian Indians. Indian J Med Res. 2016;143(4):401–404.
  • Mondal SA, Dutta D, Kumar M, et al. Neck circumference to height ratio is a reliable predictor of liver stiffness and nonalcoholic fatty liver disease in prediabetes. Indian J Endocrinol Metab. 2018;22(3):347–354.
  • Dutta D, Mukhopadhyay S. Comment on Anjana et al. incidence of diabetes and prediabetes and predictors of progression among Asian Indians: 10-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care. 2015;38: 1441–1448. Diabetes Care. 2015;38(9):e146.
  • Gupta L, Khandelwal D, Lal PR, et al. factors determining the success of therapeutic lifestyle interventions in diabetes - role of partner and family support. Eur Endocrinol. 2019;15(1):18–24.
  • Dutta D, Shrestha D, Khandelwal D, et al. A 2018 clinical practice pattern in the management of diabetes in India and Nepal: a three-city study. Int J Diabetes Dev Ctries. 2018. DOI:10.1007/s13410-018-0701-7.
  • Bahety P, Agarwal G, Khandelwal D, et al. Occurrence and predictors of depression and poor quality of life among patients with type-2 diabetes: a Northern India perspective. Indian J Endocr Metab. 2017;21:564–569.
  • Chen YH, Li HZ, Tang ZS, et al. Efficacy and safety of premixed human insulin combined with sulfonylureas in type 2 diabetic patients previously poorly controlled with insulin. Diabetes Ther. 2019;10(2):463–471.
  • Liu G, Dou J, Pan Y, et al. Comparison of the effect of glycemic control in type 2 diabetes outpatients treated with premixed and basal insulin monotherapy in China. Front Endocrinol (Lausanne). 2018;9:639.
  • Downie M, Kilov G, Wong J. Initiation and intensification strategies in type 2 diabetes management: a comparison of basal plus and premix regimens. Diabetes Ther. 2016;7(4):641–657.
  • Malone JK, Bai S, Campaigne BN, et al. Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with type 2 diabetes. Diabet Med. 2005;22(4):374–381.
  • Raskin P, Allen E, Hollander P, et al. INITIATE study group initiating insulin therapy in type 2 diabetes: a comparison of biphasic and basal insulin analogs. Diabetes Care. 2005;28(2):260–265.
  • Strojek K, Bebakar WM, Khutsoane DT, et al. Curr once-daily initiation with biphasic insulin aspart 30 versus insulin glargine in patients with type 2 diabetes inadequately controlled with oral drugs: an open-label, multinational RCT. Med Res Opin. 2009;25(12):2887–2894.
  • Davies ML, Pham DQ, Drab SR. GLP1-RA add-on therapy in patients with type 2 diabetes currently on a bolus containing insulin regimen. Pharmacotherapy. 2016;36(8):893–905.
  • Harreiter J, Kosi-Trebotic L, Lukas A, et al. Switch to combined GLP1 receptor agonist lixisenatide with basal insulin glargine in poorly controlled T2DM patients with premixed insulin therapy: a clinical observation and pilot study in nine patients. Diabetes Ther. 2017;8(3):683–692.
  • Kaku K, Araki E, Tanizawa Y, et al. Superior efficacy with the fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with insulin degludec and liraglutide in insulin-naïve Japanese subjects with type 2 diabetes in a phase 3, open-label, randomised trial. Diabetes Obes Metab. 2019 Aug 13. DOI:10.1111/dom.1385.
  • Aroda VR, González-Galvez G, Grøn R, et al. Durability of insulin degludec plus liraglutide versus insulin glargine U100 as initial injectable therapy in type 2 diabetes (DUAL VIII): a multicentre, open-label, phase 3b, randomised controlled trial. Lancet Diabetes Endocrinol. 2019;7(8):596–605.
  • Vilsbøll T, Blevins TC, Jodar E, et al. Fixed-ratio combination of insulin degludec and liraglutide (IDegLira) improves cardiovascular risk markers in patients with type 2 diabetes uncontrolled on basal insulin. Diabetes Obes Metab. 2019;21(6):1506–1512.
  • Drummond R, Malkin S, Du Preez M, et al. The management of type 2 diabetes with fixed-ratio combination insulin degludec/liraglutide (IDegLira) versus basal-bolus therapy (insulin glargine U100 plus insulin aspart): a short-term cost-effectiveness analysis in the UK setting. Diabetes Obes Metab. 2018;20(10):2371–2378.
