Wearable electroencephalography for ultra-long-term seizure monitoring: a systematic review and future prospects

References

• Fiest KM, Sauro KM, Wiebe S, et al. Prevalence and incidence of epilepsy: a systematic review and meta-analysis of international studies. Neurology. 2017 Jan 17;88(3):296–303.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Liu X, Xiao Z. Effects of perceived stigma, unemployment and depression on suicidal risk in people with epilepsy. Seizure. 2021 May 14;91:34–39.
   PubMed Web of Science ®Google Scholar
• Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. Lancet Neurol. 2016;15(1):106–115.
   PubMed Web of Science ®Google Scholar
• Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475–482.
   PubMed Web of Science ®Google Scholar
• Fisher RS, Blum DE, DiVentura B, et al. Seizure diaries for clinical research and practice: limitations and future prospects. Epilepsy Behav. 2012 Jul;24(3):304–310.
   PubMed Web of Science ®Google Scholar
• Hoppe C, Poepel A, Elger CE. Epilepsy: accuracy of patient seizure counts. Arch Neurol. 2007 Nov;64(11):1595–1599.
   PubMedGoogle Scholar
• Blachut B, Hoppe C, Surges R, et al. Counting seizures: the primary outcome measure in epileptology from the patients’ perspective. Seizure. 2015 Jul;29:97–103.
   PubMed Web of Science ®Google Scholar
• Cook MJ, O’Brien TJ, Berkovic SF, et al. Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study. Lancet Neurol. 2013;12(6):563–571.
   PubMed Web of Science ®Google Scholar
• Blum DE, Eskola J, Bortz JJ, et al. Patient awareness of seizures. Neurology. 1996 Jul;47(1):260–264.
   PubMed Web of Science ®Google Scholar
• Fattouch J, Di Bonaventura C, Lapenta L, et al. Epilepsy, unawareness of seizures and driving license: the potential role of 24-hour ambulatory EEG in defining seizure freedom. Epilepsy Behav. 2012 Sep;25(1):32–35.
   PubMed Web of Science ®Google Scholar
• Ryvlin P, Ciumas C, Wisniewski I, et al. Wearable devices for sudden unexpected death in epilepsy prevention. Epilepsia. 2018 Jun;59(Suppl 1):61–66.
   PubMedGoogle Scholar
• Harden C, Tomson T, Gloss D, et al. Practice guideline summary: sudden unexpected death in epilepsy incidence rates and risk factors: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsy Curr. 2017 May-Jun;17(3):180–187.
   PubMed Web of Science ®Google Scholar
• Blachut B, Hoppe C, Surges R, et al. Subjective seizure counts by epilepsy clinical drug trial participants are not reliable. Epilepsy Behav. 2017 Feb;67:122–127.
   PubMed Web of Science ®Google Scholar
• Beghi E. The epidemiology of epilepsy. Neuroepidemiology. 2020;54(2):185–191.
   PubMed Web of Science ®Google Scholar
• Zijlmans M, Flanagan D, Gotman J. Heart rate changes and ECG abnormalities during epileptic seizures: prevalence and definition of an objective clinical sign. Epilepsia. 2002 Aug;43(8):847–854.
   PubMed Web of Science ®Google Scholar
• Arends J, Thijs RD, Gutter T, et al. Multimodal nocturnal seizure detection in a residential care setting: a long-term prospective trial. Neurology. 2018 Nov 20;91(21):e2010–e2019.
   PubMed Web of Science ®Google Scholar
• Jeppesen J, Fuglsang-Frederiksen A, Johansen P, et al. Seizure detection using heart rate variability: a prospective validation study. Epilepsia. 2020 Nov;61(Suppl 1):S41–S46.
   PubMedGoogle Scholar
• Onorati F, Regalia G, Caborni C, et al. Multicenter clinical assessment of improved wearable multimodal convulsive seizure detectors. Epilepsia. 2017 Nov;58(11):1870–1879.
   PubMed Web of Science ®Google Scholar
• Regalia G, Onorati F, Lai M, et al. Multimodal wrist-worn devices for seizure detection and advancing research: focus on the Empatica wristbands. Epilepsy Res. 2019 Jul;153:79–82.
   PubMed Web of Science ®Google Scholar
• Beniczky S, Conradsen I, Henning O, et al. Automated real-time detection of tonic-clonic seizures using a wearable EMG device. Neurology. 2018 Jan 30;90(5):e428–e434.
   PubMed Web of Science ®Google Scholar
• Arends JB, van Dorp J, van Hoek D, et al. Diagnostic accuracy of audio-based seizure detection in patients with severe epilepsy and an intellectual disability. Epilepsy Behav. 2016 Sep;62:180–185.
   PubMed Web of Science ®Google Scholar
• Narechania AP, Garić II, Sen-Gupta I, et al. Assessment of a quasi-piezoelectric mattress monitor as a detection system for generalized convulsions. Epilepsy Behav. 2013;28(2):172–176.
   PubMed Web of Science ®Google Scholar
• Geertsema EE, Thijs RD, Gutter T, et al. Automated video-based detection of nocturnal convulsive seizures in a residential care setting. Epilepsia. 2018 Jun;59(Suppl 1):53–60.
   PubMedGoogle Scholar
• Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International league against epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017 Apr;58(4):522–530.
   PubMed Web of Science ®Google Scholar
• Jeppesen J, Fuglsang-Frederiksen A, Johansen P, et al. Seizure detection based on heart rate variability using a wearable electrocardiography device. Epilepsia. 2019 Oct;60(10):2105–2113.
   PubMed Web of Science ®Google Scholar
• Bruno E, Simblett S, Lang A, et al. Wearable technology in epilepsy: the views of patients, caregivers, and healthcare professionals. Epilepsy Behav. 2018 Aug;85:141–149.
   PubMed Web of Science ®Google Scholar
• Hoppe C, Feldmann M, Blachut B, et al. Novel techniques for automated seizure registration: patients’ wants and needs. Epilepsy Behav. 2015 Nov;52(Pt A):1–7.
   PubMedGoogle Scholar
• Duun-Henriksen J, Baud M, Richardson MP, et al. A new era in electroencephalographic monitoring? Subscalp devices for ultra-long-term recordings. Epilepsia. 2020 Sep;61(9):1805–1817.
   PubMed Web of Science ®Google Scholar
• Ryvlin P, Cammoun L, Hubbard I, et al. Noninvasive detection of focal seizures in ambulatory patients. Epilepsia. 2020 Nov;61(Suppl 1):S47–S54.
   PubMedGoogle Scholar
• Beniczky S, Wiebe S, Jeppesen J, et al. Automated seizure detection using wearable devices: a clinical practice guideline of the International league against epilepsy and the International federation of clinical neurophysiology. Epilepsia. 2021 Mar;62(3):632–646.
   PubMed Web of Science ®Google Scholar
• Beniczky S, Jeppesen J. Non-electroencephalography-based seizure detection. Curr Opin Neurol. 2019 Apr;32(2):198–204.
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71.
   PubMed Web of Science ®Google Scholar
• 2020 epilepsy pipeline conference [Internet]; [ cited 2021 Jul 04]. Available from: https://www.epilepsy.com/about-us/research-and-new-therapies/engagement/2020-epilepsy-pipeline-conference
   Google Scholar
• Device-apedia epilepsy foundation [Internet]; [cited 2021 Jul 06]. Available from: https://www.epilepsy.com/deviceapedia-listing-page
   Google Scholar
• Ouzzani M, Hammady H, Fedorowicz Z, et al. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016 Dec 5;5(1):210.
   PubMedGoogle Scholar
• Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011 Oct 18;155(8):529–536.
   PubMed Web of Science ®Google Scholar
• Weisdorf S, Gangstad SW, Duun-Henriksen J, et al. High similarity between EEG from subcutaneous and proximate scalp electrodes in patients with temporal lobe epilepsy. J Neurophysiol. 2018 Sep 1;120(3):1451–1460.
   PubMed Web of Science ®Google Scholar
• Weisdorf S, Duun-Henriksen J, Kjeldsen MJ, et al. Ultra-long-term subcutaneous home monitoring of epilepsy-490 days of EEG from nine patients. Epilepsia. 2019 Nov;60(11):2204–2214.
   PubMed Web of Science ®Google Scholar
• Viana PF, Duun-Henriksen J, Glassteter M, et al. 230 days of ultra long-term subcutaneous EEG: seizure cycle analysis and comparison to patient diary. Ann Clin Transl Neurol. 2021 Jan;8(1):288–293.
   PubMed Web of Science ®Google Scholar
• Minder [Internet]; [cited 2021 Jul 05]. Available from: https://epiminder.com/#system
   Google Scholar
• Minder clinical trial registration [Internet]; [cited 2021 Jul 05]. Available from: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378244
   Google Scholar
• Stirling RE, Maturana MI, Karoly PJ, et al. Seizure forecasting using a novel sub-scalp ultra-long term EEG monitoring system. Front Neurol. 2021;12:713794.
   PubMed Web of Science ®Google Scholar
• Neuroview Technology [Internet]. [cited 2021 Jun 14]. Available from: https://neuroviewtech.com
   Google Scholar
• Bacher D, Amini A, Friedman D, et al. Validation of an EEG seizure detection paradigm optimized for clinical use in a chronically implanted subcutaneous device. J Neurosci Methods. 2021 Jul 1;358:109220.