  • Price H, Blüher M, Prager R, et al. EXTRA study group. use and effectiveness of a fixed-ratio combination of insulin degludec/liraglutide (IDegLira) in a real-world population with type 2 diabetes: results from a European, multicentre, retrospective chart review study. Diabetes Obes Metab. 2018;20(4):954–962.
  • Cai X, Gao X, Yang W, et al. Comparison between insulin degludec/liraglutide treatment and insulin glargine/lixisenatide treatment in type 2 diabetes: a systematic review and meta-analysis. Expert Opin Pharmacother. 2017;18(17):1789–1798.
  • Watada H, Ross Agner BF, Doshi A, et al. IDegLira improves glycemic control in Japanese patients with uncontrolled type 2 diabetes on premixed insulin therapy. Diabetes Ther. 2019 Nov 23. DOI:10.1007/s13300-019-00730-y.
  • Lingvay I, Pérez Manghi F, García-Hernández P, et al. Effect of insulin glargine up-titration vs insulin degludec/liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: the DUAL V randomized clinical trial. JAMA. 2016;315(9):898–907.
  • Linjawi S, Bode BW, Chaykin LB, et al. The efficacy of IDegLira (insulin degludec/Liraglutide combination) in adults with type 2 diabetes inadequately controlled with a GLP-1 receptor agonist and oral therapy: DUAL III randomized clinical trial. Diabetes Ther. 2017;8(1):101–114.
  • Giugliano D, Chiodini P, Maiorino MI, et al. Intensification of insulin therapy with basal-bolus or premixed insulin regimens in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Endocrine. 2016;51(3):417–428.
  • Sun D, Zhang X, Hou XX. Effects of insulin treatment with glargine or premixed insulin lispro programs in type 2 diabetes mellitus patients: a meta-analysis of randomized clinical trials. Diabetes Technol Ther. 2018;20(9):622–627.
  • Deed G, Kilov G, Dunning T, et al. Use of 50/50 premixed insulin analogs in type 2 diabetes: systematic review and clinical recommendations. Diabetes Ther. 2017;8(6):1265–1296.
  • Rendell M. Premix insulins in type 1 diabetes: the coming of degludec/aspart. Expert Opin Drug Metab Toxicol. 2019;15(4):341–348.
  • Patoulias D, Doumas M, Kotsis V, et al. Liraglutide as adjunct to insulin treatment in patients with type 1 diabetes: a systematic review and meta-analysis. Curr Diabetes Rev. 2019 Jun 14. DOI:10.2174/1573399815666190614141918.
  • Chou WY, Li YR, Chan WK, et al. Association of diabetic ketoacidosis, severe hypoglycemia and glycemic control among children and young adults with type 1 diabetes mellitus treated with premixed versus basal-bolus insulin therapy. Biomed J. 2018;41(6):348–355.
  • Unger J. Diabetes management in primary care. Philadelphia, PA, USA: Lippincott Williams & Wilkins; 2013.
  • Novolin mix 70/30 prescribing information. [Cited 2019 Nov 1]. Available from: https://www.novo-pi.com/novolin7030.pdf
  • Novolog mix 70/30 prescribing information. [Cited 2019 Nov 1]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021172s062lbl.pdf
  • Humalog mix 25/75 prescribing information. [Cited 2019 Nov 1]. Available from: http://pi.lilly.com/us/humalog7525-pi.pdf
  • Mixtard prescribing information. [Cited 2019 Nov 1]. Available from: https://www.ema.europa.eu/en/documents/product-information/mixtard-epar-product-information_en.pdf
  • Novolog mix 50/50 prescribing information. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021810s015lbl.pdf
  • Humalog 50/50 mix prescribing information. [Cited 2019 Nov 1]. Available from: http://uspl.lilly.com/humalog5050/humalog5050.html#pi
  • Ryzodec 70/30 prescribing information. [Cited 2019 Nov 1]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/203313s002lbl.pdf
  • Soliqua 100/33 prescribing information. [Cited 2019 Nov 1]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208673s007lbl.pdf
  • Xultophy 100/3.6 prescribing information. [Cited 2019 Nov 1]. Accessed from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208583s000lbl.pdf
  • Das AK, Sahay BK, Seshiah V, et al. Indian National Consensus Group: national guidelines on initiation and intensification of insulin therapy with premixed insulin analogs. API India, medicine update. 2013. Chapter 51:227–236
  • ADA. Standards of medical care in diabetes—2019 abridged for primary care providers. [Cited 2018 Dec 19]. Available from: http://clinical.diabetesjournals.org/content/diaclin/early/2018/12/16/cd18-0105.full.pdf
  • Davies MJ, D’Alessio DA, Fradkin J, et al. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2018;61(12):2461–2498.
  • Garber AJ, Abrahamson MJ, Barzilay JI, et al. Consensus statement by the American association of clinical endocrinologists and American college of endocrinology on the comprehensive type 2 diabetes management algorithm–2019 executive summary. Endocr Pract. 2019;25(1):69–100.
  • Diabetes Canada clinical practice guidelines expert committee. Diabetes Canada 2018 clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes. 2018;42(Suppl 1):S1–S325.
  • Bajaj S. RSSDI clinical practice recommendations for the management of type 2 diabetes mellitus 2017. Int J Diabetes Dev Ctries. 2018;38(Suppl 1):1–115.
  • Kalra S, Czupryniak L, Kilov G, et al. expert opinion: patient selection for premixed insulin formulations in diabetes care. Diabetes Ther. 2018 Dec;9(6):2185–2199.
  • Niskanen L, Leiter LA, Franek E, et al. Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial. Eur J Endocrinol. 2012;167:287–294.
  • Gao F, Ma X, Peng J, et al. The effect of acarbose on glycemic variability in patients with type 2 diabetes mellitus using premixed insulin compared to Metformin (AIM): an open-label randomized trial. Diabetes Technol Ther. 2019 Oct 22. DOI:10.1089/dia.2019.0290.
  • www.1mg/com [homepage on the internet]. New Delhi, India. Actrapid online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/actrapid-hm-100iu-ml-penfill-248417
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  • www.1mg/com [homepage on the internet]. New Delhi, India. Humalog online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/humalog-100iu-ml-solution-for-injection-341834
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  • www.1mg/com [homepage on the internet]. New Delhi, India. Lyxumia online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/lyxumia-20-solution-for-injection-329244
  • www.1mg/com [homepage on the internet]. New Delhi, India. Huminsulin-30/70 online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/huminsulin-30-70-100iu-ml-cartridge-3ml-173414
  • www.1mg/com [homepage on the internet]. New Delhi, India. Novomix-30 online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/novomix-30-100iu-ml-penfill-289278
  • www.1mg/com [homepage on the internet]. New Delhi, India. Humalog-mix-25 online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/humalog-mix-25-100iu-ml-cartridge-341582
  • www.1mg/com [homepage on the internet]. New Delhi, India. Huminsulin-50/50 online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/huminsulin-50-50-injection-100iu-ml-125789
  • www.1mg/com [homepage on the internet]. New Delhi, India. Novomix-50 online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/novomix-50-100iu-ml-penfill-372999
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  • www.1mg/com [homepage on the internet]. New Delhi, India. Ryzodeg online purchase with a valid prescription. [Cited 2019 Nov 1]. Available from: https://www.1mg.com/drugs/ryzodeg-100iu-ml-penfill-342506
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  • Gao Y, Wang K, Chen Y, et al. A real-world anti-diabetes medication cost comparison between premixed insulin analogs and long-acting insulin analogs in Chinese patients with type 2 diabetes: a retrospective database analysis. Diabetes Ther. 2018;9(2):673–682.
  • Kawaguchi Y, Sawa J, Hamai C, et al. Comparison of the efficacy and safety of insulin degludec/aspart (twice-daily injections), insulin glargine 300 U/mL, and insulin glulisine (basal-bolus therapy). J Diabetes Investig. 2019 Mar 13. DOI:10.1111/jdi.13038.
  • Satoh J, Andersen M, Bekker Hansen B, et al. Clinical inertia in basal insulin-treated patients with type 2 diabetes - results from a retrospective database study in Japan (JDDM 43). PLoS One. 2018;13(9):e0198160.
  • Misra A, Mukherjee R, Luthra A, et al. Rising costs of drug/insulin treatment for diabetes: a perspective from India. Diabetes Technol Therapeut. 2017;19(12):693e8.
  • Suzuki K, Aoki C, Kato K, et al. Evaluation of a premixed insulin analog suspension in japanese people with type 2 diabetes and the clinical importance of improved injection techniques: a cross-sectional pilot study. Diabetes Ther. 2017;8(2):445–449.
  • Gupta S, Chattopadhyay T, Pal Singh M, et al. Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus. Proc Natl Acad Sci U S A. 2010;107(30):13246–13251.

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