   PubMed Web of Science ®Google Scholar
• Pacia SV, Doyle WK, Friedman D, et al. Intracranial EEG validation of single-channel subgaleal EEG for seizure identification. J Clin Neurophysiol. 2020 Nov 20. Available from: https://journals.lww.com/clinicalneurophys/Abstract/9000/Intracranial_EEG_Validation_of_Single_Channel.99374.aspx
   PubMedGoogle Scholar
• Epios System [Internet]. [ cited 2021 Jul 05]. Available from: https://wysscenter.ch/advances/epios-brain-monitoring
   Google Scholar
• Epios system clinical trail registration [Internet]; [ cited 2021 Jul 05]. Available from: https://www.clinicaltrials.gov/ct2/show/NCT04796597?term=Epios&draw=2&rank=1
   Google Scholar
• UltimateEEG [Internet]. [cited 2021 Jul 05]. Available from: http://soenia.fi/electrode-implant/
   Google Scholar
• Kravalis K, Schulze-Bonhage A. PIMIDES I: a pilot study to assess the feasibility of patient-controlled neurostimulation with the EASEE(R) system to treat medically refractory focal epilepsy. Neurol Res Pract. 2020;2(1):15.
   PubMedGoogle Scholar
• EASEE [Internet]. [ cited 2021 Jul 05]. Available from: https://precisis.de/en
   Google Scholar
• Frankel MA, Lehmkuhle MJ, Watson M, et al. Electrographic seizure monitoring with a novel, wireless, single-channel EEG sensor. Clin Neurophysiol Pract. 2021;6:172–178.
   PubMedGoogle Scholar
• Nasseri M, Nurse E, Glasstetter M, et al. Signal quality and patient experience with wearable devices for epilepsy management. Epilepsia. 2020 Nov;61(Suppl 1):S25–S35.
   PubMedGoogle Scholar
• Byteflies [Internet]. [ cited 2021 Jul 03]. Available from: https://www.byteflies.com
   Google Scholar
• Sensor dot clinical trial registration [Internet]. [cited 2021 Jul 05]. Available from: https://clinicaltrials.gov/ct2/show/NCT04284072?term=seizeit2&draw=2&rank=1
   Google Scholar
• Swinnen L, Chatzichristos C, Jansen K, et al. Accurate detection of typical absence seizures in adults and children using a two-channel electroencephalographic wearable behind the ears. Epilepsia. 2021 Sep 7;62(11):2741–2752.
   PubMed Web of Science ®Google Scholar
• Vandecasteele K, De Cooman T, Dan J, et al. Visual seizure annotation and automated seizure detection using behind-the-ear electroencephalographic channels. Epilepsia. 2020 Apr;61(4):766–775.
   PubMed Web of Science ®Google Scholar
• Gu Y, Cleeren E, Dan J, et al. Comparison between scalp EEG and behind-the-Ear EEG for development of a wearable seizure detection system for patients with focal epilepsy. Sensors (Basel). 2017 Dec 23;18(1):29.
   Web of Science ®Google Scholar
• Epihunter [Internet]. [cited 2021 Jul 04]. Available from: https://www.epihunter.com
   Google Scholar
• Epihunter Clinical Trial Registration [Internet]. [cited 2021 Jul 04]. Available from: https://clinicaltrials.gov/ct2/show/NCT04615442?term=epihunter&draw=2&rank=1
   Google Scholar
• Bleichner MG, Debener S. Concealed, unobtrusive ear-centered EEG acquisition: cEEGrids for transparent EEG. Front Hum Neurosci. 2017;11:163.
   PubMed Web of Science ®Google Scholar
• Lin SK, Istiqomah WLC, Wang L-C, et al. An ultra-low power smart headband for real-time epileptic seizure detection. IEEE J Transl Eng Health Med. 2018;6:2700410.
   PubMedGoogle Scholar
• Sopic D, Aminifar A, and Atienza D, editors. e-Glass: A Wearable System for Real-Time Detection of Epileptic Seizures, 2018 IEEE International Symposium on Circuits and Systems (ISCAS). 2018 IEEE International Symposium on Circuits and Systems (ISCAS). IEEE. 2018, p. 1–5. doi: https://doi.org/10.1109/ISCAS.2018.8351728.
   Google Scholar
• Looney D, Goverdovsky V, Rosenzweig I, et al. wearable in-ear encephalography sensor for monitoring sleep. Preliminary observations from nap studies. Ann Am Thorac Soc. 2016 Dec;13(12):2229–2233.
   PubMed Web of Science ®Google Scholar
• Zibrandtsen IC, Kidmose P, Christensen CB, et al. Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy - A comparison with scalp EEG monitoring. Clin Neurophysiol. 2017 Dec;128(12):2454–2461.
   PubMed Web of Science ®Google Scholar
• MJN-Seras [Internet]. [cited 2021 Jul 04]. Available from: MJN.cat/en
   Google Scholar
• Bruno E, Viana PF, Sperling MR, et al. Seizure detection at home: do devices on the market match the needs of people living with epilepsy and their caregivers?. Epilepsia. 2020 Nov;61(Suppl 1):S11–S24.
   PubMedGoogle Scholar
• Carvalho D, Mendes T, Dias AI, et al. Interictal spike quantification in continuous spike-wave of sleep (CSWS): clinical usefulness of a wearable EEG device. Epilepsy Behav. 2020 Mar;104(Pt A):106902.
   PubMedGoogle Scholar
• Wright NMK, Madill ES, Isenberg D, et al. Evaluating the utility of rapid response EEG in emergency care. Emerg Med J. 2021 May 26;38(12):923–926.
   PubMed Web of Science ®Google Scholar
• Kamousi B, Grant AM, Bachelder B, et al. Comparing the quality of signals recorded with a rapid response EEG and conventional clinical EEG systems. Clin Neurophysiol Pract. 2019;4:69–75.
   PubMedGoogle Scholar
• Titgemeyer Y, Surges R, Altenmuller DM, et al. Can commercially available wearable EEG devices be used for diagnostic purposes? An explorative pilot study. Epilepsy Behav. 2020 Feb;103(Pt A):106507.
   PubMedGoogle Scholar
• Kutafina E, Brenner A, Titgemeyer Y, et al. Comparison of mobile and clinical EEG sensors through resting state simultaneous data collection. PeerJ. 2020;8:e8969.
   PubMed Web of Science ®Google Scholar
• Biondi A, Laiou P, Bruno E, et al. Remote and long-term self-monitoring of electroencephalographic and noninvasive measurable variables at home in patients with epilepsy (EEG@HOME): protocol for an observational study. JMIR Res Protoc. 2021 Mar 19;10(3):e25309.
   PubMed Web of Science ®Google Scholar
• Heck CN, King-Stephens D, Massey AD, et al. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014 Mar;55(3):432–441.
   PubMed Web of Science ®Google Scholar
• Janse SA, Dumanis SB, Huwig T, et al. Patient and caregiver preferences for the potential benefits and risks of a seizure forecasting device: a best-worst scaling. Epilepsy Behav. 2019 Jul;96:183–191.
   PubMed Web of Science ®Google Scholar
• Karoly PJ, Rao VR, Gregg NM, et al. Cycles in epilepsy. Nat Rev Neurol. 2021 May;17(5):267–284.
   PubMed Web of Science ®Google Scholar
• Karoly PJ, Ung H, Grayden DB, et al. The circadian profile of epilepsy improves seizure forecasting. Brain. 2017 Aug 1;140(8):2169–2182.
   PubMedGoogle Scholar
• Baud MO, Kleen JK, Mirro EA, et al. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018 Jan 8;9(1):88.
   PubMedGoogle Scholar
• Drees C, Makic MB, Case K, et al. skin irritation during video-EEG monitoring. Neurodiagn J. 2016;56(3):139–150.
   PubMedGoogle Scholar
• Morrell MJ. Group RNSSiES. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology.2011 Sep 27;77(13):1295–1304.
   PubMed Web of Science ®Google Scholar
• Weisdorf S, Zibrandtsen IC, Kjaer TW. Subcutaneous EEG monitoring reveals AED response and breakthrough seizures. Case Rep Neurol Med. 2020;2020:8756917.
   PubMed Web of Science ®Google Scholar
• Arbune AA, Jeppesen J, Conradsen I, et al. Peri-ictal heart rate variability parameters as surrogate markers of seizure severity. Epilepsia. 2020 Nov;61(Suppl 1):S55–S60.
   PubMedGoogle Scholar
• Bruno E, Bottcher S, Biondi A, et al. Post-ictal accelerometer silence as a marker of post-ictal immobility. Epilepsia. 2020 Jul;61(7):1397–1405.
   PubMed Web of Science ®Google Scholar
• Fürbass F, Kampusch S, Kaniusas E, et al. Automatic multimodal detection for long-term seizure documentation in epilepsy. Clin Neurophysiol. 2017 Aug;128(8):1466–1472.
   PubMed Web of Science ®Google Scholar
• Cogan D, Birjandtalab J, Nourani M, et al. Multi-biosignal analysis for epileptic seizure monitoring. Int J Neural Syst. 2017 Feb;27(1):1650031.
   PubMed Web of Science ®Google Scholar
• Nadkarni A, Devgun J, Jamal SM, et al. Subcutaneous cardiac rhythm monitors: state of the art review. Expert Rev Med Devices. 2021 Jul;18(7):587–596.
   PubMed Web of Science ®Google Scholar
• Zibrandtsen IC, Kidmose P, Kjaer TW. Detection of generalized tonic-clonic seizures from ear-EEG based on EMG analysis. Seizure. 2018 Jul;59:54–59.
   PubMed Web of Science ®Google Scholar